{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T04:12:31Z","timestamp":1775707951805,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100003509","name":"\u00d6rebro University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003509","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Drugs"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1007\/s40272-022-00546-7","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T20:04:45Z","timestamp":1670529885000},"page":"27-41","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Interventions for the Management of Pain and Sedation in Newborns Undergoing Therapeutic Hypothermia for Hypoxic-Ischemic Encephalopathy: A Systematic Review"],"prefix":"10.1007","volume":"25","author":[{"given":"Pyrola","family":"B\u00e4cke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Bruschettini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ylva Thernstr\u00f6m","family":"Blomqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greta","family":"Sibrecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5582-6147","authenticated-orcid":false,"given":"Emma","family":"Olsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"546_CR1","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","volume":"86","author":"JJ Kurinczuk","year":"2010","unstructured":"Kurinczuk JJ, White-Koning M, Badawi N. Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. Early Human Dev. 2010;86:329\u201338.","journal-title":"Early Human Dev"},{"issue":"2","key":"546_CR2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s11910-019-0916-0","volume":"19","author":"G Wassink","year":"2019","unstructured":"Wassink G, Davidson J, Dhillon S, Zhou K, Bennet L, Thoresen M, Gunn A. Therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy. Curr Neurol Neurosci. 2019;19(2):2. https:\/\/doi.org\/10.1007\/s11910-019-0916-0.","journal-title":"Curr Neurol Neurosci"},{"issue":"1\u20132","key":"546_CR3","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/pr.2016.198","volume":"81","author":"A Gunn","year":"2017","unstructured":"Gunn A, Laptook A, Robertson N, Barks J, Thoresen M, Wassink G, et al. Therapeutic hypothermia translates from ancient history in to practice. Pediatr Res. 2017;81(1\u20132):202\u20139. https:\/\/doi.org\/10.1038\/pr.2016.198.","journal-title":"Pediatr Res"},{"key":"546_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003311.pub3","author":"S Jacobs","year":"2013","unstructured":"Jacobs S, Berg M, Hunt R, Tarnow-Mordi W, Inder T, Davis P. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 2013. https:\/\/doi.org\/10.1002\/14651858.CD003311.pub3.","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"546_CR5","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/JPN.0b013e31829dc2d3","volume":"27","author":"A Axelin","year":"2013","unstructured":"Axelin A, Cilio M, Asunis M, Peloquiin S, Franck L. Sleep-wake cycling in a neonate admitted to the NICU: a video-EEG case study during hypothermia treatment. J Perinat Neonatal Nurs. 2013;27(3):263\u201373. https:\/\/doi.org\/10.1097\/JPN.0b013e31829dc2d3.","journal-title":"J Perinat Neonatal Nurs"},{"issue":"4","key":"546_CR6","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1097\/ANC.0b013e31829d8baf","volume":"13","author":"K Hoffman","year":"2013","unstructured":"Hoffman K, Bromster T, Hakansson S, Van den Berg J. Monitoring of pain and stress in an infant with asphyxia during induced hypothermia: a case report. Adv Neonatal Care. 2013;13(4):252\u201361. https:\/\/doi.org\/10.1097\/ANC.0b013e31829d8baf.","journal-title":"Adv Neonatal Care"},{"key":"546_CR7","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.siny.2014.10.003","volume":"20","author":"G Wassink","year":"2015","unstructured":"Wassink G, Lear C, Gunn K, Dean J, Bennet L, Gunn A. Analgesics, sedatives, anticonvulsant drugs, and the cooled brain. Semin Fetal Neonatal Med. 2015;20:109\u201314.","journal-title":"Semin Fetal Neonatal Med"},{"key":"546_CR8","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.cophys.2019.04.011","volume":"11","author":"SM Walker","year":"2019","unstructured":"Walker SM. Early life pain\u2014effects in the adult. Curr Opin Physiol. 