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Wehling was employed by AstraZeneca R&D, M\u00f6lndal, as director of discovery medicine (translational medicine) from 2003 to 2006, while on sabbatical leave from his professorship at the University of Heidelberg. Since returning to this position in January 2007, he has received lecturing and consulting fees from ASPEN, Bristol Myers, Bayer, Berlin-Chemie, LEO, Mundipharma, Novartis, Pfizer, Polyphor, Helsinn, Allecra, Santhera, Allergan, Novo-Nordisk, Lilly, AstraZeneca, Roche, Heel, Sanofi-Aventis, Shire and Daichii-Sankyo. All other authors declared that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Upon submission of a written request and evaluation by the study group, the data used in this study will be provided to other researchers.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data Availability"}},{"value":"Conceptualization: Martin Wehling, Farhad Pazan. Data curation: Martin Wehling, Johanna Knorr, Christel Weiss, Kathrin Heser, Alexander Pabst, Melanie Luppa, Horst Bickel, Siegfried Weyerer, Michael Pentzek, Hans-Helmut K\u00f6nig, Dagmar L\u00fchmann, Carolin van der Leeden, Martin Scherer, Steffi G. Riedel-Heller, Michael Wagner, Farhad Pazan. Formal analysis: Farhad Pazan, Martin Wehling, Johanna Knorr, Christel Weiss. Funding acquisition: Melanie Luppa, Michael Pentzek, Horst Bickel, Siegfried Weyerer, Hans-Helmut K\u00f6nig, Martin Scherer, Steffi Riedel-Heller, Michael Wagner. Investigation: Martin Wehling, Johanna Knorr, Christel Weiss, Kathrin Heser, Alexander Pabst, Melanie Luppa, Horst Bickel, Siegfried Weyerer, Michael Pentzek, Hans-Helmut K\u00f6nig, Dagmar L\u00fchmann, Carolin van der Leeden, Martin Scherer, Steffi G. Riedel-Heller, Michael Wagner, Farhad Pazan. Methodology: Farhad Pazan, Johanna Knorr, Christel Weiss, Martin Wehling. Project administration: Farhad Pazan, Martin Wehling. Resources: Martin Wehling, Johanna Knorr, Christel Weiss, Kathrin Heser, Alexander Pabst, Melanie Luppa, Horst Bickel, Siegfried Weyerer, Michael Pentzek, Hans-Helmut K\u00f6nig, Dagmar L\u00fchmann, Carolin van der Leeden, Martin Scherer, Steffi G. Riedel-Heller, Michael Wagner, Farhad Pazan. Software: OptiMedis. Supervision: Farhad Pazan, Martin Wehling. Validation: N\/A. Visualization: Farhad Pazan, Johanna Knorr, Martin Wehling. Writing\u2014original draft: Martin Wehling, Johanna Knorr, Christel Weiss, Kathrin Heser, Alexander Pabst, Melanie Luppa, Horst Bickel, Siegfried Weyerer, Michael Pentzek, Hans-Helmut K\u00f6nig, Dagmar L\u00fchmann, Carolin van der Leeden, Martin Scherer, Steffi G. Riedel-Heller, Michael Wagner, Farhad Pazan. Writing\u2014review and editing: Martin Wehling, Johanna Knorr, Christel Weiss, Kathrin Heser, Alexander Pabst, Melanie Luppa, Horst Bickel, Siegfried Weyerer, Michael Pentzek, Hans-Helmut K\u00f6nig, Dagmar L\u00fchmann, Carolin van der Leeden, Martin Scherer, Steffi G. Riedel-Heller, Michael Wagner, Farhad Pazan.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author Contributions"}},{"value":"Approval from the ethics committees of all the participating centers had been obtained for the AgeCoDe and AgeQualiDe studies, which were conducted in compliance with The Code of Ethics of the World Medical Association. Furthermore, ethics approvals which were previously received (reference number: 2007-253E-MA) and recently renewed by the ethics committee in Mannheim, University of Heidelberg (reference number: TEMP558252-AF 11) cover the work in this paper.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent\/Statement of Human Rights"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Not available.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code Availability"}},{"value":"Not applicable.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical Trial Number"}}]}}