{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:13:11Z","timestamp":1791414791906,"version":"4.3.3"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T00:00:00Z","timestamp":1403568000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Diagn Ther"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1007\/s40291-014-0110-7","type":"journal-article","created":{"date-parts":[[2014,6,23]],"date-time":"2014-06-23T11:23:02Z","timestamp":1403522582000},"page":"567-577","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Serotonin Transporter Gene: A New Polymorphism May Affect Response to Antidepressant Treatments in Major Depressive Disorder"],"prefix":"10.1007","volume":"18","author":[{"given":"Yoshihiko","family":"Matsumoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Fabbri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Porcelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Politi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Bellino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Iofrida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Mariotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Melissari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Menchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Cappucciati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Bozzatello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Brignolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Brambilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Balestrieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Serretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,6,24]]},"reference":[{"key":"110_CR1","first-page":"38","volume":"420","author":"J Alonso","year":"2004","unstructured":"Alonso J, Angermeyer MC, Bernert S, Bruffaerts R, Brugha TS, Bryson H, et al. Disability and quality of life impact of mental disorders in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiatr Scand Suppl. 2004;420:38\u201346.","journal-title":"Acta Psychiatr Scand Suppl"},{"key":"110_CR2","volume-title":"The global burden of disease: 2004 update","author":"World Health Organization","year":"2008","unstructured":"World Health Organization. The global burden of disease: 2004 update. Genova: World Health Organization; 2008."},{"key":"110_CR3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1176\/appi.ajp.163.1.28","volume":"163","author":"MH Trivedi","year":"2006","unstructured":"Trivedi MH, Rush AJ, Wisniewski SR, Nierenberg AA, Wardren D, Ritz L, et al. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. Am J Psychiatry. 2006;163:28\u201340.","journal-title":"Am J Psychiatry"},{"key":"110_CR4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/wps.20038","volume":"12","author":"P Cuijpers","year":"2013","unstructured":"Cuijpers P, Sibrandij M, Koole SL, Andersson G, Beekman AT, Reynolds CF 3rd. The efficacy of psychotherapy and pharmacotherapy in treating depressive and anxiety disorders: a meta-analysis of direct comparisons. World Psychiatry. 2013;12:137\u201348.","journal-title":"World Psychiatry"},{"key":"110_CR5","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.pop.2012.03.010","volume":"39","author":"J Unutzer","year":"2012","unstructured":"Unutzer J, Park M. Strategies to improve the management of depression in primary care. Prim Care. 2012;39:415\u201331.","journal-title":"Prim Care"},{"key":"110_CR6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fphar.2011.00006","volume":"2","author":"C Crisafulli","year":"2011","unstructured":"Crisafulli C, Fabbri C, Porcelli S, Drago A, Spina E, De Ronchi D, Serretti A. Pharmacogenetics of antidepressants. Front Pharmacol. 2011;2:6. doi: 10.3389\/fphar.2011.00006 .","journal-title":"Front Pharmacol"},{"key":"110_CR7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1503\/jpn.100059","volume":"36","author":"S Porcelli","year":"2011","unstructured":"Porcelli S, Drago A, Fabbri C, Gibiino S, Catali R, Serretti A. Pharmacogenetics of antidepressant response. J Psychiatry Neurosci. 