{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:47:03Z","timestamp":1792813623109,"version":"4.5.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Helsinki University Hospital VTR funding"},{"name":"University of Helsinki including Helsinki University Central Hospital"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs Aging"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1007\/s40266-022-00968-5","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T08:04:57Z","timestamp":1659341097000},"page":"705-713","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Temporal Trends Over Two Decades in the Use of Anticholinergic Drugs Among Older Community-Dwelling People in Helsinki, Finland"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7812-5570","authenticated-orcid":false,"given":"Mikko-Oskari","family":"Rinkinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna-Maria","family":"Roitto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna R.","family":"\u00d6hman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu J.","family":"Kautiainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reijo S.","family":"Tilvis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo E.","family":"Strandberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisu H.","family":"Pitkala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla L.","family":"Aalto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"issue":"67","key":"968_CR1","first-page":"674","volume":"2019","author":"American Geriatrics Society","year":"2019","unstructured":"American Geriatrics Society. updated AGS Beers criteria\u00ae for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2019;2019(67):674\u201394.","journal-title":"J Am Geriatr Soc"},{"key":"968_CR2","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1001\/archinternmed.2007.106","volume":"168","author":"JL Rudolph","year":"2008","unstructured":"Rudolph JL, Salow MJ, Angelini MC, McGlinchey RE. The anticholinergic risk scale and anticholinergic adverse effects in older persons. Arch Intern Med. 2008;168:508\u201313.","journal-title":"Arch Intern Med"},{"key":"968_CR3","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1111\/j.1532-5415.2011.03491.x","volume":"59","author":"C Fox","year":"2011","unstructured":"Fox C, Richardson K, Maidment ID, et al. Anticholinergic medication use and cognitive impairment in the older population: the medical research council cognitive function and ageing study. J Am Geriatr Soc. 2011;59:1477\u201383.","journal-title":"J Am Geriatr Soc"},{"key":"968_CR4","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1007\/s40266-015-0310-9","volume":"32","author":"K Cardwell","year":"2015","unstructured":"Cardwell K, Hughes CM, Ryan C. The association between anticholinergic medication burden and health related outcomes in the \u201coldest old\u201d: a systematic review of the literature. Drugs Aging. 2015;32:835\u201348.","journal-title":"Drugs Aging"},{"key":"968_CR5","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1093\/ageing\/afu096","volume":"43","author":"C Fox","year":"2014","unstructured":"Fox C, Smith T, Maidment I, et al. Effect of medications with anti-cholinergic properties on cognitive function, delirium, physical function and mortality: a systematic review. Age Ageing. 2014;43:604\u201315.","journal-title":"Age Ageing"},{"issue":"1","key":"968_CR6","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/jgs.13206","volume":"63","author":"MS Salahudeen","year":"2015","unstructured":"Salahudeen MS, Hilmer SN, Nishtala PS. Comparison of anticholinergic risk scales and associations with adverse health outcomes in older people. J Am Geriatr Soc. 2015;63(1):85\u201390.","journal-title":"J Am Geriatr Soc"},{"issue":"3","key":"968_CR7","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1345\/aph.1Q597","volume":"46","author":"Y Haasum","year":"2012","unstructured":"Haasum Y, Fastbom J, Johnell K. Institutionalization as a risk factor for inappropriate drug use in the elderly: a Swedish nationwide register-based study. Ann Pharmacother. 2012;46(3):339\u201346.","journal-title":"Ann Pharmacother"},{"issue":"5","key":"968_CR8","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1111\/bcp.12670","volume":"80","author":"LG Pont","year":"2015","unstructured":"Pont LG, Nielen JTH, McLachlan AJ, et al. Measuring anticholinergic drug exposure in older community-dwelling Australian men: a comparison of four different measures. Br J Clin Pharmacol. 