{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:30:41Z","timestamp":1783420241101,"version":"3.54.6"},"reference-count":142,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Lac Virgen de Bego\u00f1a","award":["BC\/LIN\/002"],"award-info":[{"award-number":["BC\/LIN\/002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sports Med"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1007\/s40279-016-0620-z","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T02:22:06Z","timestamp":1475029326000},"page":"807-828","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Biological Therapies in Regenerative Sports Medicine"],"prefix":"10.1007","volume":"47","author":[{"given":"Isabel","family":"Andia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Maffulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,9,28]]},"reference":[{"issue":"4","key":"620_CR1","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1136\/bjsm.2010.082321","volume":"45","author":"H Takeda","year":"2011","unstructured":"Takeda H, Nakagawa T, Nakamura K, et al. Prevention and management of knee osteoarthritis and knee cartilage injury in sports. Br J Sports Med. 2011;45(4):304\u20139.","journal-title":"Br J Sports Med."},{"issue":"5","key":"620_CR2","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.arthro.2014.11.024","volume":"31","author":"I Andia","year":"2015","unstructured":"Andia I, Maffulli N. Muscle and tendon injuries: the role of biological interventions to promote and assist healing and recovery. Arthroscopy. 2015;31(5):999\u20131015.","journal-title":"Arthroscopy."},{"issue":"Suppl 1","key":"620_CR3","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1089\/scd.2013.0317","volume":"22","author":"S Burningham","year":"2013","unstructured":"Burningham S, Ollenberger A, Caulfield T. Commercialization and stem cell research: a review of emerging issues. Stem Cells Dev. 2013;22(Suppl 1):80\u20134.","journal-title":"Stem Cells Dev."},{"issue":"3 Pt B","key":"620_CR4","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.scr.2014.04.014","volume":"13","author":"M Munsie","year":"2014","unstructured":"Munsie M, Hyun I. A question of ethics: selling autologous stem cell therapies flaunts professional standards. Stem Cell Res. 2014;13(3 Pt B):647\u201353.","journal-title":"Stem Cell Res"},{"issue":"Suppl 1","key":"620_CR5","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1089\/scd.2014.0358","volume":"23","author":"KR Matthews","year":"2014","unstructured":"Matthews KR, Cuchiara ML. U.S. National Football League athletes seeking unproven stem cell treatments. Stem Cells Dev. 2014;23(Suppl 1):60\u20134.","journal-title":"Stem Cells Dev"},{"issue":"6 Pt B","key":"620_CR6","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.tmaid.2014.09.008","volume":"12","author":"R Connolly","year":"2014","unstructured":"Connolly R, O\u2019Brien T, Flaherty G. Stem cell tourism\u2014a web-based analysis of clinical services available to international travellers. Travel Med Infect Dis. 2014;12(6 Pt B):695\u2013701.","journal-title":"Travel Med Infect Dis"},{"key":"620_CR7","unstructured":"International Society for Stem Cell Research. Statement on delivery of unproven autologous-cell based interventions to patients. 2013. http:\/\/www.isscr.org\/docs\/default-source\/isscr-statements\/isscr-acbistatement-091113-fl.pdf . Accessed 10 Jan 2016."},{"key":"620_CR8","unstructured":"International Society for Stem Cell Research. The guidelines for the clinical translation of stem cells. 2008. http:\/\/www.isscr.org\/docs\/default-source\/clin-trans-guidelines\/isscrglclinicaltrans.pdf . Accessed 10 Jan 2016."},{"issue":"2","key":"620_CR9","doi-asserted-by":"publisher","first-page":"R79","DOI":"10.1186\/ar4520","volume":"16","author":"D Wang","year":"2014","unstructured":"Wang D, Li J, Zhang Y, et al. Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study. Arthritis Res Ther. 2014;16(2):R79.","journal-title":"Arthritis Res Ther."},{"issue":"5","key":"620_CR10","doi-asserted-by":"publisher","first-page":"632","DOI":"10.5966\/sctm.2013-0203","volume":"3","author":"RL Reger","year":"2014","unstructured":"Reger RL, Prockop DJ. Should publications on mesenchymal stem\/progenitor cells include in-process data on the preparation of the cells? Stem Cells Transl Med. 2014;3(5):632\u20135.","journal-title":"Stem Cells Transl Med."},{"key":"620_CR11","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0021-9258(18)51687-2","volume":"239","author":"M Rodbell","year":"1964","unstructured":"Rodbell M. Metabolism of isolated fat cells. Effects of hormones on glucose metabolism and lipolysis. J Biol Chem. 1964;239:375\u201380.","journal-title":"J Biol Chem."},{"issue":"4","key":"620_CR12","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8(4):315\u20137.","journal-title":"Cytotherapy."},{"key":"620_CR13","unstructured":"International Federation for Adipose Therapeutics and Science. http:\/\/www.ifats.org\/ . accessed Feb 2016."},{"issue":"2","key":"620_CR14","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1089\/107632701300062859","volume":"7","author":"PA Zuk","year":"2001","unstructured":"Zuk PA, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001;7(2):211\u201328.","journal-title":"Tissue Eng."},{"issue":"1","key":"620_CR15","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1089\/biores.2014.0059","volume":"4","author":"MS Choudhery","year":"2015","unstructured":"Choudhery MS, Badowski M, Muise A, et al. Subcutaneous adipose tissue-derived stem cell utility is independent of anatomical harvest site. Biores Open Access. 2015;4(1):131\u201345.","journal-title":"Biores Open Access."},{"key":"620_CR16","doi-asserted-by":"publisher","first-page":"362","DOI":"10.3389\/fphys.2015.00362","volume":"6","author":"MM Schimke","year":"2015","unstructured":"Schimke MM, Marozin S, Lepperdinger G. Patient specific age: the other side of the coin in advanced mesenchymal stem cell therapies. Front Physiol. 2015;6:362.","journal-title":"Front Physiol."},{"issue":"5411","key":"620_CR17","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1126\/science.284.5411.143","volume":"284","author":"MF Pittenger","year":"1999","unstructured":"Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284(5411):143\u20137.","journal-title":"Science"},{"issue":"4","key":"620_CR18","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1002\/stem.312","volume":"28","author":"KC Russell","year":"2010","unstructured":"Russell KC, Phinney DG, Lacey MR, et al. In vitro high-capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment. Stem Cells. 2010;28(4):788\u201398.","journal-title":"Stem Cells."},{"issue":"11","key":"620_CR19","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.1634\/stemcells.2007-0197","volume":"25","author":"G Chamberlain","year":"2007","unstructured":"Chamberlain G, Fox J, Ashton B, et al. Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells. 2007;25(11):2739\u201349.","journal-title":"Stem Cells."},{"key":"620_CR20","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/978-3-319-18618-4_6","volume":"871","author":"P Salmikangas","year":"2015","unstructured":"Salmikangas P, Schuessler-Lenz M, Ruiz S, et al. Marketing regulatory oversight of advanced therapy medicinal products (ATMPs) in Europe: the EMA\/CAT perspective. Adv Exp Med Biol. 2015;871:103\u201330.","journal-title":"Adv Exp Med Biol."},{"key":"620_CR21","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.transci.2004.10.007","volume":"32","author":"RL Reddy","year":"2005","unstructured":"Reddy RL. Mobilization and collection of peripheral blood progenitor cells for transplantation. Transf Apheresis Sci. 2005;32:63\u201373.","journal-title":"Transf Apheresis Sci"},{"issue":"12","key":"620_CR22","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/nrrheum.2013.141","volume":"9","author":"I Andia","year":"2013","unstructured":"Andia I, Maffulli N. Platelet-rich plasma for managing pain and inflammation in osteoarthritis. Nat Rev Rheumatol. 2013;9(12):721\u201330.","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"620_CR23","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1007\/s11999-015-4179-z","volume":"473","author":"I Andia","year":"2015","unstructured":"Andia I, Rubio-Azpeitia E, Maffulli N. Platelet-rich plasma modulates the secretion of inflammatory\/angiogenic proteins by inflamed tenocytes. Clin Orthop Relat Res. 2015;473(5):1624\u201334.","journal-title":"Clin Orthop Relat Res"},{"issue":"1","key":"620_CR24","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1177\/0363546514554190","volume":"43","author":"YS Kim","year":"2015","unstructured":"Kim YS, Choi YJ, Suh DS, et al. Mesenchymal stem cell implantation in osteoarthritic knees: is fibrin glue effective as a scaffold? Am J Sports Med. 2015;43(1):176\u201385.","journal-title":"Am J Sports Med."},{"key":"620_CR25","first-page":"3532","volume":"13","author":"AT Nurden","year":"2008","unstructured":"Nurden AT, Nurden P, Sanchez M, et al. Platelets and wound healing. Front Biosci. 2008;13:3532\u201348.","journal-title":"Front Biosci."},{"issue":"1","key":"620_CR26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.32098\/mltj.01.2014.02","volume":"4","author":"DM Dohan Ehrenfest","year":"2014","unstructured":"Dohan Ehrenfest DM, Andia I, Zumstein MA, et al. Classification of platelet concentrates (platelet-rich plasma-PRP, platelet-rich fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles Ligaments Tendons J. 2014;4(1):3\u20139.","journal-title":"Muscles Ligaments Tendons J."},{"issue":"8","key":"620_CR27","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1177\/0363546516643814","volume":"44","author":"E Rubio-Azpeitia","year":"2016","unstructured":"Rubio-Azpeitia E, Bilbao AM, S\u00e1nchez P, et al. The properties of three different plasma formulations and their effects on tendinopathic cells. Am J Sports Med. 2016;44(8):1952\u201361.","journal-title":"Am J Sports Med."},{"issue":"6","key":"620_CR28","doi-asserted-by":"publisher","first-page":"e64923","DOI":"10.1371\/journal.pone.0064923","volume":"8","author":"H Li","year":"2013","unstructured":"Li H, Usas A, Poddar M, et al. Platelet-rich plasma promotes the proliferation of human muscle derived progenitor cells and maintains their stemness. PLoS One. 2013;8(6):e64923.","journal-title":"PLoS One."},{"issue":"1","key":"620_CR29","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1089\/ten.tec.2015.0223","volume":"22","author":"JM Jalowiec","year":"2016","unstructured":"Jalowiec JM, D\u2019Este M, Bara JJ, et al. An in vitro investigation of platelet-rich plasma-gel as a cell and growth factor delivery vehicle for tissue engineering. Tissue Eng Part C Methods. 2016;22(1):49\u201358.","journal-title":"Tissue Eng Part C Methods."},{"issue":"2","key":"620_CR30","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/PRS.0000000000000392","volume":"134","author":"YR Jeon","year":"2014","unstructured":"Jeon YR, Kang EH, Yang CE, et al. The effect of platelet-rich plasma on composite graft survival. Plast Reconstr Surg. 2014;134(2):239\u201346.","journal-title":"Plast Reconstr Surg."},{"issue":"10","key":"620_CR31","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1002\/jcb.25235","volume":"116","author":"V D\u2019Esposito","year":"2015","unstructured":"D\u2019Esposito V, Passaretti F, Perruolo G, et al. Platelet-rich plasma increases growth and motility of adipose tissue-derived mesenchymal stem cells and controls adipocyte secretory function. J Cell Biochem. 2015;116(10):2408\u201318.","journal-title":"J Cell Biochem."},{"issue":"4","key":"620_CR32","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/scrt277","volume":"4","author":"P Pham Van","year":"2013","unstructured":"Van Pham P, Bui KH, Ngo DQ, et al. Activated platelet-rich plasma improves adipose-derived stem cell transplantation efficiency in injured articular cartilage. Stem Cell Res Ther. 2013;4(4):91.","journal-title":"Stem Cell Res Ther."},{"issue":"12","key":"620_CR33","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1016\/j.biochi.2013.04.017","volume":"95","author":"M Maumus","year":"2013","unstructured":"Maumus M, Jorgensen C, No\u00ebl D. Mesenchymal stem cells in regenerative medicine applied to rheumatic diseases: role of secretome and exosomes. Biochimie. 2013;95(12):2229\u201334.","journal-title":"Biochimie."},{"key":"620_CR34","doi-asserted-by":"publisher","first-page":"965849","DOI":"10.1155\/2014\/965849","volume":"2014","author":"JA Pawitan","year":"2014","unstructured":"Pawitan JA. Prospect of stem cell conditioned medium in regenerative medicine. BioMed Res Int. 2014;2014:965849.","journal-title":"BioMed Res Int."},{"issue":"5","key":"620_CR35","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/mt.2015.44","volume":"23","author":"S Rani","year":"2015","unstructured":"Rani S, Ryan AE, Griffin MD, et al. Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications. Mol Ther. 2015;23(5):812\u201323.","journal-title":"Mol Ther."},{"key":"620_CR36","unstructured":"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02003131?term=NCT+02003131&rank=1<redir.aspx?REF=K6FUxN7V-HmWjkPwWisS6odBg9QHcsGe9whHw5lWHWq1wXmNvTCAFodHRwczovL2NsaW5pY2FsdHJpYWxzmdvdi9jdDIvc2hvdy9OQ1QwMjAwMzEzMT90ZXJtPU5DVCswMjAwMzEzMSZyYW5rPTE. . Accessed 17 Aug 2016."},{"issue":"2","key":"620_CR37","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1093\/rheumatology\/keu377","volume":"54","author":"OI Eseonu","year":"2015","unstructured":"Eseonu OI, De Bari C. Homing of mesenchymal stem cells: mechanistic or stochastic? Implications for targeted delivery in arthritis. Rheumatology (Oxford). 2015;54(2):210\u20138.","journal-title":"Rheumatology (Oxford)."