{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T14:59:54Z","timestamp":1774882794471,"version":"3.50.1"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sports Med"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s40279-021-01633-4","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T10:03:42Z","timestamp":1642413822000},"page":"431-439","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["What is the Effect of Paracetamol (Acetaminophen) Ingestion on Exercise Performance? Current Findings and Future Research Directions"],"prefix":"10.1007","volume":"52","author":[{"given":"Jozo","family":"Grgic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"issue":"8","key":"1633_CR1","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1111\/jgh.12196","volume":"28","author":"S Sood","year":"2013","unstructured":"Sood S, Howell J, Sundararajan V, Angus PW, Gow PJ. Paracetamol overdose in Victoria remains a significant health-care burden. J Gastroenterol Hepatol. 2013;28(8):1356\u201360.","journal-title":"J Gastroenterol Hepatol"},{"key":"1633_CR2","doi-asserted-by":"publisher","first-page":"h3705","DOI":"10.1136\/bmj.h3705","volume":"351","author":"JW Dear","year":"2015","unstructured":"Dear JW, Antoine DJ, Park BK. Where are we now with paracetamol? BMJ. 2015;351:h3705.","journal-title":"BMJ"},{"issue":"3","key":"1633_CR3","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s10787-013-0172-x","volume":"21","author":"GG Graham","year":"2013","unstructured":"Graham GG, Davies MJ, Day RO, Mohamudally A, Scott KF. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology. 2013;21(3):201\u201332.","journal-title":"Inflammopharmacology"},{"key":"1633_CR4","doi-asserted-by":"publisher","first-page":"3853","DOI":"10.2147\/DDDT.S81004","volume":"9","author":"G Pickering","year":"2015","unstructured":"Pickering G, Kastler A, Macian N, Pereira B, Valabr\u00e8gue R, Lehericy S, et al. The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial. Drug Des Dev Ther. 2015;9:3853\u201362.","journal-title":"Drug Des Dev Ther"},{"issue":"4","key":"1633_CR5","first-page":"604","volume":"45","author":"M Garcin","year":"2005","unstructured":"Garcin M, Mille-Hamard L, Billat V, Imbenotte M, Humbert L, Lhermitte Z. Use of acetaminophen in young subelite athletes. J Sports Med Phys Fit. 2005;45(4):604\u20137.","journal-title":"J Sports Med Phys Fit"},{"issue":"3","key":"1633_CR6","doi-asserted-by":"publisher","first-page":"675","DOI":"10.2466\/pms.101.3.675-683","volume":"101","author":"M Garcin","year":"2005","unstructured":"Garcin M, Mille-Hamard L, Billat V, Humbert L, Lhermitte M. Influence of acetaminophen consumption on perceived exertion at the lactate concentration threshold. Percept Mot Skills. 2005;101(3):675\u201383.","journal-title":"Percept Mot Skills"},{"issue":"9","key":"1633_CR7","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1136\/bjsports-2015-094784","volume":"49","author":"PM Tscholl","year":"2015","unstructured":"Tscholl PM, Vaso M, Weber A, Dvorak J. High prevalence of medication use in professional football tournaments including the World Cups between 2002 and 2014: a narrative review with a focus on NSAIDs. Br J Sports Med. 2015;49(9):580\u20132.","journal-title":"Br J Sports Med"},{"key":"1633_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/tsm2.295","author":"DM Sari","year":"2021","unstructured":"Sari DM, R\u00f8nne Pedersen J, Bloch Thorlund J, Ramer Mikkelsen U, M\u00f8ller M. Pain medication use in youth athletes: a cross-sectional study of 466 youth handball players. Transl Sports Med. 2021. https:\/\/doi.org\/10.1002\/tsm2.295.","journal-title":"Transl Sports Med"},{"key":"1633_CR9","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.3389\/fphys.2017.01092","volume":"8","author":"CJ Esh","year":"2017","unstructured":"Esh CJ, Mauger AR, Palfreeman RA, Al-Janubi H, Taylor L. Acetaminophen (paracetamol): use beyond pain management and dose variability. Front Physiol. 