{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:52:17Z","timestamp":1785808337260,"version":"3.56.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Chutian Elite Program of Hubei Province for Health Professionals","award":["2024-09054"],"award-info":[{"award-number":["2024-09054"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs R D"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s40268-026-00546-9","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:59:39Z","timestamp":1781002779000},"page":"169-186","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and Optimization of a Biphasic-Release Acetazolamide Tablet-in-Tablet Formulation"],"prefix":"10.1007","volume":"26","author":[{"given":"Si-kai","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao-miao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-chun","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-hui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-yang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"546_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00526-w","volume":"10","author":"H Gatterer","year":"2024","unstructured":"Gatterer H, Villafuerte FC, Ulrich S, Bhandari SS, Keyes LE, Burtscher M. Altitude illnesses. Nat Rev Dis Primers. 2024;10:43. https:\/\/doi.org\/10.1038\/s41572-024-00526-w.","journal-title":"Nat Rev Dis Primers"},{"key":"546_CR2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0096-2016","volume":"26","author":"AM Luks","year":"2017","unstructured":"Luks AM, Swenson ER, B\u00e4rtsch P. Acute high-altitude sickness. Eur Respir Rev. 2017;26:160096. https:\/\/doi.org\/10.1183\/16000617.0096-2016.","journal-title":"Eur Respir Rev"},{"key":"546_CR3","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1001\/jama.2017.16077","volume":"318","author":"J Jin","year":"2017","unstructured":"Jin J. Acute mountain sickness. J Am Med Assoc. 2017;318:1840. https:\/\/doi.org\/10.1001\/jama.2017.16077.","journal-title":"J Am Med Assoc"},{"key":"546_CR4","doi-asserted-by":"publisher","first-page":"1397280","DOI":"10.3389\/fphys.2024.1397280","volume":"15","author":"B Wang","year":"2024","unstructured":"Wang B, Chen S, Song J, Huang D, Xiao G. Recent advances in predicting acute mountain sickness: from multidimensional cohort studies to cutting-edge model applications. Front Physiol. 2024;15:1397280. https:\/\/doi.org\/10.3389\/fphys.2024.1397280.","journal-title":"Front Physiol"},{"key":"546_CR5","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1089\/ham.2015.0022","volume":"16","author":"B Waeber","year":"2015","unstructured":"Waeber B, Kayser B, Dumont L, Lysakowski C, Tram\u00e8r MR, Elia N. Impact of study design on reported incidences of acute mountain sickness: a systematic review. High Altitude Med Biol. 2015;16:204\u201315. https:\/\/doi.org\/10.1089\/ham.2015.0022. (Mary Ann Liebert, Inc., publishers).","journal-title":"High Altitude Med Biol"},{"key":"546_CR6","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.rceng.2019.12.009","volume":"221","author":"E Garrido","year":"2021","unstructured":"Garrido E, Botella de Maglia J, Castillo O. Acute, subacute and chronic mountain sickness. Revista Cl\u00ednica Espa\u00f1ola (English Edition). 2021;221:481\u201390. https:\/\/doi.org\/10.1016\/j.rceng.2019.12.009.","journal-title":"Revista Cl\u00ednica Espa\u00f1ola (English Edition)"},{"key":"546_CR7","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1089\/ham.2016.0031","volume":"17","author":"FC Villafuerte","year":"2016","unstructured":"Villafuerte FC, Corante N. Chronic mountain sickness: Clinical aspects, etiology, management, and treatment. High Alt Med Biol. 2016;17:61\u20139. https:\/\/doi.org\/10.1089\/ham.2016.0031.","journal-title":"High Alt Med Biol"},{"key":"546_CR8","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1016\/j.chest.2022.01.024","volume":"161","author":"ER Swenson","year":"2022","unstructured":"Swenson ER. Chronic mountain sickness evolving over time: new data from on high. Chest. 