{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:36:59Z","timestamp":1781786219346,"version":"3.54.5"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Drugs"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1007\/s40272-023-00574-x","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T19:01:35Z","timestamp":1684954895000},"page":"459-466","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Diagnosis and Management of Pediatric Chronic Hand Eczema: The PeDRA CACHES Survey"],"prefix":"10.1007","volume":"25","author":[{"given":"Michael A.","family":"Haft","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen H.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Sprague","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy S.","family":"Paller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen H.","family":"Cotton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2760-0474","authenticated-orcid":false,"given":"Lawrence F.","family":"Eichenfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"issue":"Suppl 3","key":"574_CR1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/j.1610-0387.2009.07061.x","volume":"7","author":"TL Diepgen","year":"2009","unstructured":"Diepgen TL, Elsner P, Schliemann S, Fartasch M, Kollner A, Skudlik C, et al. Guideline on the management of hand eczema ICD-10 code: L20. L23. L24. L25. L30. J Dtsch Dermatol Ges. 2009;7(Suppl 3):S1-16.","journal-title":"J Dtsch Dermatol Ges."},{"issue":"5","key":"574_CR2","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1097\/DER.0000000000000659","volume":"32","author":"JI Silverberg","year":"2021","unstructured":"Silverberg JI, Guttman-Yassky E, Agner T, Bissonnette R, Cohen DE, Simpson E, et al. Chronic hand eczema guidelines from an expert panel of the international eczema council. Dermatitis. 2021;32(5):319\u201326.","journal-title":"Dermatitis"},{"issue":"5","key":"574_CR3","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1111\/ced.12619","volume":"40","author":"A Ahmed","year":"2015","unstructured":"Ahmed A, Shah R, Papadopoulos L, Bewley A. An ethnographic study into the psychological impact and adaptive mechanisms of living with hand eczema. Clin Exp Dermatol. 2015;40(5):495\u2013501.","journal-title":"Clin Exp Dermatol"},{"issue":"4","key":"574_CR4","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1111\/jdv.13479","volume":"30","author":"S Cazzaniga","year":"2016","unstructured":"Cazzaniga S, Ballmer-Weber BK, Grani N, Spring P, Bircher A, Anliker M, et al. Medical, psychological and socio-economic implications of chronic hand eczema: a cross-sectional study. J Eur Acad Dermatol Venereol. 2016;30(4):628\u201337.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"574_CR5","first-page":"2","volume":"2","author":"A Armstrong","year":"2022","unstructured":"Armstrong A, Hahn-Pedersen J, Bartlett C, Glanville J, Thyssen JP. Economic burden of chronic hand eczema: a review. Am J Clin Dermatol. 2022;2:2.","journal-title":"Am J Clin Dermatol"},{"issue":"4","key":"574_CR6","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1111\/j.1651-2227.1995.tb13659.x","volume":"84","author":"LK Dotterud","year":"1995","unstructured":"Dotterud LK, Falk ES. Contact allergy in relation to hand eczema and atopic diseases in north Norwegian schoolchildren. Acta Paediatr. 1995;84(4):402\u20136.","journal-title":"Acta Paediatr"},{"issue":"3","key":"574_CR7","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1111\/bjd.13194","volume":"171","author":"CM Gronhagen","year":"2014","unstructured":"Gronhagen CM, Liden C, Bergstrom A, Kull I, Wahlgren CF, Meding B. Prevalence and incidence of hand eczema in adolescence: report from BAMSE\u2013a population-based birth cohort. Br J Dermatol. 2014;171(3):609\u201314.","journal-title":"Br J Dermatol"},{"issue":"13","key":"574_CR8","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1471-5945-13-14","volume":"29","author":"A Johannisson","year":"2013","unstructured":"Johannisson A, Ponten A, Svensson A. Prevalence, incidence and predictive factors for hand eczema in young adults\u2014a follow-up study. BMC Dermatol. 