2011;36:87\u2013113.","journal-title":"J Psychiatry Neurosci"},{"key":"110_CR8","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1517\/17425255.2011.597740","volume":"7","author":"S Porcelli","year":"2011","unstructured":"Porcelli S, Fabbri C, Spina E, Serretti A, De Ronchi D. Genetic polymorphisms of cytochrome P450 enzymes and antidepressant metabolism. Expert Opin Drug Metab Toxicol. 2011;7:1101\u201315.","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"110_CR9","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2217\/pgs.12.1","volume":"13","author":"S Narasimhan","year":"2012","unstructured":"Narasimhan S, Lohoff FW. Pharmacogenetics of antidepressant drugs: current clinical practice and future directions. Pharmacogenomics. 2012;13:441\u201364.","journal-title":"Pharmacogenomics"},{"key":"110_CR10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0006-8993(95)00104-X","volume":"676","author":"PW Burnet","year":"1995","unstructured":"Burnet PW, Eastwood SL, Lacey K, Harrison PJ. The distribution of 5-HT1A and 5-HT2A receptor mRNA in human brain. Brain Res. 1995;676:157\u201368.","journal-title":"Brain Res"},{"key":"110_CR11","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/BF02245204","volume":"113","author":"I Kusumi","year":"1994","unstructured":"Kusumi I, Koyama T, Yamashita I. Serotonin-induced platelet intracellular calcium mobilization in depressed patients. Psychopharmacology. 1994;113:322\u20137.","journal-title":"Psychopharmacology"},{"key":"110_CR12","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/S0006-3223(98)00171-1","volume":"45","author":"R Tomiyoshi","year":"1999","unstructured":"Tomiyoshi R, Kamei K, Muraoka S, Muneoka K, Takigawa M. Serotonin-induced platelet intracellular Ca2+ responses in untreated depressed patients and imipramine responders in remission. Biol Psychiatry. 1999;45:1042\u20138.","journal-title":"Biol Psychiatry"},{"key":"110_CR13","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1046\/j.1471-4159.1997.68052186.x","volume":"68","author":"N Ozaki","year":"1997","unstructured":"Ozaki N, Manji H, Lubierman V, Lu SJ, Lappalainen J, Rosenthal NE, Goldman D. A naturally occurring amino acid substitution of the human serotonin 5-HT2A receptor influences amplitude and timing of intracellular calcium mobilization. J Neurochem. 1997;68:2186\u201393.","journal-title":"J Neurochem"},{"key":"110_CR14","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/sj.mp.4001502","volume":"9","author":"EJ Peters","year":"2004","unstructured":"Peters EJ, Slager SL, McGrath PJ, Knowles JA, Hamilton SP. Investigation of serotonin-related genes in antidepressant response. Mol Psychiatry. 2004;9:879\u201389.","journal-title":"Mol Psychiatry"},{"key":"110_CR15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/sj.tpj.6500491","volume":"9","author":"MJ Wilkie","year":"2009","unstructured":"Wilkie MJ, Smith G, Day RK, Matthews K, Smith D, Blackwood D, Reid IC, Wolf CR. Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy. Pharmacogenomics J. 2009;9:61\u201370.","journal-title":"Pharmacogenomics J"},{"key":"110_CR16","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.euroneuro.2011.10.003","volume":"22","author":"S Porcelli","year":"2012","unstructured":"Porcelli S, Fabbri C, Serretti A. Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with antidepressant efficacy. Eur Neuropsychopharmacol. 2012;22:239\u201358.","journal-title":"Eur Neuropsychopharmacol"},{"key":"110_CR17","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1161\/CIRCGENETICS.109.870386","volume":"2","author":"S Su","year":"2009","unstructured":"Su S, Zhao J, Bremner JD, Miller AH, Tang W, Bouzyk M, Snieder H, Novik O, Afzal N, Goldberg J, Vaccarino V. Serotonin transporter gene, depressive symptoms and interleukin-6. Circ Cardiovasc Genet. 2009;2:614\u201320.","journal-title":"Circ Cardiovasc Genet"},{"key":"110_CR18","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/sj.mp.4001525","volume":"9","author":"P Zill","year":"2004","unstructured":"Zill P, Banghai TC, Zwanzger P, Schule C, Eser D, Rupprecht R, Moller HJ, Bondy B, Ackenheil M. SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Mol Psychiatry. 