2022;161:1136\u20137. https:\/\/doi.org\/10.1016\/j.chest.2022.01.024.","journal-title":"Chest"},{"key":"546_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2025.102868","volume":"66","author":"J Wang","year":"2025","unstructured":"Wang J, Lian N, Tang K, Deng Y, Li T. Comparative effects of pharmacological interventions for the prevention of acute mountain sickness: a systematic review and Bayesian network meta-analysis. Travel Med Infect Dis. 2025;66:102868. https:\/\/doi.org\/10.1016\/j.tmaid.2025.102868.","journal-title":"Travel Med Infect Dis"},{"key":"546_CR10","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.7343","volume":"12","author":"I Solaimanzadeh","year":"2020","unstructured":"Solaimanzadeh I. Acetazolamide, nifedipine and phosphodiesterase inhibitors: rationale for their utilization as adjunctive countermeasures in the treatment of coronavirus disease 2019 (COVID-19). Cureus. 2020;12:e7343. https:\/\/doi.org\/10.7759\/cureus.7343.","journal-title":"Cureus."},{"key":"546_CR11","doi-asserted-by":"publisher","unstructured":"Charnigo A, Yee J. High Altitude Pulmonary Edema. J Educ Teach Emerg Med. 5:S78\u2013103. https:\/\/doi.org\/10.21980\/J8C35X","DOI":"10.21980\/J8C35X"},{"key":"546_CR12","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1089\/ham.2024.0127","volume":"26","author":"E Adams","year":"2025","unstructured":"Adams E, Peel T. Chronic mountain sickness: a comprehensive review of current management and proposals for novel therapies. High Alt Med Biol. 2025;26:318\u201327. https:\/\/doi.org\/10.1089\/ham.2024.0127.","journal-title":"High Alt Med Biol"},{"key":"546_CR13","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ijpharm.2006.09.041","volume":"332","author":"ARC Duarte","year":"2007","unstructured":"Duarte ARC, Roy C, Vega-Gonz\u00e1lez A, Duarte CMM, Subra-Paternault P. Preparation of acetazolamide composite microparticles by supercritical anti-solvent techniques. Int J Pharm. 2007;332:132\u20139. https:\/\/doi.org\/10.1016\/j.ijpharm.2006.09.041.","journal-title":"Int J Pharm"},{"key":"546_CR14","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1002\/epi4.12619","volume":"7","author":"AA Shukralla","year":"2022","unstructured":"Shukralla AA, Dolan E, Delanty N. Acetazolamide: Old drug, new evidence? Epilepsia Open. 2022;7:378\u201392. https:\/\/doi.org\/10.1002\/epi4.12619.","journal-title":"Epilepsia Open."},{"key":"546_CR15","doi-asserted-by":"publisher","first-page":"11057","DOI":"10.1039\/d3ra08333k","volume":"14","author":"AE Abdallah","year":"2024","unstructured":"Abdallah AE. Review on anti-Alzheimer drug development: approaches, challenges and perspectives. RSC Adv. 2024;14:11057\u201388. https:\/\/doi.org\/10.1039\/d3ra08333k.","journal-title":"RSC Adv"},{"key":"546_CR16","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.actaastro.2008.02.009","volume":"63","author":"R Scheuring","year":"2008","unstructured":"Scheuring R, Conkin J, Jones JA, Gernhardt ML. Risk assessment of physiological effects of atmospheric composition and pressure in Constellation vehicles. Acta Astronaut. 