2013;29(13):14.","journal-title":"BMC Dermatol"},{"issue":"3","key":"574_CR9","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1046\/j.1365-2133.2001.04078.x","volume":"144","author":"CG Mortz","year":"2001","unstructured":"Mortz CG, Lauritsen JM, Bindslev-Jensen C, Andersen KE. Prevalence of atopic dermatitis, asthma, allergic rhinitis, and hand and contact dermatitis in adolescents. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis. Br J Dermatol. 2001;144(3):523\u201332.","journal-title":"Br J Dermatol"},{"issue":"5","key":"574_CR10","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1080\/000155598443097","volume":"78","author":"M Yngveson","year":"1998","unstructured":"Yngveson M, Svensson A, Isacsson A. Prevalence of self-reported hand dermatosis in upper secondary school pupils. Acta Derm Venereol. 1998;78(5):371\u20134.","journal-title":"Acta Derm Venereol"},{"key":"574_CR11","first-page":"2","volume":"2","author":"J Wang","year":"2021","unstructured":"Wang J, Tischer C, Standl M, Weidinger S, von Berg A, Herberth G, et al. Lifetime prevalence and determinants of hand eczema in an adolescent population in Germany: 15-year follow-up of the LISA cohort study. J Eur Acad Dermatol Venereol. 2021;2:2.","journal-title":"J Eur Acad Dermatol Venereol."},{"issue":"1","key":"574_CR12","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/j.1365-2133.2010.09822.x","volume":"163","author":"JP Thyssen","year":"2010","unstructured":"Thyssen JP, Carlsen BC, Menne T, Linneberg A, Nielsen NH, Meldgaard M, et al. Filaggrin null mutations increase the risk and persistence of hand eczema in subjects with atopic dermatitis: results from a general population study. Br J Dermatol. 2010;163(1):115\u201320.","journal-title":"Br J Dermatol"},{"issue":"2","key":"574_CR13","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.jaad.2016.09.021","volume":"76","author":"CR Totri","year":"2017","unstructured":"Totri CR, Eichenfield LF, Logan K, Proudfoot L, Schmitt J, Lara-Corrales I, et al. Prescribing practices for systemic agents in the treatment of severe pediatric atopic dermatitis in the US and Canada: the PeDRA TREAT survey. J Am Acad Dermatol. 2017;76(2):281\u20135.","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"574_CR14","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1111\/ddg.12510_1","volume":"13","author":"TL Diepgen","year":"2015","unstructured":"Diepgen TL, Andersen KE, Chosidow O, Coenraads PJ, Elsner P, English J, et al. Guidelines for diagnosis, prevention and treatment of hand eczema. J Dtsch Dermatol Ges. 2015;13(1):e1-22.","journal-title":"J Dtsch Dermatol Ges"},{"issue":"6","key":"574_CR15","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.anpedi.2017.07.005","volume":"88","author":"JM Ortiz-Salvador","year":"2018","unstructured":"Ortiz-Salvador JM, Subiabre-Ferrer D, Garcia Rabasco A, Esteve-Martinez A, Zaragoza-Ninet V, de Alegre MV. Hand eczema in children. Clinical and epidemiological study of the population referred to a tertiary hospital. An Pediatr. 2018;88(6):309\u201314.","journal-title":"An Pediatr"},{"issue":"4","key":"574_CR16","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1600-0536.2011.01943.x","volume":"65","author":"F Toledo","year":"2011","unstructured":"Toledo F, Garcia-Bravo B, Fernandez-Redondo V, De la Cuadra J, Gimenez-Arnau AM, Borrego L, et al. Patch testing in children with hand eczema. A 5-year multicentre study in Spain. Contact Dermatitis. 2011;65(4):213\u20139.","journal-title":"Contact Dermatitis"},{"key":"574_CR17","first-page":"25","volume":"54","author":"JI Silverberg","year":"2021","unstructured":"Silverberg JI, Warshaw EM, Maibach HI, DeKoven JG, Taylor JS, Atwater AR, et al. Hand eczema in children referred for patch testing: North American contact dermatitis group data, 2000\u20132016. Br J Dermatol. 2021;54:25.","journal-title":"Br J Dermatol"},{"issue":"5","key":"574_CR18","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/cod.14035","volume":"86","author":"JP Thyssen","year":"2022","unstructured":"Thyssen JP, Schuttelaar MLA, Alfonso JH, Andersen KE, Angelova-Fischer I, Arents BWM, et al. Guidelines for diagnosis, prevention, and treatment of hand eczema. Contact Dermatitis. 2022;86(5):357\u201378.","journal-title":"Contact Dermatitis"},{"issue":"12","key":"574_CR19","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1001\/archderm.143.12.1578","volume":"143","author":"FJ Storrs","year":"2007","unstructured":"Storrs FJ. Acute and recurrent vesicular hand dermatitis not pompholyx or dyshidrosis. Arch Dermatol. 