{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:01:58Z","timestamp":1793289718511,"version":"4.5.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T00:00:00Z","timestamp":1455753600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs R D"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1007\/s40268-016-0124-1","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T05:06:13Z","timestamp":1455771973000},"page":"149-154","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Dabigatran Versus Warfarin After Bioprosthesis Valve Replacement for the Management of Atrial Fibrillation Postoperatively: DAWA Pilot Study"],"prefix":"10.1007","volume":"16","author":[{"given":"Andr\u00e9 Rodrigues","family":"Dur\u00e3es","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pollianna","family":"de Souza Roriz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"de Almeida Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Pinho e","family":"Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Vieira","family":"de Bulh\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre Mauricio","family":"de Souza Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roque","family":"Aras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,18]]},"reference":[{"issue":"9689","key":"124_CR1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(09)60780-7","volume":"374","author":"JC Sun","year":"2009","unstructured":"Sun JC, Davidson MJ, Lamy A, Eikelboom JW. Antithrombotic management of patients with prosthetic heart valves: current evidence and future trends. Lancet. 2009;374(9689):565\u201376.","journal-title":"Lancet"},{"issue":"4","key":"124_CR2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1093\/ejcts\/ezs455","volume":"42","author":"A Vahanian","year":"2012","unstructured":"Vahanian A, Alfieri O, Andreotti F, et al. Guidelines on the management of valvular heart disease (version 2012): the Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur J Cardiothorac Surg. 2012;42(4):S1\u201344.","journal-title":"Eur J Cardiothorac Surg"},{"issue":"15","key":"124_CR3","first-page":"60243","volume":"S0140\u20136736","author":"JL Mega","year":"2015","unstructured":"Mega JL, Simon T. Pharmacology of antithrombotic drugs: an assessment of oral antiplatelet and anticoagulant treatments. Lancet. 2015;S0140\u20136736(15):60243\u20134.","journal-title":"Lancet"},{"issue":"4","key":"124_CR4","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.clinthera.2012.01.019","volume":"34","author":"KM O\u2019Dell","year":"2012","unstructured":"O\u2019Dell KM, Igawa D, Hsin J. New oral anticoagulants for atrial fibrillation: a review of clinical trials. Clin Ther. 2012;34(4):894\u2013901.","journal-title":"Clin Ther"},{"issue":"11","key":"124_CR5","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1185\/03007995.2014.951425","volume":"30","author":"F Akwaa","year":"2014","unstructured":"Akwaa F, Spyropoulos AC. The potential of target-specific oral anticoagulants for the acute and long-term treatment of venous thromboembolism. Curr Med Res Opin. 2014;30(11):2179\u201390.","journal-title":"Curr Med Res Opin"},{"issue":"13","key":"124_CR6","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1056\/NEJMoa1300615","volume":"369","author":"JW Eikelboom","year":"2013","unstructured":"Eikelboom JW, Connolly SJ, Brueckmann M, et al. Dabigatran versus warfarin in patients with mechanical heart valves. N Engl J Med. 2013;369(13):1206\u201314.","journal-title":"N Engl J Med"},{"issue":"11","key":"124_CR7","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s11883-014-0448-7","volume":"16","author":"P Forsberg","year":"2014","unstructured":"Forsberg P, DeSancho MT. Role of novel anticoagulants for patients with mechanical heart valves. Curr Atheroscler Rep. 2014;16(11):448.","journal-title":"Curr Atheroscler Rep"},{"issue":"2","key":"124_CR8","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.2196\/resprot.3014","volume":"3","author":"AR Duraes","year":"2014","unstructured":"Duraes AR, Roriz PD, Bulhoes FV, et al. Dabigatran versus warfarin after bioprosthesis valve replacement for the management of atrial fibrillation postoperatively: protocol. JMIR Res Protoc. 2014;3(2):e21.","journal-title":"JMIR Res Protoc"},{"issue":"6","key":"124_CR9","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ahj.2015.03.016","volume":"169","author":"K Sugioka","year":"2015","unstructured":"Sugioka K, Takagi M, Sakamoto S, et al. Predictors of silent brain infarction on magnetic resonance imaging in patients with nonvalvular atrial fibrillation: a transesophageal echocardiographic study. Am Heart J. 2015;169(6):783\u201390.","journal-title":"Am Heart J"},{"issue":"4","key":"124_CR10","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/0735-1097(94)90644-0","volume":"23","author":"D Fatkin","year":"1994","unstructured":"Fatkin D, Kelly RP, Feneley MP. Relations between left atrial appendage blood flow velocity, spontaneous echocardiographic contrast and thromboembolic risk in vivo. J Am Coll Cardiol. 