{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:25:33Z","timestamp":1790256333409,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100008736","name":"Fondo de Fomento al Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["170925013"],"award-info":[{"award-number":["170925013"]}],"id":[{"id":"10.13039\/501100008736","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Drugs"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s40272-019-00371-5","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T08:02:59Z","timestamp":1578988979000},"page":"217-228","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy of Macrolides on Acute Asthma or Wheezing Exacerbations in Children with Recurrent Wheezing: A Systematic Review and Meta-analysis"],"prefix":"10.1007","volume":"22","author":[{"given":"Mauricio A.","family":"Pincheira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard B.","family":"Bacharier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-4281","authenticated-orcid":false,"given":"Jose A.","family":"Castro-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,14]]},"reference":[{"key":"371_CR1","unstructured":"Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2018. http:\/\/www.ginasthma.org. Accessed Nov 2019."},{"issue":"17","key":"371_CR2","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0140-6736(17)33311-1","volume":"391","author":"A Papi","year":"2018","unstructured":"Papi A, Brightling C, Pedersen SE, Reddel HK. Asthma. Lancet. 2018;391(17):783\u2013800.","journal-title":"Lancet."},{"issue":"1","key":"371_CR3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40733-016-0029-3","volume":"3","author":"C Nunes","year":"2017","unstructured":"Nunes C, Pereira AM, Morais-Almeida M. Asthma costs and social impact. Asthma Res Pract. 2017;3(1):1.","journal-title":"Asthma Res Pract."},{"issue":"3","key":"371_CR4","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1513\/AnnalsATS.201703-259OC","volume":"15","author":"T Nurmagambetov","year":"2018","unstructured":"Nurmagambetov T, Kuwahara R, Garbe P. The economic burden of asthma in the United States, 2008\u20132013. Ann Am Thorac Soc. 2018;15(3):348\u201356.","journal-title":"Ann Am Thorac Soc."},{"issue":"2","key":"371_CR5","first-page":"45","volume":"19","author":"R Garner","year":"2008","unstructured":"Garner R, Kohen D. Changes in the prevalence of asthma among Canadian children. Health Rep. 2008;19(2):45\u201350.","journal-title":"Health Rep."},{"issue":"4","key":"371_CR6","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1378\/chest.129.4.909","volume":"129","author":"MD Lougheed","year":"2006","unstructured":"Lougheed MD, Garvey N, Chapman KR, Cicutto L, Dales R, Day AG, et al. The Ontario asthma regional variation study: emergency department visit rates and the relation to hospitalization rates. Chest. 2006;129(4):909\u201317.","journal-title":"Chest."},{"issue":"12","key":"371_CR7","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1001\/jama.2012.340","volume":"307","author":"P Karaca-Mandic","year":"2012","unstructured":"Karaca-Mandic P, Jena AB, Joyce GF, Goldman DP. Out-of-pocket medication costs and use of medications and health care services among children with asthma. JAMA. 2012;307(12):1284\u201391.","journal-title":"JAMA"},{"issue":"5","key":"371_CR8","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.jaci.2014.05.012","volume":"134","author":"DK Radhakrishnan","year":"2014","unstructured":"Radhakrishnan DK, Dell SD, Guttmann A, Shariff SZ, Liu K, To T. Trends in the age of diagnosis of childhood asthma. J Allergy Clin Immunol. 2014;134(5):1057\u201362.","journal-title":"J Allergy Clin Immunol."},{"issue":"2","key":"371_CR9","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.anai.2011.04.008","volume":"107","author":"SJ Szefler","year":"2011","unstructured":"Szefler SJ, Zeiger RS, Haselkorn T, Mink DR, Kamath TV, Fish JE, et al. Economic burden of impairment in children with severe or difficult-to-treat asthma. Ann Allergy Asthma Immunol. 2011;107(2):110\u20139.","journal-title":"Ann Allergy Asthma Immunol."