{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T09:05:26Z","timestamp":1784106326824,"version":"3.55.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"BOF-scholarship from Hasselt University","award":["15NI06-BOF"],"award-info":[{"award-number":["15NI06-BOF"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sports Med"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s40279-018-1003-4","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T08:38:36Z","timestamp":1540370316000},"page":"255-268","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Effect of Exercise Intervention on Cardiac Function in Type 2 Diabetes Mellitus: A Systematic Review"],"prefix":"10.1007","volume":"49","author":[{"given":"Maxim","family":"Verboven","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Van Ryckeghem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal","family":"Belkhouribchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Dendale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert O.","family":"Eijnde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Bito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,24]]},"reference":[{"key":"1003_CR1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.diabres.2017.03.024","volume":"128","author":"K Ogurtsova","year":"2017","unstructured":"Ogurtsova K, da Rocha Fernandes JD, Huang Y, Linnenkamp U, Guariguata L, Cho NH, et al. IDF Diabetes Atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract. 2017;128:40\u201350.","journal-title":"Diabetes Res Clin Pract"},{"issue":"3","key":"1003_CR2","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/nrendo.2015.216","volume":"12","author":"G Jia","year":"2016","unstructured":"Jia G, DeMarco VG, Sowers JR. Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy. Nat Rev Endocrinol. 2016;12(3):144\u201353.","journal-title":"Nat Rev Endocrinol."},{"issue":"5","key":"1003_CR3","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.cardfail.2014.02.007","volume":"20","author":"S Dandamudi","year":"2014","unstructured":"Dandamudi S, Slusser J, Mahoney DW, Redfield MM, Rodeheffer RJ, Chen HH. The prevalence of diabetic cardiomyopathy: a population-based study in Olmsted County, Minnesota. J Card Fail. 2014;20(5):304\u20139.","journal-title":"J Card Fail."},{"issue":"5","key":"1003_CR4","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1177\/1479164116645583","volume":"13","author":"PG Jorgensen","year":"2016","unstructured":"Jorgensen PG, Jensen MT, Mogelvang R, von Scholten BJ, Bech J, Fritz-Hansen T, et al. Abnormal echocardiography in patients with type 2 diabetes and relation to symptoms and clinical characteristics. Diabetes Vasc Dis Res. 2016;13(5):321\u201330.","journal-title":"Diabetes Vasc Dis Res."},{"issue":"10","key":"1003_CR5","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1042\/CS20080500","volume":"116","author":"O Asghar","year":"2009","unstructured":"Asghar O, Al-Sunni A, Khavandi K, Khavandi A, Withers S, Greenstein A, et al. Diabetic cardiomyopathy. Clin Sci (Lond). 2009;116(10):741\u201360.","journal-title":"Clin Sci (Lond)."},{"issue":"25","key":"1003_CR6","doi-asserted-by":"publisher","first-page":"3213","DOI":"10.1161\/CIRCULATIONAHA.106.679597","volume":"115","author":"S Boudina","year":"2007","unstructured":"Boudina S, Abel ED. Diabetic cardiomyopathy revisited. Circulation. 2007;115(25):3213\u201323.","journal-title":"Circulation"},{"issue":"3","key":"1003_CR7","doi-asserted-by":"publisher","first-page":"404","DOI":"10.3904\/kjim.2016.208","volume":"32","author":"WS Lee","year":"2017","unstructured":"Lee WS, Kim J. Diabetic cardiomyopathy: where we are and where we are going. Korean J Intern Med. 2017;32(3):404\u201321.","journal-title":"Korean J Intern Med"},{"issue":"7","key":"1003_CR8","doi-asserted-by":"publisher","first-page":"943","DOI":"10.4239\/wjd.v6.i7.943","volume":"6","author":"MT Waddingham","year":"2015","unstructured":"Waddingham MT, Edgley AJ, Tsuchimochi H, Kelly DJ, Shirai M, Pearson JT. Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy. World J Diabetes. 2015;6(7):943\u201360.","journal-title":"World J Diabetes."},{"issue":"12","key":"1003_CR9","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.cardfail.2010.07.249","volume":"16","author":"S Murarka","year":"2010","unstructured":"Murarka S, Movahed MR. Diabetic cardiomyopathy. J Card Fail. 2010;16(12):971\u20139.","journal-title":"J Card Fail."},{"issue":"1","key":"1003_CR10","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s00125-015-3741-2","volume":"59","author":"S Cassidy","year":"2016","unstructured":"Cassidy S, Thoma C, Hallsworth K, Parikh J, Hollingsworth KG, Taylor R, et al. High intensity intermittent exercise improves cardiac structure and function and reduces liver fat in patients with type 2 diabetes: a randomised controlled trial. Diabetologia. 2016;59(1):56\u201366.","journal-title":"Diabetologia"},{"issue":"12","key":"1003_CR11","doi-asserted-by":"publisher","first-page":"e114205","DOI":"10.1371\/journal.pone.0114205","volume":"9","author":"Y Li","year":"2014","unstructured":"Li Y, Cai M, Cao L, Qin X, Zheng T, Xu X, et al. Endurance exercise accelerates myocardial tissue oxygenation recovery and reduces ischemia reperfusion injury in mice. PLoS One. 2014;9(12):e114205.","journal-title":"PLoS One"},{"issue":"4","key":"1003_CR12","doi-asserted-by":"publisher","first-page":"336","DOI":"10.2174\/1573403X10666140404110229","volume":"10","author":"E Marongiu","year":"2014","unstructured":"Marongiu E, Crisafulli A. Cardioprotection acquired through exercise: the role of ischemic preconditioning. Curr Cardiol Rev. 2014;10(4):336\u201348.","journal-title":"Curr Cardiol Rev."},{"issue":"2","key":"1003_CR13","doi-asserted-by":"publisher","first-page":"52","DOI":"10.4330\/wjc.v7.i2.52","volume":"7","author":"MA Garza","year":"2015","unstructured":"Garza MA, Wason EA, Zhang JQ. Cardiac remodeling and physical training post myocardial infarction. World J Cardiol. 2015;7(2):52\u201364.","journal-title":"World J Cardiol."},{"issue":"16","key":"1003_CR14","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1136\/hrt.2009.165571","volume":"95","author":"MD Hordern","year":"2009","unstructured":"Hordern MD, Coombes JS, Cooney LM, Jeffriess L, Prins JB, Marwick TH. Effects of exercise intervention on myocardial function in type 2 diabetes. Heart. 2009;95(16):1343\u20139.","journal-title":"Heart"},{"issue":"1","key":"1003_CR15","doi-asserted-by":"publisher","first-page":"e000163","DOI":"10.1136\/openhrt-2014-000163","volume":"2","author":"VA Sagar","year":"2015","unstructured":"Sagar VA, Davies EJ, Briscoe S, Coats AJ, Dalal HM, Lough F, et al. Exercise-based rehabilitation for heart failure: systematic review and meta-analysis. Open Heart. 2015;2(1):e000163.","journal-title":"Open Heart."},{"issue":"10","key":"1003_CR16","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1001\/jama.286.10.1218","volume":"286","author":"NG Boule","year":"2001","unstructured":"Boule NG, Haddad E, Kenny GP, Wells GA, Sigal RJ. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA. 2001;286(10):1218\u201327.","journal-title":"JAMA"},{"issue":"12","key":"1003_CR17","doi-asserted-by":"publisher","first-page":"2692","DOI":"10.2337\/dc10-1548","volume":"33","author":"SR Colberg","year":"2010","unstructured":"Colberg SR, Sigal RJ, Fernhall B, Regensteiner JG, Blissmer BJ, Rubin RR, et al. Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement executive summary. Diabetes Care. 2010;33(12):2692\u20136.","journal-title":"Diabetes Care"},{"issue":"6","key":"1003_CR18","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1097\/HJR.0b013e3282efaf50","volume":"14","author":"NP Kadoglou","year":"2007","unstructured":"Kadoglou NP, Iliadis F, Angelopoulou N, Perrea D, Ampatzidis G, Liapis CD, et al. The anti-inflammatory effects of exercise training in patients with type 2 diabetes mellitus. Eur J Cardiovasc Prev Rehabil. 2007;14(6):837\u201343.","journal-title":"Eur J Cardiovasc Prev Rehabil."},{"issue":"9","key":"1003_CR19","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.puhe.2007.02.014","volume":"121","author":"GA Kelley","year":"2007","unstructured":"Kelley GA, Kelley KS. Effects of aerobic exercise on lipids and lipoproteins in adults with type 2 diabetes: a meta-analysis of randomized-controlled trials. Public Health. 2007;121(9):643\u201355.","journal-title":"Public Health."},{"issue":"2","key":"1003_CR20","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.metabol.2007.08.021","volume":"57","author":"H Nojima","year":"2008","unstructured":"Nojima H, Watanabe H, Yamane K, Kitahara Y, Sekikawa K, Yamamoto H, et al. Effect of aerobic exercise training on oxidative stress in patients with type 2 diabetes mellitus. Metabolism. 2008;57(2):170\u20136.","journal-title":"Metabolism."},{"issue":"7258","key":"1003_CR21","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1136\/bmj.321.7258.405","volume":"321","author":"IM Stratton","year":"2000","unstructured":"Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321(7258):405\u201312.","journal-title":"BMJ"},{"issue":"7","key":"1003_CR22","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1111\/j.1476-5381.2010.00873.x","volume":"160","author":"JC McGrath","year":"2010","unstructured":"McGrath JC, Drummond GB, McLachlan EM, Kilkenny C, Wainwright CL. Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol. 2010;160(7):1573\u20136.","journal-title":"Br J Pharmacol"},{"issue":"4","key":"1003_CR23","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1054\/math.2000.0372","volume":"5","author":"C Sherrington","year":"2000","unstructured":"Sherrington C, Herbert RD, Maher CG, Moseley AM. PEDro. A database of randomized trials and systematic reviews in physiotherapy. Man Ther. 2000;5(4):223\u20136.","journal-title":"Man Ther."},{"issue":"16","key":"1003_CR24","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1016\/j.jacc.2014.07.971","volume":"64","author":"SM Hollekim-Strand","year":"2014","unstructured":"Hollekim-Strand SM, Bjorgaas MR, Albrektsen G, Tjonna AE, Wisloff U, Ingul CB. High-intensity interval exercise effectively improves cardiac function in patients with type 2 diabetes mellitus and diastolic dysfunction: a randomized controlled trial. J Am Coll Cardiol. 2014;64(16):1758\u201360.","journal-title":"J Am Coll Cardiol"},{"key":"1003_CR25","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1476-7120-5-32","volume":"5","author":"A Loimaala","year":"2007","unstructured":"Loimaala A, Groundstroem K, Rinne M, Nenonen A, Huhtala H, Vuori I. Exercise training does not improve myocardial diastolic tissue velocities in type 2 diabetes. Cardiovasc Ultrasound. 2007;5:32.","journal-title":"Cardiovasc Ultrasound."},{"issue":"9","key":"1003_CR26","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/j.metabol.2014.05.007","volume":"63","author":"JW Sacre","year":"2014","unstructured":"Sacre JW, Jellis CL, Jenkins C, Haluska BA, Baumert M, Coombes JS, et al. A six-month exercise intervention in subclinical diabetic heart disease: effects on exercise capacity, autonomic and myocardial function. Metabolism. 2014;63(9):1104\u201314.","journal-title":"Metabolism."},{"issue":"12","key":"1003_CR27","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1249\/MSS.0b013e31829ab43c","volume":"45","author":"JF Schmidt","year":"2013","unstructured":"Schmidt JF, Andersen TR, Horton J, Brix J, Tarnow L, Krustrup P, et al. Soccer training improves cardiac function in men with type 2 diabetes. Med Sci Sports Exerc. 