{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:11:57Z","timestamp":1774278717341,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T00:00:00Z","timestamp":1492473600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004761","name":"the Natural Science Foundation of Hunan province","doi-asserted-by":"crossref","award":["2015JJ3151"],"award-info":[{"award-number":["2015JJ3151"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81371434"],"award-info":[{"award-number":["81371434"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81370771"],"award-info":[{"award-number":["81370771"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Hunan Province Key Technology Support Program","award":["2015SK20191"],"award-info":[{"award-number":["2015SK20191"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Drugs"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s40272-017-0225-5","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T07:20:23Z","timestamp":1492500023000},"page":"357-365","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effectiveness and Safety of Different Once-Daily Doses of Adrenocorticotropic Hormone for Infantile Spasms"],"prefix":"10.1007","volume":"19","author":[{"given":"Jinghua","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianjin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,4,18]]},"reference":[{"key":"225_CR1","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/S0140-6736(00)40184-4","volume":"35","author":"WJ West","year":"1841","unstructured":"West WJ. On a peculiar form of infantile convulsions. Lancet. 1841;35:724\u20135.","journal-title":"Lancet"},{"key":"225_CR2","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1528-1167.2010.02522.x","volume":"51","author":"AT Berg","year":"2010","unstructured":"Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005\u20132009. Epilepsia. 2010;51:676\u201385.","journal-title":"Epilepsia"},{"key":"225_CR3","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.braindev.2013.10.008","volume":"36","author":"P Pavone","year":"2014","unstructured":"Pavone P, Striano P, Falsaperla R, et al. Infantile spasms syndrome, West syndrome and related phenotypes: what we know in 2013. Brain Dev. 2014;36:739\u201351.","journal-title":"Brain Dev"},{"key":"225_CR4","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1212\/01.WNL.0000127773.72699.C8","volume":"62","author":"MT Mackay","year":"2004","unstructured":"Mackay MT, Weiss SK, Adams-Webber T, et al. Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society. Neurology. 2004;62:1668\u201381.","journal-title":"Neurology"},{"key":"225_CR5","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1111\/j.0013-9580.2004.02404.x","volume":"45","author":"AL Lux","year":"2004","unstructured":"Lux AL, Osborne JP. A proposal for case definitions and outcome measures in studies of infantile spasms and West syndrome: consensus statement of the West Delphi group. Epilepsia. 2004;45:1416\u201328.","journal-title":"Epilepsia"},{"key":"225_CR6","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s11910-012-0334-z","volume":"13","author":"AL Lux","year":"2013","unstructured":"Lux AL. Latest American and European updates on infantile spasms. Curr Neurol Neurosci Rep. 2013;13:334.","journal-title":"Curr Neurol Neurosci Rep"},{"key":"225_CR7","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1136\/adc.2009.160606","volume":"95","author":"K Darke","year":"2010","unstructured":"Darke K, Edwards SW, Hancock E, et al. Developmental and epilepsy outcomes at age 4\u00a0years in the UKISS trial comparing hormonal treatments to vigabatrin for infantile spasms: a multi-centre randomised trial. Arch Dis Child. 