{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:08:57Z","timestamp":1776082137882,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U54AG063546"],"award-info":[{"award-number":["U54AG063546"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs Aging"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1007\/s40266-024-01178-x","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T09:47:53Z","timestamp":1737366473000},"page":"257-265","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An Educational Intervention to Promote Central Nervous System-Active Deprescribing in Dementia: A Pilot Study"],"prefix":"10.1007","volume":"42","author":[{"given":"Noah M.","family":"Barnett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E.","family":"Vordenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Myra","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly","family":"Turnwald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Strominger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda N.","family":"Leggett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Akinyemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic C.","family":"Blow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa","family":"Vanderziel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celeste","family":"Pappas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4740-2640","authenticated-orcid":false,"given":"Donovan T.","family":"Maust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"issue":"12","key":"1178_CR1","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1002\/alz.12362","volume":"17","author":"KB Rajan","year":"2021","unstructured":"Rajan KB, Weuve J, Barnes LL, McAninch EA, Wilson RS, Evans DA. Population estimate of people with clinical Alzheimer\u2019s disease and mild cognitive impairment in the United States (2020\u20132060). Alzheimers Dement. 2021;17(12):1966\u201375.","journal-title":"Alzheimers Dement"},{"key":"1178_CR2","unstructured":"GBD 2019 Dementia Forecasting Collaborators. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. Lancet Public Health. 2022;7(2):e105\u201325."},{"issue":"2","key":"1178_CR3","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/j.1532-5415.2004.52054.x","volume":"52","author":"JPW Bynum","year":"2004","unstructured":"Bynum JPW, Rabins PV, Weller W, Niefeld M, Anderson GF, Wu AW. The relationship between a dementia diagnosis, chronic illness, Medicare expenditures, and hospital use. J Am Geriatr Soc. 2004;52(2):187\u201394.","journal-title":"J Am Geriatr Soc"},{"issue":"5","key":"1178_CR4","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.jalz.2008.02.007","volume":"4","author":"JR Frytak","year":"2008","unstructured":"Frytak JR, Henk HJ, Zhao Y, Bowman L, Flynn JA, Nelson M. Health service utilization among Alzheimer\u2019s disease patients: evidence from managed care. Alzheimers Dement. 2008;4(5):361\u20137.","journal-title":"Alzheimers Dement"},{"issue":"2","key":"1178_CR5","first-page":"294","volume":"38","author":"L Lei","year":"2022","unstructured":"Lei L, Samus QM, Thomas KS, Maust DT. Medication costs and use of older Americans in assisted living settings: a nationally representative cross-sectional study. J Gen Intern Med. 2022;38(2):294\u2013301.","journal-title":"J Gen Intern Med"},{"issue":"7","key":"1178_CR6","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1001\/jama.2020.8519","volume":"324","author":"DT Maust","year":"2020","unstructured":"Maust DT, Strominger J, Bynum JPW, Langa KM, Gerlach LB, Zivin K, Marcus SC. Prevalence of psychotropic and opioid prescription fills among community-dwelling older adults with dementia in the US. JAMA. 2020;324(7):706\u20138.","journal-title":"JAMA"},{"key":"1178_CR7","doi-asserted-by":"crossref","unstructured":"2023 American Geriatrics Society Beers Criteria\u00ae Update Expert Panel. American Geriatrics Society 2023 updated AGS Beers Criteria\u00ae for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2023;71(7):2052\u201381.","DOI":"10.1111\/jgs.18372"},{"key":"1178_CR8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h2698","volume":"350","author":"TW Park","year":"2015","unstructured":"Park TW, Saitz R, Ganoczy D, Ilgen MA, Bohnert ASB. Benzodiazepine prescribing patterns and deaths from drug overdose among US veterans receiving opioid analgesics: case-cohort study. BMJ. 2015;350: h2698.","journal-title":"BMJ"},{"issue":"2","key":"1178_CR9","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/j.1532-5415.2008.02127.x","volume":"57","author":"RM Wright","year":"2009","unstructured":"Wright RM, Roumani YF, Boudreau R, et al. Effect of central nervous system medication use on decline in cognition in community-dwelling older adults: findings from the Health, Aging And Body Composition Study. J Am Geriatr Soc. 2009;57(2):243\u201350.","journal-title":"J Am Geriatr Soc"},{"issue":"6","key":"1178_CR10","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1001\/jamainternmed.2014.949","volume":"174","author":"C Tannenbaum","year":"2014","unstructured":"Tannenbaum C, Martin P, Tamblyn R, Benedetti A, Ahmed S. Reduction of inappropriate benzodiazepine prescriptions among older adults through direct patient education: the EMPOWER cluster randomized trial. JAMA Intern Med. 2014;174(6):890\u20138.","journal-title":"JAMA Intern Med"},{"issue":"6","key":"1178_CR11","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1093\/gerona\/glab377","volume":"77","author":"F Grodstein","year":"2022","unstructured":"Grodstein F, Chang C-H, Capuano AW, Power MC, Marquez DX, Barnes LL, Bennett DA, James BD, Bynum JPW. Identification of dementia in recent Medicare claims data, compared with rigorous clinical assessments. J Gerontol A Biol Sci Med Sci. 2022;77(6):1272\u20138.