},{"issue":"3","key":"371_CR10","doi-asserted-by":"crossref","first-page":"e519","DOI":"10.1542\/peds.2008-2867","volume":"123","author":"JA Castro-Rodriguez","year":"2009","unstructured":"Castro-Rodriguez JA, Rodrigo GJ. Efficacy of inhaled corticosteroids in infants and preschoolers with recurrent wheezing and asthma: a systematic review with meta-analysis. Pediatrics. 2009;123(3):e519\u201325.","journal-title":"Pediatrics."},{"issue":"6","key":"371_CR11","doi-asserted-by":"crossref","first-page":"e20154496","DOI":"10.1542\/peds.2015-4496","volume":"137","author":"SV Kaiser","year":"2016","unstructured":"Kaiser SV, Huynh T, Bacharier LB, Rosenthal JL, Bakel LA, Parkin PC, et al. Preventing exacerbations in preschoolers with recurrent wheeze: a meta-analysis. Pediatrics. 2016;137(6):e20154496.","journal-title":"Pediatrics."},{"issue":"8","key":"371_CR12","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/ppul.23429","volume":"51","author":"JA Castro-Rodriguez","year":"2016","unstructured":"Castro-Rodriguez JA, Beckhaus AA, Forno E. Efficacy of oral corticosteroids in the treatment of acute wheezing episodes in asthmatic preschoolers: systematic review with meta-analysis. Pediatr Pulmonol. 2016;51(8):868\u201376.","journal-title":"Pediatr Pulmonol."},{"issue":"5","key":"371_CR13","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2500\/aap.2015.36.3865","volume":"36","author":"A Beigelman","year":"2015","unstructured":"Beigelman A, Chipps BE, Bacharier LB. Update on the utility of corticosteroids in acute pediatric respiratory disorders. Allergy Asthma Proc. 2015;36(5):332\u20138.","journal-title":"Allergy Asthma Proc."},{"issue":"6 Suppl 1","key":"371_CR14","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1016\/j.jped.2015.08.002","volume":"91","author":"LV da Silva Filho","year":"2015","unstructured":"da Silva Filho LV, Pinto LA, Stein RT. Uso de macrol\u00eddeos em doen\u00e7as pulmonares: controv\u00e9rsias da literatura recente. J Pediatr (Rio J). 2015;91(6 Suppl 1):S52\u201360.","journal-title":"J Pediatr (Rio J)."},{"issue":"2","key":"371_CR15","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.aller.2009.12.002","volume":"38","author":"V Hernando-Sastre","year":"2010","unstructured":"Hernando-Sastre V. Macrolide antibiotics in the treatment of asthma. An update. Allergol Immunopathol (Madr). 2010;38(2):92\u20138.","journal-title":"Allergol Immunopathol (Madr)"},{"issue":"2","key":"371_CR16","doi-asserted-by":"crossref","first-page":"e20181056","DOI":"10.1542\/peds.2018-1056","volume":"143","author":"NM Poole","year":"2019","unstructured":"Poole NM, Shapiro DJ, Fleming-Dutra KE, Hicks LA, Hersh AL, Kronman MP. Antibiotic prescribing for children in United States emergency departments: 2009\u20132014. Pediatrics. 2019;143(2):e20181056.","journal-title":"Pediatrics."},{"key":"371_CR17","doi-asserted-by":"crossref","first-page":"g7647","DOI":"10.1136\/bmj.g7647","volume":"350","author":"L Shamseer","year":"2015","unstructured":"Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015;350:g7647.","journal-title":"BMJ."},{"key":"371_CR18","unstructured":"Clinical safety data management: definitions and standards for expedited reporting E2A. ICH Harmonised Tripartite Guideline. 1994. https:\/\/database.ich.org\/sites\/default\/files\/E2A_Guideline.pdf. Accessed Nov 2019."},{"key":"371_CR19","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","volume":"343","author":"JPT Higgins","year":"2011","unstructured":"Higgins JPT, Altman DG, G\u00f8tzsche PC, J\u00fcni P, Moher D, Oxman AD, et al. The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.","journal-title":"BMJ."},{"issue":"7414","key":"371_CR20","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JPT Higgins","year":"2003","unstructured":"Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557\u201360.","journal-title":"BMJ."},{"key":"371_CR21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/9780470693926.ch15","volume-title":"Systematic reviews in health care: meta-analysis in context","author":"JJ Deeks","year":"2001","unstructured":"Deeks JJ, Altman DG, Bradburn M. Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis. In: Egger M, Davey G, Altman D, editors. Systematic reviews in health care: meta-analysis in context. 