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Owing to privacy concerns and state regulations, the ethical and governance approvals for this study do not allow the MRI data and clinical and cognitive data to be made available in a public repository. Data in this manuscript can be accessed by qualified investigators after ethical and scientific review (to ensure the data are being requested for valid scientific research) and must comply with the European Union General Data Protection Regulations (GDPR), Norwegian laws and regulations, and NTNU regulations. The completion of a material transfer agreement (MTA) signed by an institutional official will be required.","order":2,"name":"Ethics","label":"Availability of data and material","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Regional Committee for Medical Research Ethics, Central Norway (REC 2012\/849). The study was performed in line with the principles of the Helsinki Declaration.","order":3,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from all participants included in the study.","order":4,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":5,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":6,"name":"Ethics","label":"Code availability","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"LSR contributed to the data collection, statistical analysis, figures, drafting, and revision of the manuscript. JP contributed to the statistical analyses and figures, and revised the manuscript. DS and UW supervised the RCT Generation 100 study, were responsible for the exercise and clinical data collection, and revised the manuscript. AKH supervised the Generation 100 Brain MRI and Cognition Substudy, organized the data collection, collected data, and drafted and revised the manuscript. All authors read and approved the final version of the manuscript.","order":7,"name":"Ethics","label":"Author contributions","group":{"name":"EthicsHeading","label":"Declarations"}}]}}