{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:51:27Z","timestamp":1783075887121,"version":"3.54.6"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T00:00:00Z","timestamp":1367280000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.5"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drugs R D"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1007\/s40268-013-0015-7","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T00:33:27Z","timestamp":1367454807000},"page":"129-135","source":"Crossref","is-referenced-by-count":9,"title":["Pharmacokinetic Dose Proportionality Between Two Strengths (12.5\u00a0mg and 25\u00a0mg) of Doxylamine Hydrogen Succinate Film-Coated Tablets in Fasting State: A Single-Dose, Randomized, Two-Period Crossover Study in Healthy Volunteers"],"prefix":"10.1007","volume":"13","author":[{"given":"Sebasti\u00e1n","family":"Videla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Cebrecos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounia","family":"Lahjou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"France","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Guibord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengguo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Cabot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Encabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio","family":"Encina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Sicard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Sans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,4,30]]},"reference":[{"key":"15_CR1","unstructured":"Zimmerman DR. Sleep aids. In: Zimmerman\u2019s complete guide to non-prescription drugs. 2nd ed. Detroit (MI): Gale Research Inc.; 1992. p. 870\u20135."},{"key":"15_CR2","first-page":"422","volume-title":"Goodman & Gilman\u2019s The pharmacological basis of therapeutics","author":"LL Brunton","year":"2006","unstructured":"Brunton LL, Parker JK. Drugs acting on the central nervous system. In: Hardman JG, Limbird LE, editors. Goodman & Gilman\u2019s The pharmacological basis of therapeutics. 11th ed. New York: McGraw Hill; 2006. p. 422\u20137.","edition":"11"},{"issue":"Suppl 1","key":"15_CR3","first-page":"24","volume":"16","author":"J Montoro","year":"2006","unstructured":"Montoro J, Sastre J, Bartra J, et al. Effect of H1 antihistamines upon the central nervous system. J Investig Allergol Clin Immunol. 2006;16(Suppl 1):24\u20138.","journal-title":"J Investig Allergol Clin Immunol"},{"key":"15_CR4","unstructured":"Garrison J. Histamine, bradykinin, 5-hydroxytryptamine and their antagonists. In: Gilman AC, Rall TW, Nies AS, Taylor P, editors. The pharmacological basis of therapeutics. New York: Pergamon; 1990."},{"key":"15_CR5","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/cpt196781part148","volume":"8","author":"F Sj\u00f6qvist","year":"1967","unstructured":"Sj\u00f6qvist F, Lasagna L. The hypnotic efficacy of doxylamine. Clin Pharmacol Ther. 1967;8:48\u201354.","journal-title":"Clin Pharmacol Ther"},{"key":"15_CR6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2165\/11641640-000000000-00000","volume":"12","author":"S Videla","year":"2012","unstructured":"Videla S, Lahjou M, Guibord P, Xu Z, Tolr\u00e0 C, Encina G, Sicard E, Sans A. Food effects on the pharmacokinetics of doxylamine hydrogen succinate 25\u00a0mg film-coated tablets: a single-dose, randomized, two-period crossover study in healthy volunteers. Drugs R D. 2012;12:217\u201325.","journal-title":"Drugs R D"},{"key":"15_CR7","unstructured":"International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. ICH harmonised tripartite guideline: guideline for good clinical practice E6(R1) [online]. Available from URL: http:\/\/www.ich.org\/fileadmin\/Public_Web_Site\/ICH_Products\/Guidelines\/Efficacy\/E6_R1\/Step4\/E6_R1__Guideline.pdf . [Accessed 2012 Nov 27]."},{"key":"15_CR8","unstructured":"European Medicines Agency. Committee for medicinal products for human use (CHMP): Guideline on the Investigation of Bioequivalence (CPMP\/EWP\/QWP\/1401\/98 Rev. 1). Available from URL: http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2010\/01\/WC500070039.pdf ."},{"key":"15_CR9","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/j.1552-4604.1985.tb02875.x","volume":"25","author":"H Friedman","year":"1985","unstructured":"Friedman H, Greenblatt DJ. The pharmacokinetics of doxylamine: use of automated gas chromatography with nitrogen-phosphorus detection. J Clin Pharmacol. 1985;25:448\u201351.","journal-title":"J Clin Pharmacol"},{"key":"15_CR10","doi-asserted-by":"crossref","unstructured":"Friedman H, Greenblatt DJ, Scavone JM, et al. Clearance of the antihistamine doxylamine. Reduced in elderly men but not in elderly women. Clin Pharmacokinet. 1989; 16:312\u20136.","DOI":"10.2165\/00003088-198916050-00003"},{"key":"15_CR11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/j.1552-4604.1989.tb03323.x","volume":"29","author":"BG Luna","year":"1989","unstructured":"Luna BG, Scavone JM, Greenblatt DJ. Doxylamine and diphenhydramine pharmacokinetics in women on low-dose estrogen oral contraceptives. J Clin Pharmacol. 1989;29:257\u201360.","journal-title":"J Clin Pharmacol"},{"key":"15_CR12","doi-asserted-by":"crossref","unstructured":"Nulman I, Koren G. Pharmacokinetic comparison of a delayed-release combination of doxylamine succinate and pyridoxine hydrocholoride (Diclectin) and oral solutions of these drugs in healthy women of childbearing age. Can J Clin Pharmacol. 2009; 16:e400\u20136.","DOI":"10.53555\/58wb8g62"},{"key":"15_CR13","unstructured":"Dormidina\u00ae 25\u00a0mg film-coated tablets. Summary of Product Characteristics. http:\/\/www.aemps.gob.es\/cima\/especialidad.do?metodo=verFichaWordPdf&codigo=58658&formato=pdf&formulario=FICHAS&file=ficha.pdf ."},{"key":"15_CR14","unstructured":"Dormidina\u00ae 12.5\u00a0mg film-coated tablets. Summary of Product Characteristics. http:\/\/www.aemps.gob.es\/cima\/especialidad.do?metodo=verFichaWordPdf&codigo=60154&formato=pdf&formulario=FICHAS&file=ficha.pdf ."}],"container-title":["Drugs in R&D"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40268-013-0015-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40268-013-0015-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40268-013-0015-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T07:53:04Z","timestamp":1745999584000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40268-013-0015-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,30]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["15"],"URL":"https:\/\/doi.org\/10.1007\/s40268-013-0015-7","relation":{},"ISSN":["1174-5886","1179-6901"],"issn-type":[{"value":"1174-5886","type":"print"},{"value":"1179-6901","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,30]]}}}