2004;9:1030\u20136.","journal-title":"Mol Psychiatry"},{"key":"110_CR19","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/sj.mp.4001712","volume":"10","author":"HA Garriock","year":"2005","unstructured":"Garriock HA, Allen JJ, Delgado P, Nahaz Z, Kling MA, Carpenter L, Burke M, Burke W, Schwartz T, Marangell LB, Husain M, Erickson RP, Moreno FA. Lack of association of TPH2 exon XI polymorphisms with major depression and treatment resistance. Mol Psychiatry. 2005;10:976\u20137.","journal-title":"Mol Psychiatry"},{"key":"110_CR20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuron.2004.12.014","volume":"45","author":"X Zhang","year":"2005","unstructured":"Zhang X, Gainetdinov RR, Beaulieu JM, Sotnikova TD, Burch LH, Williams RB, Schwartz DA, Krishnan KR, Caron MG. Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron. 2005;45:11\u20136.","journal-title":"Neuron"},{"key":"110_CR21","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1001\/archpsyc.62.10.1109","volume":"62","author":"Z Zhou","year":"2005","unstructured":"Zhou Z, Roy A, Lipsky R, Kuchipudi K, Zhu G, Taubman J, Enoch MA, Virkkunen M, Goldman D. Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations. Arch Gen Psychiatry. 2005;62:1109\u201318.","journal-title":"Arch Gen Psychiatry"},{"key":"110_CR22","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/sj.mp.4001861","volume":"11","author":"MA Bicalho","year":"2006","unstructured":"Bicalho MA, Pimenta GJ, Neves FS, Correa H, de Moraes EN, Da Marco L, Romano-Silva MA. Genotyping of the G1463A (Arg441His) TPH2 polymorphism in a geriatric population of patients with major depression. Mol Psychiatry. 2006;11:799\u2013800.","journal-title":"Mol Psychiatry"},{"key":"110_CR23","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.biopsych.2005.12.014","volume":"60","author":"R Delorme","year":"2006","unstructured":"Delorme R, Durand CM, Betancur C, Wagner M, Ruhrmann S, Grabe HJ, Nygren G, Gillberg C, Leboyer M, Bourgeron T, Courtet P, Jollant F, Buresi C, Aubry JM, Baud P, Bondolfi G, Bertschy G, Perroud N, Malafosse A. No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects. Biol Psychiatry. 2006;60:202\u20133.","journal-title":"Biol Psychiatry"},{"key":"110_CR24","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1001\/archpsyc.63.10.1103","volume":"63","author":"A Bogaert Van Den","year":"2006","unstructured":"Van Den Bogaert A, Sleegers K, De Zutter S, Heyrman L, Norrback KF, Adolfsson R, Van Broeckhoven C, Del-Favero J. Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population. Arch Gen Psychiatry. 2006;63:1103\u201310.","journal-title":"Arch Gen Psychiatry"},{"key":"110_CR25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jad.2007.07.005","volume":"107","author":"R Gizatullin","year":"2008","unstructured":"Gizatullin R, Zaboli G, Jonsson EG, Asperg M, Leopardi R. The tryptophan hydroxylase (TPH) 2 gene unlike TPH-1 exhibits no association with stress-induced depression. J Affect Disord. 2008;107:175\u20139.","journal-title":"J Affect Disord"},{"key":"110_CR26","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/sj.mp.4002127","volume":"13","author":"F Haghighi","year":"2008","unstructured":"Haghighi F, Bach-Mizrachi H, Huang YY, Arango V, Shi S, Dwork AJ, Rosoklija G, Sheng HT, Morozova I, Ju J, Russo JJ, Mann JJ. Genetic architecture of the human tryptophan hydroxylase 2 gene: existence of neural isoforms and relevance for major depression. Mol Psychiatry. 2008;13:813\u201320.","journal-title":"Mol Psychiatry"},{"key":"110_CR27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jad.2007.05.031","volume":"106","author":"JJ Mann","year":"2008","unstructured":"Mann JJ, Currier D, Murphy L, Huang YY, Galfalvy H, Brent D, Greenhill L, Oquendo M. No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover. J Affect Disord. 2008;106:117\u201321.","journal-title":"J Affect Disord"},{"key":"110_CR28","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1097\/WNR.0b013e32832eb708","volume":"20","author":"A Illi","year":"2009","unstructured":"Illi A, Setala-Soikkeli E, Vikki M, Poutanen O, Huhtala H, Mononen N, Lehtimaki T, Leinonen E, Kampan O. 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression. Neuroreport. 2009;20:1125\u20138.","journal-title":"Neuroreport"},{"key":"110_CR29","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.pnpbp.2009.02.020","volume":"33","author":"SJ Tsai","year":"2009","unstructured":"Tsai SJ, Hong CJ, Liou YJ, Yu YW, Chen TJ, Hou SJ, Yen FC. Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response. Prog Neuropsychopharmocol Biol Psychiatry. 2009;33:637\u201341.","journal-title":"Prog Neuropsychopharmocol Biol Psychiatry"},{"key":"110_CR30","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.psychres.2011.03.012","volume":"188","author":"S Claes","year":"2011","unstructured":"Claes S, Myint AM, Domschke K, Del-Favero J, Entrich K, Engelborghs S, De Deyn P, Mueller N, Baune B, Rothermundt M. The kynurenine pathway in major depression: haplotype analysis of three related functional candidate genes. Psychiatry Res. 2011;188:355\u201360.","journal-title":"Psychiatry Res"},{"key":"110_CR31","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.psychres.2011.02.001","volume":"189","author":"A Serretti","year":"2011","unstructured":"Serretti A, Chiesa A, Porcelli S, Han C, Patkar AA, Lee SJ, Park MH, Pae CU. Influence of TPH2 variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia. Psychiatry Res. 2011;189:26\u201332.","journal-title":"Psychiatry Res"},{"key":"110_CR32","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.jad.2011.04.037","volume":"133","author":"X Shen","year":"2011","unstructured":"Shen X, Wu Y, Qian M, Wang X, Hou Z, Liu Y, Sun J, Zhong H, Yang J, Lin M, Li L, Liang L, Guan T, Shen Z, Yuan Y. Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population. J Affect Disord. 2011;133:619\u201324.","journal-title":"J Affect Disord"},{"key":"110_CR33","doi-asserted-by":"crossref","first-page":"e36721","DOI":"10.1371\/journal.pone.0036721","volume":"7","author":"J Gao","year":"2012","unstructured":"Gao J, Pan Z, Jiao Z, Li F, Zhao G, Wei Q, Pan F, Evangelou E. TPH2 gene polymorphisms and major depression: a meta-analysis. Plos One. 2012;7:e36721. doi: 10.1371\/journal.pone.0036721 .","journal-title":"Plos One"},{"key":"110_CR34","doi-asserted-by":"crossref","first-page":"e253","DOI":"10.1038\/tp.2013.30","volume":"3","author":"G Quesseveur","year":"2013","unstructured":"Quesseveur G, David DJ, Gaillard MC, Pla P, Wu MV, Nguyen HT, Nicolas V, Auregan G, David I, Dranovsky A, Hantraye P, Hen R, Gardier AM, Deglon N, Guiard BP. BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities. Transl Psychiatry. 2013;3:e253. doi: 10.1038\/tp.2013.30 .","journal-title":"Transl Psychiatry"},{"key":"110_CR35","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.pnpbp.2004.11.009","volume":"29","author":"O Aydemir","year":"2005","unstructured":"Aydemir O, Deveci A, Taneli F. The effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: a preliminary study. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29:261\u20135.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"110_CR36","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0092-8674(03)00035-7","volume":"112","author":"MF Egan","year":"2003","unstructured":"Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell. 2003;112:257\u201369.","journal-title":"Cell"},{"key":"110_CR37","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.brainresbull.2009.06.022","volume":"81","author":"E Ozan","year":"2010","unstructured":"Ozan E, Okur H, Eker C, Eker OD, Gonul AS, Akarsu N. The effect of depression, BDNF gene val66met polymorphism and gender on serum BDNF levels. Brain Res Bull. 2010;81:61\u20135.","journal-title":"Brain Res Bull"},{"key":"110_CR38","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.euroneuro.2009.12.005","volume":"20","author":"YF Zou","year":"2010","unstructured":"Zou YF, Ye DQ, Feng XL, Su H, Pan FM, Liao FF. Meta-analysis of BDNF val66met polymorphism association with treatment response in patients with major depressive disorder. Eur Neuropsychopharmacol. 2010;20:535\u201344.","journal-title":"Eur Neuropsychopharmacol"},{"key":"110_CR39","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/mp.2008.116","volume":"15","author":"M Kato","year":"2010","unstructured":"Kato M, Serretti A. Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder. Mol Psychiatry. 