2017;8:1092.","journal-title":"Front Physiol"},{"issue":"11","key":"1633_CR10","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1111\/sms.13275","volume":"28","author":"TR Lundberg","year":"2018","unstructured":"Lundberg TR, Howatson G. Analgesic and anti-inflammatory drugs in sports: Implications for exercise performance and training adaptations. Scand J Med Sci Sports. 2018;28(11):2252\u201362.","journal-title":"Scand J Med Sci Sports"},{"issue":"1","key":"1633_CR11","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.pmrj.2017.07.068","volume":"10","author":"D Holgado","year":"2018","unstructured":"Holgado D, Hopker J, Sanabria D, Zabala M. Analgesics and sport performance: beyond the pain-modulating effects. PM R. 2018;10(1):72\u201382.","journal-title":"PM R"},{"key":"1633_CR12","first-page":"119","volume":"27","author":"PJ O\u2019Connor","year":"1999","unstructured":"O\u2019Connor PJ, Cook DB. Exercise and pain: the neurobiology, measurement, and laboratory study of pain in relation to exercise in humans. Exerc Sport Sci Rev. 1999;27:119\u201366.","journal-title":"Exerc Sport Sci Rev"},{"issue":"3","key":"1633_CR13","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/sms.12659","volume":"27","author":"AH Astokorki","year":"2017","unstructured":"Astokorki AH, Mauger AR. Tolerance of exercise-induced pain at a fixed rating of perceived exertion predicts time trial cycling performance. Scand J Med Sci Sports. 2017;27(3):309\u201317.","journal-title":"Scand J Med Sci Sports"},{"issue":"7","key":"1633_CR14","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1123\/jsr.2018-0030","volume":"28","author":"ME Lixandr\u00e3o","year":"2019","unstructured":"Lixandr\u00e3o ME, Roschel H, Ugrinowitsch C, Miquelini M, Alvarez IF, Libardi CA. Blood-flow restriction resistance exercise promotes lower pain and ratings of perceived exertion compared with either high- or low-intensity resistance exercise performed to muscular failure. J Sport Rehabil. 2019;28(7):706\u201310.","journal-title":"J Sport Rehabil"},{"issue":"1","key":"1633_CR15","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s00421-013-2746-0","volume":"114","author":"J Foster","year":"2014","unstructured":"Foster J, Taylor L, Chrismas BC, Watkins SL, Mauger AR. The influence of acetaminophen on repeated sprint cycling performance. Eur J Appl Physiol. 2014;114(1):41\u20138.","journal-title":"Eur J Appl Physiol"},{"issue":"5","key":"1633_CR16","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1002\/mus.10225","volume":"26","author":"T Graven-Nielsen","year":"2002","unstructured":"Graven-Nielsen T, Lund H, Arendt-Nielsen L, Danneskiold-Sams\u00f8e B, Bliddal H. Inhibition of maximal voluntary contraction force by experimental muscle pain: a centrally mediated mechanism. Muscle Nerve. 2002;26(5):708\u201312.","journal-title":"Muscle Nerve"},{"issue":"3","key":"1633_CR17","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s00421-016-3532-6","volume":"117","author":"AHY Astokorki","year":"2017","unstructured":"Astokorki AHY, Mauger AR. Transcutaneous electrical nerve stimulation reduces exercise-induced perceived pain and improves endurance exercise performance. Eur J Appl Physiol. 2017;117(3):483\u201392.","journal-title":"Eur J Appl Physiol"},{"issue":"3","key":"1633_CR18","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s40279-017-0852-6","volume":"48","author":"CJ Stevens","year":"2018","unstructured":"Stevens CJ, Mauger AR, Hassm\u00e8n P, Taylor L. Endurance performance is influenced by perceptions of pain and temperature: theory, applications and safety considerations. Sports Med. 2018;48(3):525\u201337.","journal-title":"Sports Med"},{"issue":"3","key":"1633_CR19","first-page":"190","volume":"5","author":"M Burtscher","year":"2013","unstructured":"Burtscher M, Gatterer H, Philippe M, Kr\u00fcsmann P, Kernbeiss S, Frontull V, et al. Effects of a single low-dose acetaminophen on body temperature and running performance in the heat: a pilot project. Int J Physiol Pathophysiol Pharmacol. 