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"5","key":"1178_CR12","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1001\/jamainternmed.2022.0502","volume":"182","author":"EA Bayliss","year":"2022","unstructured":"Bayliss EA, Shetterly SM, Drace ML, Norton JD, Maiyani M, Gleason KS, et al. Deprescribing education vs usual care for patients with cognitive impairment and primary care clinicians: The OPTIMIZE pragmatic cluster randomized trial. JAMA Intern Med. 2022;182(5):534\u201343.","journal-title":"JAMA Intern Med"},{"issue":"1","key":"1178_CR13","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12877-024-04953-y","volume":"24","author":"CM Hoffman","year":"2024","unstructured":"Hoffman CM, Vordenberg SE, Leggett AN, Akinyemi E, Turnwald M, Maust DT. Insights into designing educational materials for persons living with dementia: a focus group study. BMC Geriatr. 2024;24(1):61.","journal-title":"BMC Geriatr"},{"issue":"1","key":"1178_CR14","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/jgs.15603","volume":"67","author":"SL Aspinall","year":"2019","unstructured":"Aspinall SL, Springer SP, Zhao X, Cunningham FE, Thorpe CT, Semla TP, Shorr RI, Hanlon JT. Central nervous system medication burden and risk of recurrent serious falls and hip fractures in veterans affairs nursing home residents. J Am Geriatr Soc. 2019;67(1):74\u201380.","journal-title":"J Am Geriatr Soc"},{"key":"1178_CR15","unstructured":"Hamilton A. Qualitative methods in rapid turn-around health services research. Health services research & development cyberseminar. 2013. https:\/\/www.hsrd.research.va.gov\/for_researchers\/cyber_seminars\/archives\/780-notes.pdf."},{"issue":"10","key":"1178_CR16","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-019993","volume":"8","author":"B Taylor","year":"2018","unstructured":"Taylor B, Henshall C, Kenyon S, Litchfield I, Greenfield S. Can rapid approaches to qualitative analysis deliver timely, valid findings to clinical leaders? A mixed methods study comparing rapid and thematic analysis. BMJ Open. 2018;8(10): e019993.","journal-title":"BMJ Open"},{"issue":"2","key":"1178_CR17","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1093\/ijpp\/riad001","volume":"31","author":"DA Okeowo","year":"2023","unstructured":"Okeowo DA, Zaidi STR, Fylan B, Alldred DP. Barriers and facilitators of implementing proactive deprescribing within primary care: a systematic review. Int J Pharm Pract. 2023;31(2):126\u201352.","journal-title":"Int J Pharm Pract"},{"issue":"3","key":"1178_CR18","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1111\/jgs.18667","volume":"72","author":"A Silva Almod\u00f3var","year":"2024","unstructured":"Silva Almod\u00f3var A, Keller MS, Lee J, et al. Deprescribing medications among patients with multiple prescribers: a socioecological model. J Am Geriatr Soc. 2024;72(3):660\u20139.","journal-title":"J Am Geriatr Soc"},{"issue":"6","key":"1178_CR19","doi-asserted-by":"publisher","first-page":"e697","DOI":"10.1093\/geront\/gny067","volume":"59","author":"E Mansfield","year":"2019","unstructured":"Mansfield E, Noble N, Sanson-Fisher R, Mazza D, Bryant J. Primary care physicians\u2019 perceived barriers to optimal dementia care: a systematic review. Gerontologist. 2019;59(6):e697\u2013708.","journal-title":"Gerontologist"},{"issue":"13","key":"1178_CR20","doi-asserted-by":"publisher","first-page":"3176","DOI":"10.1007\/s11606-022-07537-x","volume":"37","author":"MS Keller","year":"2022","unstructured":"Keller MS, Vordenberg SE, Steinman MA. Moving deprescribing upstream. J Gen Intern Med. 2022;37(13):3176\u20137.","journal-title":"J Gen Intern Med"},{"issue":"7","key":"1178_CR21","doi-asserted-by":"publisher","first-page":"e98","DOI":"10.1093\/geronb\/gbx138","volume":"73","author":"K Weir","year":"2018","unstructured":"Weir K, Nickel B, Naganathan V, Bonner C, McCaffery K, Carter SM, McLachlan A, Jansen J. Decision-making preferences and deprescribing: perspectives of older adults and companions about their medicines. J Gerontol B Psychol Sci Soc Sci. 2018;73(7):e98\u2013107.","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"issue":"1","key":"1178_CR22","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/bcpt.13911","volume":"134","author":"KR Weir","year":"2024","unstructured":"Weir KR, Scherer AM, Vordenberg SE, Streit S, Jansen J, Jungo KT. The patient typology about deprescribing and medication-related decisions: a quantitative exploration. Basic Clin Pharmacol Toxicol. 