2010;95:382\u20136.","journal-title":"Arch Dis Child"},{"key":"225_CR8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.eplepsyres.2014.11.012","volume":"109","author":"E Widjaja","year":"2015","unstructured":"Widjaja E, Go C, McCoy B, Snead OC. Neurodevelopmental outcome of infantile spasms: a systematic review and meta-analysis. Epilepsy Res. 2015;109:155\u201362.","journal-title":"Epilepsy Res"},{"key":"225_CR9","first-page":"130","volume":"58","author":"L Sorel","year":"1958","unstructured":"Sorel L, Dusaucy-Bauloye A. Findings in 21 cases of Gibbs\u2019 hypsarrhythmia; spectacular effectiveness of ACTH. Acta Neurol Psychiatr Belg. 1958;58:130\u201341.","journal-title":"Acta Neurol Psychiatr Belg"},{"key":"225_CR10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1474-4422(16)30276-9","volume":"16","author":"R Riikonen","year":"2017","unstructured":"Riikonen R. Combination therapy for treatment of infantile spasms. Lancet Neurol. 2017;16:19\u201320.","journal-title":"Lancet Neurol"},{"key":"225_CR11","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1111\/j.1528-1167.2010.02657.x","volume":"51","author":"JM Pellock","year":"2010","unstructured":"Pellock JM, Hrachovy R, Shinnar S, et al. Infantile spasms: a U.S. consensus report. Epilepsia. 2010;51:2175\u201389.","journal-title":"Epilepsia"},{"key":"225_CR12","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1111\/j.1528-1167.2008.01606.x","volume":"49","author":"EH Kossoff","year":"2008","unstructured":"Kossoff EH, Hedderick EF, Turner Z, Freeman JM. A case-control evaluation of the ketogenic diet versus ACTH for new-onset infantile spasms. Epilepsia. 2008;49:1504\u20139.","journal-title":"Epilepsia"},{"key":"225_CR13","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0022-3476(05)81379-4","volume":"124","author":"RA Hrachovy","year":"1994","unstructured":"Hrachovy RA, Frost JJ, Glaze DG. High-dose, long-duration versus low-dose, short-duration corticotropin therapy for infantile spasms. J Pediatr. 1994;124:803\u20136.","journal-title":"J Pediatr"},{"key":"225_CR14","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0387-7604(99)00053-4","volume":"21","author":"S Yanagaki","year":"1999","unstructured":"Yanagaki S, Oguni H, Hayashi K, et al. A comparative study of high-dose and low-dose ACTH therapy for West syndrome. Brain Dev. 1999;21:461\u20137.","journal-title":"Brain Dev"},{"key":"225_CR15","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1212\/WNL.0b013e318259e2cf","volume":"78","author":"CY Go","year":"2012","unstructured":"Go CY, Mackay MT, Weiss SK, et al. Evidence-based guideline update: medical treatment of infantile spasms. Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2012;78:1974\u201380.","journal-title":"Neurology"},{"key":"225_CR16","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0387-7604(01)00307-2","volume":"23","author":"R Riikonen","year":"2001","unstructured":"Riikonen R. Long-term outcome of patients with West syndrome. Brain Dev. 2001;23:683\u20137.","journal-title":"Brain Dev"},{"key":"225_CR17","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1684\/epd.2014.0723","volume":"17","author":"JR Mytinger","year":"2015","unstructured":"Mytinger JR, Weber A, Heyer GL. The response to ACTH is determined early in the treatment of infantile spasms. Epileptic Disord. 2015;17:52\u20137.","journal-title":"Epileptic Disord"},{"key":"225_CR18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.yebeh.2016.03.025","volume":"59","author":"RM Hodgeman","year":"2016","unstructured":"Hodgeman RM, Kapur K, Paris A, et al. Effectiveness of once-daily high-dose ACTH for infantile spasms. Epilepsy Behav. 2016;59:4\u20138.","journal-title":"Epilepsy Behav"},{"key":"225_CR19","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0140-6736(04)17400-X","volume":"364","author":"AL Lux","year":"2004","unstructured":"Lux AL, Edwards SW, Hancock E, et al. The United Kingdom Infantile Spasms Study comparing vigabatrin with prednisolone or tetracosactide at 14\u00a0days: a multicentre, randomised controlled trial. Lancet. 2004;364:1773\u20138.","journal-title":"Lancet"},{"key":"225_CR20","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.yebeh.2009.01.023","volume":"14","author":"EH Kossoff","year":"2009","unstructured":"Kossoff EH, Hartman AL, Rubenstein JE, Vining EP. High-dose oral prednisolone for infantile spasms: an effective and less expensive alternative to ACTH. Epilepsy Behav. 