{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:14:02Z","timestamp":1790691242624,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T00:00:00Z","timestamp":1533254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T00:00:00Z","timestamp":1533254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Drugs"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s40272-018-0301-5","type":"journal-article","created":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T20:57:37Z","timestamp":1533243457000},"page":"475-481","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy and Safety of Intravenous Colistin in Very Low Birth Weight Preterm Infants"],"prefix":"10.1007","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6124-9796","authenticated-orcid":false,"given":"Ozkan","family":"Ilhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meltem","family":"Bor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senem Alkan","family":"Ozdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinem","family":"Akbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra Arun","family":"Ozer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,3]]},"reference":[{"key":"301_CR1","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1542\/peds.2004-1785","volume":"115","author":"H Aly","year":"2005","unstructured":"Aly H, Herson V, Duncan A, Herr J, Bender J, Patel K, et al. Is bloodstream infection preventable among premature infants? A tale of two cities. Pediatrics. 2005;115:1513\u20138.","journal-title":"Pediatrics"},{"key":"301_CR2","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1542\/peds.110.2.285","volume":"110","author":"BJ Stoll","year":"2002","unstructured":"Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics. 2002;110:285\u201391.","journal-title":"Pediatrics"},{"key":"301_CR3","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.ijantimicag.2013.02.006","volume":"41","author":"I Karaiskos","year":"2013","unstructured":"Karaiskos I, Galani L, Baziaka F, Giamarellou H. Intraventricular and intrathecal colistin as the last therapeutic resort for the treatment of multidrug-resistant and extensively drug-resistant Acinetobacter baumannii ventriculitis and meningitis: a litera-ture review. Int J Antimicrob Agents. 2013;41:499\u2013508.","journal-title":"Int J Antimicrob Agents"},{"key":"301_CR4","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.pedneo.2017.10.009","volume":"58","author":"HY Lee","year":"2017","unstructured":"Lee HY, Chiu CH. Efficacy and safety of using colistin in neonates. Pediatr Neonatol. 2017;58:473\u20134.","journal-title":"Pediatr Neonatol"},{"key":"301_CR5","doi-asserted-by":"publisher","first-page":"857","DOI":"10.7326\/0003-4819-72-6-857","volume":"72","author":"J Koch-Weser","year":"1970","unstructured":"Koch-Weser J, Sidel VW, Federman EB, Kanarek P, Finer DC, Eaton AE. Adverse effects of sodium colistimethate. Manifestations and specific reaction rates during 317 courses of therapy. Ann Intern Med. 1970;72:857\u201368.","journal-title":"Ann Intern Med"},{"key":"301_CR6","doi-asserted-by":"publisher","first-page":"548","DOI":"10.12659\/MSM.898213","volume":"23","author":"E Cagan","year":"2017","unstructured":"Cagan E, K\u0131ray Bas E, Asker HS. Use of colistin in a neonatal \u0131ntensive care unit: a cohort study of 65 patients. Med Sci Monit. 2017;23:548\u201354.","journal-title":"Med Sci Monit"},{"issue":"503","key":"301_CR7","first-page":"e1","volume":"33","author":"ME Falagas","year":"2009","unstructured":"Falagas ME, Vouloumanou EK, Rafailidis PI. Systemic colistin use in children without cystic fibrosis: a systematic review of the literature. Int J Antimicrob Agents. 2009;33(503):e1\u201313.","journal-title":"Int J Antimicrob Agents"},{"key":"301_CR8","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1007\/s00431-009-1137-3","volume":"169","author":"E Iosifidis","year":"2010","unstructured":"Iosifidis E, Antachopoulos C, Ioannidou M, Mitroudi M, Sdougka M, Drossou-Agakidou V, et al. Colistin administration to pediatric and neonatal patients. Eur J Pediatr. 2010;169:867\u201374.","journal-title":"Eur J Pediatr"},{"key":"301_CR9","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1055\/s-0034-1371361","volume":"31","author":"S Alan","year":"2014","unstructured":"Alan S, Yildiz D, Erdeve O, Cakir U, Kahvecioglu D, Okulu E, et al. Efficacy and safety of intravenous colistin in preterm infants with nosocomial sepsis caused by Acinetobacter baumannii. Am J Perinatol. 2014;31:1079\u201386.","journal-title":"Am J Perinatol"},{"key":"301_CR10","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1097\/MOP.0b013e32834f62d5","volume":"24","author":"JG Jetton","year":"2012","unstructured":"Jetton JG, Askenazi DJ. Update on acute kidney injury in the neonate. Curr Opin Pediatr. 2012;24:191\u20136.","journal-title":"Curr Opin Pediatr"},{"key":"301_CR11","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.ajic.2008.03.002","volume":"36","author":"TC Horan","year":"2008","unstructured":"Horan TC, Andrus M, Dudeck MA. CDC\/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008;36:309\u201332.","journal-title":"Am J Infect Control"},{"key":"301_CR12","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.pedneo.2016.10.002","volume":"58","author":"MS \u0130pek","year":"2017","unstructured":"\u0130pek MS, Aktar F, Okur N, Celik M, Ozbek E. Colistin use in critically ill neonates: a case-control study. Pediatr Neonatol. 