2007;143(12):1578\u201380.","journal-title":"Arch Dermatol"},{"issue":"12","key":"574_CR20","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1111\/all.13225","volume":"72","author":"JI Silverberg","year":"2017","unstructured":"Silverberg JI, Thyssen JP, Paller AS, Drucker AM, Wollenberg A, Lee KH, et al. What\u2019s in a name? Atopic dermatitis or atopic eczema, but not eczema alone. Allergy. 2017;72(12):2026\u201330.","journal-title":"Allergy"},{"issue":"1","key":"574_CR21","first-page":"6","volume":"32","author":"PE Beattie","year":"2007","unstructured":"Beattie PE, Green C, Lowe G, Lewis-Jones MS. Which children should we patch test? Clin Exp Dermatol. 2007;32(1):6\u201311.","journal-title":"Clin Exp Dermatol"},{"issue":"2","key":"574_CR22","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/cod.12129","volume":"70","author":"AB Simonsen","year":"2014","unstructured":"Simonsen AB, Deleuran M, Mortz CG, Johansen JD, Sommerlund M. Allergic contact dermatitis in Danish children referred for patch testing\u2014a nationwide multicentre study. Contact Dermatitis. 2014;70(2):104\u201311.","journal-title":"Contact Dermatitis"},{"issue":"5","key":"574_CR23","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1111\/bjd.14019","volume":"173","author":"C Gronhagen","year":"2015","unstructured":"Gronhagen C, Liden C, Wahlgren CF, Ballardini N, Bergstrom A, Kull I, et al. Hand eczema and atopic dermatitis in adolescents: a prospective cohort study from the BAMSE project. Br J Dermatol. 2015;173(5):1175\u201382.","journal-title":"Br J Dermatol"},{"issue":"5","key":"574_CR24","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1080\/000155502320624087","volume":"82","author":"CG Mortz","year":"2002","unstructured":"Mortz CG, Lauritsen JM, Bindslev-Jensen C, Andersen KE. Contact allergy and allergic contact dermatitis in adolescents: prevalence measures and associations. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis (TOACS). Acta Derm Venereol. 2002;82(5):352\u20138.","journal-title":"Acta Derm Venereol."},{"issue":"Suppl 53","key":"574_CR25","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1046\/j.1365-2133.1998.1390s3013.x","volume":"139","author":"D Abeck","year":"1998","unstructured":"Abeck D, Mempel M. Staphylococcus aureus colonization in atopic dermatitis and its therapeutic implications. Br J Dermatol. 1998;139(Suppl 53):13\u20136.","journal-title":"Br J Dermatol"},{"issue":"6","key":"574_CR26","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1111\/bjd.18643","volume":"182","author":"H Alexander","year":"2020","unstructured":"Alexander H, Paller AS, Traidl-Hoffmann C, Beck LA, De Benedetto A, Dhar S, et al. The role of bacterial skin infections in atopic dermatitis: expert statement and review from the International Eczema Council Skin Infection Group. Br J Dermatol. 2020;182(6):1331\u201342.","journal-title":"Br J Dermatol"},{"issue":"3","key":"574_CR27","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/j.jaip.2020.11.034","volume":"9","author":"T Ratchataswan","year":"2021","unstructured":"Ratchataswan T, Banzon TM, Thyssen JP, Weidinger S, Guttman-Yassky E, Phipatanakul W. Biologics for treatment of atopic dermatitis: current status and future prospect. J Allergy Clin Immunol Pract. 2021;9(3):1053\u201365.","journal-title":"J Allergy Clin Immunol Pract"},{"key":"574_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.821871","volume":"9","author":"S Ghazal","year":"2022","unstructured":"Ghazal S, Ridha Z, D\u2019Aguanno K, Nassim D, Quaiattini A, Netchiporouk E, et al. Treatment guidelines for atopic dermatitis since the approval of dupilumab: a systematic review and quality appraisal using AGREE-II. Front Med (Lausanne). 2022;9: 821871.","journal-title":"Front Med (Lausanne)."},{"issue":"2","key":"574_CR29","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1067\/S0190-9622(03)01564-0","volume":"49","author":"AR Brecher","year":"2003","unstructured":"Brecher AR, Orlow SJ. Oral retinoid therapy for dermatologic conditions in children and adolescents. J Am Acad Dermatol. 2003;49(2):171\u201382.","journal-title":"J Am Acad Dermatol."