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Hanns Lochm\u00fcller reports grants and personal fees from PTC Therapeutics, outside the submitted work. Erik Landfeldt, Sophia Abner, Astrid Pechmann, Hugh J. McMillan, and Janbernd Kirschner have nothing to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest\/Competing interests"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All data are provided within the article and the Electronic Supplementary Material.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"Concept and design: EL, SA, AP, TS, HJM, HL, and JK. Acquisition of data: EL and SA. 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