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This research was partially supported by grants of the Geneva University Hospitals\u2019 Projects Research & Development\u2019s (PRD 12-2017-I) and the Swiss Academy of Medical Sciences\u2019 Program for Research in Palliative Care (PC 04\/17).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Nathalie Dieudonn\u00e9 Rahm, Isabelle Zaccaria, B\u00e9atrice Gil Wey, Sophie Pautex, Walid Habre, and Nadia Elia have no conflicts of interest that are directly relevant to the content of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments, has received formal approval from the regulatory authorities, Swissethics (No. 2017-01211) on 26 October, 2017, and Swissmedic (ID 2018DR3056) on 18 May, 2018, and was registered in ClinicalTrials.gov (NCT03151863).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"A signed informed written consent was obtained from all participants or from their legal representative.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The datasets generated and\/or analyzed during the current study are available from the corresponding author on reasonable request.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"Conceptualization: NDR, BGW, NE, WH; design, methodology: NE (lead), NDR, WH, BGW; funding acquisition: NDR, WH, SP; investigation, acquisition of data: NDR; project administration: BGW, NDR; data curation and analysis: IZ; interpretation of results: NE (lead), IZ; drafting the manuscript, writing review and editing: NDR (lead), NE, WH; supervision: WH (sponsor of the trial), NE, SP; revising the manuscript and approval of the final version: all authors; agreement to be accountable for all aspects of the work: all authors.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}