{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:50:37Z","timestamp":1790884237000,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs R D"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s40268-022-00402-6","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T09:02:36Z","timestamp":1663837356000},"page":"271-279","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Quercetin Supplement to Aspirin Attenuates Lipopolysaccharide-Induced Pre-eclampsia-Like Impairments in Rats Through the NLRP3 Inflammasome"],"prefix":"10.1007","volume":"22","author":[{"given":"Shuangyan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"402_CR1","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1002\/uog.18959","volume":"51","author":"K Giannakou","year":"2018","unstructured":"Giannakou K, Evangelou E, Papatheodorou SI. Genetic and non-genetic risk factors for pre-eclampsia: umbrella review of systematic reviews and meta-analyses of observational studies. Ultrasound Obstet Gynecol. 2018;51:720\u201330. https:\/\/doi.org\/10.1002\/uog.18959.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"402_CR2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1002\/ijgo.13530","volume":"152","author":"WK Nicholson","year":"2021","unstructured":"Nicholson WK, Stones W, Visser GHA, Barnea ER, Nassar AH, Federation International Gynecology and Obstetrics Safe Motherhood and Newborn Health Committee. Don\u2019t forget eclampsia in the efforts to reduce maternal morbidity and mortality. Int J Gynaecol Obstet. 2021;152:165\u201371. https:\/\/doi.org\/10.1002\/ijgo.13530.","journal-title":"Int J Gynaecol Obstet"},{"key":"402_CR3","doi-asserted-by":"publisher","DOI":"10.37175\/stemedicine.v2i7.91","volume":"2","author":"Z Xiao","year":"2021","unstructured":"Xiao Z, Wang Y, Thai PN, Li X, Lu X, Pu J. Mechanisms linking hyperglycemia in pregnancy to the offspring cardiovascular system dysfunction. STEMedicine. 2021;2: e91. https:\/\/doi.org\/10.37175\/stemedicine.v2i7.91.","journal-title":"STEMedicine"},{"key":"402_CR4","doi-asserted-by":"publisher","DOI":"10.37175\/stemedicine.v3i3.129","volume":"3","author":"S Xiao","year":"2022","unstructured":"Xiao S, Zhang Q, Zhang M, Hu R, Liu R. A modified Mediterranean diet against gestational diabetes mellitus. STEMedicine. 2022;3: e129. https:\/\/doi.org\/10.37175\/stemedicine.v3i3.129.","journal-title":"STEMedicine."},{"key":"402_CR5","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1038\/s41581-019-0156-1","volume":"15","author":"EA Phipps","year":"2019","unstructured":"Phipps EA, Thadhani R, Benzing T, Karumanchi SA. Pre-eclampsia: pathogenesis, novel diagnostics and therapies. Nat Rev Nephrol. 2019;15:386. https:\/\/doi.org\/10.1038\/s41581-019-0156-1.","journal-title":"Nat Rev Nephrol"},{"key":"402_CR6","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.preghy.2018.06.012","volume":"13","author":"RD Williamson","year":"2018","unstructured":"Williamson RD, McCarthy FP, Khashan AS, Totorika A, Kenny LC, McCarthy C. Exploring the role of mitochondrial dysfunction in the pathophysiology of pre-eclampsia. Pregnancy Hypertens. 2018;13:248\u201353. https:\/\/doi.org\/10.1016\/j.preghy.2018.06.012.","journal-title":"Pregnancy Hypertens."},{"key":"402_CR7","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s00404-019-05365-9","volume":"301","author":"O Graupner","year":"2020","unstructured":"Graupner O, Karge A, Flechsenhar S, Seiler A, Haller B, Ortiz JU, et al. Role of sFlt-1\/PlGF ratio and feto-maternal Doppler for the prediction of adverse perinatal outcome in late-onset pre-eclampsia. Arch Gynecol Obstet. 2020;301:375\u201385. https:\/\/doi.org\/10.1007\/s00404-019-05365-9.","journal-title":"Arch Gynecol Obstet"},{"key":"402_CR8","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/cei.13130","volume":"193","author":"GS Stodle","year":"2018","unstructured":"Stodle GS, Silva GB, Tangeras LH, Gierman LM, Nervik I, Dahlberg UE, et al. Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts. Clin Exp Immunol. 2018;193:84\u201394. https:\/\/doi.org\/10.1111\/cei.13130.","journal-title":"Clin Exp Immunol"},{"key":"402_CR9","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1016\/s0140-6736(79)91996-2","volume":"1","author":"AJ Crandon","year":"1979","unstructured":"Crandon AJ, Isherwood DM. Effect of aspirin on incidence of pre-eclampsia. Lancet. 