{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T11:46:51Z","timestamp":1742384811969},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T00:00:00Z","timestamp":1559952000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T00:00:00Z","timestamp":1559952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Kyowa Kirin Farmac\u00e9utica SLU, Spain"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs R D"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s40268-019-0276-x","type":"journal-article","created":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T11:02:48Z","timestamp":1559991768000},"page":"247-254","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Age Among Elderly Cancer Patients on Breakthrough Pain Management with Sublingual Fentanyl Tablets"],"prefix":"10.1007","volume":"19","author":[{"given":"Jordi","family":"Guitart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Isabel","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"De Sanctis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Folch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Salazar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Coma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Ferreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Moya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Tom\u00e1s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pere","family":"Estivill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Rodelas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Javier","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almudena","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,6,8]]},"reference":[{"key":"276_CR1","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1200\/JCO.2003.12.044","volume":"21","author":"KW Yee","year":"2003","unstructured":"Yee KW, Pater JL, Pho L, et al. Enrollment of older patients in cancer treatment trials in Canada: why is age a barrier? J Clin Oncol. 2003;21:1618\u201323.","journal-title":"J Clin Oncol"},{"key":"276_CR2","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1200\/JCO.2003.08.010","volume":"21","author":"JH Lewis","year":"2003","unstructured":"Lewis JH, Kilgore ML, Goldman DP, Trimble EL, Kaplan R, Montello MJ, et al. Participation of patients 65\u00a0years of age or older in cancer clinical trials. J Clin Oncol. 2003;21:1383\u20139.","journal-title":"J Clin Oncol"},{"key":"276_CR3","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1056\/NEJM199912303412706","volume":"341","author":"LF Hutchins","year":"1999","unstructured":"Hutchins LF, Unger JM, Crowley JJ, Coltman CA Jr, Albain KS. Underrepresentation of patients 65\u00a0years of age or older in cancer-treatment trials. N Engl J Med. 1999;341:2061\u20137.","journal-title":"N Engl J Med"},{"issue":"9","key":"276_CR4","doi-asserted-by":"publisher","first-page":"761","DOI":"10.2165\/00002512-200724090-00004","volume":"24","author":"S Mercadante","year":"2007","unstructured":"Mercadante S, Arcuri E. Pharmacological management of cancer pain in the elderly. Drugs Aging. 2007;24(9):761\u201376.","journal-title":"Drugs Aging"},{"issue":"6","key":"276_CR5","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.jpainsymman.2015.12.340","volume":"51","author":"MH van den Beuken-van Everdingen","year":"2016","unstructured":"van den Beuken-van Everdingen MH, Hochstenbach LM, Joosten EA, Tjan-Heijnen VC, Janssen DJ. Update on prevalence of pain in patients with cancer: systematic review and meta-analysis. J Pain Symptom Manag. 2016;51(6):1070\u201390. \n                    https:\/\/doi.org\/10.1016\/j.jpainsymman\n                    \n                  .","journal-title":"J Pain Symptom Manag"},{"issue":"3","key":"276_CR6","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/0304-3959(90)90004-W","volume":"41","author":"RK Portenoy","year":"1990","unstructured":"Portenoy RK, Hagen NA. Breakthrough pain: definition, prevalence and characteristics. Pain. 1990;41(3):273\u201381.","journal-title":"Pain"},{"key":"276_CR7","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.ejpain.2008.06.014","volume":"13","author":"AN Davies","year":"2009","unstructured":"Davies AN, Dickman A, Reid C, Stevens AM, Zeppetella G. The management of cancer-related breakthrough pain: recommendations of a task group of the Science Committee of Association for Palliative Medicine of Great Britain and Ireland. Eur J Pain. 2009;13:331\u20138. \n                    https:\/\/doi.org\/10.1016\/j.ejpain.2008.06.014\n                    \n                  .","journal-title":"Eur J Pain"},{"issue":"3","key":"276_CR8","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1191\/0269216304pm890oa","volume":"18","author":"A Caraceni","year":"2004","unstructured":"Caraceni A, Martini C, Zecca E, Working Group of an IASP Task Force on Cancer Pain, et al. Breakthrough pain characteristics and syndromes in patients with cancer pain. An international survey. Palliat Med. 2004;18(3):177\u201383.","journal-title":"Palliat Med."