},{"issue":"2","key":"620_CR38","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s00441-008-0633-5","volume":"333","author":"H Koga","year":"2008","unstructured":"Koga H, Muneta T, Nagase T, et al. Comparison of mesenchymal tissues-derived stem cells for in vivo chondrogenesis: suitable conditions for cell therapy of cartilage defects in rabbit. Cell Tissue Res. 2008;333(2):207\u201315.","journal-title":"Cell Tissue Res."},{"issue":"7","key":"620_CR39","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1089\/ten.tea.2009.0720","volume":"16","author":"D Little","year":"2010","unstructured":"Little D, Guilak F, Ruch DS. Ligament-derived matrix stimulates a ligamentous phenotype in human adipose-derived stem cells. Tissue Eng Part A. 2010;16(7):2307\u201319.","journal-title":"Tissue Eng Part A."},{"key":"620_CR40","doi-asserted-by":"publisher","first-page":"e54","DOI":"10.1038\/emm.2013.94","volume":"45","author":"MB Murphy","year":"2013","unstructured":"Murphy MB, Moncivais K, Caplan AI. Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Exp Mol Med. 2013;45:e54.","journal-title":"Exp Mol Med."},{"issue":"8","key":"620_CR41","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/nm.3653","volume":"20","author":"SJ Forbes","year":"2014","unstructured":"Forbes SJ, Rosenthal N. Preparing the ground for tissue regeneration: from mechanism to therapy. Nat Med. 2014;20(8):857\u201369.","journal-title":"Nat Med."},{"issue":"3","key":"620_CR42","first-page":"132","volume":"3","author":"A Castagna","year":"2013","unstructured":"Castagna A, Cesari E, Garofalo R, et al. Matrix metalloproteases and their inhibitors are altered in torn rotator cuff tendons, but also in the macroscopically and histologically intact portion of those tendons. Muscles Ligaments Tendons J. 2013;3(3):132\u20138.","journal-title":"Muscles Ligaments Tendons J."},{"issue":"4","key":"620_CR43","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.bbrc.2015.05.122","volume":"463","author":"K Zhang","year":"2015","unstructured":"Zhang K, Asai S, Yu B, et al. IL-1\u03b2 irreversibly inhibits tenogenic differentiation and alters metabolism in injured tendon-derived progenitor cells in vitro. Biochem Biophys Res Commun. 2015;463(4):667\u201372.","journal-title":"Biochem Biophys Res Commun."},{"issue":"5","key":"620_CR44","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1002\/jcb.20886","volume":"98","author":"AI Caplan","year":"2006","unstructured":"Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem. 2006;98(5):1076\u201384.","journal-title":"J Cell Biochem."},{"key":"620_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.addr.2014.10.007","volume":"82\u201383","author":"C Tran","year":"2015","unstructured":"Tran C, Damaser MS. Stem cells as drug delivery methods: application of stem cell secretome for regeneration. Adv Drug Deliv Rev. 2015;82\u201383:1\u201311.","journal-title":"Adv Drug Deliv Rev."},{"issue":"4 Suppl 92","key":"620_CR46","first-page":"S58","volume":"33","author":"Y Tanaka","year":"2015","unstructured":"Tanaka Y. Human mesenchymal stem cells as a tool for joint repair in rheumatoid arthritis. Clin Exp Rheumatol. 2015;33(4 Suppl 92):S58\u201362.","journal-title":"Clin Exp Rheumatol."},{"issue":"6","key":"620_CR47","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1002\/stem.1608","volume":"32","author":"JY Oh","year":"2014","unstructured":"Oh JY, Ko JH, Lee HJ, et al. Mesenchymal stem\/stromal cells inhibit the NLRP3 inflammasome by decreasing mitochondrial reactive oxygen species. Stem Cells. 2014;32(6):1553\u201363.","journal-title":"Stem Cells."},{"key":"620_CR48","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.actbio.2015.12.021","volume":"31","author":"Y Xu","year":"2016","unstructured":"Xu Y, Fu M, Li Z, et al. A prosurvival and proangiogenic stem cell delivery system to promote ischemic limb regeneration. Acta Biomater. 2016;31:99\u2013113.","journal-title":"Acta Biomater."},{"issue":"5","key":"620_CR49","doi-asserted-by":"publisher","first-page":"645","DOI":"10.2217\/rme.13.59","volume":"8","author":"I Andia","year":"2013","unstructured":"Andia I, Abate M. Platelet-rich plasma: underlying biology and clinical correlates. Regen Med. 2013;8(5):645\u201358.","journal-title":"Regen Med."},{"key":"620_CR50","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/s13287-015-0172-4","volume":"6","author":"Y Zhou","year":"2015","unstructured":"Zhou Y, Zhang J, Wu H, et al. The differential effects of leukocyte-containing and pure platelet-rich plasma (PRP) on tendon stem\/progenitor cells\u2014implications of PRP application for the clinical treatment of tendon injuries. Stem Cell Res Ther. 2015;6:173.","journal-title":"Stem Cell Res Ther."},{"issue":"7","key":"620_CR51","doi-asserted-by":"publisher","first-page":"852","DOI":"10.5966\/sctm.2014-0111","volume":"4","author":"JA Zullo","year":"2015","unstructured":"Zullo JA, Nadel EP, Rabadi MM, et al. The secretome of hydrogel-coembedded endothelial progenitor cells and mesenchymal stem cells instructs macrophage polarization in endotoxemia. Stem Cells Transl Med. 2015;4(7):852\u201361.","journal-title":"Stem Cells Transl Med."},{"issue":"6","key":"620_CR52","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1089\/scd.2009.0188","volume":"19","author":"PA Walker","year":"2010","unstructured":"Walker PA, Harting MT, Jimenez F, et al. Direct intrathecal implantation of mesenchymal stromal cells leads to enhanced neuroprotection via an NFkappaB-mediated increase in interleukin-6 production. Stem Cells Dev. 2010;19(6):867\u201376.","journal-title":"Stem Cells Dev."},{"key":"620_CR53","doi-asserted-by":"publisher","first-page":"357014","DOI":"10.1155\/2013\/357014","volume":"2013","author":"J Platas","year":"2013","unstructured":"Platas J, Guill\u00e9n MI, del Caz MD, et al. Conditioned media from adipose-tissue-derived mesenchymal stem cells downregulate degradative mediators induced by interleukin-1\u03b2 in osteoarthritic chondrocytes. Mediat Inflamm. 2013;2013:357014.","journal-title":"Mediat Inflamm."},{"issue":"1","key":"620_CR54","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/mt.2011.211","volume":"20","author":"DJ Prockop","year":"2012","unstructured":"Prockop DJ, Oh JY. Mesenchymal stem\/stromal cells (MSCs): role as guardians of inflammation. Mol Ther. 2012;20(1):14\u201320.","journal-title":"Mol Ther."},{"issue":"47","key":"620_CR55","doi-asserted-by":"publisher","first-page":"16766","DOI":"10.1073\/pnas.1416121111","volume":"111","author":"RH Lee","year":"2014","unstructured":"Lee RH, Yu JM, Foskett AM, et al. TSG-6 as a biomarker to predict efficacy of human mesenchymal stem\/progenitor cells (hMSCs) in modulating sterile inflammation in vivo. Proc Natl Acad Sci USA. 2014;111(47):16766\u201371.","journal-title":"Proc Natl Acad Sci USA."