2013;5(3):190\u20133.","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"1633_CR20","unstructured":"Chagas TP. Efeito agudo do paracetamol na temperatura corporal, amonemia e desempenho em ciclistas durante exerc\u00edcio em ambiente termoneutro. Universidade Federal de Sergipe. S\u00e3o Crist\u00f3v\u00e3o, Brazil. Thesis. 2018."},{"issue":"2","key":"1633_CR21","first-page":"145","volume":"47","author":"A Delextrat","year":"2015","unstructured":"Delextrat A, O\u2019Connor EM, Baker CE, Matthew D, Sum A, Hayes LD. Acetaminophen ingestion improves repeated sprint cycling performance in females: a randomized crossover trial. Kinesiology. 2015;47(2):145\u201350.","journal-title":"Kinesiology"},{"issue":"1","key":"1633_CR22","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1152\/japplphysiol.00108.2021","volume":"131","author":"S Jessen","year":"2021","unstructured":"Jessen S, Eibye K, Christensen PM, Hostrup M, Bangsbo J. No additive effect of acetaminophen when co-ingested with caffeine on cycling performance in well-trained young men. J Appl Physiol. 2021;131(1):238\u201349.","journal-title":"J Appl Physiol"},{"issue":"3","key":"1633_CR23","first-page":"351","volume":"2","author":"F Kovaci","year":"2014","unstructured":"Kovaci F, Peja E, Gjerazi R. Paracetamol administration for enhancing recovery and preventing underperformance in athletes. JIARM. 2014;2(3):351\u20138.","journal-title":"JIARM"},{"issue":"1","key":"1633_CR24","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1152\/japplphysiol.00761.2009","volume":"108","author":"AR Mauger","year":"2010","unstructured":"Mauger AR, Jones AM, Williams CA. Influence of acetaminophen on performance during time trial cycling. J Appl Physiol. 2010;108(1):98\u2013104.","journal-title":"J Appl Physiol"},{"issue":"1","key":"1633_CR25","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1113\/expphysiol.2013.075275","volume":"99","author":"AR Mauger","year":"2014","unstructured":"Mauger AR, Taylor L, Harding C, Wright B, Foster J, Castle PC. Acute acetaminophen (paracetamol) ingestion improves time to exhaustion during exercise in the heat. Exp Physiol. 2014;99(1):164\u201371.","journal-title":"Exp Physiol"},{"issue":"2","key":"1633_CR26","doi-asserted-by":"publisher","first-page":"R346","DOI":"10.1152\/ajpregu.00084.2019","volume":"317","author":"PT Morgan","year":"2019","unstructured":"Morgan PT, Bailey SJ, Banks RA, Fulford J, Vanhatalo A, Jones AM. Contralateral fatigue during severe-intensity single-leg exercise: influence of acute acetaminophen ingestion. Am J Physiol Regul Integr Comp Physiol. 2019;317(2):R346\u201354.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"3","key":"1633_CR27","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s00421-017-3794-7","volume":"118","author":"PT Morgan","year":"2018","unstructured":"Morgan PT, Bowtell JL, Vanhatalo A, Jones AM, Bailey SJ. Acute acetaminophen ingestion improves performance and muscle activation during maximal intermittent knee extensor exercise. Eur J Appl Physiol. 2018;118(3):595\u2013605.","journal-title":"Eur J Appl Physiol"},{"issue":"4","key":"1633_CR28","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1139\/apnm-2018-0506","volume":"44","author":"PT Morgan","year":"2019","unstructured":"Morgan PT, Vanhatalo A, Bowtell JL, Jones AM, Bailey SJ. Acetaminophen ingestion improves muscle activation and performance during a 3-min all-out cycling test. Appl Physiol Nutr Metab. 