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Material preparation, data collection and analysis were performed by FC, AS, CMR and MD. The first draft of the manuscript was written by FC, AS, CMR, MD and AA. MD and AA have full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. FC, CMR and MD are responsible for the data analysis. All authors commented on previous versions of the manuscript. All authors have read and approved the final submitted manuscript, and agree to be accountable for the work.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors' contributions"}}]}}