2019;11:16\u201324.","journal-title":"Curr Opin Physiol."},{"key":"546_CR9","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3389\/fped.2020.00030","volume":"8","author":"M Williams","year":"2020","unstructured":"Williams M, Lascelles D. Early neonatal pain\u2014a review of clinical and experimental implications on painful conditions later in life. Front Pediatr. 2020;8:30.","journal-title":"Front Pediatr"},{"issue":"6","key":"546_CR10","doi-asserted-by":"publisher","first-page":"377","DOI":"10.3389\/fped.2020.00030","volume":"31","author":"S Zanelli","year":"2011","unstructured":"Zanelli S, Buck M, Fairchild K. Physiologic and pharmacologic considerations for hypothermia therapy in neonates. J Perinatol. 2011;31(6):377\u201386. https:\/\/doi.org\/10.3389\/fped.2020.00030.","journal-title":"J Perinatol"},{"key":"546_CR11","unstructured":"Ainsworth SB. Effects of therapeutic hypothermia on medications. In: Neonatal formulary: drug use in pregnancy and the first year of life. Seventh Edition. Wiley, West Sussex; 2015."},{"issue":"1","key":"546_CR12","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2020-000685","volume":"4","author":"IC Lutz","year":"2020","unstructured":"Lutz IC, Allegaert K, de Hoon JN, Marynissen H. Pharmacokinetics during therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy: a literature review. BMJ Paediatrics Open. 2020;4(1): e000685. https:\/\/doi.org\/10.1136\/bmjpo-2020-000685.","journal-title":"BMJ Paediatrics Open."},{"issue":"4","key":"546_CR13","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1891\/0730-0832.39.4.227","volume":"39","author":"C McPherson","year":"2020","unstructured":"McPherson C, O\u2019Mara K. Provision of sedation and treatment of seizures during neonatal therapeutic hypothermia. Neonatal Netw. 2020;39(4):227\u201335.","journal-title":"Neonatal Netw"},{"issue":"10","key":"546_CR14","doi-asserted-by":"publisher","first-page":"130","DOI":"10.3390\/children5100130","volume":"5","author":"A Mangat","year":"2018","unstructured":"Mangat A, Oei JL, Chen K, Quah-Smith I, Schm\u00f6lzer G. A review of non-pharmacological treatments for pain management in newborn infants. Children. 2018;5(10):130. https:\/\/doi.org\/10.3390\/children5100130.","journal-title":"Children"},{"key":"546_CR15","unstructured":"Olsson E, Bruschettini M, Thernstr\u00f6m Blomqvist Y, B\u00e4cke P. IPSNUT - Interventions for the management of Pain and Sedation in Newborns undergoing Therapeutic hypothermia for hypoxic-ischemic encephalopathy: a systematic review. PROSPERO 2020. CRD42020205755. https:\/\/www.crd.york.ac.uk\/prospero\/#recordDetails. Accessed 2 May 2022."},{"key":"546_CR16","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s13643-022-01982-9","volume":"11","author":"P B\u00e4cke","year":"2022","unstructured":"B\u00e4cke P, Bruschettini M, Thernstr\u00f6m Blomqvist Y, Olsson E. Interventions for the management of pain and sedation in newborns undergoing therapeutic hypothermeia for hypoxic-ischemic encephalopathy (IPSNUT): protocol of a systematic review. Syst Rev. 2022;11:101. https:\/\/doi.org\/10.1186\/s13643-022-01982-9.","journal-title":"Syst Rev"},{"key":"546_CR17","unstructured":"Covidence systematic review software (Veritas Health Innovation). www.covidence.org. Accessed 2 May 2022."},{"key":"546_CR18","unstructured":"Higgins JP, Altman DG, Sterne JA; on behalf of the Cochrane Statistical Methods Group and the Cochrane Bias Methods Group. Chapter 8: Assessing risk of bias in included studies. In: Higgins JP, Green S (eds). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. http:\/\/training.cochrane.org\/handbook\/archive\/v5.1\/. Accessed 2 May 2022."},{"key":"546_CR19","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919","volume":"355","author":"J Sterne","year":"2016","unstructured":"Sterne J, Hern\u00e1n M, Reeves B, Savovic J, Bergman N, Viswanathan M, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016;355: i4919. https:\/\/doi.org\/10.1136\/bmj.i4919.","journal-title":"BMJ"},{"issue":"3","key":"546_CR20","doi-asserted-by":"publisher","first-page":"e168","DOI":"10.1055\/s-0038-1669938","volume":"8","author":"K O\u2019Mara","year":"2018","unstructured":"O\u2019Mara K, Weiss M. Dexmedetomidine for sedation of neonates with HIE undergoing therapeutic hypothermia: a single-center experience. AJP Rep. 2018;8(3):e168\u201373.","journal-title":"AJP Rep."