2017;58:490\u20136.","journal-title":"Pediatr Neonatol"},{"key":"301_CR13","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1097\/INF.0b013e3182064bfe","volume":"30","author":"M Jajoo","year":"2011","unstructured":"Jajoo M, Kumar V, Jain M, Kumari S, Manchanda V. Intravenous colistin administration in neonates. Pediatr Infect Dis J. 2011;30:218\u201321.","journal-title":"Pediatr Infect Dis J"},{"key":"301_CR14","doi-asserted-by":"publisher","first-page":"433","DOI":"10.4103\/0971-5916.198682","volume":"144","author":"B Jasani","year":"2016","unstructured":"Jasani B, Kannan S, Nanavati R, Gogtay NJ, Thatte U. An audit of colistinuse in neonatal sepsis from a tertiary care centre of a resource-limited country. Indian J Med Res. 2016;144:433\u20139.","journal-title":"Indian J Med Res"},{"key":"301_CR15","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1007\/s12098-016-2033-2","volume":"83","author":"SS Nag","year":"2016","unstructured":"Nag SS, Dutta A, Mitra P, Majumdar R, Chatterjee M. Intravenous colistimethate sodium in neonatal sepsis. Indian J Pediatr. 2016;83:864\u20135.","journal-title":"Indian J Pediatr"},{"key":"301_CR16","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12941-016-0126-4","volume":"15","author":"M Al-Lawama","year":"2016","unstructured":"Al-Lawama M, Aljbour H, Tanash A, Badran E. Efficacy and safety of intravenous colistin in preterm infants with nosocomial sepsis caused by Acinetobacter baumannii. Ann Clin Microbiol Antimicrob. 2016;15:8.","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"301_CR17","doi-asserted-by":"publisher","first-page":"e453","DOI":"10.5812\/ijp.453","volume":"25","author":"K Serafettin Tekgunduz","year":"2015","unstructured":"Serafettin Tekgunduz K, Kara M, Caner I, Demirelli Y. Safety and efficacy of intravenous colistin in neonates with culture proven sepsis. Iran J Pediatr. 2015;25:e453.","journal-title":"Iran J Pediatr"},{"key":"301_CR18","first-page":"1157","volume":"67","author":"S Choudhry","year":"2017","unstructured":"Choudhry S, Ahmad E, Batool A, Raja N. Use of colistin for the treatment of multi drug resistant isolates in neonates. J Pak Med Assoc. 2017;67:1157\u201360.","journal-title":"J Pak Med Assoc"},{"key":"301_CR19","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1152\/ajpcell.00437.2003","volume":"286","author":"JR Lewis","year":"2004","unstructured":"Lewis JR, Lewis SA. Colistin interactions with the mammalian urothelium. Am J Physiol Cell Physiol. 2004;286:913\u201322.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"2","key":"301_CR20","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s002329900137","volume":"154","author":"JR Berg","year":"1996","unstructured":"Berg JR, Spilker CM, Lewis SA. Effects of polymyxin B on mammalian urinary bladder. J Membr Biol. 1996;154(2):119\u201330.","journal-title":"J Membr Biol"},{"key":"301_CR21","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/0272-6386(95)90161-2","volume":"26","author":"HS Mackenzie","year":"1995","unstructured":"Mackenzie HS, Brenner BM. Fewer nephrons at birth: a missing link in the etiology of essential hypertension? Am J Kidney Dis. 1995;26:91\u20138.","journal-title":"Am J Kidney Dis"},{"key":"301_CR22","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40348-016-0068-0","volume":"4","author":"A Stritzke","year":"2017","unstructured":"Stritzke A, Thomas S, Amin H, Fusch C, Lodha A. Renal consequences of preterm birth. Mol Cell Pediatr. 2017;4:2.","journal-title":"Mol Cell Pediatr"},{"key":"301_CR23","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.3109\/14767058.2013.860522","volume":"27","author":"ET Rhone","year":"2014","unstructured":"Rhone ET, Carmody JB, Swanson JR, Charlton JR. Nephrotoxic medication exposure in very low birth weight infants. J Matern Fetal Neonatal Med. 2014;27:1485\u201390.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"301_CR24","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1007\/s00467-013-2651-0","volume":"29","author":"MF Schreuder","year":"2014","unstructured":"Schreuder MF, Bueters RR, Allegaert K. The interplay between drugs and the kidney in premature neonates. Pediatr Nephrol. 2014;29:2083\u201391.","journal-title":"Pediatr Nephrol"},{"key":"301_CR25","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1093\/cid\/cir611","volume":"53","author":"JM Pogue","year":"2011","unstructured":"Pogue JM, Lee J, Marchaim D, Yee V, Zhao JJ, Chopra T, et al. Incidence of and risk factors for colistin associated nephrotoxicity in a large academic health system. Clin Infect Dis. 2011;53:879\u201384.","journal-title":"Clin Infect Dis"},{"key":"301_CR26","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/2110-5820-1-14","volume":"1","author":"H Spapen","year":"2011","unstructured":"Spapen H, Jacobs R, Van Gorp V, Troubleyn J, Honor\u00e9 PM. Renal and neurological side effects of colistin in critically ill patients. Ann Intensive Care. 2011;1:14.","journal-title":"Ann Intensive Care"}],"container-title":["Pediatric Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40272-018-0301-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40272-018-0301-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40272-018-0301-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T07:05:58Z","timestamp":1744700758000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40272-018-0301-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,3]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["301"],"URL":"https:\/\/doi.org\/10.1007\/s40272-018-0301-5","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733761053.793557343","asserted-by":"object"}]},"ISSN":["1174-5878","1179-2019"],"issn-type":[{"value":"1174-5878","type":"print"},{"value":"1179-2019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,3]]},"assertion":[{"value":"3 August 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"This study did not receive any specific funding.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Ozkan Ilhan, Meltem Bor, Senem Alkan Ozdemir, Sinem Akbay and Esra Arun Ozer have no conflicts of interest to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}