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The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Travis Nemkov, Kirk C. Hansen, and Angelo D\u2019Alessandro are co-founders of Omix Technologies, Inc. Travis Nemkov, Angelo D\u2019Alessandro, and I\u00f1igo San-Mill\u00e1n are co-founders of Altis Biosciences. Angelo D\u2019Alessandro is a SAB member or consultant for Hemanext Inc, Macopharma, and Forma Therapeutics Inc. Francesca Cendali, Davide Stefanoni, Janel L. Martinez have no conflicts of interests that are directly relevant to the content of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All study procedures were conducted in accordance with the Declaration of Helsinki and in accordance with a predefined protocol that was approved by the Colorado Multiple Institutional Review Board (COMIRB 17-1281).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all subjects.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"While identifying information is intentionally omitted from this article to maintain anonymity, all subjects provided written informed consent for publication.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All data generated as part of this study are presented in the supplementary materials.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"No code was generated as part of this study.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"ISM, TN, and AD designed the studies. JLM and ISM performed exercise tests and collected the samples in laboratory and field settings. TN, FC, DS, KCH, and AD performed omics analyses. TN performed data analyses and prepared figures. TN wrote the first version of the manuscript, which was finalized with AD and reviewed and approved by all co-authors.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}