{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T07:41:54Z","timestamp":1769067714684,"version":"3.49.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,7,23]],"date-time":"2016-07-23T00:00:00Z","timestamp":1469232000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100014850","name":"Bayer Consumer Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014850","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs R D"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s40268-016-0138-8","type":"journal-article","created":{"date-parts":[[2016,7,23]],"date-time":"2016-07-23T06:15:00Z","timestamp":1469254500000},"page":"263-269","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Gastrointestinal Safety of Aspirin for a High-Dose, Multiple-Day Treatment Regimen: A Meta-Analysis of Three Randomized Controlled Trials"],"prefix":"10.1007","volume":"16","author":[{"given":"Samantha","family":"Forder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Voelker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Lanas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,7,23]]},"reference":[{"key":"138_CR1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/pds.732","volume":"11","author":"GC Curhan","year":"2002","unstructured":"Curhan GC, Bullock AJ, Hankinson SE, et al. Frequency of use of acetaminophen, nonsteroidal anti-inflammatory drugs, and aspirin in US women. Pharmacoepidemiol Drug Saf. 2002;11:687\u201393.","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"138_CR2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1001\/jama.287.3.337","volume":"287","author":"DW Kaufman","year":"2002","unstructured":"Kaufman DW, Kelly JP, Rosenberg L, et al. Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey. JAMA. 2002;287:337\u201344.","journal-title":"JAMA"},{"key":"138_CR3","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.3399\/bjgp14X677815","volume":"64","author":"AR Koffeman","year":"2014","unstructured":"Koffeman AR, Valkhoff VE, Celik S, et al. High-risk use of over-the-counter non-steroidal anti-inflammatory drugs: a population based cross-sectional study. Br J Gen Pract. 2014;64:e191\u20138.","journal-title":"Br J Gen Pract"},{"key":"138_CR4","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/newbio231232a0","volume":"231","author":"JR Vane","year":"1971","unstructured":"Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971;231:232\u20135.","journal-title":"Nat New Biol"},{"key":"138_CR5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2165\/11593880-000000000-00000","volume":"11","author":"A Lanas","year":"2011","unstructured":"Lanas A, McCarthy D, Voelker M, et al. Short-term acetylsalicylic acid (aspirin) use for pain, fever, or colds\u2014gastrointestinal adverse effects: a meta-analysis of randomized clinical trials. Drugs R D. 2011;11:277\u201388.","journal-title":"Drugs R D"},{"key":"138_CR6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s40268-013-0011-y","volume":"13","author":"JA Baron","year":"2013","unstructured":"Baron JA, Senn S, Voelker M, et al. Gastrointestinal adverse effects of short-term aspirin use: a meta-analysis of published randomized controlled trials. Drugs R D. 2013;13:9\u201316.","journal-title":"Drugs R D"},{"key":"138_CR7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0304-3959(99)00022-6","volume":"81","author":"JE Edwards","year":"1999","unstructured":"Edwards JE, Oldman AD, Smith LA, et al. Oral aspirin in postoperative pain: a quantitative systematic review. Pain. 1999;81:289\u201397.","journal-title":"Pain"},{"key":"138_CR8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2710.2008.00989.x","volume":"34","author":"T Steiner","year":"2009","unstructured":"Steiner T, Voelker M. Gastrointestinal tolerability of aspirin and the choice of over-the-counter analgesia for shortlasting acute pain. J Clin Pharm Ther. 2009;34:177\u201386.","journal-title":"J Clin Pharm Ther"},{"key":"138_CR9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2165\/00044011-199918020-00001","volume":"18","author":"N Moore","year":"1999","unstructured":"Moore N, Van Ganse E, Le Parc JM, et al. The PAIN study: paracetamol, aspirin and ibuprofen new tolerability study. A large-scale, randomised clinical trial comparing the tolerability of aspirin, ibuprofen and paracetamol for short-term analgesia. Clin Drug Invest. 1999;18:89\u201398.","journal-title":"Clin Drug Invest"},{"key":"138_CR10","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.cgh.2007.03.011","volume":"5","author":"A Rostom","year":"2007","unstructured":"Rostom A, Muir K, Dub\u00e9 C, et al. Gastrointestinal safety of cyclooxygenase-2 inhibitors: a Cochrane Collaboration systematic review. Clin Gastroenterol Hepatol. 2007;5:818\u201328.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"138_CR11","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1136\/gut.2005.080754","volume":"55","author":"A Lanas","year":"2006","unstructured":"Lanas A, Garcia-Rodriguez LA, Arroyo MT, et al. Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional nonaspirin non-steroidal anti-inflammatory drugs, aspirin and combinations. Gut. 2006;55:1731\u20138.","journal-title":"Gut"},{"key":"138_CR12","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1056\/NEJM200009213431202","volume":"343","author":"A Lanas","year":"2000","unstructured":"Lanas A, Bajador E, Serrano P, et al. Nitrovasodilators, low-dose aspirin, other nonsteroidal anti-inflammatory drugs, and the risk of upper gastrointestinal bleeding. N Engl J Med. 2000;343:834\u20139.","journal-title":"N Engl J Med"}],"container-title":["Drugs in R&D"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40268-016-0138-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40268-016-0138-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40268-016-0138-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T01:56:23Z","timestamp":1589680583000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40268-016-0138-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,23]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["138"],"URL":"https:\/\/doi.org\/10.1007\/s40268-016-0138-8","relation":{},"ISSN":["1174-5886","1179-6901"],"issn-type":[{"value":"1174-5886","type":"print"},{"value":"1179-6901","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,23]]}}}