2013;45(12):2223\u201333.","journal-title":"Med Sci Sports Exerc"},{"issue":"5","key":"1003_CR28","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.echo.2016.01.005","volume":"29","author":"SM Hollekim-Strand","year":"2016","unstructured":"Hollekim-Strand SM, Hoydahl SF, Follestad T, Dalen H, Bjorgaas MR, Wisloff U, et al. Exercise training normalizes timing of left ventricular untwist rate, but not peak untwist rate, in individuals with type 2 diabetes and diastolic dysfunction: a pilot study. J Am Soc Echocardiogr. 2016;29(5):421\u201330.","journal-title":"J Am Soc Echocardiogr."},{"issue":"7","key":"1003_CR29","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.2337\/db12-1580","volume":"62","author":"AD Hafstad","year":"2013","unstructured":"Hafstad AD, Lund J, Hadler-Olsen E, Hoper AC, Larsen TS, Aasum E. High- and moderate-intensity training normalizes ventricular function and mechanoenergetics in mice with diet-induced obesity. Diabetes. 2013;62(7):2287\u201394.","journal-title":"Diabetes"},{"issue":"5","key":"1003_CR30","doi-asserted-by":"publisher","first-page":"H1054","DOI":"10.1152\/ajpheart.00382.2017","volume":"313","author":"NT Boardman","year":"2017","unstructured":"Boardman NT, Hafstad AD, Lund J, Rossvoll L, Aasum E. Exercise of obese mice induces cardioprotection and oxygen sparing in hearts exposed to high-fat load. Am J Physiol Heart Circ Physiol. 2017;313(5):H1054\u201362.","journal-title":"Am J Physiol Heart Circ Physiol."},{"issue":"6","key":"1003_CR31","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1161\/CIRCRESAHA.109.199810","volume":"105","author":"TO Stolen","year":"2009","unstructured":"Stolen TO, Hoydal MA, Kemi OJ, Catalucci D, Ceci M, Aasum E, et al. Interval training normalizes cardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy. Circ Res. 2009;105(6):527\u201336.","journal-title":"Circ Res"},{"key":"1003_CR32","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3389\/fphys.2015.00124","volume":"6","author":"V Kesherwani","year":"2015","unstructured":"Kesherwani V, Chavali V, Hackfort BT, Tyagi SC, Mishra PK. Exercise ameliorates high fat diet induced cardiac dysfunction by increasing interleukin 10. Front Physiol. 2015;6:124.","journal-title":"Front Physiol."},{"key":"1003_CR33","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.yjmcc.2016.01.023","volume":"92","author":"S Veeranki","year":"2016","unstructured":"Veeranki S, Givvimani S, Kundu S, Metreveli N, Pushpakumar S, Tyagi SC. Moderate intensity exercise prevents diabetic cardiomyopathy associated contractile dysfunction through restoration of mitochondrial function and connexin 43 levels in db\/db mice. J Mol Cell Cardiol. 2016;92:163\u201373.","journal-title":"J Mol Cell Cardiol"},{"issue":"6","key":"1003_CR34","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1159\/000374021","volume":"35","author":"H Wang","year":"2015","unstructured":"Wang H, Bei Y, Lu Y, Sun W, Liu Q, Wang Y, et al. Exercise prevents cardiac injury and improves mitochondrial biogenesis in advanced diabetic cardiomyopathy with PGC-1alpha and Akt activation. Cell Physiol Biochem. 2015;35(6):2159\u201368.","journal-title":"Cell Physiol Biochem"},{"issue":"2","key":"1003_CR35","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s00424-017-2076-x","volume":"470","author":"TH Ko","year":"2018","unstructured":"Ko TH, Marquez JC, Kim HK, Jeong SH, Lee S, Youm JB, et al. Resistance exercise improves cardiac function and mitochondrial efficiency in diabetic rat hearts. Pflugers Arch. 2018;470(2):263\u201375.","journal-title":"Pflugers Arch"},{"key":"1003_CR36","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/1475-2840-9-56","volume":"9","author":"L VanHoose","year":"2010","unstructured":"VanHoose L, Sawers Y, Loganathan R, Vacek JL, Stehno-Bittel L, Novikova L, et al. Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat. Cardiovasc Diabetol. 2010;9:56.","journal-title":"Cardiovasc Diabetol."},{"issue":"Suppl 1","key":"1003_CR37","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.2337\/dc18-S004","volume":"41","author":"American Diabetes Association","year":"2018","unstructured":"American Diabetes Association. 4. Lifestyle management: standards of medical care in diabetes-2018. Diabetes Care. 2018;41(Suppl 1):S38\u201350.","journal-title":"Diabetes Care."},{"key":"1003_CR38","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3389\/fendo.2017.00033","volume":"8","author":"SR Colberg","year":"2017","unstructured":"Colberg SR. Key points from the updated guidelines on exercise and diabetes. Front Endocrinol (Lausanne). 2017;8:33.","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"1","key":"1003_CR39","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/S0008-6363(97)00040-0","volume":"34","author":"K Howorka","year":"1997","unstructured":"Howorka K, Pumprla J, Haber P, Koller-Strametz J, Mondrzyk J, Schabmann A. Effects of physical training on heart rate variability in diabetic patients with various degrees of cardiovascular autonomic neuropathy. Cardiovasc Res. 1997;34(1):206\u201314.","journal-title":"Cardiovasc Res"},{"issue":"30","key":"1003_CR40","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1093\/eurheartj\/ehx396","volume":"38","author":"D Hansen","year":"2017","unstructured":"Hansen D, Coninx K, Dendale P. The EAPC EXPERT tool. Eur Heart J. 2017;38(30):2318\u201320.","journal-title":"Eur Heart J"},{"issue":"4","key":"1003_CR41","doi-asserted-by":"publisher","first-page":"H351","DOI":"10.1152\/ajpheart.00647.2014","volume":"308","author":"JP Seeger","year":"2015","unstructured":"Seeger JP, Lenting CJ, Schreuder TH, Landman TR, Cable NT, Hopman MT, et al. Interval exercise, but not endurance exercise, prevents endothelial ischemia\u2013reperfusion injury in healthy subjects. Am J Physiol Heart Circ Physiol. 2015;308(4):H351\u20137.","journal-title":"Am J Physiol Heart Circ Physiol."},{"issue":"9","key":"1003_CR42","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1139\/y98-094","volume":"76","author":"PD Chilibeck","year":"1998","unstructured":"Chilibeck PD, Bell GJ, Farrar RP, Martin TP. Higher mitochondrial fatty acid oxidation following intermittent versus continuous endurance exercise training. Can J Physiol Pharmacol. 1998;76(9):891\u20134.","journal-title":"Can J Physiol Pharmacol"},{"issue":"10","key":"1003_CR43","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s11892-017-0927-7","volume":"17","author":"EM Miele","year":"2017","unstructured":"Miele EM, Headley SAE. The effects of chronic aerobic exercise on cardiovascular risk factors in persons with diabetes mellitus. Curr Diab Rep. 2017;17(10):97.","journal-title":"Curr Diab Rep."},{"issue":"1","key":"1003_CR44","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.pharmthera.2010.04.005","volume":"128","author":"BC Bernardo","year":"2010","unstructured":"Bernardo BC, Weeks KL, Pretorius L, McMullen JR. Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies. Pharmacol Ther. 2010;128(1):191\u2013227.","journal-title":"Pharmacol Ther"},{"issue":"7","key":"1003_CR45","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","volume":"15","author":"M Nakamura","year":"2018","unstructured":"Nakamura M, Sadoshima J. Mechanisms of physiological and pathological cardiac hypertrophy. Nat Rev Cardiol. 2018;15(7):387\u2013407.","journal-title":"Nat Rev Cardiol."},{"issue":"5","key":"1003_CR46","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1249\/MSS.0b013e3181fcf034","volume":"43","author":"MG Schultz","year":"2011","unstructured":"Schultz MG, Hordern MD, Leano R, Coombes JS, Marwick TH, Sharman JE. Lifestyle change diminishes a hypertensive response to exercise in type 2 diabetes. Med Sci Sports Exerc. 