{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T22:02:41Z","timestamp":1772834561111,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,9,18]],"date-time":"2014-09-18T00:00:00Z","timestamp":1410998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs R D"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1007\/s40268-014-0059-3","type":"journal-article","created":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T17:13:38Z","timestamp":1410974018000},"page":"233-239","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Assessment of the Prophylactic Role of Aspirin and\/or Clopidogrel on Experimentally Induced Acute Myocardial Infarction in Hypercholesterolemic Rats"],"prefix":"10.1007","volume":"14","author":[{"given":"Adham R.","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wessam F.","family":"El-Hadidy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazem F.","family":"Mannaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,9,18]]},"reference":[{"key":"59_CR1","first-page":"124","volume":"59","author":"M Roffi","year":"2007","unstructured":"Roffi M, Brindle M, Robbins M, Mukherjee D. Current perspectives on coronary revascularization in diabetic patients. Indian Heart J. 2007;59:124\u201336.","journal-title":"Indian Heart J."},{"key":"59_CR2","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/hc0902.104353","volume":"105","author":"P Libby","year":"2002","unstructured":"Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002;105:1135\u201343.","journal-title":"Circulation."},{"issue":"1","key":"59_CR3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jjcc.2011.03.006","volume":"58","author":"N Kume","year":"2011","unstructured":"Kume N, Mitsuoka H, Hayashida K, Tanaka M. Pentraxin 3 as a biomarker for acute coronary syndrome: comparison with biomarkers for cardiac damage. J Cardiol. 2011;58(1):38\u201345.","journal-title":"J Cardiol."},{"issue":"2","key":"59_CR4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.tcm.2010.03.005","volume":"20","author":"GD Norata","year":"2010","unstructured":"Norata GD, Garlanda C, Catapano AL. The long pentraxin PTX3: a modulator of the immunoinflammatory response in atherosclerosis and cardiovascular diseases. Trends Cardiovasc Med. 2010;20(2):35\u201340.","journal-title":"Trends Cardiovasc Med."},{"issue":"2","key":"59_CR5","doi-asserted-by":"crossref","first-page":"970","DOI":"10.4049\/jimmunol.1100261","volume":"187","author":"N Maugeri","year":"2011","unstructured":"Maugeri N, Rovere P, Slavich M, et al. Early and transient release of leukocyte pentraxin 3 during acute myocardial infarction. J Immunol. 2011;187(2):970\u20139.","journal-title":"J Immunol."},{"issue":"Suppl (1)","key":"59_CR6","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1111\/j.1540-8183.2008.00408.x","volume":"21","author":"PA Gurbel","year":"2008","unstructured":"Gurbel PA, Tantry US. The rationale for and comparisons of different antiplatelet treatment in acute coronary syndrome. J Interv Cardiol. 2008;21(Suppl (1)):S10\u20137.","journal-title":"J Interv Cardiol"},{"key":"59_CR7","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1146\/annurev.immunol.23.021704.115756","volume":"23","author":"C Garlanda","year":"2005","unstructured":"Garlanda C, Bottazi B, Bastone A. Pentraxins at the cross roads between innate immunity, inflammation, matrix deposition. Annu Rev Immunol. 2005;23:337\u201366.","journal-title":"Annu Rev Immunol."},{"issue":"1","key":"59_CR8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1160\/TH09-03-0177","volume":"103","author":"JB Muhlestein","year":"2010","unstructured":"Muhlestein JB. Effect of antiplatelet therapy on inflammatory markers in atherothrombotic patients. Thromb Haemost. 2010;103(1):71\u201382.","journal-title":"Thromb Haemost."