{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T02:36:09Z","timestamp":1781058969637,"version":"3.54.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004418","name":"Vrije Universiteit Brussel","doi-asserted-by":"publisher","award":["IRP3"],"award-info":[{"award-number":["IRP3"]}],"id":[{"id":"10.13039\/501100004418","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004418","name":"Vrije Universiteit Brussel","doi-asserted-by":"publisher","award":["IRP12"],"award-info":[{"award-number":["IRP12"]}],"id":[{"id":"10.13039\/501100004418","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004418","name":"Vrije Universiteit Brussel","doi-asserted-by":"publisher","award":["IRP22"],"award-info":[{"award-number":["IRP22"]}],"id":[{"id":"10.13039\/501100004418","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs Aging"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1007\/s40266-025-01200-w","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T04:02:17Z","timestamp":1744084937000},"page":"445-456","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Symptoms of Orthostatic Hypotension and Drugs Affecting Autonomic Function are Associated with the Onset of Frailty in Community-Dwelling Persons Aged 80 Years and Above: A Prospective Observational Study"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5752-6498","authenticated-orcid":false,"given":"Aziz","family":"Debain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3252-3247","authenticated-orcid":false,"given":"Fien","family":"Loosveldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerle","family":"Knoop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6229-0742","authenticated-orcid":false,"given":"Axelle","family":"Costenoble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordy","family":"Saren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7506-8646","authenticated-orcid":false,"given":"Mirko","family":"Petrovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6820-9586","authenticated-orcid":false,"given":"Ivan","family":"Bautmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,29]]},"reference":[{"issue":"12","key":"1200_CR1","doi-asserted-by":"publisher","first-page":"116e31","DOI":"10.1016\/j.jamda.2016.09.010","volume":"17","author":"S Vermeiren","year":"2016","unstructured":"Vermeiren S, Vella-Azzopardi R, Beckwee D, Habbig AK, Scafoglieri A, Jansen B, et al. Frailty and the prediction of negative health outcomes: a meta-analysis. J Am Med Dir Assoc. 2016;17(12):116e31\u20131163e17.","journal-title":"J Am Med Dir Assoc"},{"issue":"8","key":"1200_CR2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.8398","volume":"2","author":"R Ofori-Asenso","year":"2019","unstructured":"Ofori-Asenso R, Chin KL, Mazidi M, Zomer E, Ilomaki J, Zullo AR, et al. Global incidence of frailty and prefrailty among community-dwelling older adults: a systematic review and meta-analysis. JAMA Netw Open. 2019;2(8):e198398.","journal-title":"JAMA Netw Open"},{"issue":"10206","key":"1200_CR3","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1016\/S0140-6736(19)31785-4","volume":"394","author":"E Dent","year":"2019","unstructured":"Dent E, Martin FC, Bergman H, Woo J, Romero-Ortuno R, Walston JD. Management of frailty: opportunities, challenges, and future directions. Lancet. 2019;394(10206):1376\u201386.","journal-title":"Lancet"},{"issue":"1","key":"1200_CR4","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1186\/s12877-023-04309-y","volume":"23","author":"AT Kolle","year":"2023","unstructured":"Kolle AT, Lewis KB, Lalonde M, Backman C. Reversing frailty in older adults: a scoping review. BMC Geriatr. 2023;23(1):751.","journal-title":"BMC Geriatr"},{"issue":"3","key":"1200_CR5","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1002\/j.2040-4603.2016.tb00714.x","volume":"6","author":"EA Wehrwein","year":"2016","unstructured":"Wehrwein EA, Orer HS, Barman SM. Overview of the anatomy, physiology, and pharmacology of the autonomic nervous system. Compr Physiol. 2016;6(3):1239\u201378.","journal-title":"Compr Physiol"},{"issue":"2","key":"1200_CR6","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1055\/s-2008-1062263","volume":"28","author":"CM Klein","year":"2008","unstructured":"Klein CM. Evaluation and management of autonomic nervous system disorders. Semin Neurol. 2008;28(2):195\u2013204.","journal-title":"Semin Neurol"},{"issue":"9","key":"1200_CR7","first-page":"539","volume":"66","author":"K Thornton","year":"2017","unstructured":"Thornton K, Mitchell MO. Autonomic dysfunction: a guide for FPs. J Fam Pract. 