2010;15:473\u2013500.","journal-title":"Mol Psychiatry"},{"key":"110_CR40","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.pnpbp.2013.05.011","volume":"45","author":"T Niitsu","year":"2013","unstructured":"Niitsu T, Fabbri C, Bentini F, Serretti A. Pharmacogenetics in major depression: a comprehensive meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2013;45:183\u201394.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"110_CR41","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35085068","volume":"2","author":"B Mayr","year":"2001","unstructured":"Mayr B, Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol. 2001;2:599\u2013609.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"110_CR42","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0896-6273(02)00828-0","volume":"35","author":"BE Lonze","year":"2002","unstructured":"Lonze BE, Ginty DD. Function and regulation of CREB family transcription factors in the nervous system. Neuron. 2002;35:605\u201323.","journal-title":"Neuron"},{"key":"110_CR43","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/ajmg.10381","volume":"114","author":"GS Zubenko","year":"2002","unstructured":"Zubenko GS, Hughes HB, Stiffler JS, Zubenko WN, Kaplan BB. Genome survey for susceptibility loci for recurrent, early-onset, major depression: results at 10\u00a0cM resolution. Am J Med Genet. 2002;114:413\u201322.","journal-title":"Am J Med Genet"},{"key":"110_CR44","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/sj.mp.4001121","volume":"7","author":"GS Zubenko","year":"2002","unstructured":"Zubenko GS, Hughes HB III, Stiffler JS, Zubenko WN, Kaplan BB. D2S2944 identifies a likely susceptibility locus for recurrent, early-onset, major depression in women. Mol Psychiatry. 2002;7:460\u20137.","journal-title":"Mol Psychiatry"},{"key":"110_CR45","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1161\/CIRCGENETICS.109.925644","volume":"3","author":"T Rankinen","year":"2010","unstructured":"Rankinen T, Argyropoulos G, Rice T, Rao DC, Bouchard C. CREB1 is a strong genetic predictor of the variation in exercise heart rate response to regular exercise: the HERITAGE Family Study. Circ Cardiovasc Genet. 2010;3:294\u20139.","journal-title":"Circ Cardiovasc Genet"},{"key":"110_CR46","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.biopsych.2010.11.019","volume":"69","author":"G Juhasz","year":"2011","unstructured":"Juhasz G, Dunham JS, Mckie S, Thomas E, Downey D, Chase D, Lloyd-Williams K, Toth ZG, Platt H, Mekli K, Payton A, Elliott R, Williams SR, Anderson IM, Deakin JF. The CREB1-BDNF-NTRK2 pathway in depression: multiple gene\u2013cognition\u2013environment interactions. Biol Psychiatry. 2011;69:762\u201371.","journal-title":"Biol Psychiatry"},{"key":"110_CR47","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jad.2010.06.025","volume":"128","author":"A Serretti","year":"2011","unstructured":"Serretti A, Chiesa A, Calati R, Massat I, Linotte S, Kasper S, Lecrubier Y, Antonijevic I, Forray C, Snyder L, Bollen J, Zohar J, De Ronchi D, Souery D, Mendlewicz J. A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression. J Affect Disord. 2011;128:56\u201363.","journal-title":"J Affect Disord"},{"key":"110_CR48","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4306\/pi.2013.10.2.180","volume":"10","author":"A Serretti","year":"2013","unstructured":"Serretti A, Fabbri C, Pellegrini S, Porcelli S, Politi P, Bellino S, Menchetti M, Mariotti V, Demi C, Martinelli V, Cappucciati M, Bozzatello P, Brignolo E, Brambilla P, Pae CU, Balestrieri M, De Ronchi D. No effect of serotoninergic gene variants on response to interpersonal counseling and antidepressants in major depression. Psychiatry Investig. 2013;10:180\u20139.","journal-title":"Psychiatry Investig"},{"key":"110_CR49","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/hup.311","volume":"16","author":"FK Judd","year":"2001","unstructured":"Judd FK, Piterman L, Cockram AM, McCall L, Weissman MM. A comparative study of venlafaxine with a focused education and psychotherapy program versus venlafaxine alone in the treatment of depression in general practice. Hum Psychopharmacol. 