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Fresinius Kabi provided the infusion pumps required for the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Injectomat TIVA Agilia with covariates model was provided by Fresenius Kabi (Brezins, France). SS received consultant honoraria from Fresenius Kabi and lecture honoraria from Aspen Pharmaceuticals. CH received consultant honoraria from Integra LifeSciences and lecture honoraria from AstraZeneca. MS, RC, NS and SM have no conflicts of interest that are directly relevant to the content of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest\/Competing interests"}},{"value":"Ethical approval was granted for the study by the West of Scotland Research Ethics Committee on 9 April, 2010 (reference number: 10\/S0709\/8) and registered with ClinicalTrials.gov (NCT01492712). The study was conducted in accordance with the ethical standards as laid down in the Declaration of Helsinki.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The datasets generated during and\/or analysed during the current study are available from the corresponding author on reasonable request.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"SS, NS and CH contributed to study conception and design. SS, NS, CH and SM contributed to the study conduct and data collection. CH, MS and RC contributed to the data analyses. The first draft of the manuscript was written by CH and RC and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 contributions"}},{"value":"Presented in part at the World Congress of Anaesthesiologists, Hong Kong, September 2016 []. Presented in part at the Anaesthetic Research Society Meeting, Aberdeen, June 2012 []. Submitted in part as part of a doctoral thesis for Dr. C. Hawthorne [].","order":10,"name":"Ethics","group":{"name":"EthicsHeading","label":"Previous presentations\/publications"}}]}}