2008;63:727\u201339. https:\/\/doi.org\/10.1016\/j.actaastro.2008.02.009.","journal-title":"Acta Astronaut"},{"key":"546_CR17","doi-asserted-by":"publisher","unstructured":"Acetazolamide: best prophylaxis of acute mountain sickness when slow ascent is not possible. Drugs Ther Perspect. Springer International Publishing; 1996;7:11\u20133. https:\/\/doi.org\/10.2165\/00042310-199607060-00006","DOI":"10.2165\/00042310-199607060-00006"},{"key":"546_CR18","doi-asserted-by":"publisher","first-page":"204589402110499","DOI":"10.1177\/20458940211049948","volume":"11","author":"LA Shimoda","year":"2021","unstructured":"Shimoda LA, Suresh K, Undem C, Jiang H, Yun X, Sylvester JT, et al. Acetazolamide prevents hypoxia-induced reactive oxygen species generation and calcium release in pulmonary arterial smooth muscle. Pulm Circ. 2021;11:20458940211049948. https:\/\/doi.org\/10.1177\/20458940211049948.","journal-title":"Pulm Circ."},{"key":"546_CR19","doi-asserted-by":"publisher","first-page":"00767","DOI":"10.1183\/23120541.00767-2024","volume":"11","author":"RF Kind","year":"2025","unstructured":"Kind RF, Furian M, Buergin A, Scheiwiller PM, Mayer L, Schneider SR, et al. Effects of acetazolamide on exercise performance in patients with COPD going to high altitude: randomised controlled trial. ERJ Open Res. 2025;11:00767\u20132024. https:\/\/doi.org\/10.1183\/23120541.00767-2024.","journal-title":"ERJ Open Res."},{"key":"546_CR20","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1089\/ham.2016.0080","volume":"17","author":"E Donegani","year":"2016","unstructured":"Donegani E, Paal P, K\u00fcpper T, Hefti U, Basnyat B, Carceller A, et al. Drug use and misuse in the mountains: a UIAA MedCom consensus guide for medical professionals. High Alt Med Biol. 2016;17:157\u201384. https:\/\/doi.org\/10.1089\/ham.2016.0080.","journal-title":"High Alt Med Biol"},{"key":"546_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13020311","volume":"13","author":"V Bilgeri","year":"2024","unstructured":"Bilgeri V, Spitaler P, Puelacher C, Messner M, Adukauskaite A, Barbieri F, et al. Decongestion in acute heart failure\u2014time to rethink and standardize current clinical practice? J Clin Med. 2024;13:311. https:\/\/doi.org\/10.3390\/jcm13020311.","journal-title":"J Clin Med"},{"key":"546_CR22","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1089\/152702904322963672","volume":"5","author":"C Carlsten","year":"2004","unstructured":"Carlsten C, Swenson ER, Ruoss S. A dose\u2013response study of acetazolamide for acute mountain sickness prophylaxis in vacationing tourists at 12,000 feet (3630 m). High Alt Med Biol. 2004;5:33\u20139. https:\/\/doi.org\/10.1089\/152702904322963672.","journal-title":"High Alt Med Biol"},{"key":"546_CR23","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s002280050422","volume":"54","author":"I Yano","year":"1998","unstructured":"Yano I, Takayama A, Takano M, Inatani M, Tanihara H, Ogura Y, et al. Pharmacokinetics and pharmacodynamics of acetazolamide in patients with transient intraocular pressure elevation. Eur J Clin Pharmacol. 1998;54:63\u20138. https:\/\/doi.org\/10.1007\/s002280050422.","journal-title":"Eur J Clin Pharmacol"},{"key":"546_CR24","doi-asserted-by":"publisher","unstructured":"Crowley KL, Webber S. Immunosuppressive agents in pediatric heart transplantation. In: Munoz R, da Cruz EM, Vetterly CG, Cooper DS, Berry D, editors. Handbook of pediatric cardiovascular drugs. London: Springer; 2014. p. 329\u201363. https:\/\/doi.org\/10.1007\/978-1-4471-2464-1_10","DOI":"10.1007\/978-1-4471-2464-1_10"},{"key":"546_CR25","doi-asserted-by":"publisher","first-page":"49","DOI":"10.22159\/ijap.2019v11i4.32617","volume":"11","author":"D Prasanthi","year":"2019","unstructured":"Prasanthi D, Prashanti S, Meghana G. Formulation and evaluation of press coated tablets of lansoprazole. Int J Appl Pharmaceutics. 