2011;43(5):764\u20139.","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"1003_CR47","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1152\/physrev.00015.2009","volume":"90","author":"GD Lopaschuk","year":"2010","unstructured":"Lopaschuk GD, Ussher JR, Folmes CD, Jaswal JS, Stanley WC. Myocardial fatty acid metabolism in health and disease. Physiol Rev. 2010;90(1):207\u201358.","journal-title":"Physiol Rev"},{"issue":"2","key":"1003_CR48","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s11897-013-0133-0","volume":"10","author":"K Drosatos","year":"2013","unstructured":"Drosatos K, Schulze PC. Cardiac lipotoxicity: molecular pathways and therapeutic implications. Curr Heart Fail Rep. 2013;10(2):109\u201321.","journal-title":"Curr Heart Fail Rep."},{"issue":"20","key":"1003_CR49","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1016\/j.jacc.2009.07.031","volume":"54","author":"EJ Anderson","year":"2009","unstructured":"Anderson EJ, Kypson AP, Rodriguez E, Anderson CA, Lehr EJ, Neufer PD. Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart. J Am Coll Cardiol. 2009;54(20):1891\u20138.","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"1003_CR50","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.2337\/db12-0927","volume":"62","author":"T Pulinilkunnil","year":"2013","unstructured":"Pulinilkunnil T, Kienesberger PC, Nagendran J, Waller TJ, Young ME, Kershaw EE, et al. Myocardial adipose triglyceride lipase overexpression protects diabetic mice from the development of lipotoxic cardiomyopathy. Diabetes. 2013;62(5):1464\u201377.","journal-title":"Diabetes"},{"issue":"21","key":"1003_CR51","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.1161\/01.CIR.0000017264.66561.3D","volume":"105","author":"J Diez","year":"2002","unstructured":"Diez J, Querejeta R, Lopez B, Gonzalez A, Larman M, Martinez Ubago JL. Losartan-dependent regression of myocardial fibrosis is associated with reduction of left ventricular chamber stiffness in hypertensive patients. Circulation. 2002;105(21):2512\u20137.","journal-title":"Circulation"},{"issue":"3","key":"1003_CR52","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1253\/circj.72.378","volume":"72","author":"M Motoyasu","year":"2008","unstructured":"Motoyasu M, Kurita T, Onishi K, Uemura S, Tanigawa T, Okinaka T, et al. Correlation between late gadolinium enhancement and diastolic function in hypertrophic cardiomyopathy assessed by magnetic resonance imaging. Circ J. 2008;72(3):378\u201383.","journal-title":"Circ J"},{"issue":"7","key":"1003_CR53","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/j.bbamcr.2011.01.014","volume":"1813","author":"JG Duncan","year":"2011","unstructured":"Duncan JG. Mitochondrial dysfunction in diabetic cardiomyopathy. Biochim Biophys Acta. 2011;1813(7):1351\u20139.","journal-title":"Biochim Biophys Acta"},{"issue":"17","key":"1003_CR54","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1089\/ars.2015.6304","volume":"22","author":"AD Hafstad","year":"2015","unstructured":"Hafstad AD, Boardman N, Aasum E. How exercise may amend metabolic disturbances in diabetic cardiomyopathy. Antioxid Redox Signal. 2015;22(17):1587\u2013605.","journal-title":"Antioxid Redox Signal"},{"issue":"12","key":"1003_CR55","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1093\/ehjci\/jew082","volume":"17","author":"SF Nagueh","year":"2016","unstructured":"Nagueh SF, Smiseth OA, Appleton CP, Byrd BF 3rd, Dokainish H, Edvardsen T, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2016;17(12):1321\u201360.","journal-title":"Eur Heart J Cardiovasc Imaging."