},{"issue":"5","key":"574_CR30","doi-asserted-by":"publisher","first-page":"S176","DOI":"10.1067\/mjd.2001.113721","volume":"45","author":"JJ DiGiovanna","year":"2001","unstructured":"DiGiovanna JJ. Isotretinoin effects on bone. J Am Acad Dermatol. 2001;45(5):S176\u201382.","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"574_CR31","first-page":"4","volume":"24","author":"TE Woo","year":"2019","unstructured":"Woo TE, Kuzel P. Crisaborole 2% ointment (eucrisa) for atopic dermatitis. Skin Therapy Lett. 2019;24(2):4\u20136.","journal-title":"Skin Therapy Lett."}],"container-title":["Pediatric Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40272-023-00574-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40272-023-00574-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40272-023-00574-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T23:02:21Z","timestamp":1702508541000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40272-023-00574-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,24]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["574"],"URL":"https:\/\/doi.org\/10.1007\/s40272-023-00574-x","relation":{},"ISSN":["1174-5878","1179-2019"],"issn-type":[{"value":"1174-5878","type":"print"},{"value":"1179-2019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,24]]},"assertion":[{"value":"28 April 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No sources of funding were used to conduct this study or prepare this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Dr Haft has no conflicts of interest to report. Dr Park has no conflicts of interest to report. Dr Lee has no conflicts of interest to report. Dr Sprague has no conflicts of interest to report. Dr Paller reports the following: AbbVie, Eli Lilly, Incyte, Regeneron\u2014investigator; Abbvie, Almirall, Arcutis, Arena, BiomX, Bristol Myers Squibb, Catawba, Eli Lilly, Galderma, Gilead, Incyte, Janssen, Leo, Novartis, Pfizer, RAPT, Regeneron, Sanofi\/Genzyme, Seanergy\u2014consultant with honorarium; Bausch, Galderma\u2014Data Safety Monitoring Board. Dr Cotton did not receive any direct support for this study. She received partial salary support from Regeneron and Sanofi as a sub-investigator of clinical research trials. Dr Thyssen is an advisor for AbbVie, Almirall, Arena Pharmaceuticals, Coloplast, OM Pharma, Aslan Pharmaceuticals, Union Therapeutics, Eli Lilly & Co, LEO Pharma, Pfizer, Regeneron, and Sanofi-Genzyme, a speaker for AbbVie, Almirall, Eli Lilly & Co, LEO Pharma, Pfizer, Regeneron, and Sanofi-Genzyme, and received research grants from Pfizer, Regeneron, and Sanofi-Genzyme. Dr Eichenfield has served as an advisory board member, and\/or speaker, consultant, or clinical trial investigator for AbbVie, Arena, Aslan, Bausch, Castle Biosciences, Dermavant, Eli Lilly, Forte, Galderma, Incyte, Leo Pharma, Novartis, Otsuka, Pfizer, Regeneron, Sanofi Genzyme and UCB.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Reviewed and approved by University of California, San Diego Investigational Review Board; approval #210154. The study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Informed consent was obtained to publish anonymous survey data. For the photo associated with vignette 1 in the supplementary materials: Image used with permission from VisualDx. For the photo associated with vignette 2 in the supplementary materials: Image by Raimo Suhonen, MD courtesy of DermNetNZ (). Image used with permission from Raimo Suhonen, MD and DermNetNZ. For the photo associated with vignette 3 in the supplementary materials: Human hand with dermatitis.jpg by James Heilman, MD courtesy of Wikimedia Commons licensed under CC BY-SA 3.0. Go toto read the full license text. For the photo associated with vignette 4 in the supplementary materials: Image by BSIP SA courtesy of Alamy Inc. is licensed under the Alamy License Agreement purchased for use in magazines and books in perpetuity worldwide. Go toto read the full license text.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The datasets generated during and\/or analyzed during the current study are available from the corresponding author on reasonable request.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by MAH. The first draft of the manuscript was written by MAH and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}