},{"issue":"1","key":"276_CR9","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jpainsymman.2013.02.015","volume":"47","author":"S Deandrea","year":"2014","unstructured":"Deandrea S, Corli O, Consonni D, Villani W, Greco MT, Apolone G. Prevalence of breakthrough cancer pain: a systematic review and a pooled analysis of published literature. J Pain Symptom Manag. 2014;47(1):57\u201376. \n                    https:\/\/doi.org\/10.1016\/j.jpainsymman.2013.02.015\n                    \n                  \n                           (Epub 2013 Jun 21).","journal-title":"J Pain Symptom Manag"},{"issue":"suppl 1","key":"276_CR10","first-page":"S3","volume":"8","author":"R Payne","year":"2007","unstructured":"Payne R. Recognition and diagnosis of breakthrough pain. Pin Med. 2007;8(suppl 1):S3\u20137.","journal-title":"Pin Med"},{"key":"276_CR11","doi-asserted-by":"publisher","first-page":"559","DOI":"10.2147\/JPR.S36428","volume":"5","author":"C Margarit","year":"2012","unstructured":"Margarit C, Juli\u00e1 J, L\u00f3pez R, et al. Breakthrough cancer pain\u2014still a challenge. J Pain Res. 2012;5:559\u201366.","journal-title":"J Pain Res."},{"issue":"6","key":"276_CR12","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s40266-014-0181-5","volume":"31","author":"S Pautex","year":"2014","unstructured":"Pautex S, Vogt-Ferrier N, Zulian GB. Breakthrough pain in elderly patients with cancer: treatment options. Drugs Aging. 2014;31(6):405\u201311. \n                    https:\/\/doi.org\/10.1007\/s40266-014-0181-5\n                    \n                  \n                           (Review).","journal-title":"Drugs Aging"},{"issue":"3","key":"276_CR13","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1177\/0269216309356138","volume":"24","author":"B Lennern\u00e4s","year":"2010","unstructured":"Lennern\u00e4s B, Frank-Lissbrant I, Lennern\u00e4s H, K\u00e4lkner KM, Derrick R, Howell J. Sublingual administration of fentanyl to cancer patients is an effective treatment for breakthrough pain: results from a randomized phase II study. Palliat Med. 2010;24(3):286\u201393. \n                    https:\/\/doi.org\/10.1177\/0269216309356138\n                    \n                  \n                           (Epub 2009 Dec 16).","journal-title":"Palliat Med"},{"issue":"1","key":"276_CR14","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1542\/peds.100.1.143","volume":"100","author":"American Academy of Pediatrics","year":"1997","unstructured":"American Academy of Pediatrics, Committee on Drugs. Alternative routes of drug administration-advantages and disadvantages (subject review). Pediatrics. 1997;100(1):143\u201352.","journal-title":"Pediatrics"},{"issue":"17","key":"276_CR15","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.2165\/11200910-000000000-00000","volume":"70","author":"CM Chwieduk","year":"2010","unstructured":"Chwieduk CM, McKeage K. Fentanyl sublingual: in breakthrough pain in opioid-tolerant adults with cancer. Drugs. 2010;70(17):2281\u20138. \n                    https:\/\/doi.org\/10.2165\/11200910-000000000-00000\n                    \n                  .","journal-title":"Drugs."},{"issue":"12","key":"276_CR16","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.1185\/03007990903368310","volume":"25","author":"RL Rauck","year":"2009","unstructured":"Rauck RL, Tark M, Reyes E, Hayes TG, Bartkowiak AJ, Hassman D, Nalamachu S, Derrick R, Howell J. Efficacy and long-term tolerability of sublingual fentanyl orally disintegrating tablet in the treatment of breakthrough cancer pain. Curr Med Res Opin. 2009;25(12):2877\u201385.","journal-title":"Curr Med Res Opin"},{"issue":"7","key":"276_CR17","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1185\/03007995.2011.583231","volume":"27","author":"MA \u00dcberall","year":"2011","unstructured":"\u00dcberall MA, M\u00fcller-Schwefe GH. Sublingual fentanyl orally disintegrating tablet in daily practice: efficacy, safety and tolerability in patients with breakthrough cancer pain. Curr Med Res Opin. 2011;27(7):1385\u201394. \n                    https:\/\/doi.org\/10.1185\/03007995.2011.583231\n                    \n                  \n                           (Epub 2011 May 11).","journal-title":"Curr Med Res Opin"},{"issue":"3","key":"276_CR18","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s40268-017-0198-4","volume":"17","author":"J Guitart","year":"2017","unstructured":"Guitart J, Vargas MI, De Sanctis V, Folch J, Salazar R, Fuentes J, Coma J, Ferreras J, Moya J, Tom\u00e1s A, Estivill P, Rodelas F, Jim\u00e9nez AJ, Sanz A. Breakthrough pain management with sublingual fentanyl tablets in patients with cancer: age subgroup analysis of a multicenter prospective study. Drugs R D. 2017;17(3):419\u201325. \n                    https:\/\/doi.org\/10.1007\/s40268-017-0198-4\n                    \n                  .","journal-title":"Drugs R D."