{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:26:44Z","timestamp":1784780804210,"version":"3.55.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Drugs"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s40272-017-0277-6","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T06:43:34Z","timestamp":1513233814000},"page":"173-180","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Application of Pyridostigmine in Pediatric Gastrointestinal Motility Disorders: A Case Series"],"prefix":"10.1007","volume":"20","author":[{"given":"Mhd Louai","family":"Manini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Camilleri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayna","family":"Grothe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Di Lorenzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"issue":"6","key":"277_CR1","first-page":"567","volume":"64","author":"AK Yeung","year":"2012","unstructured":"Yeung AK, Di Lorenzo C. Primary gastrointestinal motility disorders in childhood. Minerva Pediatr. 2012;64(6):567\u201384.","journal-title":"Minerva Pediatr"},{"issue":"1","key":"277_CR2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0031-3955(03)00107-X","volume":"49","author":"SZ Hussain","year":"2002","unstructured":"Hussain SZ, Di Lorenzo C. Motility disorders. Diagnosis and treatment for the pediatric patient. Pediatr Clin N Am. 2002;49(1):27\u201351.","journal-title":"Pediatr Clin N Am"},{"issue":"5","key":"277_CR3","doi-asserted-by":"crossref","first-page":"G1228","DOI":"10.1152\/ajpgi.2001.281.5.G1228","volume":"281","author":"NM Law","year":"2001","unstructured":"Law NM, Bharucha AE, Undale AS, Zinsmeister AR. Cholinergic stimulation enhances colonic motor activity, transit, and sensation in humans. Am J Physiol Gastrointest Liver Physiol. 2001;281(5):G1228\u201337.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"277_CR4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0016-5085(61)80002-4","volume":"40","author":"NA Chaudhary","year":"1961","unstructured":"Chaudhary NA, Truelove SC. Human colonic motility: a comparative study of normal subjects, patients with ulcerative colitis, and patients with the irritable colon syndrome. II. The effect of prostigmin. Gastroenterology. 1961;40:18\u201326.","journal-title":"Gastroenterology"},{"issue":"4","key":"277_CR5","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s10286-008-0476-x","volume":"18","author":"AE Bharucha","year":"2008","unstructured":"Bharucha AE, Low PA, Camilleri M, Burton D, Gehrking TL, Zinsmeister AR. Pilot study of pyridostigmine in constipated patients with autonomic neuropathy. Clin Auton Res. 2008;18(4):194\u2013202.","journal-title":"Clin Auton Res"},{"key":"277_CR6","doi-asserted-by":"publisher","unstructured":"Di Nardo G, Di Lorenzo C, Lauro A, Stanghellini V, Thapar N, Karunaratne TB, et al. Chronic intestinal pseudo-obstruction in children and adults: diagnosis and therapeutic options. Neurogastroenterol Motil. 2017;29(1). https:\/\/doi.org\/10.1111\/nmo.12945","DOI":"10.1111\/nmo.12945"},{"issue":"8","key":"277_CR7","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1111\/j.1572-0241.2008.01866.x","volume":"103","author":"A Accarino","year":"2008","unstructured":"Accarino A, Perez F, Azpiroz F, Quiroga S, Malagelada J-R. Intestinal gas and bloating: effect of prokinetic stimulation. Am J Gastroenterol. 2008;103(8):2036\u201342.","journal-title":"Am J Gastroenterol"},{"issue":"7","key":"277_CR8","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1053\/gast.2002.33658","volume":"122","author":"MP Caldarella","year":"2002","unstructured":"Caldarella MP, Serra J, Azpiroz F, Malagelada J-R. Prokinetic effects in patients with intestinal gas retention. Gastroenterology. 