1979;1:1356. https:\/\/doi.org\/10.1016\/s0140-6736(79)91996-2.","journal-title":"Lancet"},{"key":"402_CR10","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/s0140-6736(78)91367-3","volume":"2","author":"RC Goodlin","year":"1978","unstructured":"Goodlin RC, Haesslein HO, Fleming J. Aspirin for the treatment of recurrent toxaemia. Lancet. 1978;2:51. https:\/\/doi.org\/10.1016\/s0140-6736(78)91367-3.","journal-title":"Lancet"},{"key":"402_CR11","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.ejogrb.2017.12.052","volume":"221","author":"K Navaratnam","year":"2018","unstructured":"Navaratnam K, Alfirevic A, Jorgensen A, Alfirevic Z. Aspirin non-responsiveness in pregnant women at high-risk of pre-eclampsia. Eur J Obstet Gynecol Reprod Biol. 2018;221:144\u201350. https:\/\/doi.org\/10.1016\/j.ejogrb.2017.12.052.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"402_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247782","volume":"16","author":"R Van Doorn","year":"2021","unstructured":"Van Doorn R, Mukhtarova N, Flyke IP, Lasarev M, Kim K, Hennekens CH, et al. Dose of aspirin to prevent preterm preeclampsia in women with moderate or high-risk factors: a systematic review and meta-analysis. PLoS\u00a0One. 2021;16: e0247782. https:\/\/doi.org\/10.1371\/journal.pone.0247782.","journal-title":"PLoS\u00a0One"},{"key":"402_CR13","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/bdrb.10007","volume":"68","author":"U Gupta","year":"2003","unstructured":"Gupta U, Cook JC, Tassinari MS, Hurtt ME. Comparison of developmental toxicology of aspirin, (acetylsalicylic acid) in rats using selected dosing paradigms. Birth Defects Res Dev Reprod Toxicol. 2003;68:27\u201337. https:\/\/doi.org\/10.1002\/bdrb.10007.","journal-title":"Birth Defects Res Dev Reprod Toxicol"},{"key":"402_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110122","volume":"127","author":"QH Li","year":"2020","unstructured":"Li QH, Yin LX, Si YR, Zhang CJ, Meng YH, Yang WW. The bioflavonoid quercetin improves pathophysiology in a rat model of preeclampsia. Biomed Pharmacother. 2020;127: 110122. https:\/\/doi.org\/10.1016\/j.biopha.2020.110122.","journal-title":"Biomed Pharmacother"},{"key":"402_CR15","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s11906-017-0757-7","volume":"19","author":"LM Amaral","year":"2017","unstructured":"Amaral LM, Wallace K, Owens M, LaMarca B. Pathophysiology and current clinical management of preeclampsia. Curr Hypertens Rep. 2017;19:61. https:\/\/doi.org\/10.1007\/s11906-017-0757-7.","journal-title":"Curr Hypertens Rep"},{"key":"402_CR16","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1039\/c7ra09475b","volume":"8","author":"J Xie","year":"2018","unstructured":"Xie J, Zhang AH, Sun H, Yan GL, Wang XJ. Recent advances and effective strategies in the discovery and applications of natural products. RSC Adv. 2018;8:812\u201324. https:\/\/doi.org\/10.1039\/c7ra09475b.","journal-title":"RSC Adv"},{"key":"402_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061578","volume":"19","author":"NE Thomford","year":"2018","unstructured":"Thomford NE, Senthebane DA, Rowe A, Munro D, Seele P, Maroyi A, et al. Natural products for drug discovery in the 21st century: innovations for novel drug discovery. Int J Mol Sci. 2018;19: 1578. https:\/\/doi.org\/10.3390\/ijms19061578.","journal-title":"Int J Mol Sci"},{"key":"402_CR18","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.jff.2017.10.047","volume":"40","author":"M Lesjak","year":"2018","unstructured":"Lesjak M, Beara I, Simin N, Pintac D, Majkic T, Bekvalac K, et al. Antioxidant and anti-inflammatory activities of quercetin and its derivatives. J Funct Foods. 2018;40:68\u201375. https:\/\/doi.org\/10.1016\/j.jff.2017.10.047.","journal-title":"J Funct Foods"},{"key":"402_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0014-2999(93)90968-N","volume":"239","author":"J Duarte","year":"1993","unstructured":"Duarte J, Perezvizcaino F, Zarzuelo A, Jimenez J, Tamargo J. Vasodilator effects of quercetin in isolated rat vascular smooth-muscle. Eur J Pharmacol. 1993;239:1\u20137. https:\/\/doi.org\/10.1016\/0014-2999(93)90968-N.","journal-title":"Eur J Pharmacol"},{"key":"402_CR20","doi-asserted-by":"publisher","first-page":"5814","DOI":"10.3390\/molecules18055814","volume":"18","author":"FJ Luna-Vazquez","year":"2013","unstructured":"Luna-Vazquez FJ, Ibarra-Alvarado C, Rojas-Molina A, Rojas-Molina I, Zavala-Sanchez MA. Vasodilator compounds derived from plants and their mechanisms of action. Molecules. 