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Stefanie Gr\u00f6ls performed the experiments and collected the data. Dr. Dr. Charalabos-Markos Dintsios and Stefanie Gr\u00f6ls conducted the formal analysis and curated the data. Dr. Dr. Charalabos-Markos Dintsios and Prof. Dr. Dr. Dr.\u00a0Andrea Icks . provided supervision and project administration. Stefanie Gr\u00f6ls wrote the original draft of the manuscript. All authors reviewed and edited the manuscript. All authors read and approved the final manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}},{"value":"No external funding was received for this study. The work was conducted using internal support provided by Institute for Health Services Research and Health Economics, Heinrich Heine University D\u00fcsseldorf (Germany).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Dr. Dr. Charalabos-Markos Dintsios is employed by Bayer Vital, Germany, in addition to his academic affiliation. The employment had no influence on the study design, data interpretation, or manuscript preparation. All other authors declare no potential conflicts of interest with respect to the research, authorship, and\/or publication of this article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The author confirms that all data generated or analyzed during this study are included in this published article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability statement"}},{"value":"This study was approved by the Institutional Review Board of Heinrich Heine University\u00a0D\u00fcsseldorf (approval no. 2022-1874) and conducted in accordance with the Declaration of Helsinki.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from all participants.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}