2017;66(9):539\u201343.","journal-title":"J Fam Pract"},{"issue":"1","key":"1200_CR8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.5114\/aoms.2010.13500","volume":"6","author":"A Zygmunt","year":"2010","unstructured":"Zygmunt A, Stanczyk J. Methods of evaluation of autonomic nervous system function. Arch Med Sci. 2010;6(1):11\u20138.","journal-title":"Arch Med Sci"},{"issue":"3","key":"1200_CR9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.121.010573","volume":"15","author":"A Fedorowski","year":"2022","unstructured":"Fedorowski A, Ricci F, Hamrefors V, Sandau KE, Hwan Chung T, Muldowney JAS, et al. Orthostatic hypotension: management of a complex, but common, medical problem. Circ Arrhythm Electrophysiol. 2022;15(3):e010573.","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"2","key":"1200_CR10","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s10286-011-0119-5","volume":"21","author":"R Freeman","year":"2011","unstructured":"Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011;21(2):69\u201372.","journal-title":"Clin Auton Res"},{"issue":"4","key":"1200_CR11","doi-asserted-by":"publisher","first-page":"814","DOI":"10.36660\/abc.20200420","volume":"116","author":"EA Rocha","year":"2021","unstructured":"Rocha EA, Mehta N, T\u00e1vora-Mehta MZP, Roncari CF, Cidr\u00e3o AAL, Elias NJ. Dysautonomia: a forgotten condition - part 1. Arq Bras Cardiol. 2021;116(4):814\u201335.","journal-title":"Arq Bras Cardiol"},{"key":"1200_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijchy.2020.100071","volume":"8","author":"EM Christopoulos","year":"2021","unstructured":"Christopoulos EM, Tran J, Hillebrand SL, Lange PW, Iseli RK, Meskers CGM, et al. Initial orthostatic hypotension and orthostatic intolerance symptom prevalence in older adults: a systematic review. Int J Cardiol Hypertens. 2021;8:100071.","journal-title":"Int J Cardiol Hypertens."},{"issue":"1","key":"1200_CR13","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12877-019-1082-6","volume":"19","author":"BH Shaw","year":"2019","unstructured":"Shaw BH, Borrel D, Sabbaghan K, Kum C, Yang Y, Robinovitch SN, et al. Relationships between orthostatic hypotension, frailty, falling and mortality in elderly care home residents. BMC Geriatr. 2019;19(1):80.","journal-title":"BMC Geriatr"},{"key":"1200_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101925","volume":"87","author":"A Debain","year":"2023","unstructured":"Debain A, Loosveldt FA, Knoop V, Costenoble A, Lieten S, Petrovic M, et al. Frail older adults are more likely to have autonomic dysfunction: a systematic review and meta-analysis. Ageing Res Rev. 2023;87:101925.","journal-title":"Ageing Res Rev"},{"issue":"3","key":"1200_CR15","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.archger.2015.01.008","volume":"60","author":"MD O\u2019Connell","year":"2015","unstructured":"O\u2019Connell MD, Savva GM, Fan CW, Kenny RA. Orthostatic hypotension, orthostatic intolerance and frailty: the Irish longitudinal study on aging-TILDA. Arch Gerontol Geriatr. 2015;60(3):507\u201313.","journal-title":"Arch Gerontol Geriatr"},{"issue":"1","key":"1200_CR16","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/s43587-020-00017-z","volume":"1","author":"LP Fried","year":"2021","unstructured":"Fried LP, Cohen AA, Xue QL, Walston J, Bandeen-Roche K, Varadhan R. The physical frailty syndrome as a transition from homeostatic symphony to cacophony. Nat Aging. 2021;1(1):36\u201346.","journal-title":"Nat Aging"},{"key":"1200_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2023.112333","volume":"184","author":"RS Zeidan","year":"2023","unstructured":"Zeidan RS, McElroy T, Rathor L, Martenson MS, Lin Y, Mankowski RT. Sex differences in frailty among older adults. Exp Gerontol. 2023;184:112333.","journal-title":"Exp Gerontol"},{"key":"1200_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2022.104880","volume":"106","author":"DC de Oliveira","year":"2023","unstructured":"de Oliveira DC, Maximo RO, Ramirez PC, de Souza AF, Luiz MM, Delinocente MLB, et al. Does the incidence of frailty differ between men and women over time? Arch Gerontol Geriatr. 2023;106:104880.","journal-title":"Arch Gerontol Geriatr"},{"issue":"1","key":"1200_CR19","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12877-024-04785-w","volume":"24","author":"YW Lu","year":"2024","unstructured":"Lu YW, Chang CC, Chou RH, Lee WJ, Chen LK, Huang PH, et al. Sex differences in the frailty phenotype and mortality in the I-Lan longitudinal aging study cohort. BMC Geriatr. 2024;24(1):182.","journal-title":"BMC Geriatr"},{"issue":"1","key":"1200_CR20","doi-asserted-by":"publisher","first-page":"7341","DOI":"10.1038\/s41598-022-11358-7","volume":"12","author":"N Mielke","year":"2022","unstructured":"Mielke N, Schneider A, Huscher D, Ebert N, Schaeffner E. Gender differences in frailty transition and its prediction in community-dwelling old adults. Sci Rep. 2022;12(1):7341.","journal-title":"Sci Rep"},{"issue":"2","key":"1200_CR21","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1177\/0733464821991007","volume":"41","author":"A Costenoble","year":"2022","unstructured":"Costenoble A, Knoop V, Debain A, Vermeiren S, Vella Azzopardi R, Rossi G, et al. Prefrailty: the relationship between daily activities and social participation in older persons. J Appl Gerontol. 