2001;16:423\u20138.","journal-title":"Hum Psychopharmacol"},{"key":"110_CR50","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3109\/08039480903402227","volume":"64","author":"O Oranta","year":"2010","unstructured":"Oranta O, Luutonen S, Salokangas RK, Vahlberg T, Leino-Kilpi H. The outcomes of interpersonal counselling on depressive symptoms and distress after myocardial infarction. Nord J Psychiatry. 2010;64:78\u201386.","journal-title":"Nord J Psychiatry"},{"key":"110_CR51","volume-title":"Interpersonal counselling for stress and distress in primary care: a treatment manual","author":"M Weissman","year":"1988","unstructured":"Weissman M. Interpersonal counselling for stress and distress in primary care: a treatment manual. New York: Columbia University; 1988."},{"key":"110_CR52","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1471-244X-10-97","volume":"10","author":"M Menchetti","year":"2010","unstructured":"Menchetti M, Bortolotti B, Rucci P, Scocco P, Bombi A, Berardi D, et al. Depression in primary care: interpersonal counseling vs selective serotonin reuptake inhibitors. The DEPICS study. A multicenter randomized controlled trial. Relationale and design. BMC Psychiatry. 2010;10:97. doi: 10.1186\/1471-244X-10-97 .","journal-title":"BMC Psychiatry"},{"key":"110_CR53","unstructured":"Guy W. Dosage record and treatment emergent symptom scale [DOTES]. In: US Department of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse and Mental Health Administration, NIMH Psychopharmocology Research Branch, Division of Extramural Research Programs, editors. ECDEU Assessment manual for psychopharmacology. Revised. Rockville: National Institute of Mental Health; 1976. pp. 223\u2013244."},{"key":"110_CR54","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/BF02900219","volume":"247","author":"UH Frommberger","year":"1997","unstructured":"Frommberger UH, Bauer J, Haselbeuer P, Fraulin A, Riemann D, Berger M. Interleukin-6-(IL-6) plasma levels in depression and schizophrenia: comparison between the acute state and after remission. Eur Arch Psychiatry Clin Neurosci. 1997;247:228\u201333.","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"110_CR55","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0893-133X(99)00134-7","volume":"22","author":"S Lanquilon","year":"2000","unstructured":"Lanquilon S, Krieg JC, Bening-Abu-Shach U, Vedder H. Cytokine production and treatment response in major depressive disorder. Neuropsychopharmacology. 2000;22:370\u20139.","journal-title":"Neuropsychopharmacology"},{"key":"110_CR56","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.pnpbp.2009.03.020","volume":"33","author":"R Yoshimura","year":"2009","unstructured":"Yoshimura R, Hori H, Ikenouchi-Sugita A, Uneme-Nakano W, Ueda N, Nakamura J. Higher plasma interleukin-6 (IL-6) level is associated with SSRI- or SNRI-refractory depression. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:722\u20136.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"110_CR57","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.biopsych.2009.04.030","volume":"66","author":"NR Wray","year":"2009","unstructured":"Wray NR, James MR, Gordon SD, Dumenil T, Ryan L, Coventry WL, Statham DJ, Pergadia ML, Madden PA, Heath AC, Montgomery GW, Martin NG. Accurate, large-scale genotyping of 5HTTLPR and flanking single nucleotide polymorphisms in an association study of depression, anxiety, and personality measures. Biol Psychiatry. 2009;66:468\u201376.","journal-title":"Biol Psychiatry"},{"key":"110_CR58","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/FPC.0b013e3282fb02cb","volume":"18","author":"MV Tzvetkov","year":"2008","unstructured":"Tzvetkov MV, Brockmoller J, Roots I, Kirchheiner J. Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment. Pharmacogenet Genomics. 2008;18:495\u2013506.","journal-title":"Pharmacogenet Genomics"},{"key":"110_CR59","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0304-3940(01)01704-9","volume":"303","author":"C Minov","year":"2001","unstructured":"Minov C, Baghai TC, Schule C, Zwanzger P, Schwarz MJ, Zill P, Rupprecht R, Bondy B. Serotonin-2A-receptor and -transporter polymorphisms: lack of association in patients with major depression. Neurosci Lett. 2001;303:119\u201322.","journal-title":"Neurosci Lett"},{"key":"110_CR60","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/ajmg.b.20026","volume":"123B","author":"SJ Tsai","year":"2003","unstructured":"Tsai SJ, Cheng CY, Yu YW, Chen TJ, Hong CJ. Association study of a brain-derived neurotrophic-factor genetic polymorphism and major depressive disorders, symptomatology, and antidepressant response. Am J Med Genet B Neuropsychiatr Genet. 