2015;80(5):1169\u201375.","journal-title":"Br J Clin Pharmacol"},{"issue":"4","key":"968_CR9","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1093\/ageing\/aft199","volume":"43","author":"D Sumukadas","year":"2014","unstructured":"Sumukadas D, McMurdo MET, Mangoni AA, Guthrie B. Temporal trends in anticholinergic medication prescription in older people: repeated cross-sectional analysis of population prescribing data. Age Ageing. 2014;43(4):515\u201321.","journal-title":"Age Ageing"},{"issue":"7","key":"968_CR10","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1007\/s00228-013-1499-3","volume":"69","author":"CE Dur\u00e1n","year":"2013","unstructured":"Dur\u00e1n CE, Azermai M, Vander Stichele RH. Systematic review of anticholinergic risk scales in older adults. Eur J Clin Pharmacol. 2013;69(7):1485\u201396.","journal-title":"Eur J Clin Pharmacol"},{"issue":"4","key":"968_CR11","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1111\/fcp.12450","volume":"33","author":"SD Germay","year":"2019","unstructured":"Germay SD, Rueter M, Montastruc F, Rousseau V, Lapeyre-Mestre M, Montastruc J. Trends of atropinic (anticholinergic) exposure in the elderly: a 10-year analysis in the french EGB database. Fundam Clin Pharmacol. 2019;33(4):471\u20138.","journal-title":"Fundam Clin Pharmacol"},{"issue":"7","key":"968_CR12","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1111\/jgs.15357","volume":"66","author":"TG Rhee","year":"2018","unstructured":"Rhee TG, Choi YC, Ouellet GM, Ross JS. National prescribing trends for high-risk anticholinergic medications in older adults. J Am Geriatr Soc. 2018;66(7):1382\u20137.","journal-title":"J Am Geriatr Soc"},{"issue":"3","key":"968_CR13","doi-asserted-by":"publisher","first-page":"311","DOI":"10.2217\/1745509X.4.3.311","volume":"4","author":"M Boustani","year":"2008","unstructured":"Boustani M, Campbell N, Munger S, Maidment I, Fox C. Impact of anticholinergics on the aging brain: a review and practical application. Aging health. 2008;4(3):311\u201320.","journal-title":"Aging health"},{"issue":"1","key":"968_CR14","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/s12877-020-01657-x","volume":"20","author":"CM Grossi","year":"2020","unstructured":"Grossi CM, Richardson K, Savva GM, et al. Increasing prevalence of anticholinergic medication use in older people in England over 20 years: cognitive function and ageing study I and II. BMC Geriatr. 2020;20(1):267.","journal-title":"BMC Geriatr"},{"issue":"1","key":"968_CR15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s40266-019-00720-6","volume":"37","author":"UL Aalto","year":"2020","unstructured":"Aalto UL, Roitto H, Finne-Soveri H, Kautiainen H, Pitk\u00e4l\u00e4 KH. Temporal trends in the use of anticholinergic drugs among older people living in long-term care facilities in helsinki. Drugs Aging. 2020;37(1):27\u201334.","journal-title":"Drugs Aging"},{"issue":"3","key":"968_CR16","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1080\/02813432.2017.1358855","volume":"35","author":"H Karppinen","year":"2017","unstructured":"Karppinen H, Pitk\u00e4l\u00e4 KH, Kautiainen H, et al. Changes in disability, self-rated health, comorbidities and psychological wellbeing in community-dwelling 75\u201395-year-old cohorts over two decades in Helsinki. Scand J Prim Health Care. 2017;35(3):279\u201385.","journal-title":"Scand J Prim Health Care"},{"issue":"5","key":"968_CR17","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373\u201383.","journal-title":"J Chronic Dis"},{"key":"968_CR18","unstructured":"WHOCC\u2014ATC\/DDD index (online). 2021. https:\/\/www.whocc.no\/atc_ddd_index\/. Accessed 22 Sep 2021."},{"issue":"3","key":"968_CR19","first-page":"140","volume":"57","author":"E Gorup","year":"2018","unstructured":"Gorup E, Rifel J, Petek\u0161ter M. Anticholinergic burden and most common anticholinergic-acting medicines in older general practice patients. Zdr Varst. 2018;57(3):140\u20137.","journal-title":"Zdr Varst"},{"issue":"11","key":"968_CR20","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1007\/s00228-017-2312-5","volume":"73","author":"M Guti\u00e9rrez-Valencia","year":"2017","unstructured":"Guti\u00e9rrez-Valencia M, Mart\u00ednez-Velilla N, Vetrano D, et al. Anticholinergic burden and health outcomes among older adults discharged from hospital: results from the CRIME study. Eur J Clin Pharmacol. 