},{"issue":"2","key":"1003_CR56","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.echo.2014.11.003","volume":"28","author":"JU Voigt","year":"2015","unstructured":"Voigt JU, Pedrizzetti G, Lysyansky P, Marwick TH, Houle H, Baumann R, et al. Definitions for a common standard for 2D speckle tracking echocardiography: consensus document of the EACVI\/ASE\/Industry Task Force to standardize deformation imaging. J Am Soc Echocardiogr. 2015;28(2):183\u201393.","journal-title":"J Am Soc Echocardiogr"},{"issue":"11","key":"1003_CR57","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1249\/mss.0b013e318145b642","volume":"39","author":"P Brassard","year":"2007","unstructured":"Brassard P, Legault S, Garneau C, Bogaty P, Dumesnil JG, Poirier P. Normalization of diastolic dysfunction in type 2 diabetics after exercise training. Med Sci Sports Exerc. 2007;39(11):1896\u2013901.","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"1003_CR58","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.pmrj.2014.09.004","volume":"7","author":"L Cugusi","year":"2015","unstructured":"Cugusi L, Cadeddu C, Nocco S, Orru F, Bandino S, Deidda M, et al. Effects of an aquatic-based exercise program to improve cardiometabolic profile, quality of life, and physical activity levels in men with type 2 diabetes mellitus. PM&R. 2015;7(2):141\u20138 (quiz 8).","journal-title":"PM&R."},{"issue":"2","key":"1003_CR59","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1148\/radiol.13121631","volume":"269","author":"JT Jonker","year":"2013","unstructured":"Jonker JT, de Mol P, de Vries ST, Widya RL, Hammer S, van Schinkel LD, et al. Exercise and type 2 diabetes mellitus: changes in tissue-specific fat distribution and cardiac function. Radiology. 2013;269(2):434\u201342.","journal-title":"Radiology"},{"key":"1003_CR60","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1475-2840-10-47","volume":"10","author":"VB Schrauwen-Hinderling","year":"2011","unstructured":"Schrauwen-Hinderling VB, Meex RC, Hesselink MK, van de Weijer T, Leiner T, Schar M, et al. Cardiac lipid content is unresponsive to a physical activity training intervention in type 2 diabetic patients, despite improved ejection fraction. Cardiovasc Diabetol. 2011;10:47.","journal-title":"Cardiovasc Diabetol."},{"key":"1003_CR61","unstructured":"The Norwegian Diabetes Association. Type 2-diabetes og fysisk aktivitet. \n                    https:\/\/www.diabetes.no\/globalassets\/om-diabetes\/innvandrere\/engelsk\/faktaark\/engelsk_diabetes2ogfysisk.pdf\n                    \n                  . Accessed Sept 2015."}],"container-title":["Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40279-018-1003-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40279-018-1003-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40279-018-1003-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T20:23:54Z","timestamp":1571862234000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40279-018-1003-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,24]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["1003"],"URL":"https:\/\/doi.org\/10.1007\/s40279-018-1003-4","relation":{},"ISSN":["0112-1642","1179-2035"],"issn-type":[{"value":"0112-1642","type":"print"},{"value":"1179-2035","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,24]]},"assertion":[{"value":"24 October 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"No sources of funding were used to assist in the preparation of this article. Funding was provided by BOF-scholarship from Hasselt University (Grant no. 15NI06-BOF).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Maxim Verboven, Lisa Van Ryckeghem, Jamal Belkhouribchia, Paul Dendale, Bert O.\u00a0Eijnde, Dominique Hansen, and Virginie Bito declare that they have no conflicts of interest relevant to the content of this review.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}