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D.A.K prepared the figures and drafted and revised the manuscript. Exemplary data were collected and analysed by D.A.K. and D.I. The online application was designed by F.M.M. with input from D.A.K., J.M.M., and D.I. All authors contributed to the drafting and revising of the manuscript. All authors approved the final manuscript and agree to be accountable for all aspects of the work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 contributions"}},{"value":"The representative data assembled in the figures are the product of a research and equipment grant awarded to J.M.K by the Natural Science and Engineering Research Council of Canada (NSERC; RGP-2015-00084) and to J.M.M by the NSERC (RGPIN-2016-03698) and the Heart and Stroke Foundation of Canada (1047725).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Daniel A. Keir, Danilo Iannetta, Felipe Mattioni Maturana, John M. Kowalchuk, and Juan M. Murias declare that they have no conflicts of interest relevant to the content of this review.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}