2nd ed. London: BMJ Publishing Group; 2001. p. 285\u2013312.","edition":"2"},{"key":"371_CR22","doi-asserted-by":"crossref","DOI":"10.1002\/9780470743386","volume-title":"Introduction to meta-analysis","author":"M Borenstein","year":"2009","unstructured":"Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. Introduction to meta-analysis. Chichester: Wiley; 2009."},{"issue":"7","key":"371_CR23","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1080\/02770900802005251","volume":"45","author":"B Volovitz","year":"2008","unstructured":"Volovitz B, Bilavsky E, Nussinovitch M. Effectiveness of high repeated doses of inhaled budesonide or fluticasone in controlling acute asthma exacerbations in young children. J Asthma. 2008;45(7):561\u20137.","journal-title":"J Asthma."},{"issue":"4","key":"371_CR24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S1081-1206(10)60935-0","volume":"97","author":"M Fonseca-Aten","year":"2006","unstructured":"Fonseca-Aten M, Okada PJ, Bowlware KL, Chavez-Bueno S, Mejias A, Rios AM, et al. Effect of clarithromycin on cytokines and chemokines in children with an acute exacerbation of recurrent wheezing: a double-blind, randomized, placebo-controlled trial. Ann Allergy Asthma Immunol. 2006;97(4):457\u201363.","journal-title":"Ann Allergy Asthma Immunol."},{"issue":"19","key":"371_CR25","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1001\/jama.2015.13896","volume":"314","author":"LB Bacharier","year":"2015","unstructured":"Bacharier LB, Guilbert TW, Mauger DT, Boehmer S, Beigelman A, Fitzpatrick AM, et al. Early administration of azithromycin and prevention of severe lower respiratory tract illnesses in preschool children with a history of such illnesses a randomized clinical trial. JAMA. 2015;314(19):2034\u201344.","journal-title":"JAMA."},{"issue":"4","key":"371_CR26","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1399-3038.2012.01280.x","volume":"23","author":"I Koutsoubari","year":"2012","unstructured":"Koutsoubari I, Papaevangelou V, Konstantinou GN, Makrinioti H, Xepapadaki P, Kafetzis D, et al. Effect of clarithromycin on acute asthma exacerbations in children: an open randomized study. Pediatr Allergy Immunol. 2012;23(4):385\u201390.","journal-title":"Pediatr Allergy Immunol."},{"issue":"1","key":"371_CR27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S2213-2600(15)00500-7","volume":"4","author":"J Stokholm","year":"2016","unstructured":"Stokholm J, Chawes BL, Vissing NH, Bjarnad\u00f3ttir E, Pedersen TM, Vinding RK, et al. Azithromycin for episodes with asthma-like symptoms in young children aged 1-3\u00a0years: a randomised, double-blind, placebo-controlled trial. Lancet Respir Med. 2016;4(1):19\u201326.","journal-title":"Lancet Respir Med."},{"issue":"8","key":"371_CR28","doi-asserted-by":"crossref","first-page":"e0182411","DOI":"10.1371\/journal.pone.0182411","volume":"12","author":"PJ Mandhane","year":"2017","unstructured":"Mandhane PJ, Paredes Zambrano de Silbernagel P, Aung YN, Williamson J, Lee BE, Spier S, et al. Treatment of preschool children presenting to the emergency department with wheeze with azithromycin: a placebo-controlled randomized trial. PLoS One. 2017;12(8):e0182411.","journal-title":"PLoS One."},{"issue":"1","key":"371_CR29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S2213-2600(15)00500-7","volume":"4","author":"J Stokholm","year":"2016","unstructured":"Stokholm J, Chawes BL, Vissing NH, Bjarnad\u00f3ttir E, Pedersen TM, Vinding RK, et al. Supplement to: azithromycin for episodes with asthma-like symptoms in young children aged 1\u20133\u00a0years: a randomised, double-blind, placebo-controlled trial. Lancet Respir Med. 2016;4(1):19\u201326.","journal-title":"Lancet Respir Med."},{"key":"371_CR30","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002741.pub2","author":"R Normansell","year":"2018","unstructured":"Normansell R, Sayer B, Waterson S, Dennett EJ, Del Forno M, Dunleavy A. Antibiotics for exacerbations of asthma. Cochrane Database Syst Rev. 2018. https:\/\/doi.org\/10.1002\/14651858.CD002741.pub2.","journal-title":"Cochrane Database Syst Rev."},{"key":"371_CR31","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.2147\/DDDT.S183527","volume":"12","author":"W Lei","year":"2018","unstructured":"Lei W, Tsai M, Liu S, Yeh T. The effects of macrolides in children with reactive airway disease: a systematic review and meta- analysis of randomized controlled trials. Drug Des Dev Ther. 2018;12:3825\u201345.","journal-title":"Drug Des Dev Ther."