2022;41(2):430\u201340.","journal-title":"J Appl Gerontol"},{"issue":"8","key":"1200_CR22","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1093\/gerona\/glac224","volume":"78","author":"V Knoop","year":"2023","unstructured":"Knoop V, Costenoble A, Debain A, Bravenboer B, Jansen B, Scafoglieri A, et al. Muscle endurance and self-perceived fatigue predict decline in gait speed and activities of daily living after 1-year follow-up: results from the BUTTERFLY study. J Gerontol A Biol Sci Med Sci. 2023;78(8):1402\u20139.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"6","key":"1200_CR23","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.mad.2012.05.005","volume":"133","author":"J Collerton","year":"2012","unstructured":"Collerton J, Martin-Ruiz C, Davies K, Hilkens CM, Isaacs J, Kolenda C, et al. Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85+ study. Mech Ageing Dev. 2012;133(6):456\u201366.","journal-title":"Mech Ageing Dev"},{"issue":"3","key":"1200_CR24","doi-asserted-by":"publisher","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","volume":"56","author":"LP Fried","year":"2001","unstructured":"Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146\u201356.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"1200_CR25","first-page":"236","volume":"41","author":"N Steverink","year":"2001","unstructured":"Steverink N, Slaets J, Schuurmans H, Lis M. Measuring frailty: developing and testing the GFI (Groningen Frailty Indicator). Gerontologist. 2001;41:236\u20137.","journal-title":"Gerontologist"},{"key":"1200_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2021.111440","volume":"152","author":"V Knoop","year":"2021","unstructured":"Knoop V, Costenoble A, Debain A, Vella Azzopardi R, Vermeiren S, van Laere S, et al. The interrelationship between grip work, self-perceived fatigue and pre-frailty in community-dwelling octogenarians. Exp Gerontol. 2021;152:111440.","journal-title":"Exp Gerontol"},{"issue":"9","key":"1200_CR27","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s12603-011-0131-4","volume":"15","author":"J Sirola","year":"2011","unstructured":"Sirola J, Pitkala KH, Tilvis RS, Miettinen TA, Strandberg TE. Definition of frailty in older men according to questionnaire data (RAND-36\/SF-36): the Helsinki businessmen study. J Nutr Health Aging. 2011;15(9):783\u20137.","journal-title":"J Nutr Health Aging"},{"issue":"2","key":"1200_CR28","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1123\/japa.2021-0366","volume":"32","author":"V Knoop","year":"2023","unstructured":"Knoop V, Costenoble A, Debain A, Van der Meulen K, De Vriendt P, Gorus E, et al. Impact of COVID-19 on physical activity, fatigue, and frailty in community-dwelling older adults: a cross-sectional study. J Aging Phys Act. 2023;32(2):172\u201384.","journal-title":"J Aging Phys Act"},{"issue":"21\u201322","key":"1200_CR29","doi-asserted-by":"publisher","first-page":"3914","DOI":"10.1111\/jocn.14976","volume":"28","author":"AF Bolina","year":"2019","unstructured":"Bolina AF, Gomes NC, Marchiori GF, Pegorari MS, Tavares D. Potentially inappropriate medication use and frailty phenotype among community-dwelling older adults: a population-based study. J Clin Nurs. 2019;28(21\u201322):3914\u201322.","journal-title":"J Clin Nurs"},{"issue":"9","key":"1200_CR30","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-029221","volume":"9","author":"R Lim","year":"2019","unstructured":"Lim R, Kalisch Ellett LM, Widagdo IS, Pratt NL, Roughead EE. Analysis of anticholinergic and sedative medicine effects on physical function, cognitive function, appetite and frailty: a cross-sectional study in Australia. BMJ Open. 2019;9(9):e029221.","journal-title":"BMJ Open"},{"issue":"9921","key":"1200_CR31","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/S0140-6736(13)61752-3","volume":"383","author":"SS Mahmood","year":"2014","unstructured":"Mahmood SS, Levy D, Vasan RS, Wang TJ. The Framingham heart study and the epidemiology of cardiovascular disease: a historical perspective. Lancet. 2014;383(9921):999\u20131008.","journal-title":"Lancet"},{"issue":"3","key":"1200_CR32","doi-asserted-by":"publisher","first-page":"e275","DOI":"10.7861\/clinmed.2020-1044","volume":"21","author":"M Dani","year":"2021","unstructured":"Dani M, Dirksen A, Taraborrelli P, Panagopolous D, Torocastro M, Sutton R, et al. Orthostatic hypotension in older people: considerations, diagnosis and management. Clin Med (Lond). 