{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:44:52Z","timestamp":1792107892850,"version":"4.4.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs Aging"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s40266-026-01339-0","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:42:11Z","timestamp":1790754131000},"page":"897-908","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intravenous Iron Therapy in Very Old Adults with Heart Failure: A Frailty-Oriented Therapeutic Perspective"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8002-4845","authenticated-orcid":false,"given":"R\u00e9mi","family":"Esser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Harboun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Larbaneix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Mondragon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marl\u00e8ne","family":"Esteban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Farges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Palermo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Pages","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Nisse Durgeat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Maurou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"issue":"10","key":"1339_CR1","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1161\/CIRCRESAHA.121.318172","volume":"128","author":"VL Roger","year":"2021","unstructured":"Roger VL. Epidemiology of heart failure: a contemporary perspective. Circ Res. 2021;128(10):1421\u201334. https:\/\/doi.org\/10.1161\/CIRCRESAHA.121.318172.","journal-title":"Circ Res"},{"issue":"37","key":"1339_CR2","doi-asserted-by":"publisher","first-page":"3627","DOI":"10.1093\/eurheartj\/ehad195","volume":"44","author":"TA McDonagh","year":"2023","unstructured":"McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, B\u00f6hm M, et al. 2023 focused update of the 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2023;44(37):3627\u201339. https:\/\/doi.org\/10.1093\/eurheartj\/ehad195.","journal-title":"Eur Heart J"},{"issue":"19","key":"1339_CR3","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1016\/j.jacc.2018.03.022","volume":"71","author":"DE Forman","year":"2018","unstructured":"Forman DE, Maurer MS, Boyd C, Brindis R, Salive ME, Horne FM, et al. Multimorbidity in older adults with cardiovascular disease. J Am Coll Cardiol. 2018;71(19):2149\u201361. https:\/\/doi.org\/10.1016\/j.jacc.2018.03.022.","journal-title":"J Am Coll Cardiol"},{"issue":"25","key":"1339_CR4","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.1056\/NEJMoa0908355","volume":"361","author":"SD Anker","year":"2009","unstructured":"Anker SD, Comin Colet J, Filippatos G, Willenheimer R, Dickstein K, Drexler H, et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med. 2009;361(25):2436\u201348. https:\/\/doi.org\/10.1056\/NEJMoa0908355.","journal-title":"N Engl J Med"},{"issue":"15","key":"1339_CR5","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1093\/eurheartj\/ehq158","volume":"31","author":"EA Jankowska","year":"2010","unstructured":"Jankowska EA, Rozentryt P, Witkowska A, Nowak J, Hartmann O, Ponikowska B, et al. Iron deficiency: an ominous sign in patients with systolic chronic heart failure. Eur Heart J. 2010;31(15):1872\u201380. https:\/\/doi.org\/10.1093\/eurheartj\/ehq158.","journal-title":"Eur Heart J"},{"issue":"1","key":"1339_CR6","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1182\/blood-2018-06-856500","volume":"133","author":"G Weiss","year":"2019","unstructured":"Weiss G, Ganz T, Goodnough LT. Anemia of inflammation. Blood. 2019;133(1):40\u201350. https:\/\/doi.org\/10.1182\/blood-2018-06-856500.","journal-title":"Blood"},{"issue":"4","key":"1339_CR7","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.ahj.2013.01.017","volume":"165","author":"C Enjuanes","year":"2013","unstructured":"Enjuanes C, Banasiak W, Lok DJ, Rosentryt P, Torrens A, Polonski L, et al. Iron deficiency in chronic heart failure: an international pooled analysis. Am Heart J. 2013;165(4):575-582.e3. https:\/\/doi.org\/10.1016\/j.ahj.2013.01.017.","journal-title":"Am Heart J"},{"issue":"12","key":"1339_CR8","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.jchf.2019.10.005","volume":"7","author":"A Pandey","year":"2019","unstructured":"Pandey A, Kitzman D, Reeves G. Frailty is intertwined with heart failure: mechanisms, prevalence, prognosis, assessment, and management. JACC Heart Fail. 2019;7(12):1001\u201311. https:\/\/doi.org\/10.1016\/j.jchf.2019.10.005.","journal-title":"JACC Heart Fail."