{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T18:59:11Z","timestamp":1772045951150,"version":"3.50.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs R D"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s40268-016-0141-0","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T15:09:29Z","timestamp":1473779369000},"page":"279-283","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Tailored Approach to the Treatment of a Patient with a Severe Dynamic Manifestation of Rosacea: A Case Report"],"prefix":"10.1007","volume":"16","author":[{"given":"Martin","family":"Schaller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Gonser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,9,13]]},"reference":[{"issue":"6","key":"141_CR1","first-page":"725","volume":"11","author":"HE Baldwin","year":"2012","unstructured":"Baldwin HE. Diagnosis and treatment of rosacea: state of the art. J Drugs Dermatol. 2012;11(6):725\u201330.","journal-title":"J Drugs Dermatol."},{"issue":"3","key":"141_CR2","first-page":"26","volume":"5","author":"JQ Rosso Del","year":"2012","unstructured":"Del Rosso JQ. Advances in understanding and managing rosacea: part 2: the central role, evaluation, and medical management of diffuse and persistent facial erythema of rosacea. J Clin Aesthet Dermatol. 2012;5(3):26\u201336.","journal-title":"J Clin Aesthet Dermatol."},{"issue":"5","key":"141_CR3","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1046\/j.1365-4362.1998.00442.x","volume":"37","author":"C Torresani","year":"1998","unstructured":"Torresani C. Clarithromycin: a new perspective in rosacea treatment. Int J Dermatol. 1998;37(5):347\u20139.","journal-title":"Int J Dermatol."},{"issue":"2","key":"141_CR4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1365-4632.2004.01958.x","volume":"43","author":"O Bakar","year":"2004","unstructured":"Bakar O, Demircay Z, Gurbuz O. Therapeutic potential of azithromycin in rosacea. Int J Dermatol. 2004;43(2):151\u20134.","journal-title":"Int J Dermatol."},{"issue":"2","key":"141_CR5","first-page":"1","volume":"12","author":"HE Baldwin","year":"2007","unstructured":"Baldwin HE. Systemic therapy for rosacea. Skin Therapy Lett. 2007;12(2):1\u20139.","journal-title":"Skin Therapy Lett."},{"key":"141_CR6","doi-asserted-by":"publisher","unstructured":"Reinholz M, Tietze JK, Kilian K, Schaller M, Schofer H, Lehmann P, et al. Rosacea\u2014S1 guideline [in English, German]. J Dtsch Dermatol Ges. 2013;11(8):768\u201380; 768\u201379. doi: 10.1111\/ddg.12101 .","DOI":"10.1111\/ddg.12101"},{"issue":"9","key":"141_CR7","first-page":"22","volume":"4","author":"JQ Rosso Del","year":"2011","unstructured":"Del Rosso JQ, Levin J. The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. J Clin Aesthet Dermatol. 2011;4(9):22\u201342.","journal-title":"J Clin Aesthet Dermatol."},{"issue":"6","key":"141_CR8","first-page":"694","volume":"11","author":"JQ Rosso Del","year":"2012","unstructured":"Del Rosso JQ, Gallo RL, Kircik L, Thiboutot D, Baldwin HE, Cohen D. Why is rosacea considered to be an inflammatory disorder? The primary role, clinical relevance, and therapeutic correlations of abnormal innate immune response in rosacea-prone skin. J Drugs Dermatol. 2012;11(6):694\u2013700.","journal-title":"J Drugs Dermatol."},{"issue":"3","key":"141_CR9","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1111\/j.1365-2133.2011.10716.x","volume":"166","author":"J Fowler","year":"2012","unstructured":"Fowler J, Jarratt M, Moore A, Meadows K, Pollack A, Steinhoff M, et al. Once-daily topical brimonidine tartrate gel 0.5\u00a0% is a novel treatment for moderate to severe facial erythema of rosacea: results of two multicentre, randomized and vehicle-controlled studies. Br J Dermatol. 2012;166(3):633\u201341. doi: 10.1111\/j.1365-2133.2011.10716.x .","journal-title":"Br J Dermatol."},{"key":"141_CR10","unstructured":"European Medicines Agency. MIRVASO\u00ae\u2014Summary of product characteristics. February 2014. http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Product_Information\/human\/002642\/WC500163121.pdf . Accessed 31 Aug 2016."},{"issue":"9","key":"141_CR11","first-page":"54","volume":"4","author":"H Park","year":"2011","unstructured":"Park H, Del Rosso JQ. Use of oral isotretinoin in the management of rosacea. J Clin Aesthet Dermatol. 2011;4(9):54\u201361.","journal-title":"J Clin Aesthet Dermatol."},{"issue":"5","key":"141_CR12","first-page":"557","volume":"4","author":"ZD Draelos","year":"2005","unstructured":"Draelos ZD. Assessment of skin barrier function in rosacea patients with a novel 1\u00a0% metronidazole gel. J Drugs Dermatol. 2005;4(5):557\u201362.","journal-title":"J Drugs Dermatol."}],"container-title":["Drugs in R&amp;D"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40268-016-0141-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40268-016-0141-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40268-016-0141-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T22:40:50Z","timestamp":1498344050000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40268-016-0141-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["141"],"URL":"https:\/\/doi.org\/10.1007\/s40268-016-0141-0","relation":{},"ISSN":["1174-5886","1179-6901"],"issn-type":[{"value":"1174-5886","type":"print"},{"value":"1179-6901","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9]]}}}