{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:32:31Z","timestamp":1793410351718,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"SAMWASSM","award":["Grant Nr. YTCR 25\/19"],"award-info":[{"award-number":["Grant Nr. YTCR 25\/19"]}]},{"name":"SAMWASSM","award":["SAMWASSM"],"award-info":[{"award-number":["SAMWASSM"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs Aging"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s40266-026-01285-x","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:39:32Z","timestamp":1773315572000},"page":"425-432","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Harms of Continued Antihypertensives: An Overview of Reviews"],"prefix":"10.1007","volume":"43","author":[{"given":"Carmen","family":"Floriani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Edith","family":"Schulthess-Lisibach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Zangger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"von Gernler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja Josephine Lundberg","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Streit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"issue":"7","key":"1285_CR1","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1161\/CIRCRESAHA.118.313236","volume":"124","author":"A Benetos","year":"2019","unstructured":"Benetos A, Petrovic M, Strandberg T. Hypertension management in older and frail older patients. Circ Res. 2019;124(7):1045\u201360.","journal-title":"Circ Res"},{"issue":"22","key":"1285_CR2","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1056\/NEJMoa1511939","volume":"373","author":"The SPRINT Research Group","year":"2015","unstructured":"The SPRINT Research Group. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med. 2015;373(22):2103\u201316.","journal-title":"N Engl J Med"},{"issue":"3","key":"1285_CR3","doi-asserted-by":"publisher","first-page":"171","DOI":"10.2165\/00002512-199405030-00003","volume":"5","author":"CJ Bulpitt","year":"1994","unstructured":"Bulpitt CJ, Fletcher AE, Amery A, Coope J, Evans JG, Lightowlers S, et al. The hypertension in the very elderly trial (HYVET). Rationale, methodology and comparison with previous trials. Drugs Aging. 1994;5(3):171\u201383.","journal-title":"Drugs Aging"},{"key":"1285_CR4","doi-asserted-by":"crossref","unstructured":"Bogaerts JMK, von Ballmoos LM, Achterberg WP, Gussekloo J, Streit S, van der Ploeg MA, et al. Do we AGREE on the targets of antihypertensive drug treatment in older adults: a systematic review of guidelines on primary prevention of cardiovascular diseases. Age Ageing. 2021;51(1):afab192.","DOI":"10.1093\/ageing\/afab192"},{"issue":"8","key":"1285_CR5","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s40266-022-00957-8","volume":"39","author":"MH Duong","year":"2022","unstructured":"Duong MH, Gnjidic D, McLachlan AJ, Sakiris MA, Goyal P, Hilmer SN. The prevalence of adverse drug reactions and adverse drug events from heart failure medications in frail older adults: a systematic review. Drugs Aging. 2022;39(8):631\u201343.","journal-title":"Drugs Aging"},{"key":"1285_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012565.pub2","author":"S Safi","year":"2021","unstructured":"Safi S, Sethi NJ, Korang SK, Nielsen EE, Feinberg J, Gluud C, et al. Beta-blockers in patients without heart failure after myocardial infarction. Cochrane Heart Group, editor. Cochrane Database Syst Rev Internet. 2021. https:\/\/doi.org\/10.1002\/14651858.CD012565.pub2.","journal-title":"Cochrane Database Syst Rev Internet."},{"issue":"5","key":"1285_CR7","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.jacc.2016.10.077","volume":"69","author":"C Bavishi","year":"2017","unstructured":"Bavishi C, Bangalore S, Messerli FH. Outcomes of intensive blood pressure lowering in older hypertensive patients. J Am Coll Cardiol. 