},{"issue":"11","key":"371_CR32","doi-asserted-by":"crossref","first-page":"432","DOI":"10.3390\/jcm7110432","volume":"7","author":"C Lin","year":"2018","unstructured":"Lin C, Yeh T, Liu S, Lin H, Cheng Y, Hung H, et al. Effects of macrolide treatment during the hospitalization of children with childhood wheezing disease : a systematic review and meta-analysis. J Clin Med. 2018;7(11):432.","journal-title":"J Clin Med."},{"key":"371_CR33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1155\/2012\/584262","volume":"2012","author":"HC Steel","year":"2012","unstructured":"Steel HC, Theron AJ, Cockeran R, Anderson R, Feldman C. Pathogen- and host-directed anti-inflammatory activities of macrolide antibiotics. Mediat Inflamm. 2012;2012:17.","journal-title":"Mediat Inflamm."},{"issue":"1","key":"371_CR34","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000320319","volume":"81","author":"J Altenburg","year":"2011","unstructured":"Altenburg J, de Graaff CS, van der Werf TS, Boersma WG. Immunomodulatory effects of macrolide antibiotics\u2014part 1: biological mechanisms. Respiration. 2011;81(1):67\u201374.","journal-title":"Respiration."},{"issue":"2","key":"371_CR35","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1378\/chest.08-3056","volume":"136","author":"A Beigelman","year":"2009","unstructured":"Beigelman A, Gunsten S, Mikols CL, Vidavsky I, Cannon CL, Brody SL, et al. Azithromycin attenuates airway inflammation in a noninfectious mouse model of allergic asthma. Chest. 2009;136(2):498\u2013506.","journal-title":"Chest."},{"key":"371_CR36","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3389\/fimmu.2018.00302","volume":"9","author":"P Zimmermann","year":"2018","unstructured":"Zimmermann P, Ziesenitz VC, Curtis N, Ritz N. The immunomodulatory effects of macrolides-A systematic review of the underlying mechanisms. Front Immunol. 2018;9:302.","journal-title":"Front Immunol."},{"issue":"5","key":"371_CR37","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.jaci.2014.10.001","volume":"135","author":"A Beigelman","year":"2015","unstructured":"Beigelman A, Isaacson-schmid M, Sajol G, Baty J, Rodriguez OM, Leege E, et al. Randomized trial to evaluate azithromycin \u2019 s effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis. J Allergy Clin Immunol. 2015;135(5):1171\u20138.","journal-title":"J Allergy Clin Immunol."},{"issue":"14","key":"371_CR38","first-page":"1","volume":"2600","author":"EHC Wong","year":"2014","unstructured":"Wong EHC, Porter JD, Edwards MR, Johnston SL. The role of macrolides in asthma: current evidence and future directions. Lancet Respir. 2014;2600(14):1\u201314.","journal-title":"Lancet Respir."},{"issue":"3","key":"371_CR39","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1128\/CMR.00078-09","volume":"23","author":"S Kanoh","year":"2010","unstructured":"Kanoh S, Rubin BK. Mechanisms of action and clinical application of macrolides as immunomodulatory medications. Clin Microbiol Rev. 2010;23(3):590\u2013615.","journal-title":"Clin Microbiol Rev."},{"issue":"2","key":"371_CR40","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.antiviral.2009.05.003","volume":"83","author":"M Asada","year":"2009","unstructured":"Asada M, Yoshida M, Suzuki T, Hatachi Y, Sasaki T, Yasuda H, et al. Macrolide antibiotics inhibit respiratory syncytial virus infection in human airway epithelial cells. Antiviral Res. 2009;83(2):191\u2013200.","journal-title":"Antiviral Res."},{"key":"371_CR41","first-page":"9","volume":"2012","author":"JY Min","year":"2012","unstructured":"Min JY, Jang YJ. Macrolide therapy in respiratory viral infections. Mediat Inflamm. 2012;2012:9.","journal-title":"Mediat Inflamm."},{"issue":"3","key":"371_CR42","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1183\/09031936.00095809","volume":"36","author":"V Gielen","year":"2010","unstructured":"Gielen V, Johnston SL, Edwards MR. Azithromycin induces anti-viral responses in bronchial epithelial cells. Eur Respir J. 2010;36(3):646\u201354.","journal-title":"Eur Respir J."