},{"issue":"2","key":"276_CR19","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s40268-018-0231-2","volume":"18","author":"J Guitart","year":"2018","unstructured":"Guitart J, Vargas MI, De Sanctis V, Folch J, Salazar R, Fuentes J, Coma J, Ferreras J, Moya J, Tom\u00e1s A, Estivill P, Rodelas F, Jim\u00e9nez AJ, Sanz A. Efficacy and safety of sublingual fentanyl tablets in breakthrough cancer pain management according to cancer stage and background opioid medication. Drugs R D. 2018;18(2):119\u201328. \n                    https:\/\/doi.org\/10.1007\/s40268-018-0231-2\n                    \n                  .","journal-title":"Drugs R D."},{"issue":"4","key":"276_CR20","doi-asserted-by":"publisher","first-page":"184","DOI":"10.4103\/2229-3485.167099","volume":"6","author":"P Shenoy","year":"2015","unstructured":"Shenoy P, Harugeri A. Elderly patients\u2019 participation in clinical trials. Perspect Clin Res. 2015;6(4):184\u20139.","journal-title":"Perspect Clin Res."},{"issue":"3","key":"276_CR21","doi-asserted-by":"publisher","first-page":"248","DOI":"10.4103\/apjon.apjon_11_18","volume":"5","author":"JM Brant","year":"2018","unstructured":"Brant JM. Assessment and management of cancer pain in older adults: strategies for success. Asia Pac J Oncol Nurs. 2018;5(3):248\u201353.","journal-title":"Asia Pac J Oncol Nurs."},{"issue":"12 Suppl","key":"276_CR22","doi-asserted-by":"publisher","first-page":"3479","DOI":"10.1002\/cncr.23937","volume":"113","author":"KM Bellizzi","year":"2008","unstructured":"Bellizzi KM, Mustian KM, Bowen DJ, Resnick B, Miller SM. Aging in the context of cancer prevention and control: perspectives from behavioral medicine. Cancer. 2008;113(12 Suppl):3479\u201383.","journal-title":"Cancer"},{"key":"276_CR23","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1472-8206.2007.00473.x","volume":"21","author":"SN Hilmer","year":"2007","unstructured":"Hilmer SN, McLachlan AJ, Le Couteur DG. Clinical pharmacology in the geriatric patient. Fundam Clin Pharmacol. 2007;21:217\u201330.","journal-title":"Fundam Clin Pharmacol"},{"key":"276_CR24","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/clpt.2009.1","volume":"85","author":"AJ McLachlan","year":"2009","unstructured":"McLachlan AJ, Hilmer SN, Le Couteur DG. Variability in response to medicines in older people\u2014phenotypic and genotypic factors. Clin Pharmacol Ther. 2009;85:431\u20133.","journal-title":"Clin Pharmacol Ther"},{"issue":"1","key":"276_CR25","doi-asserted-by":"publisher","first-page":"37","DOI":"10.2190\/AG.77.1.c","volume":"77","author":"J Cohen-Mansfield","year":"2013","unstructured":"Cohen-Mansfield J, Shmotkin D, Blumstein Z, Shorek A, Eyal N, Hazan H, et al. The old, old\u2013old, and the oldest old: continuation or distinct categories? An examination of the relationship between age and changes in health, function, and wellbeing. Int J Aging Hum Dev. 2013;77(1):37\u201357 (PMID: 23986979).","journal-title":"Int J Aging Hum Dev"},{"key":"276_CR26","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jaging.2012.12.006","volume":"27","author":"SS Alterovitz","year":"2013","unstructured":"Alterovitz SS, Mendelsohn GA. Relationship goals of middle-aged, young\u2013old, and old\u2013old internet daters: an analysis of online personal ads. J Aging Stud. 2013;27:159\u201365.","journal-title":"J Aging Stud."},{"key":"276_CR27","unstructured":"Valasek DL. Retirement satisfaction: Is there a young\/old, old\/old difference? In: Joint Annual Meeting of the Scientific Gerontological Society (34th) and the Scientific & Educational Canadian Association on Gerontology (10th); Toronto, Ontario, Canada; 1981."},{"issue":"2","key":"276_CR28","first-page":"135","volume":"20","author":"L Balducci","year":"2006","unstructured":"Balducci L. Management of cancer in the elderly. Oncology. 2006;20(2):135\u201352 (PubMed: 16562648).","journal-title":"Oncology."},{"issue":"12","key":"276_CR29","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1007\/s40261-015-0344-0","volume":"35","author":"J Guitart","year":"2015","unstructured":"Guitart J, Vargas MI, De Sanctis V, et al. Sublingual fentanyl tablets for relief of breakthrough pain in cancer patients and association with quality-of-life outcomes. Clin Drug Investig. 2015;35(12):815\u201322 (Erratum in: Clin Drug Investig 2016).","journal-title":"Clin Drug Investig."},{"issue":"6","key":"276_CR30","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","volume":"67","author":"AS Zigmond","year":"1983","unstructured":"Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67(6):361\u201370.","journal-title":"Acta Psychiatr Scand."