},{"issue":"6","key":"1339_CR9","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1001\/archinternmed.2011.31","volume":"171","author":"A Cherubini","year":"2011","unstructured":"Cherubini A, Oristrell J, Pla X, Ruggiero C, Ferretti R, Diestre G, et al. The persistent exclusion of older patients from ongoing clinical trials regarding heart failure. Arch Intern Med. 2011;171(6):550\u20136. https:\/\/doi.org\/10.1001\/archinternmed.2011.31.","journal-title":"Arch Intern Med"},{"issue":"10","key":"1339_CR10","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","volume":"14","author":"C Franceschi","year":"2018","unstructured":"Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A. Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol. 2018;14(10):576\u201390. https:\/\/doi.org\/10.1038\/s41574-018-0059-4.","journal-title":"Nat Rev Endocrinol"},{"issue":"8","key":"1339_CR11","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/nri3863","volume":"15","author":"T Ganz","year":"2015","unstructured":"Ganz T, Nemeth E. Iron homeostasis in host defence and inflammation. Nat Rev Immunol. 2015;15(8):500\u201310. https:\/\/doi.org\/10.1038\/nri3863.","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"1339_CR12","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.kint.2015.10.002","volume":"89","author":"IC Macdougall","year":"2016","unstructured":"Macdougall IC, Bircher AJ, Eckardt KU, Obrador GT, Pollock CA, Stenvinkel P, et al. Iron management in chronic kidney disease: conclusions from a \u201cKidney Disease: Improving Global Outcomes\u201d (KDIGO) controversies conference. Kidney Int. 2016;89(1):28\u201339. https:\/\/doi.org\/10.1016\/j.kint.2015.10.002.","journal-title":"Kidney Int"},{"key":"1339_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01960","volume":"8","author":"T Fulop","year":"2018","unstructured":"Fulop T, Larbi A, Dupuis G, Le Page A, Frost EH, Cohen AA, et al. Immunosenescence and inflamm-aging as two sides of the same coin: friends or foes? Front Immunol. 2018;8:1960. https:\/\/doi.org\/10.3389\/fimmu.2017.01960.","journal-title":"Front Immunol"},{"issue":"19","key":"1339_CR14","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1056\/NEJMra1401038","volume":"372","author":"C Camaschella","year":"2015","unstructured":"Camaschella C. Iron-deficiency anemia. N Engl J Med. 2015;372(19):1832\u201343. https:\/\/doi.org\/10.1056\/NEJMra1401038.","journal-title":"N Engl J Med"},{"issue":"5","key":"1339_CR15","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1111\/bjh.12311","volume":"161","author":"DW Thomas","year":"2013","unstructured":"Thomas DW, Hinchliffe RF, Briggs C, Macdougall IC, Littlewood T, Cavill I. Guideline for the laboratory diagnosis of functional iron deficiency. Br J Haematol. 2013;161(5):639\u201348. https:\/\/doi.org\/10.1111\/bjh.12311.","journal-title":"Br J Haematol"},{"key":"1339_CR16","doi-asserted-by":"publisher","unstructured":"Okonko DO, Mandal AK, Missouris CG, Poole-Wilson PA. Disordered iron homeostasis in chronic heart failure: prevalence, predictors, and relation to anemia, exercise capacity, and survival. J Am Coll Cardiol. 13 Sep 2011;58(12):1241-51. https:\/\/doi.org\/10.1016\/j.jacc.2011.04.040.","DOI":"10.1016\/j.jacc.2011.04.040"},{"issue":"4","key":"1339_CR17","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.hfc.2015.07.010","volume":"11","author":"S Katsanos","year":"2015","unstructured":"Katsanos S, Bistola V, Parissis JT. Acute heart failure syndromes in the elderly: the European perspective. Heart Fail Clin. 2015;11(4):637\u201345. https:\/\/doi.org\/10.1016\/j.hfc.2015.07.010.","journal-title":"Heart Fail Clin"},{"issue":"11","key":"1339_CR18","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1093\/eurheartj\/ehu385","volume":"36","author":"P Ponikowski","year":"2015","unstructured":"Ponikowski P, van Veldhuisen DJ, Comin-Colet J, Ertl G, Komajda M, Mareev V, et al. Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency. Eur Heart J. 2015;36(11):657\u201368. https:\/\/doi.org\/10.1093\/eurheartj\/ehu385.","journal-title":"Eur Heart J"},{"issue":"1","key":"1339_CR19","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1093\/eurheartj\/ehr504","volume":"34","author":"J Comin-Colet","year":"2013","unstructured":"Comin-Colet J, Lainscak M, Dickstein K, Filippatos GS, Johnson P, L\u00fcscher TF, et al. The effect of intravenous ferric carboxymaltose on health-related quality of life in patients with chronic heart failure and iron deficiency: a subanalysis of the FAIR-HF study. Eur Heart J. 2013;34(1):30\u20138. https:\/\/doi.org\/10.1093\/eurheartj\/ehr504.","journal-title":"Eur Heart J"},{"key":"1339_CR20","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1146\/annurev.nu.06.070186.000305","volume":"6","author":"PR Dallman","year":"1986","unstructured":"Dallman PR. Biochemical basis for the manifestations of iron deficiency. Annu Rev Nutr. 1986;6:13\u201340. https:\/\/doi.org\/10.1146\/annurev.nu.06.070186.000305.","journal-title":"Annu Rev Nutr"},{"issue":"2S-2","key":"1339_CR21","doi-asserted-by":"publisher","first-page":"676S","DOI":"10.1093\/jn\/131.2.676S","volume":"131","author":"JD Haas","year":"2001","unstructured":"Haas JD, Brownlie T 4th. Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship. J Nutr. 2001;131(2S-2):676S-688S. https:\/\/doi.org\/10.1093\/jn\/131.2.676S.","journal-title":"J Nutr"},{"issue":"9","key":"1339_CR22","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.cjca.2016.03.019","volume":"32","author":"JA Dodson","year":"2016","unstructured":"Dodson JA, Matlock DD, Forman DE. Geriatric cardiology: an emerging discipline. Can J Cardiol. 2016;32(9):1056\u201364. https:\/\/doi.org\/10.1016\/j.cjca.2016.03.019.","journal-title":"Can J Cardiol"},{"issue":"10191","key":"1339_CR23","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","volume":"393","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft AJ, Sayer AA. Sarcopenia. Lancet. 2019;393(10191):2636\u201346. https:\/\/doi.org\/10.1016\/S0140-6736(19)31138-9.","journal-title":"Lancet"},{"key":"1339_CR24","doi-asserted-by":"publisher","unstructured":"Boyd CM, Darer J, Boult C, Fried LP, Boult L, Wu AW. Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. JAMA. 2005;294(6):716-24. https:\/\/doi.org\/10.1001\/jama.294.6.716.","DOI":"10.1001\/jama.294.6.716"},{"issue":"8","key":"1339_CR25","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.jacc.2013.09.070","volume":"63","author":"J Afilalo","year":"2014","unstructured":"Afilalo J, Alexander KP, Mack MJ, Maurer MS, Green P, Allen LA, et al. Frailty assessment in the cardiovascular care of older adults. J Am Coll Cardiol. 2014;63(8):747\u201362. https:\/\/doi.org\/10.1016\/j.jacc.2013.09.070.","journal-title":"J Am Coll Cardiol"},{"issue":"10266","key":"1339_CR26","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1016\/S0140-6736(20)32339-4","volume":"396","author":"P Ponikowski","year":"2020","unstructured":"Ponikowski P, Kirwan BA, Anker SD, McDonagh T, Dorobantu M, Drozdz J, et al. Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial. Lancet. 2020;396(10266):1895\u2013904. https:\/\/doi.org\/10.1016\/S0140-6736(20)32339-4.","journal-title":"Lancet"},{"issue":"10369","key":"1339_CR27","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1016\/S0140-6736(22)02083-9","volume":"400","author":"PR Kalra","year":"2022","unstructured":"Kalra PR, Cleland JGF, Petrie MC, Thomson EA, Kalra PA, Squire IB, et al. Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial. Lancet. 2022;400(10369):2199\u2013209. https:\/\/doi.org\/10.1016\/S0140-6736(22)02083-9.","journal-title":"Lancet"},{"key":"1339_CR28","doi-asserted-by":"publisher","unstructured":"van Veldhuisen DJ, Ponikowski P, van der Meer P, Metra M, B\u00f6hm M, Doletsky A, et al. Effect of ferric carboxymaltose on exercise capacity in patients with chronic heart failure and iron deficiency. Circulation. 2017;136(15):1374-1383. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.117.027497.","DOI":"10.1161\/CIRCULATIONAHA.117.027497"},{"issue":"7","key":"1339_CR29","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1002\/ejhf.473","volume":"18","author":"EA Jankowska","year":"2016","unstructured":"Jankowska EA, Tkaczyszyn M, Suchocki T, Drozd M, von Haehling S, Doehner W, et al. Effects of intravenous iron therapy in iron-deficient patients with systolic heart failure: a meta-analysis of randomized controlled trials. Eur J Heart Fail. 2016;18(7):786\u201395. https:\/\/doi.org\/10.1002\/ejhf.473.","journal-title":"Eur J Heart Fail"},{"key":"1339_CR30","doi-asserted-by":"publisher","unstructured":"Mentz