},{"issue":"3\u20134","key":"620_CR56","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1089\/ten.tea.2013.0651","volume":"21","author":"X Fu","year":"2015","unstructured":"Fu X, Chen Y, Xie FN, et al. Comparison of immunological characteristics of mesenchymal stem cells derived from human embryonic stem cells and bone marrow. Tissue Eng Part A. 2015;21(3\u20134):616\u201326.","journal-title":"Tissue Eng Part A."},{"issue":"5","key":"620_CR57","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1002\/jcb.24046","volume":"113","author":"DJ Prockop","year":"2012","unstructured":"Prockop DJ, Oh JY. Medical therapies with adult stem\/progenitor cells (MSCs): a backward journey from dramatic results in vivo to the cellular and molecular explanations. J Cell Biochem. 2012;113(5):1460\u20139.","journal-title":"J Cell Biochem."},{"issue":"2","key":"620_CR58","doi-asserted-by":"publisher","first-page":"211","DOI":"10.2217\/rme.13.10","volume":"8","author":"U Stochaj","year":"2013","unstructured":"Stochaj U, Kodiha M, Shum-Tim D, et al. Implications of multipotent mesenchymal stromal cell aging. Regen Med. 2013;8(2):211\u201322.","journal-title":"Regen Med."},{"key":"620_CR59","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/1741-7015-11-146","volume":"11","author":"G Siegel","year":"2013","unstructured":"Siegel G, Kluba T, Hermanutz-Klein U, et al. Phenotype, donor age and gender affect function of human bone marrow-derived mesenchymal stromal cells. BMC Med. 2013;11:146.","journal-title":"BMC Med."},{"issue":"1","key":"620_CR60","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.yexcr.2014.03.013","volume":"324","author":"Z Yan","year":"2014","unstructured":"Yan Z, Zhuansun Y, Chen R, et al. Immunomodulation of mesenchymal stromal cells on regulatory T cells and its possible mechanism. Exp Cell Res. 2014;324(1):65\u201374.","journal-title":"Exp Cell Res."},{"issue":"1 Pt A","key":"620_CR61","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.imlet.2014.09.013","volume":"162","author":"Z Yan","year":"2014","unstructured":"Yan Z, Zhuansun Y, Liu G, et al. Mesenchymal stem cells suppress T cells by inducing apoptosis and through PD-1\/B7-H1 interactions. Immunol Lett. 2014;162(1 Pt A):248\u2013255.36.","journal-title":"Immunol Lett"},{"issue":"9","key":"620_CR62","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/jcmm.12092","volume":"17","author":"P Li","year":"2013","unstructured":"Li P, Li SH, Wu J, et al. Interleukin-6 downregulation with mesenchymal stem cell differentiation results in loss of immunoprivilege. J Cell Mol Med. 2013;17(9):1136\u201345.","journal-title":"J Cell Mol Med."},{"key":"620_CR63","first-page":"234095","volume":"2014","author":"A Sharma","year":"2014","unstructured":"Sharma A, Sane H, Gokulchandran N, et al. Autologous bone marrow mononuclear cells intrathecal transplantation in chronic stroke. Stroke Res Treat. 2014;2014:234095.","journal-title":"Stroke Res Treat."},{"issue":"4","key":"620_CR64","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.arthro.2014.11.023","volume":"31","author":"S Oussedik","year":"2015","unstructured":"Oussedik S, Tsitskaris K, Parker D. Treatment of articular cartilage lesions of the knee by microfracture or autologous chondrocyte implantation: a systematic review. Arthroscopy. 2015;31(4):732\u201344.","journal-title":"Arthroscopy."},{"issue":"10","key":"620_CR65","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1136\/bjsports-2014-094036","volume":"49","author":"AB Laudy","year":"2015","unstructured":"Laudy AB, Bakker EW, Rekers M, et al. Efficacy of platelet-rich plasma injections in osteoarthritis of the knee: a systematic review and meta-analysis. Br J Sports Med. 2015;49(10):657\u201372.","journal-title":"Br J Sports Med."},{"key":"620_CR66","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516643716","author":"J Fitzpatrick","year":"2016","unstructured":"Fitzpatrick J, Bulsara M, Zheng MH. The effectiveness of platelet-rich plasma in the treatment of tendinopathy: a meta-analysis of randomized controlled clinical trials. Am J Sports Med. 2016. doi: 10.1177\/0363546516643716 .","journal-title":"Am J Sports Med."},{"issue":"4","key":"620_CR67","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1136\/bjsm.2008.056457","volume":"43","author":"D Connell","year":"2009","unstructured":"Connell D, Datir A, Alyas F, et al. Treatment of lateral epicondylitis using skin-derived tenocyte-like cells. Br J Sports Med. 2009;43(4):293\u20138.","journal-title":"Br J Sports Med."},{"issue":"7","key":"620_CR68","doi-asserted-by":"crossref","first-page":"559","DOI":"10.47102\/annals-acadmedsg.V37N7p559","volume":"37","author":"YL Moon","year":"2008","unstructured":"Moon YL, Jo SH, Song CH, et al. Autologous bone marrow plasma injection after arthroscopic debridement for elbow tendinosis. Ann Acad Med Singapore. 2008;37(7):559\u201363.","journal-title":"Ann Acad Med Singapore."},{"issue":"2","key":"620_CR69","doi-asserted-by":"publisher","first-page":"389","DOI":"10.4103\/0976-9668.136198","volume":"5","author":"A Singh","year":"2014","unstructured":"Singh A, Gangwar DS, Singh S. Bone marrow injection: a novel treatment for tennis elbow. J Nat Sci Biol Med. 2014;5(2):389\u201391.","journal-title":"J Nat Sci Biol Med."},{"issue":"7","key":"620_CR70","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1177\/0363546515579185","volume":"43","author":"A Wang","year":"2015","unstructured":"Wang A, Mackie K, Breidahl W, et al. Evidence for the durability of autologous tenocyte injection for treatment of chronic resistant lateral epicondylitis: mean 4.5-year clinical follow-up. Am J Sports Med. 2015;43(7):1775\u201383.","journal-title":"Am J Sports Med."},{"issue":"12","key":"620_CR71","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1177\/0363546513504285","volume":"41","author":"A Wang","year":"2013","unstructured":"Wang A, Breidahl W, Mackie KE, et al. Autologous tenocyte injection for the treatment of severe, chronic resistant lateral epicondylitis: a pilot study. Am J Sports Med. 2013;41(12):2925\u201332.","journal-title":"Am J Sports Med."},{"key":"620_CR72","first-page":"269","volume":"8","author":"CJ Centeno","year":"2015","unstructured":"Centeno CJ, Al-Sayegh H, Bashir J, et al. A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis. J Pain Res. 2015;8:269\u201376.","journal-title":"J Pain Res."},{"issue":"2","key":"620_CR73","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s00167-011-1607-9","volume":"20","author":"JL Ellera Gomes","year":"2012","unstructured":"Ellera Gomes JL, da Silva RC, Silla LM, et al. Conventional rotator cuff repair complemented by the aid of mononuclear autologous stem cells. Knee Surg Sports Traumatol Arthrosc. 