2003;123B:19\u201322.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"110_CR61","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/FPC.0b013e32801a3be6","volume":"17","author":"MJ Wilkie","year":"2007","unstructured":"Wilkie MJ, Smith D, Reid IC, Day RK, Matthews K, Wolf CR, Blackwood D, Smith G. A splice site polymorphism in the G-protein beta subunit influences antidepressant efficacy in depression. Pharmacogenet Genomics. 2007;17:207\u201315.","journal-title":"Pharmacogenet Genomics"},{"key":"110_CR62","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1177\/0269881109105457","volume":"24","author":"RH Kang","year":"2010","unstructured":"Kang RH, Chang HS, Wong ML, Choi MJ, Park JY, Lee HY, Jung IK, Joe SH, Kim L, Kim SH, Kim YK, Han CS, Ham BJ, Lee HJ, Ko YU, Lee MS, Lee MS. Brain-derived neurotrophic factor gene polymorphisms and mirtazapine responses in Koreans with major depression. J Psychopharmacol. 2010;24:1755\u201363.","journal-title":"J Psychopharmacol"},{"key":"110_CR63","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1001\/archgenpsychiatry.2009.38","volume":"66","author":"J Licinio","year":"2009","unstructured":"Licinio J, Dong C, Wong ML. Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response. Arch Gen Psychiatry. 2009;66:488\u201397.","journal-title":"Arch Gen Psychiatry"},{"key":"110_CR64","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1017\/S1461145709000030","volume":"13","author":"K Domschke","year":"2010","unstructured":"Domschke K, Lawford B, Laje G, Berger K, Young R, Morris P, Deckert J, Arolt V, McMahon FJ, Baune BT. Brain-derived neurotrophic factor (BDNF) gene: no major impact on antidepressant response. Int J Neuropsychopharmacol. 2010;13:93\u2013101.","journal-title":"Int J Neuropsychopharmacol"},{"key":"110_CR65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/YIC.0b013e32833d18f8","volume":"26","author":"NA Kocabas","year":"2011","unstructured":"Kocabas NA, Antonijevic I, Faghel C, Forray C, Kasper S, Lecrubier Y, Linotte S, Massat I, Mendlewicz J, Noro M, Montogomery S, Oswald P, Snyder L, Zohar J, Souery D. Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder. Int Clin Psychopharmacol. 2011;26:1\u201310.","journal-title":"Int Clin Psychopharmacol"},{"key":"110_CR66","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.pnpbp.2011.02.009","volume":"35","author":"R Yoshimura","year":"2011","unstructured":"Yoshimura R, Kishi T, Suzuki A, Uneme-Nakano W, Ikenouchi-Sugita A, Hori H, Otani K, Iwata N, Nakamura J. The brain-derived neurotrophic factor (BDNF) polymorphism val66met is associated with neither serum BDNF level nor response to selective serotonin reuptake inhibitors in depressed Japanese patients. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35:1022\u20135.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"110_CR67","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00406-012-0364-1","volume":"263","author":"R Musil","year":"2013","unstructured":"Musil R, Zill P, Seemuller F, Bondy B, Obermeier M, Spellmann I, Bender W, Adli M, Heuser I, Zeiler J, Gaebel W, Maier W, Rietschel M, Rujescu D, Schennach R, Moller HJ, Riedel M. No influence of brain-derived neurotrophic factor (BDNF) polymorphisms on treatment response in a naturalistic sample of patients with major depression. Eur Arch Psychiatry Clin Neurosci. 2013;263:405\u201312.","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"110_CR68","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/JCP.0b013e318267b6da","volume":"32","author":"S Tsuchimine","year":"2012","unstructured":"Tsuchimine S, Yasui-Furukori N, Nakagami T, Sato Y, Kaneko S. DRD3 but not BDNF, genotype affects treatment response to paroxetine in major depressive disorder: a preliminary study. J Clin Psychopharmacol. 