{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:41:09Z","timestamp":1776156069573,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs Aging"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s40266-022-00984-5","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T01:02:33Z","timestamp":1668819753000},"page":"915-921","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Treating Hypertension in Older Adults in Light of the Recent STEP Trial: Can We Implement the Findings in Geriatric Practice?"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6039-5866","authenticated-orcid":false,"given":"Gulistan","family":"Bahat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0994-1152","authenticated-orcid":false,"given":"Serdar","family":"Ozkok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7506-8646","authenticated-orcid":false,"given":"Mirko","family":"Petrovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,19]]},"reference":[{"issue":"22","key":"984_CR1","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1056\/NEJMoa1511939","volume":"373","author":"The SPRINT Research Group","year":"2015","unstructured":"The SPRINT Research Group. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med. 2015;373(22):2103\u201316.","journal-title":"N Engl J Med"},{"issue":"18","key":"984_CR2","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1056\/NEJMoa0801369","volume":"358","author":"NS Beckett","year":"2008","unstructured":"Beckett NS, et al. Treatment of hypertension in patients 80 years of age or older. N Engl J Med. 2008;358(18):1887\u201398.","journal-title":"N Engl J Med"},{"issue":"14","key":"984_CR3","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1056\/NEJMoa2111437","volume":"385","author":"W Zhang","year":"2021","unstructured":"Zhang W, et al. Trial of intensive blood-pressure control in older patients with hypertension. N Engl J Med. 2021;385(14):1268\u201379.","journal-title":"N Engl J Med"},{"issue":"3","key":"984_CR4","doi-asserted-by":"publisher","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","volume":"56","author":"LP Fried","year":"2001","unstructured":"Fried LP, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146\u201356.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"7","key":"984_CR5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102589","volume":"9","author":"CY Wu","year":"2014","unstructured":"Wu CY, et al. Association of body mass index with all-cause and cardiovascular disease mortality in the elderly. PLoS ONE. 2014;9(7): e102589.","journal-title":"PLoS ONE"},{"key":"984_CR6","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3389\/fendo.2014.00121","volume":"5","author":"A Lorenzini","year":"2014","unstructured":"Lorenzini A. How much should we weigh for a long and healthy life span? The need to reconcile caloric restriction versus longevity with body mass index versus mortality data. Front Endocrinol (Lausanne). 2014;5:121.","journal-title":"Front Endocrinol (Lausanne)."},{"key":"984_CR7","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/178780","volume":"2013","author":"S Tringali","year":"2013","unstructured":"Tringali S, Oberer CW, Huang J. Low diastolic blood pressure as a risk for all-cause mortality in VA patients. Int J Hypertens. 2013;2013: 178780.","journal-title":"Int J Hypertens"},{"issue":"5","key":"984_CR8","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1093\/ageing\/afaa028","volume":"49","author":"JAH Masoli","year":"2020","unstructured":"Masoli JAH, et al. Blood pressure in frail older adults: associations with cardiovascular outcomes and all-cause mortality. Age Ageing. 2020;49(5):807\u201313.","journal-title":"Age Ageing"},{"issue":"34","key":"984_CR9","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","volume":"42","author":"FLJ Visseren","year":"2021","unstructured":"Visseren FLJ, et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021;42(34):3227\u2013337.","journal-title":"Eur Heart J"},{"issue":"3","key":"984_CR10","first-page":"272","volume":"16","author":"SE Kocyigit","year":"2019","unstructured":"Kocyigit SE, et al. What is the relationship between frailty and orthostatic hypotension in older adults? J Geriatr Cardiol. 2019;16(3):272\u20139.","journal-title":"J Geriatr Cardiol"},{"key":"984_CR11","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1016\/S1878-7649(15)30034-6","volume":"6","author":"B Ilhan","year":"2015","unstructured":"Ilhan B, et al. O-020: hypotension in nursing home residents on antihypertensive treatment: how significant is it? Eur Geriatric Med. 2015;6:S10\u20131.","journal-title":"Eur Geriatric Med."},{"issue":"6","key":"984_CR12","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s40266-022-00951-0","volume":"39","author":"G Bahat","year":"2022","unstructured":"Bahat G, et al. Hypotension under antihypertensive treatment and incident hospitalizations of nursing home residents. Drugs Aging. 