2019;44(4):434\u201342.","journal-title":"Appl Physiol Nutr Metab"},{"issue":"3","key":"1633_CR29","first-page":"106","volume":"21","author":"FD Pagotto","year":"2018","unstructured":"Pagotto FD, Paradisis G, Maridaki M, Papavassiliou T, Zacharogiannis E. Effect of acute acetaminophen injestion on running endurance performance. J Exerc Physiol Online. 2018;21(3):106\u201318.","journal-title":"J Exerc Physiol Online"},{"issue":"5S","key":"1633_CR30","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1249\/01.mss.0000477338.09149.8e","volume":"47","author":"FD Pagotto","year":"2015","unstructured":"Pagotto FD, Zacharogiannis E, Paradisis G, Argeitaki P, Pilianidis T. Influence of acute acetaminophen ingestion on time limit at VO2max velocity. Med Sci Sports Exerc. 2015;47(5S):338.","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"1633_CR31","doi-asserted-by":"publisher","first-page":"58","DOI":"10.26582\/k.48.1.11","volume":"48","author":"LL Park","year":"2016","unstructured":"Park LL, Baker CE, Sum A, Hayes LD. The influence of acetaminophen on sprint interval treadmill running: a randomized crossover trial. Kinesiology. 2016;48(1):58\u201362.","journal-title":"Kinesiology"},{"issue":"4","key":"1633_CR32","first-page":"2669","volume":"17","author":"D Petr\u016f","year":"2017","unstructured":"Petr\u016f D, Py\u0161n\u00fd L, Py\u0161n\u00e1 J. Effect of paracetamol and acetylsalicylic acid intake on short term anaerobic performance. J Phys Educ Sport. 2017;17(4):2669\u201373.","journal-title":"J Phys Educ Sport"},{"key":"1633_CR33","doi-asserted-by":"publisher","first-page":"100181","DOI":"10.1016\/j.phanu.2020.100181","volume":"12","author":"F Tomazini","year":"2020","unstructured":"Tomazini F, Santos-Mariano AC, Andrade-Souza VA, Sebben VC, De Maria CAB, Coelho DB, et al. Caffeine but not acetaminophen increases 4-km cycling time-trial performance. PharmaNutrition. 2020;12:100181.","journal-title":"PharmaNutrition."},{"issue":"13","key":"1633_CR34","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1080\/02640414.2021.1877440","volume":"39","author":"T Zandonai","year":"2021","unstructured":"Zandonai T, Holgado D, Ciria LF, Zabala M, Hopker J, Bekinschtein T, et al. Novel evidence on the effect of tramadol on self-paced high-intensity cycling. J Sports Sci. 2021;39(13):1452\u201360.","journal-title":"J Sports Sci"},{"issue":"8","key":"1633_CR35","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1080\/17461391.2014.911354","volume":"14","author":"JT Costello","year":"2014","unstructured":"Costello JT, Bieuzen F, Bleakley CM. Where are all the female participants in Sports and Exercise Medicine research? Eur J Sport Sci. 2014;14(8):847\u201351.","journal-title":"Eur J Sport Sci"},{"issue":"Suppl 1","key":"1633_CR36","doi-asserted-by":"publisher","first-page":"32","DOI":"10.2106\/JBJS.20.00237","volume":"102","author":"KJ Templeton","year":"2020","unstructured":"Templeton KJ. Sex and gender issues in pain management. J Bone Jt Surg Am. 2020;102(Suppl 1):32\u20135.","journal-title":"J Bone Jt Surg Am"},{"issue":"2","key":"1633_CR37","first-page":"350","volume":"29","author":"J W\u00f3jcicki","year":"1979","unstructured":"W\u00f3jcicki J, Gawro\u0144ska-Szklarz B, Kazimierczyk J, Baskiewicz Z, Raczy\u0144ski A. Comparative pharmacokinetics of paracetamol in men and women considering follicular and luteal phases. Arzneimittelforschung. 