2017;69(5):486\u201393.","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"1285_CR8","doi-asserted-by":"publisher","first-page":"895","DOI":"10.2165\/00002018-200326120-00004","volume":"26","author":"A Agusti","year":"2003","unstructured":"Agusti A, Bonet S, M Arnau J, Vidal X, Laporte JR. Adverse effects of ACE inhibitors in patients with chronic heart failure and\/or ventricular dysfunction: meta-analysis of randomised clinical trials. Drug Saf. 2003;26(12):895\u2013908.","journal-title":"Drug Saf"},{"issue":"9","key":"1285_CR9","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-026686","volume":"9","author":"M Brunstr\u00f6m","year":"2019","unstructured":"Brunstr\u00f6m M, Carlberg B. Benefits and harms of lower blood pressure treatment targets: systematic review and meta-analysis of randomised placebo-controlled trials. BMJ Open. 2019;9(9):e026686.","journal-title":"BMJ Open"},{"issue":"11","key":"1285_CR10","doi-asserted-by":"publisher","first-page":"895","DOI":"10.7326\/M20-2037","volume":"173","author":"KE D\u2019Anci","year":"2020","unstructured":"D\u2019Anci KE, Tipton K, Hedden-Gross A, Rouse B, Hermanson L, Fontanarosa J. Effect of intensive blood pressure lowering on cardiovascular outcomes: a systematic review prepared for the 2020 U.S. Department of Veterans Affairs\/U.S. Department of Defense Guidelines. Ann Intern Med. 2020;173(11):895\u2013903.","journal-title":"Ann Intern Med"},{"issue":"1","key":"1285_CR11","doi-asserted-by":"publisher","first-page":"f360","DOI":"10.1136\/bmj.f360","volume":"346","author":"H Makani","year":"2013","unstructured":"Makani H, Bangalore S, Desouza KA, Shah A, Messerli FH. Efficacy and safety of dual blockade of the renin-angiotensin system: meta-analysis of randomised trials. BMJ. 2013;346(jan28 1):f360.","journal-title":"BMJ"},{"issue":"8","key":"1285_CR12","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/j.amjcard.2007.05.057","volume":"100","author":"S Bangalore","year":"2007","unstructured":"Bangalore S, Parkar S, Grossman E, Messerli FH. A meta-analysis of 94,492 patients with hypertension treated with beta blockers to determine the risk of new-onset diabetes mellitus. Am J Cardiol. 2007;100(8):1254\u201362.","journal-title":"Am J Cardiol"},{"key":"1285_CR13","doi-asserted-by":"crossref","unstructured":"Aubert CE, Ha J, Kim HM, Rodondi N, Kerr EA, Hofer TP, et al. Clinical outcomes of modifying hypertension treatment intensity in older adults treated to low blood pressure. J Am Geriatr Soc. 2021;69(10):2831\u201341.","DOI":"10.1111\/jgs.17295"},{"issue":"1","key":"1285_CR14","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/j.1532-5415.1999.tb01899.x","volume":"47","author":"RM Leipzig","year":"1999","unstructured":"Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: a systematic review and meta\u2010analysis: II. Cardiac and analgesic drugs. J Am Geriatr Soc. 1999;47(1):40\u201350.","journal-title":"J Am Geriatr Soc"},{"key":"1285_CR15","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.gerinurse.2023.05.009","volume":"52","author":"X Bai","year":"2023","unstructured":"Bai X, Han B, Zhang M, Liu J, Cui Y, Jiang H. The association between diuretics and falls in older adults: a systematic review and meta-analysis. Geriatr Nurs. 2023;52:106\u201314.","journal-title":"Geriatr Nurs"},{"issue":"7","key":"1285_CR16","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s40266-018-0561-3","volume":"35","author":"HT Ang","year":"2018","unstructured":"Ang HT, Lim KK, Kwan YH, Tan PS, Yap KZ, Banu Z, et al. A systematic review and meta-analyses of the association between anti-hypertensive classes and the risk of falls among older adults. Drugs Aging. 2018;35(7):625\u201335.","journal-title":"Drugs Aging"},{"key":"1285_CR17","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n189","volume":"10","author":"A Albasri","year":"2021","unstructured":"Albasri A, Hattle M, Koshiaris C, Dunnigan A, Paxton B, Fox SE, et al. Association between antihypertensive treatment and adverse events: systematic review and meta-analysis. BMJ. 2021;10:n189.","journal-title":"BMJ"},{"issue":"24","key":"1285_CR18","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022240","volume":"10","author":"D Tharmaratnam","year":"2021","unstructured":"Tharmaratnam D, Karayiannis CC, Collyer TA, Arima H, McClure LA, Chalmers J, et al. Is blood pressure lowering in the very elderly with previous stroke associated with a higher risk of adverse events? J Am Heart Assoc. 