},{"issue":"1","key":"276_CR31","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1477-7525-1-29","volume":"1","author":"RP Snaith","year":"2003","unstructured":"Snaith RP. The Hospital Anxiety and Depression Scale. Health Qual Life Outcomes. 2003;1(1):29.","journal-title":"Health Qual Life Outcomes."},{"issue":"8","key":"276_CR32","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1111\/papr.12253","volume":"15","author":"JV Pergolizzi","year":"2015","unstructured":"Pergolizzi JV, Gharibo C, Ho KY. Treatment considerations for cancer pain: a global perspective. Pain Pract. 2015;15(8):778\u201392. \n                    https:\/\/doi.org\/10.1111\/papr.12253\n                    \n                  \n                           (Epub 2014 Dec 3).","journal-title":"Pain Pract."},{"issue":"7","key":"276_CR33","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1185\/03007995.2014.901942","volume":"30","author":"S Mercadante","year":"2014","unstructured":"Mercadante S, Giarratano A. Assessing age and gender in studies of breakthrough pain medications. Curr Med Res Opin. 2014;30(7):1353\u20136. \n                    https:\/\/doi.org\/10.1185\/03007995.2014.901942\n                    \n                  .","journal-title":"Curr Med Res Opin"},{"issue":"2","key":"276_CR34","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s005200050026","volume":"8","author":"S Mercadante","year":"2000","unstructured":"Mercadante S, Casuccio A, Pumo S, Fulfaro F. Factors influencing the opioid response in advanced cancer patients with pain followed at home: the effects of age and gender. Support Care Cancer. 2000;8(2):123\u201330.","journal-title":"Support Care Cancer"},{"issue":"10","key":"276_CR35","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1111\/j.1526-4637.2010.00957.x","volume":"11","author":"CR Green","year":"2010","unstructured":"Green CR, Hart-Johnson T. Cancer pain: an age-based analysis. Pain Med. 2010;11(10):1525\u201336. \n                    https:\/\/doi.org\/10.1111\/j.1526-4637.2010.00957.x\n                    \n                  .","journal-title":"Pain Med."},{"key":"276_CR36","first-page":"213","volume":"283","author":"A Dickman","year":"2009","unstructured":"Dickman A. Basics of managing breakthrough cancer pain. Pharm J. 2009;283:213\u20136.","journal-title":"Pharm J."},{"issue":"4","key":"276_CR37","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s40266-015-0253-1","volume":"32","author":"S Mercadante","year":"2015","unstructured":"Mercadante S, Aielli F, Masedu F, Valenti M, Ficorella C, Porzio G. Pain characteristics and analgesic treatment in an aged adult population: a 4-week retrospective analysis of advanced cancer patients followed at home. Drugs Aging. 2015;32(4):315\u201320. \n                    https:\/\/doi.org\/10.1007\/s40266-015-0253-1\n                    \n                  .","journal-title":"Drugs Aging"},{"issue":"4","key":"276_CR38","first-page":"275","volume":"12","author":"D Swaminathan","year":"2015","unstructured":"Swaminathan D, Swaminathan V. Geriatric oncology: problems with under-treatment within this population. Cancer Biol Med. 2015;12(4):275\u201383.","journal-title":"Cancer Biol Med."},{"key":"276_CR39","first-page":"243","volume":"6","author":"V Swaminathan","year":"2012","unstructured":"Swaminathan V, Audisio RA. Cancer in older patients: an analysis of elderly oncology. Ecancermedicalscience. 2012;6:243.","journal-title":"Ecancermedicalscience"}],"container-title":["Drugs in R&amp;D"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40268-019-0276-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40268-019-0276-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40268-019-0276-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T23:21:34Z","timestamp":1591485694000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40268-019-0276-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,8]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["276"],"URL":"https:\/\/doi.org\/10.1007\/s40268-019-0276-x","relation":{},"ISSN":["1174-5886","1179-6901"],"issn-type":[{"value":"1174-5886","type":"print"},{"value":"1179-6901","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,8]]},"assertion":[{"value":"8 June 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"This study was funded by Kyowa Kirin Farmac\u00e9utica SLU, Spain.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors received research funding from Kyowa Kirin Farmac\u00e9utica SLU for this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Financial disclosure"}},{"value":"Antonio Javier Jim\u00e9nez and Almudena Sanz are employees of Kyowa Kirin Farmac\u00e9utica SLU. The authors declared they have no further competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}