2009;14:674\u20136.","journal-title":"Epilepsy Behav"},{"key":"225_CR21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.braindev.2014.02.005","volume":"37","author":"Z Yi","year":"2015","unstructured":"Yi Z, Wu H, Yu X, et al. Efficacy and tolerability of high-dose prednisone in Chinese children with infantile spasms. Brain Dev. 2015;37:23\u20138.","journal-title":"Brain Dev"},{"key":"225_CR22","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1212\/WNL.33.8.966","volume":"33","author":"OC Snead 3rd","year":"1983","unstructured":"Snead OC 3rd, Benton JW, Myers GJ. ACTH and prednisone in childhood seizure disorders. Neurology. 1983;33:966\u201370.","journal-title":"Neurology"},{"key":"225_CR23","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1542\/peds.97.3.375","volume":"97","author":"TZ Baram","year":"1996","unstructured":"Baram TZ, Mitchell WG, Tournay A, et al. High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study. Pediatrics. 1996;97:375\u20139.","journal-title":"Pediatrics"},{"key":"225_CR24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1474-4422(16)30294-0","volume":"16","author":"FJ O\u2019Callaghan","year":"2017","unstructured":"O\u2019Callaghan FJ, Edwards SW, Alber FD, et al. Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS): a randomised, multicentre, open-label trial. Lancet Neurol. 2017;16:33\u201342.","journal-title":"Lancet Neurol"},{"key":"225_CR25","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s40272-016-0188-y","volume":"18","author":"A Iyer","year":"2016","unstructured":"Iyer A, Appleton R. Improving outcomes in infantile spasms: role of pharmacotherapy. Paediatr Drugs. 2016;18:357\u201366.","journal-title":"Paediatr Drugs"},{"key":"225_CR26","doi-asserted-by":"crossref","unstructured":"Hancock EC, Osborne JP, Edwards SW. Treatment of infantile spasms. Cochrane Database Syst Rev. 2013;6:CD001770.","DOI":"10.1002\/14651858.CD001770.pub3"},{"key":"225_CR27","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1111\/j.1528-1157.1997.tb00063.x","volume":"38","author":"F Vigevano","year":"1997","unstructured":"Vigevano F, Cilio MR. Vigabatrin versus ACTH as first-line treatment for infantile spasms: a randomized, prospective study. Epilepsia. 1997;38:1270\u20134.","journal-title":"Epilepsia"},{"key":"225_CR28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.15844\/pedneurbriefs-29-12-4","volume":"29","author":"JG Millichap","year":"2015","unstructured":"Millichap JG, Millichap JJ. Prediction of infantile spasms recurrence after ACTH therapy. Pediatr Neurol Briefs. 2015;29:93.","journal-title":"Pediatr Neurol Briefs"},{"key":"225_CR29","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1136\/adc.55.9.664","volume":"55","author":"R Riikonen","year":"1980","unstructured":"Riikonen R, Donner M. ACTH therapy in infantile spasms: side effects. Arch Dis Child. 1980;55:664\u201372.","journal-title":"Arch Dis Child"},{"key":"225_CR30","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1177\/0883073807310988","volume":"22","author":"A Partikian","year":"2007","unstructured":"Partikian A, Mitchell WG. Major adverse events associated with treatment of infantile spasms. J Child Neurol. 2007;22:1360\u20136.","journal-title":"J Child Neurol"}],"container-title":["Pediatric Drugs"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40272-017-0225-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40272-017-0225-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40272-017-0225-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T15:33:44Z","timestamp":1658936024000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40272-017-0225-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,18]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["225"],"URL":"https:\/\/doi.org\/10.1007\/s40272-017-0225-5","relation":{},"ISSN":["1174-5878","1179-2019"],"issn-type":[{"value":"1174-5878","type":"print"},{"value":"1179-2019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,18]]}}}