2012;20(2):373\u20137.","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"3","key":"620_CR74","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1177\/0363546510387095","volume":"39","author":"AW Clarke","year":"2011","unstructured":"Clarke AW, Alyas F, Morris T, et al. Skin-derived tenocyte-like cells for the treatment of patellar tendinopathy. Am J Sports Med. 2011;39(3):614\u201323.","journal-title":"Am J Sports Med"},{"key":"620_CR75","doi-asserted-by":"publisher","unstructured":"Pascual-Garrido C, Rol\u00f3n A, Makino A. Treatment of chronic patellar tendinopathy with autologous bone marrow stem cells: a 5-year-followup. Stem Cells Int. 2012;2012:953510.","DOI":"10.1155\/2012\/953510"},{"key":"620_CR76","first-page":"e895","volume":"5","author":"K Tate-Oliver","year":"2013","unstructured":"Tate-Oliver K, Alexander RW. Combination of autologous adipose-derived tissue stromal vascular fraction plus high-density platelet rich plasma or bone marrow concentrates in Achilles tendon tears. J Prolotherapy. 2013;5:e895\u2013912.","journal-title":"J Prolotherapy."},{"key":"620_CR77","first-page":"437","volume":"8","author":"CJ Centeno","year":"2015","unstructured":"Centeno CJ, Pitts J, Al-Sayegh H, et al. Anterior cruciate ligament tears treated with percutaneous injection of autologous bone marrow nucleated cells: a case series. J Pain Res. 2015;8:437\u201347.","journal-title":"J Pain Res."},{"issue":"5\u20136","key":"620_CR78","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s10354-013-0222-4","volume":"164","author":"CJ Centeno","year":"2014","unstructured":"Centeno CJ, Freeman MD. Percutaneous injection of autologous, culture-expanded mesenchymal stem cells into carpometacarpal hand joints: a case series with an untreated comparison group. Wien Med Wochenschr. 2014;164(5\u20136):83\u20137.","journal-title":"Wien Med Wochenschr."},{"issue":"4","key":"620_CR79","doi-asserted-by":"publisher","first-page":"368","DOI":"10.2174\/157488811797904371","volume":"6","author":"CJ Centeno","year":"2011","unstructured":"Centeno CJ, Schultz JR, Cheever M, et al. Safety and complications reporting update on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique. Curr Stem Cell Res Ther. 2011;6(4):368\u201378.","journal-title":"Curr Stem Cell Res Ther."},{"issue":"2","key":"620_CR80","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/j.1756-185X.2011.01599.x","volume":"14","author":"F Davatchi","year":"2011","unstructured":"Davatchi F, Abdollahi BS, Mohyeddin M, et al. Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients. Int J Rheum Dis. 2011;14(2):211\u20135.","journal-title":"Int J Rheum Dis"},{"issue":"7","key":"620_CR81","first-page":"422","volume":"15","author":"M Emadedin","year":"2012","unstructured":"Emadedin M, Aghdami N, Taghiyar L, et al. Intra-articular injection of autologous mesenchymal stem cells in six patients with knee osteoarthritis. Arch Iran Med. 2012;15(7):422\u20138.","journal-title":"Arch Iran Med."},{"issue":"5","key":"620_CR82","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1002\/stem.1634","volume":"32","author":"CH Jo","year":"2014","unstructured":"Jo CH, Lee YG, Shin WH, et al. Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. Stem Cells. 2014;32(5):1254\u201366.","journal-title":"Stem Cells."},{"issue":"11","key":"620_CR83","doi-asserted-by":"publisher","first-page":"2738","DOI":"10.1177\/0363546515599632","volume":"43","author":"YS Kim","year":"2015","unstructured":"Kim YS, Kwon OR, Choi YJ, et al. Comparative matched-pair analysis of the injection versus implantation of mesenchymal stem cells for knee osteoarthritis. Am J Sports Med. 2015;43(11):2738\u201346.","journal-title":"Am J Sports Med."},{"issue":"12","key":"620_CR84","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1097\/TP.0b013e318291a2da","volume":"95","author":"L Orozco","year":"2013","unstructured":"Orozco L, Munar A, Soler R, et al. Treatment of knee osteoarthritis with autologous mesenchymal stem cells: a pilot study. Transplantation. 2013;95(12):1535\u201341.","journal-title":"Transplantation."},{"issue":"11","key":"620_CR85","doi-asserted-by":"publisher","first-page":"e66","DOI":"10.1097\/TP.0000000000000167","volume":"97","author":"L Orozco","year":"2014","unstructured":"Orozco L, Munar A, Soler R, et al. Treatment of knee osteoarthritis with autologous mesenchymal stem cells: two-year follow-up results. Transplantation. 2014;97(11):e66\u20138.","journal-title":"Transplantation."},{"issue":"6","key":"620_CR86","first-page":"1","volume":"5","author":"R Soler Rich","year":"2015","unstructured":"Soler Rich R, Munar A, Soler Romagosa F, et al. Treatment of knee osteoarthritis with autologous expanded bone marrow mesenchymal stem cells: 50 cases clinical and MRI results at one year follow-up. J Stem Cell Res Ther. 2015;5(6):1\u20137.","journal-title":"J Stem Cell Res Ther"},{"issue":"2","key":"620_CR87","doi-asserted-by":"publisher","first-page":"90","DOI":"10.2106\/JBJS.M.00058","volume":"96","author":"CT Vangsness Jr","year":"2014","unstructured":"Vangsness CT Jr, Farr J 2nd, Boyd J, et al. Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study. J Bone Joint Surg Am. 2014;96(2):90\u20138.","journal-title":"J Bone Joint Surg Am."},{"issue":"8","key":"620_CR88","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1097\/TP.0000000000000678","volume":"99","author":"A Vega","year":"2015","unstructured":"Vega A, Mart\u00edn-Ferrero MA, Del Canto F, et al. Treatment of knee osteoarthritis with allogeneic bone marrow mesenchymal stem cells: a randomized controlled trial. Transplantation. 2015;99(8):1681\u201390.","journal-title":"Transplantation."},{"issue":"1","key":"620_CR89","doi-asserted-by":"publisher","first-page":"2","DOI":"10.7603\/s40730-014-0002-9","volume":"1","author":"K Bui","year":"2014","unstructured":"Bui K, Duong T, Nguyen N, et al. Symptomatic knee osteoarthritis treatment using autologous adipose derived stem cells and platelet rich plasma: a clinical study. Biomed Res Therapy. 2014;1(1):2\u20138.","journal-title":"Biomed Res Therapy."},{"key":"620_CR90","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1186\/s12891-015-0714-z","volume":"16","author":"CJ Centeno","year":"2015","unstructured":"Centeno CJ, Al-Sayegh H, Bashir J, et al. A dose response analysis of a specific bone marrow concentrate treatment protocol for knee osteoarthritis. BMC Musculoskelet Disord. 2015;16:258.","journal-title":"BMC Musculoskelet Disord."},{"key":"620_CR91","doi-asserted-by":"publisher","first-page":"370621","DOI":"10.1155\/2014\/370621","volume":"2014","author":"C Centeno","year":"2014","unstructured":"Centeno C, Pitts J, Al-Sayegh H, et al. Efficacy of autologous bone marrow concentrate for knee osteoarthritis with and without adipose graft. BioMed Res Int. 2014;2014:370621.","journal-title":"BioMed Res Int."},{"issue":"2","key":"620_CR92","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1093\/asj\/sjv135","volume":"36","author":"PB Fodor","year":"2016","unstructured":"Fodor PB, Paulseth SG. Adipose derived stromal cell (ADSC) injections for pain management of osteoarthritis in the human knee joint. Aesthet Surg J. 2016;36(2):229\u201336.","journal-title":"Aesthet Surg J."