2012;32:724\u20136.","journal-title":"J Clin Psychopharmacol"},{"key":"110_CR69","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/YPG.0b013e32834c0c87","volume":"22","author":"G Xu","year":"2012","unstructured":"Xu G, Lin K, Rao D, Dang Y, Ouyang H, Mai G, Zhang M. Brain-derived neurotrophic factor gene polymorphism (Val66Met) and the early response to antidepressant in Chinese Han population. Psychiatr Genet. 2012;22:214\u20135.","journal-title":"Psychiatr Genet"},{"key":"110_CR70","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.euroneuro.2013.03.009","volume":"23","author":"AR Brunoni","year":"2013","unstructured":"Brunoni AR, Kemp AH, Shiozawa P, Cordeiro Q, Valiengo LC, Goulart AC, Coprerski B, Lotufo PA, Brunori D, Perez AB, Fregni F, Bensenor IM. Impact of 5-HTTLPR and BDNF polymorphisms on response to sertraline versus transcranial direct current stimulation: implications for the serotonergic system. Eur Neuropsychopharmcol. 2013;23:1530\u201340.","journal-title":"Eur Neuropsychopharmcol"},{"key":"110_CR71","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/FPC.0b013e328360b175","volume":"23","author":"GM Murphy Jr","year":"2013","unstructured":"Murphy GM Jr, Sarginson JE, Ryan HS, O\u2019Hara R, Schatzberg AF, Lazzeroni LC. BDNF and CREB1 genetic variants interact to affect antidepressant treatment outcomes in geriatric depression. Pharmacogenet Genomics. 2013;23:301\u201313.","journal-title":"Pharmacogenet Genomics"},{"key":"110_CR72","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/mp.2008.109","volume":"15","author":"M Verhagen","year":"2010","unstructured":"Verhagen M, van der Meij A, van Deurzen PAM, Janzing JGE, Arias-Vasquez A, Buitelaar JK, Franke B. Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. Mol Psychiatry. 2010;15:260\u201371.","journal-title":"Mol Psychiatry"},{"key":"110_CR73","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000209350","volume":"78","author":"JM Koch","year":"2009","unstructured":"Koch JM, Hinze-Selch D, Stingele K, Huchzermeier C, Goder R, Seeck-Hirschner M, Aldenhoff JB. Changes in CREB Phosphorylation and BDNF plasma levels during psychotherapy of depression. Psychother Psychosom. 2009;78:187\u201392.","journal-title":"Psychother Psychosom"},{"key":"110_CR74","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0022-3956(02)00056-0","volume":"36","author":"JM Koch","year":"2002","unstructured":"Koch JM, Kell S, Hinze-Selch D, Aldenhoff JB. Changes in CREB-phosphorylation during recovery from major depression. J Psychiatr Res. 2002;36:369\u201375.","journal-title":"J Psychiatr Res"},{"key":"110_CR75","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.psychres.2011.08.022","volume":"198","author":"C Crisafulli","year":"2012","unstructured":"Crisafulli C, Shim DS, Andrisano C, Pae CU, Chiesa A, Han C, Patkar AA, Lee SJ, Serretti A, De Ronchi D. Case-control association study of 14 variants of CREB1, CREBBP and CREM on diagnosis and treatment outcome in major depressive disorder and bipolar disorder. Psychiatry Res. 2012;198:39\u201346.","journal-title":"Psychiatry Res"},{"key":"110_CR76","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1037\/a0029396","volume":"80","author":"JC Levenson","year":"2012","unstructured":"Levenson JC, Wallace ML, Fournier JC, Rucci P, Frank E. The role of personality pathology in depression treatment outcome with psychotherapy and pharmacotherapy. J Counsult Clin Psychol. 2012;80:719\u201329.","journal-title":"J Counsult Clin Psychol"}],"container-title":["Molecular Diagnosis & Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40291-014-0110-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40291-014-0110-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40291-014-0110-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T02:59:16Z","timestamp":1649473156000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40291-014-0110-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,24]]},"references-count":76,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["110"],"URL":"https:\/\/doi.org\/10.1007\/s40291-014-0110-7","relation":{},"ISSN":["1177-1062","1179-2000"],"issn-type":[{"value":"1177-1062","type":"print"},{"value":"1179-2000","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,24]]}}}