1979;29(2):350\u20132.","journal-title":"Arzneimittelforschung"},{"issue":"8","key":"1633_CR38","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1007\/s40279-018-0939-8","volume":"48","author":"K Southward","year":"2018","unstructured":"Southward K, Rutherfurd-Markwick KJ, Ali A. The effect of acute caffeine ingestion on endurance performance: a systematic review and meta-analysis. Sports Med. 2018;48(8):1913\u201328.","journal-title":"Sports Med"},{"issue":"10","key":"1633_CR39","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1007\/s40279-018-0967-4","volume":"48","author":"K Southward","year":"2018","unstructured":"Southward K, Rutherfurd-Markwick KJ, Ali A. Correction to: the effect of acute caffeine ingestion on endurance performance: a systematic review and meta-analysis. Sports Med. 2018;48(10):2425\u201341.","journal-title":"Sports Med"},{"issue":"1","key":"1633_CR40","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12970-021-00458-w","volume":"18","author":"J Grgic","year":"2021","unstructured":"Grgic J, Pedisic Z, Saunders B, Artioli GG, Schoenfeld BJ, McKenna MJ, et al. International Society of Sports Nutrition position stand: sodium bicarbonate and exercise performance. J Int Soc Sports Nutr. 2021;18(1):61.","journal-title":"J Int Soc Sports Nutr"},{"issue":"15","key":"1633_CR41","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1080\/02640414.2017.1410875","volume":"36","author":"LA Gough","year":"2018","unstructured":"Gough LA, Deb SK, Sparks SA, McNaughton LR. Sodium bicarbonate improves 4 km time trial cycling performance when individualised to time to peak blood bicarbonate in trained male cyclists. J Sports Sci. 2018;36(15):1705\u201312.","journal-title":"J Sports Sci"},{"issue":"9","key":"1633_CR42","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3390\/sports9090126","volume":"9","author":"J Grgic","year":"2021","unstructured":"Grgic J, Mikulic P. Effects of paracetamol (acetaminophen) ingestion on endurance performance: a systematic review and meta-analysis. Sports. 2021;9(9):126.","journal-title":"Sports"},{"issue":"2","key":"1633_CR43","doi-asserted-by":"publisher","first-page":"93","DOI":"10.2165\/00003088-198207020-00001","volume":"7","author":"JA Forrest","year":"1982","unstructured":"Forrest JA, Clements JA, Prescott LF. Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet. 1982;7(2):93\u2013107.","journal-title":"Clin Pharmacokinet"},{"issue":"Suppl 2","key":"1633_CR44","doi-asserted-by":"publisher","first-page":"291S","DOI":"10.1111\/j.1365-2125.1980.tb01812.x","volume":"10","author":"LF Prescott","year":"1980","unstructured":"Prescott LF. Kinetics and metabolism of paracetamol and phenacetin. Br J Clin Pharmacol. 1980;10(Suppl 2):291S-S298.","journal-title":"Br J Clin Pharmacol"},{"issue":"11","key":"1633_CR45","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1080\/02640414.2017.1368691","volume":"36","author":"SL Coakley","year":"2018","unstructured":"Coakley SL, Passfield L. Cycling performance is superior for time-to-exhaustion versus time-trial in endurance laboratory tests. J Sports Sci. 2018;36(11):1228\u201334.","journal-title":"J Sports Sci"},{"key":"1633_CR46","first-page":"54","volume":"7","author":"J Foster","year":"2016","unstructured":"Foster J, Mauger A, Thomasson K, White S, Taylor L. Effect of acetaminophen ingestion on thermoregulation of normothermic, non-febrile humans. Front Pharmacol. 2016;7:54.","journal-title":"Front Pharmacol"},{"issue":"11","key":"1633_CR47","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1249\/MSS.0b013e3182656f13","volume":"44","author":"DE Janse","year":"2012","unstructured":"Janse DE, Jonge XA, Thompson MW, Chuter VH, Silk LN, Thom JM. Exercise performance over the menstrual cycle in temperate and hot, humid conditions. Med Sci Sports Exerc. 2012;44(11):2190\u20138.","journal-title":"Med Sci Sports Exerc"},{"issue":"4","key":"1633_CR48","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1152\/japplphysiol.00822.2005","volume":"100","author":"PC Castle","year":"2006","unstructured":"Castle PC, Macdonald AL, Philp A, Webborn A, Watt PW, Maxwell NS. Precooling leg muscle improves intermittent sprint exercise performance in hot, humid conditions. J Appl Physiol. 