2019;11:49\u201356. https:\/\/doi.org\/10.22159\/ijap.2019v11i4.32617.","journal-title":"Int J Appl Pharmaceutics"},{"key":"546_CR26","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1208\/s12249-015-0350-9","volume":"16","author":"S Amidon","year":"2015","unstructured":"Amidon S, Brown JE, Dave VS. Colon-targeted oral drug delivery systems: design trends and approaches. AAPS PharmSciTech. 2015;16:731\u201341. https:\/\/doi.org\/10.1208\/s12249-015-0350-9.","journal-title":"AAPS PharmSciTech"},{"key":"546_CR27","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.tibtech.2021.10.001","volume":"40","author":"KS Ogueri","year":"2022","unstructured":"Ogueri KS, Shamblin SL. Osmotic-controlled release oral tablets: technology and functional insights. Trends Biotechnol. 2022;40:606\u201319. https:\/\/doi.org\/10.1016\/j.tibtech.2021.10.001. (Elsevier).","journal-title":"Trends Biotechnol"},{"key":"546_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0264457","volume":"17","author":"W Lin","year":"2022","unstructured":"Lin W, Li Y, Shi Q, Liao X, Zeng Y, Tian W, et al. Preparation and evaluation of bilayer-core osmotic pump tablets contained topiramate. PLoS ONE. 2022;17:e0264457. https:\/\/doi.org\/10.1371\/journal.pone.0264457.","journal-title":"PLoS ONE"},{"key":"546_CR29","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29010264","volume":"29","author":"B Rojek","year":"2024","unstructured":"Rojek B, Bartyzel A, Sawicki W, Plenis A. DSC, TGA-FTIR and FTIR assisted by chemometric factor analysis and PXRD in assessing the incompatibility of the antiviral drug Arbidol Hydrochloride with pharmaceutical excipients. Molecules. 2024;29:264. https:\/\/doi.org\/10.3390\/molecules29010264.","journal-title":"Molecules"},{"key":"546_CR30","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1055\/s-0032-1331755","volume":"63","author":"M Barzegar-Jalali","year":"2013","unstructured":"Barzegar-Jalali M, Hanaee J, Omidi Y, Ghanbarzadeh S, Ziaee S, Bairami-Atashgah R, et al. Preparation and evaluation of sustained release calcium alginate beads and matrix tablets of acetazolamide. Drug Research. 2013;63:60\u20134. https:\/\/doi.org\/10.1055\/s-0032-1331755.","journal-title":"Drug Research"},{"key":"546_CR31","volume-title":"Pharmacopoeia of the People\u2019s Republic of China (2025 edition)","author":"National Pharmacopoeia Commission","year":"2025","unstructured":"National Pharmacopoeia Commission. Pharmacopoeia of the People\u2019s Republic of China (2025 edition). Beijing: China Medical Science Press; 2025."},{"key":"546_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/pr10061094","volume":"10","author":"P Trucillo","year":"2022","unstructured":"Trucillo P. Drug carriers: a review on the most used mathematical models for drug release. Processes. 2022;10:1094. https:\/\/doi.org\/10.3390\/pr10061094.","journal-title":"Processes"},{"key":"546_CR33","doi-asserted-by":"publisher","first-page":"125","DOI":"10.7324\/JAPS.2017.70418","volume":"7","author":"S Azadi","year":"2017","unstructured":"Azadi S, Ashrafi H, Azadi A. Mathematical modeling of drug release from swellable polymeric nanoparticles. J Appl Pharm Sci. 2017;7:125\u201333. https:\/\/doi.org\/10.7324\/JAPS.2017.70418.","journal-title":"J Appl Pharm Sci"},{"key":"546_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/538917","volume":"2013","author":"AE Ozel","year":"2013","unstructured":"Ozel AE, Gunduz SK, Celik S, Akyuz S. Structural and vibrational study on monomer and dimer forms and water clusters of Acetazolamide. J Spectrosc. 2013;2013:1\u201313. https:\/\/doi.org\/10.1155\/2013\/538917.","journal-title":"J Spectrosc"},{"key":"546_CR35","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1007\/s10973-022-11849-9","volume":"148","author":"B Rojek","year":"2023","unstructured":"Rojek B, Wesolowski M. A combined differential scanning calorimetry and thermogravimetry approach for the effective assessment of drug substance-excipient compatibility. J Therm Anal Calorim. 