},{"key":"546_CR21","doi-asserted-by":"publisher","first-page":"i63","DOI":"10.1093\/qjmed\/hcy200.139","volume":"111","author":"N Abo Shady","year":"2018","unstructured":"Abo Shady N, Ismail R, Abdi El Aal M. Pentoxifylline use for neuroprotection in neonates with hypoxic ischemic encephalopathy. QJM. 2018;111:i63\u20134.","journal-title":"QJM"},{"issue":"2","key":"546_CR22","doi-asserted-by":"publisher","first-page":"24","DOI":"10.26641\/2307-0404.2019.2.170123","volume":"24","author":"D Surkov","year":"2019","unstructured":"Surkov D. Using of dexmedetomidine in term neonates with hypoxic-ischemic encephalopathy. Med Perspekt. 2019;24(2):24\u201333.","journal-title":"Med Perspekt."},{"issue":"1","key":"546_CR23","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1089\/ther.2018.0052","volume":"10","author":"N Liow","year":"2020","unstructured":"Liow N, Montaldo P, Lally P, Teiserskas J, Bassett P, Oliviera V, et al. Preemptive morphine during therapeutic hypothermai after neonatal encephalopathy: a secondary analysis. Ther Hypothermia Temp Manag. 2020;10(1):45\u201352.","journal-title":"Ther Hypothermia Temp Manag."},{"key":"546_CR24","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1159\/000499330","volume":"116","author":"L Favi\u00e9","year":"2019","unstructured":"Favi\u00e9 L, Groenendaal F, van den Broek M, Rademakere C, de Haan T, van Straaten H, et al. Phenobarbital, midazolam pharmacokinetics, effectiveness, and drug-drug interaction in asphyxiated neonates undergoing therapeutic hypothermia. Neonatology. 2019;116:154\u201362.","journal-title":"Neonatology"},{"issue":"2","key":"546_CR25","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.jpeds.2010.04.005","volume":"157","author":"D Meyn","year":"2010","unstructured":"Meyn D, Ness J, Ambalavanan N, Carlo W. Prophylactic phenobarbital and whole-body cooling for neonatal hypoxic-ischemic encephalopathy. J Pediatr. 2010;157(2):334\u20136.","journal-title":"J Pediatr"},{"issue":"4","key":"546_CR26","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1177\/0883073811419317","volume":"27","author":"G Sant\u2019Anna","year":"2012","unstructured":"Sant\u2019Anna G, Laptook A, Shankaran S, Bara R, McDonald S, Higgins R, et al. Phenobarbital and temperature profile during hypothermia for hypoxic-ischemic encephalopathy. J Child Neurol. 2012;27(4):451\u20137.","journal-title":"J Child Neurol"},{"key":"546_CR27","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.yebeh.2018.09.015","volume":"88","author":"L Rao","year":"2018","unstructured":"Rao L, Hussain S, Zaki T, Cho A, Chanlaw T, Garg M, et al. A comparison of levetiracetam and phenobarbital for the treatment of neonatal seizures associated with hypoxic-iischemic encephalopathy. Epilepsy Behav. 2018;88:212\u20137.","journal-title":"Epilepsy Behav"},{"issue":"1","key":"546_CR28","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/s41372-019-0533-4","volume":"40","author":"M Berube","year":"2020","unstructured":"Berube M, Lemmon M, Pizoli C, Bidegani M, Tolia V, Cotton C. Opioid and benzodiazepine use durint therapeutic hypothermia in encephalopathic neonates. J Perinatol. 2020;40(1):79\u201388.","journal-title":"J Perinatol"},{"key":"546_CR29","doi-asserted-by":"publisher","first-page":"3","DOI":"10.26641\/2307-0404.2021.3.242347","volume":"26","author":"D Surkov","year":"2021","unstructured":"Surkov D. Correction: Using of dexmedetomidine in term neonates with hypoxic-ischemic encephalopathy. Medicini perspektivi. 2021;26:3. https:\/\/doi.org\/10.26641\/2307-0404.2021.3.242347.","journal-title":"Medicini perspektivi."},{"issue":"1","key":"546_CR30","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/jp.2011.41","volume":"32","author":"S Sarkar","year":"2012","unstructured":"Sarkar S, Barks J, Bapuraj J, Bhagat I, Dechert R, Schumacher R, et al. Does phenobarbital imiprove the effectiveness of therapeutic hypothermia in infants with hypoxic-ischemic encephalopathy? J Perinatol. 