},{"key":"620_CR93","doi-asserted-by":"publisher","first-page":"799","DOI":"10.2147\/JPR.S92090","volume":"8","author":"N Gibbs","year":"2015","unstructured":"Gibbs N, Diamond R, Sekyere EO, et al. Management of knee osteoarthritis by combined stromal vascular fraction cell therapy, platelet-rich plasma, and musculoskeletal exercises: a case series. J Pain Res. 2015;8:799\u2013806.","journal-title":"J Pain Res."},{"issue":"8","key":"620_CR94","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1007\/s00590-013-1393-9","volume":"24","author":"JD Kim","year":"2014","unstructured":"Kim JD, Lee GW, Jung GH, et al. Clinical outcome of autologous bone marrow aspirates concentrate (BMAC) injection in degenerative arthritis of the knee. Eur J Orthop Surg Traumatol. 2014;24(8):1505\u201311.","journal-title":"Eur J Orthop Surg Traumatol."},{"issue":"4","key":"620_CR95","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/j.arthro.2012.11.017","volume":"29","author":"YG Koh","year":"2013","unstructured":"Koh YG, Jo SB, Kwon OR, et al. Mesenchymal stem cell injections improve symptoms of knee osteoarthritis. Arthroscopy. 2013;29(4):748\u201355.","journal-title":"Arthroscopy."},{"issue":"6","key":"620_CR96","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/j.knee.2012.04.001","volume":"19","author":"YG Koh","year":"2012","unstructured":"Koh YG, Choi YJ. Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis. Knee. 2012;19(6):902\u20137.","journal-title":"Knee"},{"key":"620_CR97","first-page":"e937","volume":"7","author":"KS Oliver","year":"2015","unstructured":"Oliver KS, Bayes M, Crane D, et al. Clinical outcome of bone marrow concentrate in osteoarthritis. J Prolotherapy. 2015;7:e937\u201346.","journal-title":"J Prolotherapy."},{"issue":"5","key":"620_CR98","doi-asserted-by":"publisher","first-page":"e64569","DOI":"10.1371\/journal.pone.0064569","volume":"8","author":"J Pak","year":"2013","unstructured":"Pak J, Lee JH, Lee SH. A novel biological approach to treat chondromalacia patellae. PLoS One. 2013;8(5):e64569.","journal-title":"PLoS One."},{"key":"620_CR99","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1186\/1471-2474-14-337","volume":"14","author":"J Pak","year":"2013","unstructured":"Pak J, Chang JJ, Lee JH, et al. Safety reporting on implantation of autologous adipose tissue-derived stem cells with platelet-rich plasma into human articular joints. BMC Musculoskelet Disord. 2013;14:337.","journal-title":"BMC Musculoskelet Disord."},{"issue":"2","key":"620_CR100","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s00402-014-2136-z","volume":"135","author":"I Akgun","year":"2015","unstructured":"Akgun I, Unlu MC, Erdal OA, et al. Matrix-induced autologous mesenchymal stem cell implantation versus matrix-induced autologous chondrocyte implantation in the treatment of chondral defects of the knee: a 2-year randomized study. Arch Orthop Trauma Surg. 2015;135(2):251\u201363.","journal-title":"Arch Orthop Trauma Surg."},{"issue":"4","key":"620_CR101","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1177\/1947603510366027","volume":"1","author":"AM Haleem","year":"2010","unstructured":"Haleem AM, Singergy AA, Sabry D, et al. The clinical use of human culture-expanded autologous bone marrow mesenchymal stem cells transplanted on platelet-rich fibrin glue in the treatment of articular cartilage defects: a pilot study and preliminary results. Cartilage. 2010;1(4):253\u201361.","journal-title":"Cartilage."},{"issue":"7","key":"620_CR102","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1177\/0363546514529641","volume":"42","author":"YG Koh","year":"2014","unstructured":"Koh YG, Choi YJ, Kwon OR, et al. Second-look arthroscopic evaluation of cartilage lesions after mesenchymal stem cell implantation in osteoarthritic knees. Am J Sports Med. 2014;42(7):1628\u201337.","journal-title":"Am J Sports Med."},{"key":"620_CR103","first-page":"511e7","volume":"41","author":"KB Lee","year":"2012","unstructured":"Lee KB, Wang VT, Chan YH, et al. A novel, minimally-invasive technique of cartilage repair in the human knee using arthroscopic microfracture and injections of mesenchymal stem cells and hyaluronic acid a prospective comparative study on safety and short-term efficacy. Ann Acad Med Singapore. 2012;41:511e7.","journal-title":"Ann Acad Med Singapore"},{"issue":"6","key":"620_CR104","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1177\/0363546509359067","volume":"38","author":"H Nejadnik","year":"2010","unstructured":"Nejadnik H, Hui JH, Feng Choong EP, et al. Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study. Am J Sports Med. 2010;38(6):1110\u20136.","journal-title":"Am J Sports Med."},{"issue":"4","key":"620_CR105","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.arthro.2012.12.008","volume":"29","author":"KY Saw","year":"2013","unstructured":"Saw KY, Anz A, Siew-Yoke Jee C, et al. Articular cartilage regeneration with autologous peripheral blood stem cells versus hyaluronic acid: a randomized controlled trial. Arthroscopy. 2013;29(4):684\u201394.","journal-title":"Arthroscopy."},{"issue":"7","key":"620_CR106","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1007\/s11999-015-4324-8","volume":"473","author":"I Sekiya","year":"2015","unstructured":"Sekiya I, Muneta T, Horie M, et al. Arthroscopic transplantation of synovial stem cells improves clinical outcomes in knees with cartilage defects. Clin Orthop Relat Res. 2015;473(7):2316\u201326.","journal-title":"Clin Orthop Relat Res."},{"key":"620_CR107","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1007\/s11999-012-2338-z","volume":"471","author":"BJ Teo","year":"2013","unstructured":"Teo BJ, Buhary K, Tai BC, et al. Cell-based therapy improves function in adolescents and young adults with patellar osteo-chondritis dissecans. Clin Orthop Relat Res. 2013;471:1152.","journal-title":"Clin Orthop Relat Res"},{"issue":"12","key":"620_CR108","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1016\/j.arthro.2013.09.074","volume":"29","author":"KL Wong","year":"2013","unstructured":"Wong KL, Lee KB, Tai BC, et al. Injectable cultured bone marrow-derived mesenchymal stem cells in varus knees with cartilage defects undergoing high tibial osteotomy: a prospective, randomized controlled clinical trial with 2 years\u2019 follow-up. Arthroscopy. 2013;29(12):2020\u20138.","journal-title":"Arthroscopy."},{"key":"620_CR109","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s00402-015-2344-1","volume":"136","author":"R Buda","year":"2016","unstructured":"Buda R, Castagnini F, Cavallo M, et al. \u201cOne-step\u201d bone marrow-derived cells transplantation and joint debridement for osteochondral lesions of the talus in ankle osteoarthritis: clinical and radiological outcomes at 36 months. Arch Orthop Trauma Surg. 2016;136:107\u201316.","journal-title":"Arch Orthop Trauma Surg."