2023;148:845\u201358. https:\/\/doi.org\/10.1007\/s10973-022-11849-9. (Springer International Publishing;).","journal-title":"J Therm Anal Calorim"},{"key":"546_CR36","doi-asserted-by":"publisher","first-page":"515","DOI":"10.56042\/jsir.v82i05.1080","volume":"82","author":"RN Sahoo","year":"2023","unstructured":"Sahoo RN, Dash R, Nandi S, Bose A, Si SC, Mallick S. Controlled crystallization of Acetazolamide from aqueous polymeric solutions for enhancing dissolution rate: application of statistical moment theory and molecular docking. J Sci Indust Res (JSIR). 2023;82:515\u201321. https:\/\/doi.org\/10.56042\/jsir.v82i05.1080.","journal-title":"J Sci Indust Res (JSIR)"},{"key":"546_CR37","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1007\/s12034-015-0980-2","volume":"38","author":"NK Singh","year":"2015","unstructured":"Singh NK, Verma ML, Minakshi M. PEO nanocomposite polymer electrolyte for solid state symmetric capacitors. Bull Mater Sci. 2015;38:1577\u201388. https:\/\/doi.org\/10.1007\/s12034-015-0980-2.","journal-title":"Bull Mater Sci"},{"key":"546_CR38","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/978-1-4939-1519-4_5","volume-title":"Hydrophilic matrix tablets for oral controlled release","author":"LM Martin","year":"2014","unstructured":"Martin LM, Rajabi-Siahboomi AR. Applications of Polyethylene Oxide (POLYOX) in Hydrophilic Matrices. In: Timmins P, Pygall SR, Melia CD, editors. Hydrophilic matrix tablets for oral controlled release. New York: Springer; 2014. p. 123\u201341. https:\/\/doi.org\/10.1007\/978-1-4939-1519-4_5."},{"key":"546_CR39","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s13346-016-0344-5","volume":"7","author":"S Shojaee","year":"2017","unstructured":"Shojaee S, Nokhodchi A, Maniruzzaman M. Evaluation of the drug solubility and rush ageing on drug release performance of various model drugs from the modified release polyethylene oxide matrix tablets. Drug Deliv Transl Res. 2017;7:111\u201324. https:\/\/doi.org\/10.1007\/s13346-016-0344-5. (Springer US).","journal-title":"Drug Deliv Transl Res"},{"key":"546_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/polym11091384","volume":"11","author":"M Polaskova","year":"2019","unstructured":"Polaskova M, Peer P, Cermak R, Ponizil P. Effect of thermal treatment on crystallinity of Poly(ethylene oxide) electrospun fibers. Polymers (Basel). 2019;11:1384. https:\/\/doi.org\/10.3390\/polym11091384. (Multidisciplinary Digital Publishing Institute).","journal-title":"Polymers (Basel)"},{"key":"546_CR41","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2023.2291336","volume":"39","author":"D Tsikas","year":"2023","unstructured":"Tsikas D. Acetazolamide and human carbonic anhydrases: retrospect, review and discussion of an intimate relationship. J Enzyme Inhib Med Chem. 2023;39:2291336. https:\/\/doi.org\/10.1080\/14756366.2023.2291336.","journal-title":"J Enzyme Inhib Med Chem"},{"key":"546_CR42","doi-asserted-by":"publisher","first-page":"3691","DOI":"10.1002\/jps.21282","volume":"97","author":"GE Granero","year":"2008","unstructured":"Granero GE, Longhi MR, Becker C, Junginger HE, Kopp S, Midha KK, et al. Biowaiver monographs for immediate release solid oral dosage forms: acetazolamide. J Pharm Sci. 2008;97:3691\u20139. https:\/\/doi.org\/10.1002\/jps.21282.","journal-title":"J Pharm Sci"},{"key":"546_CR43","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/ja.2011.58","volume":"64","author":"P Gao","year":"2011","unstructured":"Gao P, Nie X, Zou M, Shi Y, Cheng G. Recent advances in materials for extended-release antibiotic delivery system. J Antibiot (Tokyo). 