},{"issue":"4","key":"371_CR43","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1398-9995.2010.02505.x","volume":"66","author":"NG Papadopoulos","year":"2011","unstructured":"Papadopoulos NG, Christodoulou I, Rohde G, Agache I, Almqvist C, Bruno A, et al. Viruses and bacteria in acute asthma exacerbations\u2014A GA2LEN-DARE systematic review. Allergy. 2011;66(4):458\u201368.","journal-title":"Allergy."},{"issue":"3","key":"371_CR44","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1016\/S2213-2600(16)00064-3","volume":"4","author":"DL Hahn","year":"2016","unstructured":"Hahn DL, Webley W. Chronic Chlamydia pneumoniae lung infection: a neglected explanation for macrolide effects in wheezing and asthma? Lancet Respir. 2016;4(3):e8.","journal-title":"Lancet Respir."},{"issue":"1","key":"371_CR45","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11882-009-0086-2","volume":"10","author":"DR Rollins","year":"2010","unstructured":"Rollins DR, Beuther DA, Martin RJ. Update on infection and antibiotics in asthma. Curr Allergy Asthma Rep. 2010;10(1):67\u201373.","journal-title":"Curr Allergy Asthma Rep."},{"issue":"19","key":"371_CR46","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1001\/jama.2015.14953","volume":"314","author":"RT Cohen","year":"2015","unstructured":"Cohen RT, Pelton SI. Individual benefit vs societal effect of antibiotic prescribing for preschool children with recurrent wheeze. JAMA. 2015;314(19):2027\u20139.","journal-title":"JAMA."},{"issue":"19","key":"371_CR47","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1001\/jama.2016.0918","volume":"315","author":"KE Fleming-Dutra","year":"2016","unstructured":"Fleming-Dutra KE, Friedman CR, Hicks LA. Early azithromycin treatment to prevent severe lower respiratory tract illnesses in children. JAMA. 2016;315(19):2121\u20132.","journal-title":"JAMA."},{"key":"371_CR48","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011825.pub2","author":"MP Hansen","year":"2019","unstructured":"Hansen MP, Scott AM, McCullough A, Thorning S, Aronson JK, Beller EM, et al. Adverse events in people taking macrolide antibiotics versus placebo for any indication. Cochrane Database Syst Rev. 2019. https:\/\/doi.org\/10.1002\/14651858.CD011825.pub2.","journal-title":"Cochrane Database Syst Rev."}],"updated-by":[{"DOI":"10.1007\/s40272-020-00390-7","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:00:00Z","timestamp":1584057600000}}],"container-title":["Pediatric Drugs"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40272-019-00371-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40272-019-00371-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40272-019-00371-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T21:53:11Z","timestamp":1610574791000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40272-019-00371-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,14]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["371"],"URL":"https:\/\/doi.org\/10.1007\/s40272-019-00371-5","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s40272-020-00390-7","asserted-by":"object"}]},"ISSN":["1174-5878","1179-2019"],"issn-type":[{"value":"1174-5878","type":"print"},{"value":"1179-2019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,14]]},"assertion":[{"value":"14 January 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2020","order":2,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":3,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"An Online First version of this article was made available online at https:\/\/link.springer.com\/article\/10.1007\/s40272-019-00371-5 on 14 January 2020. An error was subsequently identified in the article, and the following correction should be noted:","order":4,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Dr. Castro-Rodriguez\u2019s contribution was funded in part by CONICYT PIA\/ANILLO (Grant no. 170925013) from the Chilean Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica (CONICYT).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors have no financial relationships relevant to this article to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Financial disclosure"}},{"value":"The authors declare that they have no conflict of interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}