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R.S. is funded via a Senior Wellcome Fellowship awarded to grant number 207457\/Z\/17\/Z. N.v.d.H. is funded by an Alberta Innovates Postdoctoral Fellowship. None of the authors have any conflicts of interest to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent"}},{"value":"Data sharing is not applicable to this article, as no datasets were generated or analyzed during the current study.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data Availability Statement"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code Availability"}},{"value":"J.t.B. drafted the manuscript. G.v.d.B., R.S., N.v.d.H., I.R., and S.S. revisited the manuscript critically for important intellectual content. All authors have approved the final version of the manuscript.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author Contributions"}}]}}