},{"issue":"5","key":"620_CR110","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s00264-015-2685-y","volume":"39","author":"R Buda","year":"2015","unstructured":"Buda R, Vannini F, Castagnini F, et al. Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus one-step bone marrow derived cells transplantation. Int Orthop. 2015;39(5):893\u2013900.","journal-title":"Int Orthop."},{"issue":"3","key":"620_CR111","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1177\/1947603515574286","volume":"6","author":"R Buda","year":"2015","unstructured":"Buda R, Cavallo M, Castagnini F, et al. Treatment of hemophilic ankle arthropathy with one-step arthroscopic bone marrow-derived cells transplantation. Cartilage. 2015;6(3):150\u20135.","journal-title":"Cartilage."},{"issue":"3","key":"620_CR112","first-page":"102","volume":"1","author":"R Buda","year":"2014","unstructured":"Buda R, Vannini F, Cavallo M, et al. One-step bone marrow-derived cell transplantation in talar osteochondral lesions: mid-term results. Joints. 2014;1(3):102\u20137.","journal-title":"Joints."},{"issue":"Suppl 2","key":"620_CR113","doi-asserted-by":"publisher","first-page":"2","DOI":"10.2106\/JBJS.J.00813","volume":"92","author":"R Buda","year":"2010","unstructured":"Buda R, Vannini F, Cavallo M, et al. Osteochondral lesions of the knee: a new one-step repair technique with bone-marrow-derived cells. J Bone Joint Surg Am. 2010;92(Suppl 2):2\u201311.","journal-title":"J Bone Joint Surg Am."},{"issue":"2","key":"620_CR114","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s12306-013-0242-7","volume":"97","author":"R Buda","year":"2013","unstructured":"Buda R, Vannini F, Cavallo M, et al. One-step arthroscopic technique for the treatment of osteochondral lesions of the knee with bone-marrow-derived cells: three years results. Musculoskelet Surg. 2013;97(2):145\u201351.","journal-title":"Musculoskelet Surg."},{"issue":"1","key":"620_CR115","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.knee.2014.10.003","volume":"22","author":"D Enea","year":"2015","unstructured":"Enea D, Cecconi S, Calcagno S, et al. One-step cartilage repair in the knee: collagen-covered microfracture and autologous bone marrow concentrate. A pilot study. Knee. 2015;22(1):30\u20135.","journal-title":"Knee."},{"issue":"12","key":"620_CR116","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1007\/s11999-009-0885-8","volume":"467","author":"S Giannini","year":"2009","unstructured":"Giannini S, Buda R, Vannini F, et al. One-step bone marrow-derived cell transplantation in talar osteochondral lesions. Clin Orthop Relat Res. 2009;467(12):3307\u201320.","journal-title":"Clin Orthop Relat Res."},{"issue":"3","key":"620_CR117","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1177\/0363546512467622","volume":"41","author":"S Giannini","year":"2013","unstructured":"Giannini S, Buda R, Battaglia M, et al. One-step repair in talar osteochondral lesions: 4-year clinical results and t2-mapping capability in outcome prediction. Am J Sports Med. 2013;41(3):511\u20138.","journal-title":"Am J Sports Med."},{"issue":"3","key":"620_CR118","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1177\/1947603510392023","volume":"2","author":"A Gobbi","year":"2011","unstructured":"Gobbi A, Karnatzikos G, Scotti C, et al. One-step cartilage repair with bone marrow aspirate concentrated cells and collagen matrix in full-thickness knee cartilage lesions: results at 2-year follow-up. Cartilage. 2011;2(3):286\u201399.","journal-title":"Cartilage."},{"issue":"3","key":"620_CR119","first-page":"395","volume":"94","author":"C Kasemkijwattana","year":"2011","unstructured":"Kasemkijwattana C, Hongeng S, Kesprayura S, et al. Autologous bone marrow mesenchymal stem cells implantation for cartilage defects: two cases report. J Med Assoc Thai. 2011;94(3):395\u2013400.","journal-title":"J Med Assoc Thai."},{"issue":"9","key":"620_CR120","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1177\/0363546515588317","volume":"43","author":"YS Kim","year":"2015","unstructured":"Kim YS, Choi YJ, Koh YG. Mesenchymal stem cell implantation in knee osteoarthritis: an assessment of the factors influencing clinical outcomes. Am J Sports Med. 2015;43(9):2293\u2013301.","journal-title":"Am J Sports Med."},{"issue":"2","key":"620_CR121","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.joca.2015.08.009","volume":"24","author":"YS Kim","year":"2016","unstructured":"Kim YS, Choi YJ, Lee SW, et al. Assessment of clinical and MRI outcomes after mesenchymal stem cell implantation in patients with knee osteoarthritis: a prospective study. Osteoarthr Cartil. 2016;24(2):237\u201345.","journal-title":"Osteoarthr Cartil."},{"issue":"5","key":"620_CR122","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1177\/0363546513479018","volume":"41","author":"YS Kim","year":"2013","unstructured":"Kim YS, Park EH, Kim YC, et al. Clinical outcomes of mesenchymal stem cell injection with arthroscopic treatment in older patients with osteochondral lesions of the talus. Am J Sports Med. 2013;41(5):1090\u20139.","journal-title":"Am J Sports Med."},{"issue":"10","key":"620_CR123","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1177\/0363546514541778","volume":"42","author":"YS Kim","year":"2014","unstructured":"Kim YS, Lee HJ, Choi YJ, et al. Does an injection of a stromal vascular fraction containing adipose-derived mesenchymal stem cells influence the outcomes of marrow stimulation in osteochondral lesions of the talus? A clinical and magnetic resonance imaging study. Am J Sports Med. 2014;42(10):2424\u201334.","journal-title":"Am J Sports Med."},{"issue":"1","key":"620_CR124","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.arthro.2015.09.010","volume":"32","author":"YG Koh","year":"2016","unstructured":"Koh YG, Kwon OR, Kim YS, et al. Adipose-derived mesenchymal stem cells with microfracture versus microfracture alone: 2-year follow-up of a prospective randomized trial. Arthroscopy. 2016;32(1):97\u2013109.","journal-title":"Arthroscopy."},{"issue":"5","key":"620_CR125","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1007\/s00167-013-2807-2","volume":"23","author":"YG Koh","year":"2015","unstructured":"Koh YG, Choi YJ, Kwon SK, et al. Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2015;23(5):1308\u201316.","journal-title":"Knee Surg Sports Traumatol Arthrosc."},{"issue":"11","key":"620_CR126","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/j.arthro.2014.05.036","volume":"30","author":"YG Koh","year":"2014","unstructured":"Koh YG, Kwon OR, Kim YS, et al. Comparative outcomes of open-wedge high tibial osteotomy with platelet-rich plasma alone or in combination with mesenchymal stem cell treatment: a prospective study. Arthroscopy. 2014;30(11):1453\u201360.","journal-title":"Arthroscopy."