2021;10(24):e022240.","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"1285_CR19","doi-asserted-by":"publisher","first-page":"58","DOI":"10.7326\/M20-4298","volume":"174","author":"SP Juraschek","year":"2021","unstructured":"Juraschek SP, Hu JR, Cluett JL, Ishak A, Mita C, Lipsitz LA, et al. Effects of intensive blood pressure treatment on orthostatic hypotension\u202f: a systematic review and individual participant-based meta-analysis. Ann Intern Med. 2021;174(1):58\u201368.","journal-title":"Ann Intern Med"},{"issue":"3","key":"1285_CR20","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1007\/s12020-016-1201-5","volume":"55","author":"YZ Cheng","year":"2017","unstructured":"Cheng YZ, Huang ZZ, Shen ZF, Wu HY, Peng JX, Waye MMY, et al. ACE inhibitors and the risk of fractures: a meta-analysis of observational studies. Endocrine. 2017;55(3):732\u201340.","journal-title":"Endocrine"},{"issue":"5","key":"1285_CR21","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.bone.2012.07.013","volume":"51","author":"S Yang","year":"2012","unstructured":"Yang S, Nguyen ND, Eisman JA, Nguyen TV. Association between beta-blockers and fracture risk: a Bayesian meta-analysis. Bone. 2012;51(5):969\u201374.","journal-title":"Bone"},{"issue":"9","key":"1285_CR22","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1111\/nep.12134","volume":"18","author":"Y He","year":"2013","unstructured":"He Y, Feng L, Huo D, Yang Z, Liao Y. Enalapril versus losartan for adults with chronic kidney disease: a systematic review and meta\u2010analysis. Nephrology. 2013;18(9):605\u201314.","journal-title":"Nephrology"},{"issue":"4","key":"1285_CR23","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1097\/MBP.0b013e32833a23d4","volume":"15","author":"Y Lv","year":"2010","unstructured":"Lv Y, Zou Z, Chen G, Jia HX, Zhong J, Fang WW. Amlodipine and angiotensin-converting enzyme inhibitor combination versus amlodipine monotherapy in hypertension: a meta-analysis of randomized controlled trials. Blood Press Monit. 2010;15(4):195\u2013204.","journal-title":"Blood Press Monit"},{"issue":"2","key":"1285_CR24","doi-asserted-by":"publisher","first-page":"131","DOI":"10.2165\/00002512-200825020-00005","volume":"25","author":"MR Andrus","year":"2008","unstructured":"Andrus MR, Loyed JV. Use of \u03b2-adrenoceptor antagonists in older patients with chronic obstructive pulmonary disease and cardiovascular co-morbidity: safety issues. Drugs Aging. 2008;25(2):131\u201344.","journal-title":"Drugs Aging"},{"issue":"1","key":"1285_CR25","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1177\/10600280221098121","volume":"57","author":"V Rotshild","year":"2023","unstructured":"Rotshild V, Rabkin N, Matok I. The risk for prostate cancer with calcium channel blockers: a systematic review, meta-analysis, and meta-regression. Ann Pharmacother. 2023;57(1):16\u201328.","journal-title":"Ann Pharmacother"},{"issue":"3","key":"1285_CR26","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1001\/jamadermatol.2021.5866","volume":"158","author":"K Bommareddy","year":"2022","unstructured":"Bommareddy K, Hamade H, Lopez-Olivo MA, Wehner M, Tosh T, Barbieri JS. Association of spironolactone use with risk of cancer: a systematic review and meta-analysis. JAMA Dermatol. 2022;158(3):275.","journal-title":"JAMA Dermatol"},{"issue":"1","key":"1285_CR27","doi-asserted-by":"publisher","first-page":"60","DOI":"10.2174\/0127724328291047240409062436","volume":"20","author":"R Rahimi","year":"2025","unstructured":"Rahimi R, Hashemi Rafsanjani SMR, Heidari-Soureshjani S, Sherwin CMT, Kasiri K. The association between use of renin-angiotensin-aldosterone system inhibitors and the risk and mortality of pancreatic cancer: a systematic review and meta-analysis. Curr Rev Clin Exp Pharmacol. 2025;20(1):60\u201371.","journal-title":"Curr Rev Clin Exp Pharmacol"},{"issue":"2","key":"1285_CR28","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/s41416-022-02029-5","volume":"128","author":"Z Wu","year":"2023","unstructured":"Wu Z, Yao T, Wang Z, Liu B, Wu N, Lu M, et al. Association between angiotensin-converting enzyme inhibitors and the risk of lung cancer: a systematic review and meta-analysis. Br J Cancer. 