2017;73(11):1467\u201374.","journal-title":"Eur J Clin Pharmacol"},{"issue":"12","key":"968_CR21","doi-asserted-by":"publisher","first-page":"2797","DOI":"10.1111\/jgs.16776","volume":"68","author":"I Malagaris","year":"2020","unstructured":"Malagaris I, Mehta HB, Li S, Goodwin JS. Decrease of anticholinergic drug use in nursing home residents in the United States, 2009 to 2017. J Am Geriatr Soc. 2020;68(12):2797\u2013804.","journal-title":"J Am Geriatr Soc"},{"issue":"15","key":"968_CR22","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1001\/jama.294.15.1934","volume":"294","author":"LS Schneider","year":"2005","unstructured":"Schneider LS, Dagerman KS, Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA. 2005;294(15):1934\u201343.","journal-title":"JAMA"},{"issue":"2","key":"968_CR23","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/pme.12613","volume":"16","author":"MA Steinman","year":"2015","unstructured":"Steinman MA, Komaiko KDR, Fung KZ, Ritchie CS. Use of opioids and other analgesics by older adults in the United States, 1999\u20132010. Pain Med. 2015;16(2):319\u201327.","journal-title":"Pain Med"},{"issue":"3","key":"968_CR24","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s11916-018-0670-z","volume":"22","author":"N Vadivelu","year":"2018","unstructured":"Vadivelu N, Kai AM, Kodumudi V, Sramcik J, Kaye AD. The opioid crisis: a comprehensive overview. Curr Pain Headache Rep. 2018;22(3):16.","journal-title":"Curr Pain Headache Rep"},{"issue":"3","key":"968_CR25","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1002\/nau.24880","volume":"41","author":"A Sripad","year":"2022","unstructured":"Sripad A, Raker C, Shireman T, Sung V. Overactive bladder medication prescription trends from 2014 to 2018. Neurourol Urodyn. 2022;41(3):806\u201312.","journal-title":"Neurourol Urodyn"}],"container-title":["Drugs & Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-022-00968-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40266-022-00968-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-022-00968-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T06:07:38Z","timestamp":1666073258000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40266-022-00968-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,1]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["968"],"URL":"https:\/\/doi.org\/10.1007\/s40266-022-00968-5","relation":{},"ISSN":["1170-229X","1179-1969"],"issn-type":[{"value":"1170-229X","type":"print"},{"value":"1179-1969","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,1]]},"assertion":[{"value":"14 July 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2022","order":3,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":4,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Brief wording: Missing Open Access funding information has been added in the Funding Note","order":5,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Open access funding provided by University of Helsinki including Helsinki University Central Hospital. This study was supported by the P\u00e4ivikki and Sakari Sohlberg Foundation and Helsinki University Hospital VTR (Valtion tutkimusrahoitus) funding.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors have no conflicts of interest to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The Helsinki Ageing Study received ethical permission from Helsinki University Hospital. The study was conducted according to guidelines of the Declaration of Helsinki.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The participants provided written consent in the questionnaire.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The data are available on request from the corresponding author.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"Not available.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"Design\/conduct of the study (M-OR, HR, HR\u00d6, RST, TES, KHP, ULA); acquisition of subjects and\/or data (M-OR, HJK, RST, TES, KHP, ULA); analysis and interpretation of data (M-OR, HJK, KHP, ULA); preparation of manuscript (M-OR, HR, HR\u00d6, HJK, RST, TES, KHP, ULA). All authors read and approved the final submitted manuscript, and agree to be accountable for the work.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors' contributions"}}]}}