2012;32(1):15\u201320.","journal-title":"J Perinatol"},{"key":"546_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.12.009","author":"RD Higgins","year":"2006","unstructured":"Higgins RD, Raju TNK, Perlman J, Azzopardi DV, Blackmon LR, Clark R, et al. Hypothermia and perinatal asphyxia: Executive summary of the National Institute of Child Health and Human Development workshop. J Pediatr. 2006. https:\/\/doi.org\/10.1016\/j.jpeds.2005.12.009.","journal-title":"J Pediatr"},{"key":"546_CR32","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1124\/dmd.112.045567","volume":"41","author":"T Bjelland","year":"2012","unstructured":"Bjelland T, Klepstad P, Haugen B, Nilsen T, Dalo O. Effects of hypothermia on the disposition of morphine, midazolam, fentanyl, and propofol in intensive care unit patients. Drug Metabol Dispos. 2012;41:214\u201323.","journal-title":"Drug Metabol Dispos."},{"key":"546_CR33","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1007\/s00134-012-2540-1","volume":"38","author":"T Bjelland","year":"2014","unstructured":"Bjelland T, Dale O, Kaisen K, Haugen B, Lydersen S, Strand K, Klepstad P. Propofol and remifentanil versus midazolam and fentanyl for sedation during therapeutic hypothermia after cardiac arrest: a randomised trial. Intensive Care Med. 2014;38:959\u201367.","journal-title":"Intensive Care Med"},{"issue":"3","key":"546_CR34","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1111\/apa.15071","volume":"109","author":"P Lago","year":"2020","unstructured":"Lago P, Spada C, Lugli L, Garetti E, Pirelli A, Savant Levet P, et al. Pain management during therapeutic hypothermia in newborn infants with hypoxic-ischaemic encephalopathy. Acta Paediatr. 2020;109(3):628\u20139. https:\/\/doi.org\/10.1111\/apa.15071.","journal-title":"Acta Paediatr"},{"key":"546_CR35","doi-asserted-by":"publisher","first-page":"CD015023","DOI":"10.1002\/1465858.CD015023","volume":"11","author":"P B\u00e4cke","year":"2022","unstructured":"B\u00e4cke P, Bruschettini M, Sibrecht G, Thernstr\u00f6m-Blomqvist Y, Olsson E. Pharmacological interventions for pain and sedation management in newborn infants undergoing therapeutic. Cochrane Database Syste Rev. 2022;11:CD015023. https:\/\/doi.org\/10.1002\/14651858.CD015023.pub2.","journal-title":"Cochrane Database Syste Rev"}],"container-title":["Pediatric Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40272-022-00546-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40272-022-00546-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40272-022-00546-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T01:08:14Z","timestamp":1672794494000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40272-022-00546-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,8]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["546"],"URL":"https:\/\/doi.org\/10.1007\/s40272-022-00546-7","relation":{},"ISSN":["1174-5878","1179-2019"],"issn-type":[{"value":"1174-5878","type":"print"},{"value":"1179-2019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,8]]},"assertion":[{"value":"6 November 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Open access funding provided by \u00d6rebro University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Pyrola B\u00e4cke, Matteo Bruschettini, Ylva Thernstr\u00f6m Blomqvist, Greta Sibrecht, and Emma Olsson declare they have no competing interests in relation to this systematic review.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent for participation and publication"}},{"value":"All data generated and\/or analyzed during this study are included in this published article (and its supplementary information files).","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"PB, MB, YTB, and EO planned and designed the study. PB, MB, YTB, GS, and EO have made substantial contributions in refining the study and drafting the manuscript. All authors approved the final version of the manuscript.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 contributions"}}]}}