2013;18:5814\u201357. https:\/\/doi.org\/10.3390\/molecules18055814.","journal-title":"Molecules"},{"key":"402_CR21","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/nu8030167","volume":"8","author":"Y Li","year":"2016","unstructured":"Li Y, Yao JY, Han CY, Yang JX, Chaudhry MT, Wang SN, Liu HN, Yin YL. Quercetin, inflammation and immunity. Nutrients. 2016;8:167. https:\/\/doi.org\/10.3390\/nu8030167.","journal-title":"Nutrients"},{"key":"402_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108969","volume":"116","author":"SY Yang","year":"2019","unstructured":"Yang SY, Song LL, Shi XF, Zhao N, Ma YX. Ameliorative effects of pre-eclampsia by quercetin supplement to aspirin in a rat model induced by l-NAME. Biomed Pharmacother. 2019;116: 108969. https:\/\/doi.org\/10.1016\/j.biopha.2019.108969.","journal-title":"Biomed Pharmacother"},{"key":"402_CR23","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/cmi.2015.95","volume":"13","author":"EK Jo","year":"2016","unstructured":"Jo EK, Kim JK, Shin DM, Sasakawa C. Molecular mechanisms regulating NLRP3 inflammasome activation. Cell Mol Immunol. 2016;13:148\u201359. https:\/\/doi.org\/10.1038\/cmi.2015.95.","journal-title":"Cell Mol Immunol"},{"key":"402_CR24","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/1471-2172-11-59","volume":"11","author":"A Szarka","year":"2010","unstructured":"Szarka A, Rigo J Jr, Lazar L, Beko G, Molvarec A. Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array. BMC Immunol. 2010;11:59. https:\/\/doi.org\/10.1186\/1471-2172-11-59.","journal-title":"BMC Immunol"},{"key":"402_CR25","doi-asserted-by":"publisher","first-page":"e244","DOI":"10.1055\/s-0039-1694028","volume":"3","author":"AR Stainer","year":"2019","unstructured":"Stainer AR, Sasikumar P, Bye AP, Unsworth AJ, Holbrook LM, Tindall M, et al. The metabolites of the dietary flavonoid quercetin possess potent antithrombotic activity, and interact with aspirin to enhance antiplatelet effects. TH Open. 2019;3:e244\u201358. https:\/\/doi.org\/10.1055\/s-0039-1694028.","journal-title":"TH Open"},{"key":"402_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102010","volume":"44","author":"XJ Han","year":"2021","unstructured":"Han XJ, Xu TS, Fang QJ, Zhang HJ, Yue LJ, Hu G, et al. Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy. Redox Biol. 2021;44: 1347. https:\/\/doi.org\/10.1016\/j.redox.2021.102010.","journal-title":"Redox Biol"}],"container-title":["Drugs in R&amp;D"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40268-022-00402-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40268-022-00402-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40268-022-00402-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T09:53:25Z","timestamp":1669370005000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40268-022-00402-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,22]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["402"],"URL":"https:\/\/doi.org\/10.1007\/s40268-022-00402-6","relation":{},"ISSN":["1174-5886","1179-6901"],"issn-type":[{"value":"1174-5886","type":"print"},{"value":"1179-6901","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,22]]},"assertion":[{"value":"16 August 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No funding was received for the preparation of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors have no conflicts of interest that are directly relevant to the content of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"The animal study was approved by the Ethics Committee of Cangzhou Central Hospital.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Data and materials could be obtained upon request to the corresponding author.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of Data and Material"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code Availability"}},{"value":"SY, JZ, DC, JD, YZ, and LS conducted the experiments, analyzed the data, and wrote the manuscript; SY and JZ conceived the study, reviewed the data, and revised the manuscript.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author Contributions"}}]}}