2002;122(7):1748\u201355.","journal-title":"Gastroenterology"},{"issue":"3","key":"277_CR9","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1213\/ane.0b013e318163fbfe","volume":"106","author":"E Caliskan","year":"2008","unstructured":"Caliskan E, Turkoz A, Sener M, Bozdogan N, Gulcan O, Turkoz R. A prospective randomized double-blind study to determine the effect of thoracic epidural neostigmine on postoperative ileus after abdominal aortic surgery. Anesth Analg. 2008;106(3):959\u201364 (table of contents).","journal-title":"Anesth Analg"},{"issue":"4","key":"277_CR10","first-page":"111","volume":"97","author":"K Borchert","year":"1972","unstructured":"Borchert K, Pietsch P, Busch H. Use of cholinesterase inhibitors in postoperative care. Zentralbl Chir. 1972;97(4):111\u20136.","journal-title":"Zentralbl Chir"},{"issue":"2","key":"277_CR11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1053\/cgh.2003.50012","volume":"1","author":"B Behm","year":"2003","unstructured":"Behm B, Stollman N. Postoperative ileus: etiologies and interventions. Clin Gastroenterol Hepatol. 2003;1(2):71\u201380.","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"277_CR12","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/00002517-200112000-00014","volume":"14","author":"PL Althausen","year":"2001","unstructured":"Althausen PL, Gupta MC, Benson DR, Jones DA. The use of neostigmine to treat postoperative ileus in orthopedic spinal patients. J Spinal Disord. 2001;14(6):541\u20135.","journal-title":"J Spinal Disord"},{"key":"277_CR13","first-page":"541950","volume":"2014","author":"G Xiao","year":"2014","unstructured":"Xiao G, Xie X, Fan J, Deng J, Tan S, Zhu Y, et al. Efficacy and safety of acotiamide for the treatment of functional dyspepsia: systematic review and meta-analysis. Sci World J. 2014;2014:541950.","journal-title":"Sci World J"},{"issue":"6","key":"277_CR14","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1136\/gutjnl-2011-301454","volume":"61","author":"K Matsueda","year":"2012","unstructured":"Matsueda K, Hongo M, Tack J, Saito Y, Kato H. A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia. Gut. 2012;61(6):821\u20138.","journal-title":"Gut"},{"issue":"6","key":"277_CR15","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1463-1318.2009.01838.x","volume":"12","author":"CJ O\u2019Dea","year":"2010","unstructured":"O\u2019Dea CJ, Brookes JH, Wattchow DA. The efficacy of treatment of patients with severe constipation or recurrent pseudo-obstruction with pyridostigmine. Colorectal Dis. 2010;12(6):540\u20138.","journal-title":"Colorectal Dis"},{"issue":"2","key":"277_CR16","first-page":"195","volume":"51","author":"O Boybeyi","year":"2009","unstructured":"Boybeyi O, Ciftci AO, Topaloglu H. An unusual presentation of gastrointestinal obstruction in a three-year-old boy. Turk J Pediatr. 2009;51(2):195\u20138.","journal-title":"Turk J Pediatr"},{"issue":"1","key":"277_CR17","first-page":"19","volume":"7","author":"I Soufi-Afshar","year":"2016","unstructured":"Soufi-Afshar I, Moghadamnia A, Bijani A, Kazemi S, Shokri-Shirvani J. Comparison of pyridostigmine and bisacodyl in the treatment of refractory chronic constipation. Casp J Intern Med. 2016;7(1):19\u201324.","journal-title":"Casp J Intern Med"},{"issue":"5","key":"277_CR18","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1136\/gutjnl-2012-302483","volume":"62","author":"AE Bharucha","year":"2013","unstructured":"Bharucha AE, Low P, Camilleri M, Veil E, Burton D, Kudva Y, et al. A randomised controlled study of the effect of cholinesterase inhibition on colon function in patients with diabetes mellitus and constipation. Gut. 2013;62(5):708\u201315.","journal-title":"Gut"},{"issue":"3","key":"277_CR19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3171\/2014.6.PEDS13636","volume":"14","author":"KG Hooten","year":"2014","unstructured":"Hooten KG, Oliveria SF, Larson SD, Pincus DW. Ogilvie\u2019s syndrome after pediatric spinal deformity surgery: successful treatment with neostigmine. J Neurosurg Pediatr. 