2021;21(3):e275\u201382.","journal-title":"Clin Med (Lond)"},{"issue":"7","key":"1200_CR33","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1111\/ggi.12553","volume":"16","author":"J Frith","year":"2016","unstructured":"Frith J, Newton JL. Validation of a questionnaire for orthostatic hypotension for routine clinical use. Geriatr Gerontol Int. 2016;16(7):785\u201390.","journal-title":"Geriatr Gerontol Int"},{"issue":"2","key":"1200_CR34","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1080\/03602530902722679","volume":"41","author":"U Klotz","year":"2009","unstructured":"Klotz U. Pharmacokinetics and drug metabolism in the elderly. Drug Metab Rev. 2009;41(2):67\u201376.","journal-title":"Drug Metab Rev"},{"issue":"2","key":"1200_CR35","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1093\/ageing\/afu145","volume":"44","author":"D O\u2019Mahony","year":"2015","unstructured":"O\u2019Mahony D, O\u2019Sullivan D, Byrne S, O\u2019Connor MN, Ryan C, Gallagher P. STOPP\/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing. 2015;44(2):213\u20138.","journal-title":"Age Ageing"},{"key":"1200_CR36","doi-asserted-by":"crossref","unstructured":"American Geriatrics Society. By the expert panel 2023 Beers Criteria\u00ae Update Expert Panel. American Geriatrics Society 2023 updated AGS Beers Criteria\u00ae for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2023;71(7):2052\u201381.","DOI":"10.1111\/jgs.18372"},{"issue":"1\u20132","key":"1200_CR37","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/S1566-0702(01)00276-4","volume":"90","author":"JL Elghozi","year":"2001","unstructured":"Elghozi JL, Girard A, Laude D. Effects of drugs on the autonomic control of short-term heart rate variability. Auton Neurosci. 2001;90(1\u20132):116\u201321.","journal-title":"Auton Neurosci"},{"issue":"1","key":"1200_CR38","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1186\/s12872-021-02081-8","volume":"21","author":"Z Xie","year":"2021","unstructured":"Xie Z, Zhang J, Wang C, Yan X. Chronotherapy for morning blood pressure surge in hypertensive patients: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2021;21(1):274.","journal-title":"BMC Cardiovasc Disord"}],"container-title":["Drugs &amp; Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-025-01200-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40266-025-01200-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-025-01200-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T13:42:08Z","timestamp":1746452528000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40266-025-01200-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,29]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["1200"],"URL":"https:\/\/doi.org\/10.1007\/s40266-025-01200-w","relation":{},"ISSN":["1170-229X","1179-1969"],"issn-type":[{"value":"1170-229X","type":"print"},{"value":"1179-1969","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,29]]},"assertion":[{"value":"6 March 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study is partly funded by an \u201cInterdisciplinary Research Program\u201d grant (grant no. IRP3, IRP12, and IRP22) from the research council of the Vrije Universiteit Brussel (VUB). The funders had no role in the study design, collection, analyses, interpretation of the data, writing the manuscript, or the decision to publish the results.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Each participant gave written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"Financial: The authors declare they have no financial interests. Non-financial: Mirko PETROVIC is an Editorial Board Member of Drugs and Aging. Mirko PETROVIC was not involved in the selection of peer reviewers for the manuscript, nor in the subsequent editorial decisions.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The ethics committee of the University Hospital of Brussels (UZ Brussels, Jette) gave permission for this study (B.U.N. 143201421976).","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Ivan Bautmans conceived the study and secured the funding. Aziz Debain, Fien Loosveldt, Veerle Knoop, and Axelle Costenoble contributed to the data collection. Aziz Debain, Fien Loosveldt, Jordy Saren, and Ivan Bautmans contributed to the data analysis and interpretation. Aziz Debain wrote the original manuscript draft. Fien Loosveldt, Veerle Knoop, Axelle Costenoble, Jordy Saren, Mirko Petrovic, and Ivan Bautmans commented on previous versions of the manuscript. All authors read and approved the final manuscript.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}},{"value":"The datasets and\/or data analyses used during the current study are available from the corresponding author upon reasonable request.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}}]}}