2006;100(4):1377\u201384.","journal-title":"J Appl Physiol"},{"issue":"Suppl 1","key":"1633_CR49","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/sms.12336","volume":"25","author":"GB Coombs","year":"2015","unstructured":"Coombs GB, Cramer MN, Ravanelli NM, Morris NB, Jay O. Acute acetaminophen ingestion does not alter core temperature or sweating during exercise in hot-humid conditions. Scand J Med Sci Sports. 2015;25(Suppl 1):96\u2013103.","journal-title":"Scand J Med Sci Sports"},{"issue":"4","key":"1633_CR50","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1080\/02640410310001641610","volume":"22","author":"CB Trewin","year":"2004","unstructured":"Trewin CB, Hopkins WG, Pyne DB. Relationship between world-ranking and Olympic performance of swimmers. J Sports Sci. 2004;22(4):339\u201345.","journal-title":"J Sports Sci"},{"issue":"11","key":"1633_CR51","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1249\/MSS.0b013e31821d3f8e","volume":"43","author":"TB Smith","year":"2011","unstructured":"Smith TB, Hopkins WG. Variability and predictability of finals times of elite rowers. Med Sci Sports Exerc. 2011;43(11):2155\u201360.","journal-title":"Med Sci Sports Exerc"},{"issue":"5","key":"1633_CR52","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s40279-013-0029-x","volume":"43","author":"M Buchheit","year":"2013","unstructured":"Buchheit M, Laursen PB. High-intensity interval training, solutions to the programming puzzle: Part I: cardiopulmonary emphasis. Sports Med. 2013;43(5):313\u201338.","journal-title":"Sports Med"},{"key":"1633_CR53","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1113\/jphysiol.2006.112094","volume":"575","author":"MJ Gibala","year":"2006","unstructured":"Gibala MJ, Little JP, van Essen M, Wilkin GP, Burgomaster KA, Safdar A, et al. Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance. J Physiol. 2006;575:901\u201311.","journal-title":"J Physiol"},{"issue":"7","key":"1633_CR54","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1123\/ijspp.2016-0200","volume":"12","author":"K Tomazin","year":"2017","unstructured":"Tomazin K, Morin JB, Millet GY. Etiology of neuromuscular fatigue after repeated sprints depends on exercise modality. Int J Sports Physiol Perform. 2017;12(7):878\u201385.","journal-title":"Int J Sports Physiol Perform"},{"issue":"3","key":"1633_CR55","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1080\/07315724.2016.1246989","volume":"36","author":"M Purpura","year":"2017","unstructured":"Purpura M, Rathmacher JA, Sharp MH, Lowery RP, Shields KA, Partl JM, et al. Oral adenosine-5\u2032-triphosphate (ATP) administration increases postexercise ATP levels, muscle excitability, and athletic performance following a repeated sprint bout. J Am Coll Nutr. 2017;36(3):177\u201383.","journal-title":"J Am Coll Nutr"},{"issue":"2","key":"1633_CR56","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1139\/cjpp-2012-0213","volume":"91","author":"AR Mauger","year":"2013","unstructured":"Mauger AR, Hopker JG. The effect of acetaminophen ingestion on cortico-spinal excitability. Can J Physiol Pharmacol. 2013;91(2):187\u20139.","journal-title":"Can J Physiol Pharmacol"},{"issue":"6","key":"1633_CR57","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1080\/02640410600874849","volume":"25","author":"S Hill-Haas","year":"2007","unstructured":"Hill-Haas S, Bishop D, Dawson B, Goodman C, Edge J. Effects of rest interval during high-repetition resistance training on strength, aerobic fitness, and repeated-sprint ability. J Sports Sci. 2007;25(6):619\u201328.","journal-title":"J Sports Sci"},{"issue":"7","key":"1633_CR58","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1111\/sms.12678","volume":"27","author":"F Pareja-Blanco","year":"2017","unstructured":"Pareja-Blanco F, Rodr\u00edguez-Rosell D, S\u00e1nchez-Medina L, Sanchis-Moysi J, Dorado C, Mora-Custodio R, et al. Effects of velocity loss during resistance training on athletic performance, strength gains and muscle adaptations. Scand J Med Sci Sports. 