},{"issue":"4","key":"59_CR9","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.phrs.2005.05.004","volume":"52","author":"K Srinivasan","year":"2005","unstructured":"Srinivasan K, Viswanad B, Lydia A, Kaul CL, Romarao P. Combination of high-fat diet-fed and low-dose streptozotocin\u2014treated rat: a model for type 2 diabetes and pharmacological screening. Pharmacol Res. 2005;52(4):313\u201320.","journal-title":"Pharmacol Res."},{"issue":"1\u20133","key":"59_CR10","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ejphar.2012.06.022","volume":"691","author":"SA Zaitone","year":"2012","unstructured":"Zaitone SA, Abo-Gresha NM. Rosuvastatin promotes angiogenesis and reverse isoproterenol- induced acute myocardial infarction in rats: role of iNOS and VEGF. Eur J Pharmacol. 2012;691(1\u20133):134\u201342.","journal-title":"Eur J Pharmacol."},{"issue":"3","key":"59_CR11","first-page":"545","volume":"293","author":"Y Fu","year":"2007","unstructured":"Fu Y, Wang Z, Chen WL, Moore PK, Zhu YZ. Cardioprotective effects of nitric-oxide aspirin in myocardial ischemia\u2014reperfused rats. Am J Physiol Heart Circ Physiol. 2007;293(3):545\u201352.","journal-title":"Am J Physiol Heart Circ Physiol."},{"issue":"5","key":"59_CR12","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1161\/CIRCEP.113.000591","volume":"6","author":"TS Dhanjal","year":"2013","unstructured":"Dhanjal TS, Medina RA, Leem J, Clark JE, South Worth R, Curtis MJ. Trapped platelets activated in ischemia initiate ventricular fibrillation. Circ Arrhythm Electrophysiol. 2013;6(5):995\u20131001.","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"1","key":"59_CR13","doi-asserted-by":"crossref","first-page":"L144","DOI":"10.1152\/ajplung.00002.2006","volume":"292","author":"D Okutani","year":"2007","unstructured":"Okutani D, Han B, Mura M, Waddell TK, Keshavjee S, Liu M. High-volume ventilation induces pentraxin 3 expression in multiple acute lung injury models in rats. Am J Physiol Lung Cell Mol Physiol. 2007;292(1):L144\u201353.","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"issue":"5","key":"59_CR14","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1097\/00024382-200116050-00010","volume":"6","author":"M Varedi","year":"2001","unstructured":"Varedi M, Jeschke MG, Englander EW, Herndon DN, Barrow RE. Serum TGF-beta in thermally injured rats. Shock. 2001;6(5):380\u20132.","journal-title":"Shock."},{"issue":"6","key":"59_CR15","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/clinchem\/17.6.548","volume":"17","author":"C Bishop","year":"1971","unstructured":"Bishop C, Chu TM, Shihabi ZK. Single stable reagent for creatine kinase assay. Clin Chem. 1971;17(6):548\u201350.","journal-title":"Clin Chem."},{"issue":"7","key":"59_CR16","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1093\/clinchem\/19.7.766","volume":"19","author":"AL Babson","year":"1973","unstructured":"Babson AL, Babson SR. Kinetic calorimetric measurement of serum lactate dehydrogenase activity. Clin Chem. 1973;19(7):766\u20139.","journal-title":"Clin Chem."},{"key":"59_CR17","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/clinchem\/20.4.470","volume":"20","author":"CC Allain","year":"1974","unstructured":"Allain CC, Poon LS, Chan CSG, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974;20:470\u20135.","journal-title":"Clin Chem."},{"issue":"5","key":"59_CR18","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/clinchem\/19.5.476","volume":"19","author":"G Bucolo","year":"1973","unstructured":"Bucolo G, David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem. 1973;19(5):476\u201382.","journal-title":"Clin Chem."},{"issue":"1","key":"59_CR19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ahj.2007.08.013","volume":"155","author":"S Suzuki","year":"2008","unstructured":"Suzuki S, Takeishi Y, Niizeki T, et al. Pentraxin 3, a new marker for vascular inflammation, predicts adverse clinical outcomes in patients with heart failure. Am Heart J. 2008;155(1):75\u201381.","journal-title":"Am Heart J."