1994;23(4):961\u20139.","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"124_CR11","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1538-7836.2005.01204.x","volume":"3","author":"S Schulman","year":"2005","unstructured":"Schulman S, Kearon C. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J Thromb Haemost. 2005;3(4):692\u20134.","journal-title":"J Thromb Haemost"},{"issue":"5","key":"124_CR12","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1378\/chest.10-0134","volume":"138","author":"R Pisters","year":"2010","unstructured":"Pisters R, Lane DA, Nieuwlaat R, et al. A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey. Chest. 2010;138(5):1093\u2013100.","journal-title":"Chest"},{"issue":"5","key":"124_CR13","first-page":"466","volume":"101","author":"AR Duraes","year":"2013","unstructured":"Duraes AR, Duraes MA, Correia LC, et al. Antithrombotic strategy in the three first months following bioprosthetic heart valve implantation. Arq Bras Cardiol. 2013;101(5):466\u201372.","journal-title":"Arq Bras Cardiol"},{"issue":"5","key":"124_CR14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.acvd.2014.02.002","volume":"107","author":"B Iung","year":"2014","unstructured":"Iung B, Vahanian A. Lessons from the RE-ALIGN trial. Arch Cardiovasc Dis. 2014;107(5):277\u20139.","journal-title":"Arch Cardiovasc Dis"},{"key":"124_CR15","doi-asserted-by":"crossref","unstructured":"Ramos AI, Magalhaes AM, Maldonado M, et al. Incidence of intracardiac thrombus and thromboembolism in the first three months after bioprosthetic valve implantation. Arq Bras.Cardiol. 2004;83 Spec No:46\u201352.","DOI":"10.1590\/S0066-782X2004001900009"},{"issue":"11","key":"124_CR16","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.jacc.2004.11.071","volume":"45","author":"P Bernhardt","year":"2005","unstructured":"Bernhardt P, Schmidt H, Hammerstingl C, et al. Patients with atrial fibrillation and dense spontaneous echo contrast at high risk: a prospective and serial follow-up over 12 months with transesophageal echocardiography and cerebral magnetic resonance imaging. J Am Coll Cardiol. 2005;45(11):1807\u201312.","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"124_CR17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/CIRCULATIONAHA.112.001139","volume":"128","author":"SJ Connolly","year":"2013","unstructured":"Connolly SJ, Wallentin L, Ezekowitz MD. The long-term multicenter observational study of dabigatran treatment in patients with atrial fibrillation (RELY-ABLE) study. Circulation. 2013;128(3):237\u201343.","journal-title":"Circulation"},{"issue":"9921","key":"124_CR18","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","volume":"383","author":"CT Ruff","year":"2014","unstructured":"Ruff CT, Giugliano RP, Braunwald E. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet. 2014;383(9921):955\u201362.","journal-title":"Lancet"},{"issue":"47","key":"124_CR19","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1093\/eurheartj\/ehu352","volume":"35","author":"R Caterina De","year":"2014","unstructured":"De Caterina R, Camm AJ. What is \u2018valvular\u2019 atrial fibrillation? A reappraisal. Eur Heart J. 2014;35(47):3328\u201335.","journal-title":"Eur Heart J."},{"issue":"5","key":"124_CR20","first-page":"466","volume":"101","author":"AR Duraes","year":"2013","unstructured":"Duraes AR, Duraes Milena AO, Correia LCL, et al. Antithrombotic strategy in the three first months following bioprosthetic heart valve implantation. Arq Bras Cardiol. 2013;101(5):466\u201372.","journal-title":"Arq Bras Cardiol"}],"container-title":["Drugs in R&amp;D"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40268-016-0124-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40268-016-0124-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40268-016-0124-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T15:14:24Z","timestamp":1553613264000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40268-016-0124-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,18]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["124"],"URL":"https:\/\/doi.org\/10.1007\/s40268-016-0124-1","relation":{},"ISSN":["1174-5886","1179-6901"],"issn-type":[{"value":"1174-5886","type":"print"},{"value":"1179-6901","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,18]]}}}