RJ, Garg J, Rockhold FW, Butler J, De Pasquale CG, Ezekowitz JA, et al. Ferric carboxymaltose in heart failure with iron deficiency. N Engl J Med. 2023;389(11):975-986. https:\/\/doi.org\/10.1056\/NEJMoa2304968.","DOI":"10.1056\/NEJMoa2304968"},{"key":"1339_CR31","doi-asserted-by":"publisher","unstructured":"Anker SD, Friede T, Butler J, Talha KM, Placzek M, Diek M, et al. Intravenous ferric carboxymaltose in heart failure with iron deficiency: the FAIR-HF2 DZHK05 randomized clinical trial. JAMA. 2025;333(22):1965-1976. https:\/\/doi.org\/10.1001\/jama.2025.3833.","DOI":"10.1001\/jama.2025.3833"},{"issue":"1","key":"1339_CR32","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/ehf2.14905","volume":"12","author":"M Ahmed","year":"2025","unstructured":"Ahmed M, Shafiq A, Javaid H, Singh P, Shahbaz H, Maniya MT, et al. Intravenous iron therapy for heart failure and iron deficiency: an updated meta-analysis of randomized clinical trials. ESC Heart Fail. 2025;12(1):43\u201353. https:\/\/doi.org\/10.1002\/ehf2.14905.","journal-title":"ESC Heart Fail"},{"issue":"37","key":"1339_CR33","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.1093\/eurheartj\/ehae479","volume":"45","author":"S von Haehling","year":"2024","unstructured":"von Haehling S, Doehner W, Evertz R, Garfias-Veitl T, Derad C, Diek M, et al. Ferric carboxymaltose and exercise capacity in heart failure with preserved ejection fraction and iron deficiency: the FAIR-HFpEF trial. Eur Heart J. 2024;45(37):3789\u2013800. https:\/\/doi.org\/10.1093\/eurheartj\/ehae479.","journal-title":"Eur Heart J"},{"issue":"13","key":"1339_CR34","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1136\/heartjnl-2024-324908","volume":"111","author":"S Sze","year":"2025","unstructured":"Sze S, Squire I, Kalra PR, Cleland JG, Petrie MC, Kalra PA, et al. Age-stratified effects of intravenous ferric derisomaltose in heart failure with iron deficiency: insights from the IRONMAN trial. Heart. 2025;111(13):634\u201341. https:\/\/doi.org\/10.1136\/heartjnl-2024-324908.","journal-title":"Heart"},{"key":"1339_CR35","doi-asserted-by":"publisher","unstructured":"Forman DE, Rich MW, Alexander KP, Zieman S, Maurer MS, Najjar SS, et al. Cardiac care for older adults. Time for a new paradigm. J Am Coll Cardiol. 2011;57(18):1801-10. https:\/\/doi.org\/10.1016\/j.jacc.2011.02.014.","DOI":"10.1016\/j.jacc.2011.02.014"},{"issue":"13","key":"1339_CR36","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1056\/NEJMoa0909087","volume":"362","author":"TM Gill","year":"2010","unstructured":"Gill TM, Gahbauer EA, Han L, Allore HG. Trajectories of disability in the last year of life. N Engl J Med. 2010;362(13):1173\u201380. https:\/\/doi.org\/10.1056\/NEJMoa0909087.","journal-title":"N Engl J Med"},{"issue":"19","key":"1339_CR37","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1001\/jama.2017.5427","volume":"317","author":"GD Lewis","year":"2017","unstructured":"Lewis GD, Malhotra R, Hernandez AF, McNulty SE, Smith A, Felker GM, et al. Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency: the IRONOUT HF randomized clinical trial. JAMA. 2017;317(19):1958\u201366. https:\/\/doi.org\/10.1001\/jama.2017.5427.","journal-title":"JAMA"},{"issue":"11","key":"1339_CR38","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.3324\/haematol.2014.111492","volume":"99","author":"D Rampton","year":"2014","unstructured":"Rampton D, Folkersen J, Fishbane S, Hedenus M, Howaldt S, Locatelli F, et al. Hypersensitivity reactions to intravenous iron: guidance for risk minimization and management. Haematologica. 2014;99(11):1671\u20136. https:\/\/doi.org\/10.3324\/haematol.2014.111492.","journal-title":"Haematologica"},{"issue":"23","key":"1339_CR39","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124486","volume":"3","author":"M Wolf","year":"2018","unstructured":"Wolf M, Chertow GM, Macdougall IC, Kaper R, Krop J, Strauss W. Randomized trial of intravenous iron-induced hypophosphatemia. JCI Insight. 2018;3(23):e124486. https:\/\/doi.org\/10.1172\/jci.insight.124486.","journal-title":"JCI Insight"},{"issue":"5","key":"1339_CR40","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.1111\/bcp.14643","volume":"87","author":"B Schaefer","year":"2021","unstructured":"Schaefer B, Tobiasch M, Viveiros A, Tilg H, Kennedy NA, Wolf M, et al. Hypophosphataemia after treatment of iron deficiency with intravenous ferric carboxymaltose or iron isomaltoside \u2013 a systematic review and meta-analysis. Br J Clin Pharmacol. 