},{"issue":"1","key":"620_CR127","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1177\/0363546515609597","volume":"44","author":"AJ Krych","year":"2016","unstructured":"Krych AJ, Nawabi DH, Farshad-Amacker NA, et al. Bone marrow concentrate improves early cartilage phase maturation of a scaffold plug in the knee: a comparative magnetic resonance imaging analysis to platelet-rich plasma and control. Am J Sports Med. 2016;44(1):91\u20138.","journal-title":"Am J Sports Med."},{"key":"620_CR128","doi-asserted-by":"publisher","DOI":"10.3727\/096368915X686760","author":"J Michalek","year":"2015","unstructured":"Michalek J, Moster R, Lukac L, et al. Autologous adipose tissue-derived stromal vascular fraction cells application in patients with osteoarthritis. Cell Transpl. 2015;. doi: 10.3727\/096368915X686760 .","journal-title":"Cell Transpl."},{"issue":"10","key":"620_CR129","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1016\/j.arthro.2015.03.038","volume":"31","author":"KY Saw","year":"2015","unstructured":"Saw KY, Anz A, Jee CS, et al. High tibial osteotomy in combination with chondrogenesis after stem cell therapy: a histologic report of 8 cases. Arthroscopy. 2015;31(10):1909\u201320.","journal-title":"Arthroscopy."},{"issue":"3","key":"620_CR130","doi-asserted-by":"publisher","first-page":"195","DOI":"10.5604\/15093492.1058409","volume":"15","author":"J Skowro\u0144ski","year":"2013","unstructured":"Skowro\u0144ski J, Rutka M. Osteochondral lesions of the knee reconstructed with mesenchymal stem cells\u2014results. Ortop Traumatol Rehabil. 2013;15(3):195\u2013204.","journal-title":"Ortop Traumatol Rehabil."},{"issue":"1","key":"620_CR131","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s00167-012-2279-9","volume":"22","author":"A Silva","year":"2014","unstructured":"Silva A, Sampaio R, Fernandes R, et al. Is there a role for adult non-cultivated bone marrow stem cells in ACL reconstruction? Knee Surg Sports Traumatol Arthrosc. 2014;22(1):66\u201371.","journal-title":"Knee Surg Sports Traumatol Arthrosc."},{"issue":"3","key":"620_CR132","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1053\/joca.2001.0504","volume":"10","author":"S Wakitani","year":"2002","unstructured":"Wakitani S, Imoto K, Yamamoto T, et al. Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Osteoarthr Cartil. 2002;10(3):199\u2013206.","journal-title":"Osteoarthr Cartil"},{"issue":"2","key":"620_CR133","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1002\/term.299","volume":"5","author":"S Wakitani","year":"2011","unstructured":"Wakitani S, Okabe T, Horibe S, et al. Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months. J Tissue Eng Regen Med. 2011;5(2):146\u201350.","journal-title":"J Tissue Eng Regen Med."},{"key":"620_CR134","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s13287-016-0281-8","volume":"7","author":"F Geburek","year":"2016","unstructured":"Geburek F, Mundle K, Conrad S, et al. Tracking of autologous adipose tissue-derived mesenchymal stromal cells with in vivo magnetic resonance imaging and histology after intralesional treatment of artificial equine tendon lesions\u2014a pilot study. Stem Cell Res Ther. 2016;7:21.","journal-title":"Stem Cell Res Ther."},{"issue":"346","key":"620_CR135","doi-asserted-by":"publisher","first-page":"f3012","DOI":"10.1136\/bmj.f3012","volume":"18","author":"P McCulloch","year":"2013","unstructured":"McCulloch P, Cook JA, Altman DG, IDEAL Group, et al. IDEAL framework for surgical innovation 1: the idea and development stages. BMJ. 2013;18(346):f3012.","journal-title":"BMJ."},{"issue":"10","key":"620_CR136","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1016\/j.joca.2013.06.025","volume":"21","author":"CM Peeters","year":"2013","unstructured":"Peeters CM, Leijs MJ, Reijman M, et al. Safety of intra-articular cell-therapy with culture-expanded stem cells in humans: a systematic literature review. Osteoarthr Cartil. 2013;21(10):1465\u201373.","journal-title":"Osteoarthr Cartil"},{"key":"620_CR137","doi-asserted-by":"publisher","unstructured":"Centeno CJ, Al-Sayegh H, Freeman MD, et al. A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions. Int Orthop. 2016 Mar 30. [Epub ahead of print].","DOI":"10.1007\/s00264-016-3162-y"},{"key":"620_CR138","unstructured":"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02033525?term=NCT02033525&rank=1<redir.aspx?REF=CDehAp5WnUaaCF04MORaKf_GKqyot7JSK4XAoVNB3Wq1wXmNvTCAFodHRwczovL2NsaW5pY2FsdHJpYWxzmdvdi9jdDIvc2hvdy9OQ1QwMjAzMzUyNT90ZXJtPU5DVDAyMDMzNTI1JnJhbms9MQ. . Accessed 17 Aug 2016."},{"key":"620_CR139","unstructured":"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02582489?term=NCT02582489&rank=1<redir.aspx?REF=0pcIQhFVYnBesMFmtVDwC2hVufvw_BiztIZg3OKH7nWq1wXmNvTCAFodHRwczovL2NsaW5pY2FsdHJpYWxzLmdvdi9jdDIvc2hvdy9OQ1QwMjU4MjQ4OT90ZXJtPU5DVDAyNTgyNDg5JnJhbm9MQ. . Accessed 17 Aug 2016."},{"issue":"4","key":"620_CR140","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1007\/s00167-012-1980-z","volume":"21","author":"A Vadal\u00e0","year":"2013","unstructured":"Vadal\u00e0 A, Iorio R, De Carli A, et al. Platelet-rich plasma: does it help reduce tunnel widening after ACL reconstruction? Knee Surg Sports Traumatol Arthrosc. 2013;21(4):824\u20139.","journal-title":"Knee Surg Sports Traumatol Arthrosc."},{"issue":"4","key":"620_CR141","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.arthro.2010.11.054","volume":"27","author":"KY Saw","year":"2011","unstructured":"Saw KY, Anz A, Merican S, et al. Articular cartilage regeneration with autologous peripheral blood progenitor cells and hyaluronic acid after arthroscopic subchondral drilling: a report of 5 cases with histology. Arthroscopy. 2011;27(4):493\u2013506.","journal-title":"Arthroscopy."},{"issue":"6","key":"620_CR142","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1089\/ten.teb.2013.0771","volume":"20","author":"RA Somoza","year":"2014","unstructured":"Somoza RA, Welter JF, Correa D, et al. Chondrogenic differentiation of mesenchymal stem cells: challenges and unfulfilled expectations. Eng Part B Rev. 2014;20(6):596\u2013608.","journal-title":"Eng Part B Rev."}],"container-title":["Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40279-016-0620-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40279-016-0620-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40279-016-0620-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T16:49:39Z","timestamp":1718815779000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40279-016-0620-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,28]]},"references-count":142,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["620"],"URL":"https:\/\/doi.org\/10.1007\/s40279-016-0620-z","relation":{},"ISSN":["0112-1642","1179-2035"],"issn-type":[{"value":"0112-1642","type":"print"},{"value":"1179-2035","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,28]]}}}