2023;128(2):168\u201376.","journal-title":"Br J Cancer"},{"issue":"6","key":"1285_CR29","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1007\/s00228-022-03299-x","volume":"78","author":"AC De Macedo Andrade","year":"2022","unstructured":"De Macedo Andrade AC, Felix FA, Fran\u00e7a GM, Ribeiro ILA, Barboza CAG, De Castro RD, et al. Hydrochlorothiazide use is associated with the risk of cutaneous and lip squamous cell carcinoma: a systematic review and meta-analysis. Eur J Clin Pharmacol. 2022;78(6):919\u201330.","journal-title":"Eur J Clin Pharmacol"},{"issue":"9","key":"1285_CR30","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.33353","volume":"6","author":"MJ Lennon","year":"2023","unstructured":"Lennon MJ, Lam BCP, Lipnicki DM, Crawford JD, Peters R, Schutte AE, et al. Use of Antihypertensives, blood pressure, and estimated risk of dementia in late life: an individual participant data meta-analysis. JAMA Netw Open. 2023;6(9):e2333353.","journal-title":"JAMA Netw Open"},{"key":"1285_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1043714","volume":"13","author":"\u0141 Wo\u0142owiec","year":"2023","unstructured":"Wo\u0142owiec \u0141, Grze\u015bk G, Osiak J, Wijata A, M\u0119dlewska M, Gaborek P, et al. Beta-blockers in cardiac arrhythmias-clinical pharmacologist\u2019s point of view. Front Pharmacol. 2023;13:1043714. https:\/\/doi.org\/10.3389\/fphar.2022.1043714.","journal-title":"Front Pharmacol"},{"key":"1285_CR32","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.hjc.2024.09.007","volume":"83","author":"W Widiarti","year":"2025","unstructured":"Widiarti W, Saputra PBT, Savitri CG, Putranto JNE, Alkaff FF. The impact of cardiovascular drugs on hyperglycemia and diabetes: a review of \u2018unspoken\u2019 side effects. Hellenic J Cardiol. 2025;83:71\u20137. https:\/\/doi.org\/10.1016\/j.hjc.2024.09.007.","journal-title":"Hellenic J Cardiol"},{"issue":"4","key":"1285_CR33","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1111\/dom.14295","volume":"23","author":"DSH Bell","year":"2021","unstructured":"Bell DSH, Goncalves E. Diabetogenic effects of cardioprotective drugs. Diabetes Obes Metab. 2021;23(4):877\u201385. https:\/\/doi.org\/10.1111\/dom.14295.","journal-title":"Diabetes Obes Metab"},{"issue":"6","key":"1285_CR34","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1001\/jamainternmed.2024.0507","volume":"184","author":"CV Dave","year":"2024","unstructured":"Dave CV, Li Y, Steinman MA, Lee SJ, Liu X, Jing B, et al. Antihypertensive medication and fracture risk in older veterans health administration nursing home residents. JAMA Intern Med. 2024;184(6):661.","journal-title":"JAMA Intern Med"},{"key":"1285_CR35","volume":"48","author":"J Wiersinga","year":"2025","unstructured":"Wiersinga J, Jansen S, Peters MJL, Rhodius-Meester HFM, Trappenburg MC, Claassen JAHR, et al. Hypertension and orthostatic hypotension in the elderly: a challenging balance. Lancet Reg Health. 2025;48:101154.","journal-title":"Lancet Reg Health"},{"issue":"38","key":"1285_CR36","doi-asserted-by":"publisher","first-page":"3912","DOI":"10.1093\/eurheartj\/ehae178","volume":"45","author":"JW McEvoy","year":"2024","unstructured":"McEvoy JW, McCarthy CP, Bruno RM, Brouwers S, Canavan MD, Ceconi C, et al. 2024 ESC Guidelines for the management of elevated blood pressure and hypertension. Eur Heart J. 2024;45(38):3912\u20134018.","journal-title":"Eur Heart J"},{"issue":"10","key":"1285_CR37","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2024.39.e84","volume":"39","author":"JY Choi","year":"2024","unstructured":"Choi JY, Lee HY, Lee JH, Hong Y, Park SK, Ryu DR, et al. Characteristics according to frailty status among older Korean patients with hypertension. J Korean Med Sci. 2024;39(10):e84.","journal-title":"J Korean Med Sci"},{"issue":"5","key":"1285_CR38","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.clpt.2006.08.004","volume":"80","author":"PA Th\u00fcrmann","year":"2006","unstructured":"Th\u00fcrmann PA, Haack S, Werner U, Szymanski J, Haase G, Drewelow B, et al. Tolerability of \u03b2-blockers metabolized via cytochrome P450 2D6 is sex-dependent. Clin Pharmacol Ther. 2006;80(5):551\u20133. https:\/\/doi.org\/10.1016\/j.clpt.2006.08.004.","journal-title":"Clin Pharmacol Ther"},{"key":"1285_CR39","doi-asserted-by":"publisher","unstructured":"Li X, Zhang J, Xing Z, Liu Q, Zhou S, Xiao Y. Intensive blood pressure control for patients aged over 60: a meta-analysis of the SPRINT, STEP, and ACCORD BP randomized controlled trials. Maturitas. 