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All authors are employees of Evidera, a business unit of PPD, part of Thermo Fisher Scientific. The views expressed in this study are those of the authors and not necessarily those of Evidera.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Data supporting the results reported in the article are available upon request.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"Available\u00a0in Appendix B of the ESM under the MIT license.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"Author contributions were as follows: conceptualisation, GB and JM; data curation, GB and JM; formal analysis, GB and JM; investigation, GB, JM and JS; methodology, GB and JM; supervision, all authors; validation, GB and VK; visualisation, GB and JM; original draft, GB and JS; writing (review and editing), all authors.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}