2022;39(6):477\u201384.","journal-title":"Drugs Aging"},{"issue":"11","key":"984_CR13","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1016\/j.jamda.2021.03.004","volume":"22","author":"G Bahat","year":"2021","unstructured":"Bahat G, et al. Hypotension in nursing home residents on antihypertensive treatment: is it associated with mortality? J Am Med Dir Assoc. 2021;22(11):2319-2324.e4.","journal-title":"J Am Med Dir Assoc"},{"issue":"6","key":"984_CR14","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1093\/ageing\/afw120","volume":"45","author":"Y Morrissey","year":"2016","unstructured":"Morrissey Y, et al. Older people remain on blood pressure agents despite being hypotensive resulting in increased mortality and hospital admission. Age Ageing. 2016;45(6):783\u20138.","journal-title":"Age Ageing"},{"issue":"6","key":"984_CR15","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1001\/jamainternmed.2014.8012","volume":"175","author":"A Benetos","year":"2015","unstructured":"Benetos A, et al. Treatment with multiple blood pressure medications, achieved blood pressure, and mortality in older nursing home residents: the PARTAGE study. JAMA Intern Med. 2015;175(6):989\u201395.","journal-title":"JAMA Intern Med"},{"issue":"4","key":"984_CR16","doi-asserted-by":"publisher","first-page":"288","DOI":"10.7326\/L17-0287","volume":"167","author":"G Bahat","year":"2017","unstructured":"Bahat G, et al. Intensive blood pressure treatment in adults aged 60 years or older. Ann Intern Med. 2017;167(4):288.","journal-title":"Ann Intern Med"},{"issue":"7","key":"984_CR17","doi-asserted-by":"publisher","first-page":"e319","DOI":"10.1016\/j.amjmed.2016.12.045","volume":"130","author":"G Bahat","year":"2017","unstructured":"Bahat G, et al. Blood pressure goals in functionally limited elderly patients. Am J Med. 2017;130(7):e319\u201320.","journal-title":"Am J Med"},{"issue":"5","key":"984_CR18","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1007\/s12603-020-1582-2","volume":"25","author":"G Bahat","year":"2021","unstructured":"Bahat G, et al. Success of simpler modified fried frailty scale to predict mortality among nursing home residents. J Nutr Health Aging. 2021;25(5):606\u201310.","journal-title":"J Nutr Health Aging"},{"issue":"7","key":"984_CR19","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1007\/s12603-012-0084-2","volume":"16","author":"JE Morley","year":"2012","unstructured":"Morley JE, Malmstrom TK, Miller DK. A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans. J Nutr Health Aging. 2012;16(7):601\u20138.","journal-title":"J Nutr Health Aging"},{"issue":"4","key":"984_CR20","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1007\/s12603-020-1543-9","volume":"25","author":"G Bahat","year":"2021","unstructured":"Bahat G, et al. SARC-F questionnaire detects frailty in older adults. J Nutr Health Aging. 2021;25(4):448\u201353.","journal-title":"J Nutr Health Aging"},{"issue":"8","key":"984_CR21","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.jamda.2015.04.003","volume":"16","author":"J Woo","year":"2015","unstructured":"Woo J. Walking speed: a summary indicator of frailty? J Am Med Dir Assoc. 2015;16(8):635\u20137.","journal-title":"J Am Med Dir Assoc"},{"issue":"33","key":"984_CR22","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.1093\/eurheartj\/ehy418","volume":"39","author":"R Peters","year":"2018","unstructured":"Peters R, et al. Orthostatic hypotension and symptomatic subclinical orthostatic hypotension increase risk of cognitive impairment: an integrated evidence review and analysis of a large older adult hypertensive cohort. Eur Heart J. 2018;39(33):3135\u201343.","journal-title":"Eur Heart J"}],"container-title":["Drugs &amp; Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-022-00984-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40266-022-00984-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-022-00984-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T18:06:06Z","timestamp":1670522766000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40266-022-00984-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,19]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["984"],"URL":"https:\/\/doi.org\/10.1007\/s40266-022-00984-5","relation":{},"ISSN":["1170-229X","1179-1969"],"issn-type":[{"value":"1170-229X","type":"print"},{"value":"1179-1969","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,19]]},"assertion":[{"value":"12 October 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No external funding was used in the preparation of this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Gulistan Bahat, Serdar Ozkok and Mirko Petrovic declare that they have no potential conflicts of interest that might be relevant to the contents of this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Data sharing is not applicable to this article as no datasets were generated and\/or analyzed during the current study.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"GB: conceptualization, methodology, writing\u2014reviewing and editing. SO: investigation, writing\u2014original draft preparation, writing\u2014reviewing and editing. MP: writing\u2014reviewing and editing.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 contributions"}}]}}