2023;172:52\u20139. https:\/\/doi.org\/10.1016\/j.maturitas.2023.04.009.","DOI":"10.1016\/j.maturitas.2023.04.009"},{"key":"1285_CR40","doi-asserted-by":"publisher","unstructured":"De Vries M, Seppala LJ, Daams JG, Van De Glind EMM, Masud T, Van Der Velde N, et al. Fall-risk-increasing drugs: a systematic review and meta-analysis: I. cardiovascular drugs. J Am Med Dir Assoc. 2018;19(4):371.e1-371.e9. https:\/\/doi.org\/10.1016\/j.jamda.2017.12.013","DOI":"10.1016\/j.jamda.2017.12.013"},{"key":"1285_CR41","doi-asserted-by":"publisher","unstructured":"Klop M, Maier AB, Meskers CGM, Steiner JM, Helsloot DO, Van Wezel RJA, et al. The eff ect of a change in antihypertensive treatment on orthostatic hypotension in older adults: a systematic review and meta-analysis. ExpGerontol. 2024;193:112461. https:\/\/doi.org\/10.1016\/j.exger.2024.112461.","DOI":"10.1016\/j.exger.2024.112461"},{"key":"1285_CR42","doi-asserted-by":"publisher","unstructured":"Zhang Q, Luan H, Wang L, Zhang M, Chen Y, Lv Y, et al. Hyperkalemia of angiotensin-converting enzyme inhibitors orangiotensin receptor blockers in hemodialysis: a meta-analysis. J Huazhong Univ Sci Technolog Med Sci. 2012;32(5):785\u201392. https:\/\/doi.org\/10.1007\/s11596-012-1035-1.","DOI":"10.1007\/s11596-012-1035-1"},{"key":"1285_CR43","doi-asserted-by":"publisher","unstructured":"Makani H, Bangalore S, Romero J, Wever-Pinzon O, Messerli FH. Effect of renin-angiotensin system blockade on calcium channel blocker-associated peripheral edema. Am J Med. 2011;124(2):128\u201335. https:\/\/doi.org\/10.1016\/j.amjmed.2010.08.007.","DOI":"10.1016\/j.amjmed.2010.08.007"},{"key":"1285_CR44","doi-asserted-by":"publisher","unstructured":"Makani H, Messerli FH, Romero J, Wever-Pinzon O, Korniyenko A, Berrios RS, et al. Meta-analysis of randomized trials of angioedema as an adverse event of renin\u2013angiotensin system inhibitors. Am J Cardiol. 2012;110(3):383\u201391. https:\/\/doi.org\/10.1016\/j.amjcard.2012.03.034.","DOI":"10.1016\/j.amjcard.2012.03.034"}],"container-title":["Drugs &amp; Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-026-01285-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40266-026-01285-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-026-01285-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:02:23Z","timestamp":1793408543000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40266-026-01285-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,12]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["1285"],"URL":"https:\/\/doi.org\/10.1007\/s40266-026-01285-x","relation":{},"ISSN":["1170-229X","1179-1969"],"issn-type":[{"value":"1170-229X","type":"print"},{"value":"1179-1969","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,12]]},"assertion":[{"value":"6 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article was originally published under the subscription model but it is now published under an Open Access license","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics Approval and Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare they have no conflicts of interest relevant to the contents of this article.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Literature Search: MvG. Study concept and design: CF, AESL. Title\/abstract and full-text screening: AESL, CF, MJLA, MZ. Data extraction: AESL, CF. Writing the manuscript: CF, AESL. Critical contribution and revision of manuscript: AESL, CF, SS. All authors reviewed the manuscript and approved the content.","order":4,"name":"Ethics","label":"Author Contributions","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Data supporting the findings of this study were derived from resources available in the public domain. The authors confirm that the data are available within the article and\/or its supplementary materials. Any additional data are available from the corresponding author upon request.","order":5,"name":"Ethics","label":"Availability of Data And Materials","group":{"name":"EthicsHeading","label":"Declarations"}}]}}