},{"issue":"8","key":"59_CR20","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1161\/CIRCULATIONAHA.107.749234","volume":"117","author":"M Salio","year":"2008","unstructured":"Salio M, Chimenti S, De Angelis N, et al. Cardioprotective function of the long pentraxin PTX3 in acute myocardial infarction. Circulation. 2008;117(8):1055\u201364.","journal-title":"Circulation."},{"key":"59_CR21","doi-asserted-by":"crossref","first-page":"920517","DOI":"10.1155\/2012\/920517","volume":"2012","author":"P Kunes","year":"2012","unstructured":"Kunes P, Holubcova Z, Kolackova M, Krejisek J. Pentraxin 3 (PTX3): an endogenous modulator of the inflammatory response. Mediators Inflamm. 2012;2012:920517.","journal-title":"Mediators Inflamm."},{"issue":"7","key":"59_CR22","first-page":"588","volume":"11","author":"M Ustundag","year":"2011","unstructured":"Ustundag M, Orak M, Gulog C, Sayhan MB, Alyano O, Kale E. Comparative diagnostic accuracy of serum levels of neutrophil activating peptide-2 and pentraxin 3 versus troponin-I in acute coronary syndrome. Anadolu Kardiyol Derg. 2011;11(7):588\u201394.","journal-title":"Anadolu Kardiyol Derg."},{"issue":"12","key":"59_CR23","doi-asserted-by":"crossref","first-page":"e 53030","DOI":"10.1371\/journal.pone.0053030","volume":"7","author":"E Barbati","year":"2012","unstructured":"Barbati E, Specchia C, Villella M, et al. Influence of pentraxin3 (PTX3) genetic variants on myocardial infarction risk and PTX3 plasma levels. Plos One. 2012;7(12):e 53030.","journal-title":"Plos One"},{"issue":"1","key":"59_CR24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1253\/circj.CJ-13-0329","volume":"78","author":"S Kimura","year":"2013","unstructured":"Kimura S, Inagaki H, Haraguchi G, et al. Relationships of elevated systemic pentraxin 3 levels with high risk coronary plaque components and impaired myocardial perfusion after percutaneous coronary intervention in patients with ST-elevation acute myocardial infarction. Circ J. 2013;78(1):159\u201369.","journal-title":"Circ J."},{"issue":"16\u201317","key":"59_CR25","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.clinbiochem.2013.08.014","volume":"46","author":"KM Eggers","year":"2013","unstructured":"Eggers KM, Armstrong PW, Califf RM, et al. Clinical and prognostic implications of circulating pentraxin 3 levels in non-ST-elevation acute coronary syndrome. Clin Biochem. 2013;46(16\u201317):1655\u20139.","journal-title":"Clin Biochem."},{"issue":"2","key":"59_CR26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/1358863X07077462","volume":"12","author":"SR Steinhubl","year":"2007","unstructured":"Steinhubl SR, Badimon JJ, Bhatt DL, Herbert JM, L\u00fcscher TF. Clinical evidence for anti-inflammatory effects of antiplatelet therapy in patients with atherothrombotic disease. Vasc Med. 2007;12(2):113\u201322.","journal-title":"Vasc Med."},{"key":"59_CR27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3122\/jabfm.2009.01.070282","volume":"22","author":"C Terpening","year":"2009","unstructured":"Terpening C. An appraisal of dual antiplatelet therapy with clopidogrel and aspirin for prevention of cardiovascular events. J Am Board Fam Med. 2009;22:51\u20136.","journal-title":"J Am Board Fam Med."},{"issue":"1","key":"59_CR28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2329-9495.1000108","volume":"1","author":"T Yamasaki","year":"2013","unstructured":"Yamasaki T, Koizumi T, Tamaki T, et al. Differing behavior of plasma pentraxin 3 and high-sensitive CRP at the very onset of myocardial infarction with ST-segment elevation. Angiol. 2013;1(1):1\u20135.","journal-title":"Angiol."},{"key":"59_CR29","doi-asserted-by":"crossref","first-page":"608414","DOI":"10.1155\/2014\/608414","volume":"2014","author":"R Helseth","year":"2014","unstructured":"Helseth R, Solheim S, Opstad T, Hoffmann P, Arnesen H, Seljeflot I. The time profile of pentraxin 3 in patients with acute ST-elevation myocardial infarction and stable angina pectoris undergoing percutaneous coronary intervention. Mediators Inflamm. 