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Jouni Sirvi\u00f6 has received a fee from Orion Pharma for medical writing of this article.","order":1,"name":"Ethics","label":"Conflicts of Interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study (protocol ID PJF17-P1-03, sponsored by Pola Chemical Industries Inc, Japan) was conducted at NS Clinic, Seikokai Medical Corporation, Japan between September 1999 and January 2000, after obtaining approval by the Institutional Review Board. It was conducted in full compliance with the Declaration of Helsinki, Good Clinical Practice, and in accordance with all local and national regulations to maximize the human rights, welfare, and safety of the study subjects.","order":2,"name":"Ethics","label":"Ethics Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from each subject before the start of study procedures.","order":3,"name":"Ethics","label":"Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The datasets generated and\/or analyzed during the current study are not publicly available owing to patients not providing consent to individual data being shared publicly.","order":5,"name":"Ethics","label":"Availability of Data and Material","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":6,"name":"Ethics","label":"Code Availability","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"TA-S and PR prepared the concept of the manuscript. All authors contributed to data interpretation of the study results. JS prepared the first draft of the manuscript. MK prepared the illustrations. All the authors revised and critically reviewed all manuscript drafts, approved the submitted version of the manuscript, and made the decision to submit the manuscript for publication.","order":7,"name":"Ethics","label":"Authors\u2019 Contributions","group":{"name":"EthicsHeading","label":"Declarations"}}]}}