2017;27(7):724\u201335.","journal-title":"Scand J Med Sci Sports"},{"key":"1633_CR59","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000003487","author":"C Galiano","year":"2020","unstructured":"Galiano C, Pareja-Blanco F, Hidalgo de Mora J, S\u00e1ez de Villarreal E. Low-velocity loss induces similar strength gains to moderate-velocity loss during resistance training. J Strength Cond Res. 2020. https:\/\/doi.org\/10.1519\/JSC.0000000000003487.","journal-title":"J Strength Cond Res"},{"issue":"3","key":"1633_CR60","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1249\/MSS.0b013e3181915670","volume":"41","author":"American College of Sports Medicine","year":"2009","unstructured":"American College of Sports Medicine. American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med Sci Sports Exerc. 2009;41(3):687\u2013708.","journal-title":"Med Sci Sports Exerc"},{"key":"1633_CR61","doi-asserted-by":"crossref","unstructured":"Derry CJ, Derry S, Moore RA. Caffeine as an analgesic adjuvant for acute pain in adults. Cochrane Database Syst Rev. 2012;(3):CD009281.","DOI":"10.1002\/14651858.CD009281.pub2"},{"key":"1633_CR62","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.neubiorev.2016.09.001","volume":"71","author":"TM McLellan","year":"2016","unstructured":"McLellan TM, Caldwell JA, Lieberman HR. A review of caffeine\u2019s effects on cognitive, physical and occupational performance. Neurosci Biobehav Rev. 2016;71:294\u2013312.","journal-title":"Neurosci Biobehav Rev"},{"issue":"11","key":"1633_CR63","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1007\/s40279-021-01521-x","volume":"51","author":"J Grgic","year":"2021","unstructured":"Grgic J. Effects of caffeine on resistance exercise: a review of recent research. Sports Med. 2021;51(11):2281\u201398.","journal-title":"Sports Med"},{"issue":"4","key":"1633_CR64","first-page":"561","volume":"31","author":"JR Lisse","year":"1991","unstructured":"Lisse JR, MacDonald K, Thurmond-Anderle ME, Fuchs JE Jr. A double-blind, placebo-controlled study of acetylsalicylic acid (ASA) in trained runners. J Sports Med Phys Fit. 1991;31(4):561\u20134.","journal-title":"J Sports Med Phys Fit"},{"issue":"5","key":"1633_CR65","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1055\/s-2007-1021050","volume":"15","author":"GS Roi","year":"1994","unstructured":"Roi GS, Garagiola U, Verza P, Spadari G, Radice D, Zecca L, et al. Aspirin does not affect exercise performance. Int J Sports Med. 1994;15(5):224\u20137.","journal-title":"Int J Sports Med"},{"issue":"6","key":"1633_CR66","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1519\/JSC.0b013e31818219cb","volume":"22","author":"GM Hudson","year":"2008","unstructured":"Hudson GM, Green JM, Bishop PA, Richardson MT. Effects of caffeine and aspirin on light resistance training performance, perceived exertion, and pain perception. J Strength Cond Res. 2008;22(6):1950\u20137.","journal-title":"J Strength Cond Res"},{"issue":"3","key":"1633_CR67","doi-asserted-by":"publisher","first-page":"E551","DOI":"10.1152\/ajpendo.00352.2001","volume":"282","author":"TA Trappe","year":"2002","unstructured":"Trappe TA, White F, Lambert CP, Cesar D, Hellerstein M, Evans WJ. Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis. Am J Physiol Endocrinol Metab. 2002;282(3):E551\u20136.","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"4","key":"1633_CR68","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1152\/japplphysiol.00922.2017","volume":"124","author":"AC D'Lugos","year":"2018","unstructured":"D\u2019Lugos AC, Patel SH, Ormsby JC, Curtis DP, Fry CS, Carroll CC, et al. Prior acetaminophen consumption impacts the early adaptive cellular response of human skeletal muscle to resistance exercise. J Appl Physiol. 