2024;134(1):39\u201350.","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"3","key":"1178_CR23","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.pec.2021.06.021","volume":"105","author":"NJ Ailabouni","year":"2022","unstructured":"Ailabouni NJ, Rebecca Weir K, Reeve E, Turner JT, Wilson Norton J, Gray SL. Barriers and enablers of older adults initiating a deprescribing conversation. Patient Educ Couns. 2022;105(3):615\u201324.","journal-title":"Patient Educ Couns"},{"issue":"1","key":"1178_CR24","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s40266-023-01080-y","volume":"41","author":"CM Boyd","year":"2024","unstructured":"Boyd CM, Shetterly SM, Powers JD, et al. Evaluating the safety of an educational deprescribing intervention: lessons from the optimize trial. Drugs Aging. 2024;41(1):45\u201354.","journal-title":"Drugs Aging"},{"issue":"8","key":"1178_CR25","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.37281","volume":"6","author":"KR Weir","year":"2023","unstructured":"Weir KR, Shang J, Choi J, Rana R, Vordenberg SE. Factors important to older adults who disagree with a deprescribing recommendation. JAMA Netw Open. 2023;6(8): e2337281.","journal-title":"JAMA Netw Open"},{"key":"1178_CR26","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-024-08945-x","author":"SE Vordenberg","year":"2024","unstructured":"Vordenberg SE, Kirch M, Singer D, Solway E, Roberts JS, Zikmund-Fisher BJ, Kullgren JT. Interest in medication deprescribing among US adults aged 50\u201380. J Gen Intern Med. 2024. https:\/\/doi.org\/10.1007\/s11606-024-08945-x.","journal-title":"J Gen Intern Med"},{"key":"1178_CR27","doi-asserted-by":"crossref","unstructured":"Choi J, Vordenberg SE. Older adults' perceptions of deprescribing chronic benzodiazepines. J Am Pharm Assoc (2003). 2021;61(5):533\u20138.e3.","DOI":"10.1016\/j.japh.2021.04.003"},{"issue":"8","key":"1178_CR28","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1007\/s11606-007-0205-5","volume":"22","author":"JM Cook","year":"2007","unstructured":"Cook JM, Biyanova T, Masci C, Coyne JC. Older patient perspectives on long-term anxiolytic benzodiazepine use and discontinuation: a qualitative study. J Gen Intern Med. 2007;22(8):1094\u2013100.","journal-title":"J Gen Intern Med"},{"issue":"10","key":"1178_CR29","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1001\/jamainternmed.2024.5632","volume":"184","author":"S Singh","year":"2024","unstructured":"Singh S, Li X, Cocoros NM, et al. High-risk medications in persons living with dementia: a randomized clinical trial. JAMA Intern Med. 2024;184(10):1426\u201333.","journal-title":"JAMA Intern Med"}],"container-title":["Drugs & Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-024-01178-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40266-024-01178-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-024-01178-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T14:02:14Z","timestamp":1741096934000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40266-024-01178-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,20]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["1178"],"URL":"https:\/\/doi.org\/10.1007\/s40266-024-01178-x","relation":{},"ISSN":["1170-229X","1179-1969"],"issn-type":[{"value":"1170-229X","type":"print"},{"value":"1179-1969","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,20]]},"assertion":[{"value":"23 December 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"NIH U54AG063546 (pilot funding to DM) and Michigan Alzheimer\u2019s Disease Center P30AG072931 (AL)","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors have no conflicts of interest to report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This study was conducted with a waiver of informed consent for the main intervention, so participants did not consent to the sharing of their data. Therefore, because of privacy and confidentiality regulations, data are not available on request. The interview guide is available in the supplemental appendix.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"Approved by the Advarra Institutional Review Board (HUM00218048)","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Approved with a waiver of informed consent from patients; clinicians provided consent to participate in interviews.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"H. Myra Kim, Sarah Vordenberg, Amanda Leggett, Esther Akinyemi, Fred Blow, and Donovan Maust contributed to the conception and design of the work. Noah Barnett, Molly Turnwald, Julie Strominger, and Alyssa Vanderziel contributed to analysis and interpretation of the data. N.B., M.T., J.S., S.V., and D.M. drafted this work; all authors reviewed it critically for important intellectual content. All authors provided final approval of the published version and agree to be accountable for all aspects of the work.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}