2014;2014:608414.","journal-title":"Mediators Inflamm."},{"issue":"3","key":"59_CR30","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1365-2362.2011.02587.x","volume":"42","author":"C Herder","year":"2012","unstructured":"Herder C, Peeters W, Zierer A, de Kleijn DP, Moll FL, Roden M. TGF-\u03b21 content in atherosclerotic plaques, TGF-\u03b21 serum concentrations and incident coronary events. Eur J Clin Invest. 2012;42(3):329\u201337.","journal-title":"Eur J Clin Invest."},{"issue":"5","key":"59_CR31","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/MAJ.0b013e318215908a","volume":"342","author":"RA Najar","year":"2011","unstructured":"Najar RA, Ghaderian SM, Panah AS. Association of transforming growth factor\u2013\u03b21 gene polymorphism with genetic susceptibility to acute myocardial infarction. Am J Med Sci. 2011;342(5):365\u201370.","journal-title":"Am J Med Sci."},{"key":"59_CR32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2261-14-18","volume":"14","author":"C Chen","year":"2014","unstructured":"Chen C, Lei W, Chen W, et al. Serum TGF-\u03b21 and SMAD3 levels are closely associated with coronary artery disease. BMC Cardiovas Disord. 2014;14:18.","journal-title":"BMC Cardiovas Disord."},{"issue":"4","key":"59_CR33","first-page":"257","volume":"21","author":"B Hudzik","year":"2010","unstructured":"Hudzik B, Szkodzinski J, Danikiewicz K, et al. Effect of omeperazole on the concentration of interleukin-6 and transforming growth factor\u2013\u03b21 in patients receiving dual antiplatelet therapy after percutaneous coronary intervention. Eur Cytokine Netw. 2010;21(4):257\u201363.","journal-title":"Eur Cytokine Netw."},{"issue":"3","key":"59_CR34","doi-asserted-by":"crossref","first-page":"469","DOI":"10.5935\/1678-9741.20110024","volume":"26","author":"HG Lobo","year":"2011","unstructured":"Lobo HG, Fereira NL, Sousa RB, Carvalho ER, Lobo PL. Experimental model of myocardial infarction induced by isoproterenol in rats. Rev Bras Circ Cardiovasc. 2011;26(3):469\u201376.","journal-title":"Rev Bras Circ Cardiovasc."},{"key":"59_CR35","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1039\/c3mb70222g","volume":"9","author":"L Yue-tao","year":"2013","unstructured":"Yue-tao L, Hong-mei J, Xing-chang C, Hong-wu Z, Zhong-mei Z. The metabolic disturbances of isoproterenol induced myocardial infarction in rats based on tissue targeted metabonomics. Mol Biosyst. 2013;9:2823\u201334.","journal-title":"Mol Biosyst."},{"issue":"24","key":"59_CR36","first-page":"1682","volume":"90","author":"CH Wang","year":"2010","unstructured":"Wang CH, Yang J, Shen ZJ, Fang Q, Zhang SY, Fan ZJ. Effect of duration of clopidogrel use on clinical follow-up outcomes in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention. Zhonghua Yi Xue Za Zhi. 2010;90(24):1682\u20135.","journal-title":"Zhonghua Yi Xue Za Zhi."},{"issue":"5","key":"59_CR37","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3810\/pgm.2013.09.2694","volume":"125","author":"S Acharji","year":"2013","unstructured":"Acharji S, Lakshmanodoss U, Rudzinski W, Stapleton D, Kaluski E. Use of antiplatelet agents in patients with atherosclerotic diseases. Postgrad Med. 2013;125(5):19\u201330.","journal-title":"Postgrad Med."}],"container-title":["Drugs in R&amp;D"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40268-014-0059-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40268-014-0059-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40268-014-0059-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T08:17:31Z","timestamp":1650183451000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40268-014-0059-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,18]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["59"],"URL":"https:\/\/doi.org\/10.1007\/s40268-014-0059-3","relation":{},"ISSN":["1174-5886","1179-6901"],"issn-type":[{"value":"1174-5886","type":"print"},{"value":"1179-6901","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,18]]}}}