2011;64:625\u201334. https:\/\/doi.org\/10.1038\/ja.2011.58.","journal-title":"J Antibiot (Tokyo)"},{"key":"546_CR44","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1208\/s12249-008-9060-x","volume":"9","author":"H Li","year":"2008","unstructured":"Li H, Hardy RJ, Gu X. Effect of drug solubility on polymer hydration and drug dissolution from polyethylene oxide (PEO) matrix tablets. AAPS PharmSciTech. 2008;9:437\u201343. https:\/\/doi.org\/10.1208\/s12249-008-9060-x.","journal-title":"AAPS PharmSciTech"},{"key":"546_CR45","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics10030161","volume":"10","author":"P Thapa","year":"2018","unstructured":"Thapa P, Jeong SH. Effects of formulation and process variables on gastroretentive floating tablets with a high-dose soluble drug and experimental design approach. Pharmaceutics. 2018;10:161. https:\/\/doi.org\/10.3390\/pharmaceutics10030161.","journal-title":"Pharmaceutics"},{"key":"546_CR46","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14040876","volume":"14","author":"A Dular Vovko","year":"2022","unstructured":"Dular Vovko A, Hod\u017ei\u0107 B, Brec T, Hudovornik G, Vre\u010der F. Influence of formulation factors, process parameters, and selected quality attributes on Carvedilol release from roller-compacted hypromellose-based matrix tablets. Pharmaceutics. 2022;14:876. https:\/\/doi.org\/10.3390\/pharmaceutics14040876.","journal-title":"Pharmaceutics"}],"container-title":["Drugs in R&amp;D"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40268-026-00546-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40268-026-00546-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40268-026-00546-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:43:46Z","timestamp":1785807826000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40268-026-00546-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["546"],"URL":"https:\/\/doi.org\/10.1007\/s40268-026-00546-9","relation":{},"ISSN":["1174-5886","1179-6901"],"issn-type":[{"value":"1174-5886","type":"print"},{"value":"1179-6901","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"18 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Conception and design of the work were performed by Hui Liu, Xiang-yang Xie, and Yuan Zeng. Material preparation, data collection, and analysis were performed by Si-kai Wang, Wei Li, Miao-miao Guo, Man Han, Ze-chun Long, and Jin-hui He. The first draft of the manuscript was written by Hui Liu and Xiang-yang Xie, and all authors edited or commented on versions of the manuscript. All authors read and approved the final version.","order":1,"name":"Ethics","label":"Authors\u2019 Contribution Statements","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research was supported by Chutian Elite Program of Hubei Province for Health Professionals (Grant No. 2024-09054).","order":2,"name":"Ethics","label":"Funding","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or nonfinancial interests to disclose.","order":3,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All data generated or analyzed during this study are included in this published article and its supplementary version.","order":4,"name":"Ethics","label":"Data Availability","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":5,"name":"Ethics","label":"Ethics Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":6,"name":"Ethics","label":"Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":7,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":8,"name":"Ethics","label":"Code Availability","group":{"name":"EthicsHeading","label":"Declarations"}}]}}