2014;14(3):255\u20138.","journal-title":"J Neurosurg Pediatr"},{"issue":"5","key":"277_CR20","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1007\/s001340100926","volume":"27","author":"JI Spoel van der","year":"2001","unstructured":"van der Spoel JI, Oudemans-van Straaten HM, Stoutenbeek CP, Bosman RJ, Zandstra DF. Neostigmine resolves critical illness-related colonic ileus in intensive care patients with multiple organ failure\u2014a prospective, double-blind, placebo-controlled trial. Intensive Care Med. 2001;27(5):822\u20137.","journal-title":"Intensive Care Med"},{"issue":"12","key":"277_CR21","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1111\/nmo.12669","volume":"27","author":"G Parthasarathy","year":"2015","unstructured":"Parthasarathy G, Ravi K, Camilleri M, Andrews C, Szarka LA, Low PA, et al. Effect of neostigmine on gastroduodenal motility in patients with suspected gastrointestinal motility disorders. Neurogastroenterol Motil. 2015;27(12):1736\u201346.","journal-title":"Neurogastroenterol Motil"},{"key":"277_CR22","doi-asserted-by":"publisher","unstructured":"Nakamura K, Tomita T, Oshima T, Asano H, Yamasaki T, Okugawa T, et al. A double-blind placebo controlled study of acotiamide hydrochloride for efficacy on gastrointestinal motility of patients with functional dyspepsia. J Gastroenterol. 2016;52(5):602\u201310. https:\/\/doi.org\/10.1007\/s00535-016-1260-7","DOI":"10.1007\/s00535-016-1260-7"},{"issue":"10","key":"277_CR23","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1001\/archneur.1987.00520220005002","volume":"44","author":"WA Grogan","year":"1987","unstructured":"Grogan WA. Treatment of myasthenia gravis with pyridostigmine. Arch Neurol. 1987;44(10):995\u20136.","journal-title":"Arch Neurol"},{"issue":"2","key":"277_CR24","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.pediatrneurol.2012.07.008","volume":"48","author":"CM Ionita","year":"2013","unstructured":"Ionita CM, Acsadi G. Management of juvenile myasthenia gravis. Pediatr Neurol. 2013;48(2):95\u2013104.","journal-title":"Pediatr Neurol"},{"issue":"1","key":"277_CR25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF02775924","volume":"10","author":"A Oigaard","year":"1975","unstructured":"Oigaard A. The motor-stimulating effect of metoclopramide and pyridostigemine bromide in normal man and laparotomized patients. A combined study of duodenal electric and motor activity. Scand J Gastroenterol. 1975;10(1):65\u201371.","journal-title":"Scand J Gastroenterol"},{"issue":"5","key":"277_CR26","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1053\/j.gastro.2006.06.018","volume":"131","author":"SF Pasha","year":"2006","unstructured":"Pasha SF, Lunsford TN, Lennon VA. Autoimmune gastrointestinal dysmotility treated successfully with pyridostigmine. Gastroenterology. 2006;131(5):1592\u20136.","journal-title":"Gastroenterology"},{"issue":"3","key":"277_CR27","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/MCG.0b013e318167b89d","volume":"43","author":"W Blonski","year":"2009","unstructured":"Blonski W, Vela MF, Freeman J, Sharma N, Castell DO. The effect of oral buspirone, pyridostigmine, and bethanechol on esophageal function evaluated with combined multichannel esophageal impedance-manometry in healthy volunteers. J Clin Gastroenterol. 2009;43(3):253\u201360.","journal-title":"J Clin Gastroenterol"}],"container-title":["Pediatric Drugs"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40272-017-0277-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40272-017-0277-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40272-017-0277-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T00:36:36Z","timestamp":1570494996000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40272-017-0277-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,14]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["277"],"URL":"https:\/\/doi.org\/10.1007\/s40272-017-0277-6","relation":{},"ISSN":["1174-5878","1179-2019"],"issn-type":[{"value":"1174-5878","type":"print"},{"value":"1179-2019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,14]]}}}