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The authors were responsible for all content and editorial decisions, and they received no honoraria related to the development of this publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"TED is an employee and owner of PAI. PAI received research funding from Novartis for this study. CE and MH are employees of PAI. PAI received research funding from Novartis for this study. QM, RR, SRI, and JZ are employees of Novartis. Novartis provided research funding to PAI for this study. RTM: Honoraria, membership on an entity\u2019s Board of Directors or advisory committees and research funding: Novartis; Consultancy and honoraria: Incyte, Juno; Honoraria: Kite, Jazz Pharmaceuticals; Patents & Royalties: Athersys, Inc.; Employment: Oregon Health & Science University (OHSU); with regard to the consultant services and payment from Novartis, this potential conflict of interest has been reviewed and managed by OHSU.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that all input data to parameterize the model are available within the article. The model can be re-built entirely based on the information provided.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability statement"}},{"value":"The information reported in this article is sufficient to replicate the results of the study. The model used in the article includes a proprietary code and is not provided.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"TED, CE, MH, QM: Study design, data collection, data analysis, interpretation of results, writing of draft and final manuscript. RR, JZ, SRI, RTM: Data collection, data analysis, interpretation of results, writing of draft and review of final manuscript.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}