2021;87(5):2256\u201373. https:\/\/doi.org\/10.1111\/bcp.14643.","journal-title":"Br J Clin Pharmacol"},{"issue":"14","key":"1339_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14144861","volume":"14","author":"G Rosano","year":"2025","unstructured":"Rosano G, Ezekowitz J, Nemeth E, Ponikowski P, Rauner M, Seid M, et al. Evaluating the risk of hypophosphatemia with ferric carboxymaltose and the recommended approaches for management: a consensus statement. J Clin Med. 2025;14(14):4861. https:\/\/doi.org\/10.3390\/jcm14144861.","journal-title":"J Clin Med"},{"key":"1339_CR42","doi-asserted-by":"publisher","unstructured":"Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005;173(5):489-95. https:\/\/doi.org\/10.1503\/cmaj.050051.","DOI":"10.1503\/cmaj.050051"},{"issue":"6","key":"1339_CR43","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1056\/NEJMra2301292","volume":"391","author":"DH Kim","year":"2024","unstructured":"Kim DH, Rockwood K. Frailty in older adults. N Engl J Med. 2024;391(6):538\u201348. https:\/\/doi.org\/10.1056\/NEJMra2301292.","journal-title":"N Engl J Med"},{"issue":"1","key":"1339_CR44","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1093\/eurjpc\/zwaa167","volume":"29","author":"D Richter","year":"2022","unstructured":"Richter D, Guasti L, Walker D, Lambrinou E, Lionis C, Abreu A, et al. Frailty in cardiology: definition, assessment and clinical implications for general cardiology. A consensus document of the Council for Cardiology Practice (CCP), Association for Acute Cardio Vascular Care (ACVC), Association of Cardiovascular Nursing and Allied Professions (ACNAP), European Association of Preventive Cardiology (EAPC), European Heart Rhythm Association (EHRA), Council on Valvular Heart Diseases (VHD), Council on Hypertension (CHT), Council of Cardio-Oncology (CCO), Working Group (WG) Aorta and Peripheral Vascular Diseases, WG e-Cardiology, WG Thrombosis, of the European Society of Cardiology and European Primary Care Cardiology Society (EPCCS). Eur J Prev Cardiol. 2022;29(1):216\u201327. https:\/\/doi.org\/10.1093\/eurjpc\/zwaa167.","journal-title":"Eur J Prev Cardiol"},{"issue":"9","key":"1339_CR45","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.2105\/ajph.89.9.1322","volume":"89","author":"RE Glasgow","year":"1999","unstructured":"Glasgow RE, Vogt TM, Boles SM. Evaluating the public health impact of health promotion interventions: the RE-AIM framework. Am J Public Health. 1999;89(9):1322\u20137. https:\/\/doi.org\/10.2105\/ajph.89.9.1322.","journal-title":"Am J Public Health"}],"container-title":["Drugs &amp; Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-026-01339-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40266-026-01339-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-026-01339-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:53:15Z","timestamp":1792104795000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40266-026-01339-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["1339"],"URL":"https:\/\/doi.org\/10.1007\/s40266-026-01339-0","relation":{},"ISSN":["1170-229X","1179-1969"],"issn-type":[{"value":"1170-229X","type":"print"},{"value":"1179-1969","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"11 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Sophie Nisse Durgeat and Nicolas Pages are employed by NP Medical. R\u00e9mi Esser, Marc Harboun, Marine Larbaneix, Alejandro Mondragon, Marl\u00e8ne Esteban, Christine Farges, Vincenzo Palermo and Olivier Maurou declare that they have no potential conflicts of interest that might be relevant to the contents of this manuscript.","order":1,"name":"Ethics","label":"Conflict of Interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was not required because this study was based exclusively on previously published literature and did not involve recruiting new human participants.","order":2,"name":"Ethics","label":"Ethical Approval and Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Patients and\/or members of the public were not involved in the design, conduct, reporting or dissemination plans of this narrative review.","order":4,"name":"Ethics","label":"Patient and Public Involvement","group":{"name":"EthicsHeading","label":"Declarations"}}]}}