2018;124(4):1012\u201324.","journal-title":"J Appl Physiol"},{"issue":"3","key":"1633_CR69","doi-asserted-by":"publisher","first-page":"R655","DOI":"10.1152\/ajpregu.00611.2010","volume":"300","author":"TA Trappe","year":"2011","unstructured":"Trappe TA, Carroll CC, Dickinson JM, LeMoine JK, Haus JM, Sullivan BE, et al. Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults. Am J Physiol Regul Integr Comp Physiol. 2011;300(3):R655\u201362.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"7281","key":"1633_CR70","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1136\/bmj.322.7281.290","volume":"322","author":"SD Ryder","year":"2001","unstructured":"Ryder SD, Beckingham IJ. ABC of diseases of liver, pancreas, and biliary system. Other causes of parenchymal liver disease. BMJ. 2001;322(7281):290\u20132.","journal-title":"BMJ"},{"issue":"4","key":"1633_CR71","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s00421-014-2852-7","volume":"114","author":"G Lippi","year":"2014","unstructured":"Lippi G, Sanchis-Gomar F. Acetaminophen and sport performance: doping or what? Eur J Appl Physiol. 2014;114(4):881\u20132.","journal-title":"Eur J Appl Physiol"},{"key":"1633_CR72","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.3389\/fpsyg.2020.01908","volume":"11","author":"SD Pettersen","year":"2020","unstructured":"Pettersen SD, Aslaksen PM, Pettersen SA. Pain processing in elite and high-level athletes compared to non-athletes. Front Psychol. 2020;11:1908.","journal-title":"Front Psychol"},{"issue":"4","key":"1633_CR73","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1002\/ejp.1335","volume":"23","author":"T Assa","year":"2019","unstructured":"Assa T, Geva N, Zarkh Y, Defrin R. The type of sport matters: pain perception of endurance athletes versus strength athletes. Eur J Pain. 2019;23(4):686\u201396.","journal-title":"Eur J Pain"},{"issue":"1","key":"1633_CR74","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1093\/bja\/aet127","volume":"111","author":"EJ Bartley","year":"2013","unstructured":"Bartley EJ, Fillingim RB. Sex differences in pain: a brief review of clinical and experimental findings. Br J Anaesth. 2013;111(1):52\u20138.","journal-title":"Br J Anaesth"},{"issue":"5","key":"1633_CR75","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1093\/bja\/aei109","volume":"94","author":"PL Moller","year":"2005","unstructured":"Moller PL, Sindet-Pedersen S, Petersen CT, Juhl GI, Dillenschneider A, Skoglund LA. Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery. Br J Anaesth. 2005;94(5):642\u20138.","journal-title":"Br J Anaesth"}],"container-title":["Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40279-021-01633-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40279-021-01633-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40279-021-01633-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T11:14:30Z","timestamp":1653995670000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40279-021-01633-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,17]]},"references-count":75,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["1633"],"URL":"https:\/\/doi.org\/10.1007\/s40279-021-01633-4","relation":{},"ISSN":["0112-1642","1179-2035"],"issn-type":[{"value":"0112-1642","type":"print"},{"value":"1179-2035","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,17]]},"assertion":[{"value":"15 December 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No sources of funding were used to assist in the preparation of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Jozo Grgic declares he has no conflicts of interest relevant to the content of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and materials"}}]}}