{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:15:54Z","timestamp":1789085754224,"version":"build-2803163510"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T00:00:00Z","timestamp":1489363200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS PS09\/01830"],"award-info":[{"award-number":["FIS PS09\/01830"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS PS09\/01685"],"award-info":[{"award-number":["FIS PS09\/01685"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS PS09\/00839"],"award-info":[{"award-number":["FIS PS09\/00839"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Diagn Ther"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s40291-017-0268-x","type":"journal-article","created":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T10:35:30Z","timestamp":1489401330000},"page":"303-313","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluating the Calling Performance of a Rare Disease NGS Panel for Single Nucleotide and Copy Number Variants"],"prefix":"10.1007","volume":"21","author":[{"given":"P.","family":"Cacheiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ord\u00f3\u00f1ez-Ugalde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Quint\u00e1ns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Pi\u00f1eiro-Hermida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Amigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Garc\u00eda-Murias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. I.","family":"Pascual-Pascual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Grandas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Arpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Carracedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Sobrido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,13]]},"reference":[{"key":"268_CR1","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1007\/s00415-013-7008-x","volume":"260","author":"KR Kumar","year":"2013","unstructured":"Kumar KR, Blair NF, Vandebona H, et al. Targeted next generation sequencing in SPAST-negative hereditary spastic paraplegia. J Neurol. 2013;260:2516\u201322.","journal-title":"J Neurol"},{"key":"268_CR2","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1399-0004.2011.01715.x","volume":"80","author":"NA Schlipf","year":"2011","unstructured":"Schlipf NA, Sch\u00fcle R, Klimpe S, et al. Amplicon-based high-throughput pooled sequencing identifies mutations in CYP7B1 and SPG7 in sporadic spastic paraplegia patients. Clin Genet. 2011;80:148\u201360.","journal-title":"Clin Genet"},{"key":"268_CR3","doi-asserted-by":"crossref","first-page":"e0133210","DOI":"10.1371\/journal.pone.0133210","volume":"10","author":"J Crona","year":"2015","unstructured":"Crona J, Ljungstr\u00f6m V, Welin S, Walz MK, Hellman P, Bj\u00f6rklund P. Bioinformatic challenges in clinical diagnostic application of targeted next generation sequencing: experience from pheochromocytoma. PLoS One. 2015;10:e0133210.","journal-title":"PLoS One"},{"key":"268_CR4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/gm432","volume":"5","author":"J O\u2019Rawe","year":"2013","unstructured":"O\u2019Rawe J, Jiang T, Sun G, et al. Low concordance of multiple variant-calling pipelines: practical implications for exome and genome sequencing. Genome Med. 2013;5:28.","journal-title":"Genome Med."},{"key":"268_CR5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1479-7364-8-14","volume":"8","author":"M Pirooznia","year":"2014","unstructured":"Pirooznia M, Kramer M, Parla J, et al. Validation and assessment of variant calling pipelines for next-generation sequencing. Hum Genomics. 2014;8:14.","journal-title":"Hum Genomics."},{"key":"268_CR6","doi-asserted-by":"crossref","first-page":"e75619","DOI":"10.1371\/journal.pone.0075619","volume":"8","author":"X Liu","year":"2013","unstructured":"Liu X, Han S, Wang Z, Gelernter J, Yang BZ. Variant callers for next-generation sequencing data: a comparison study. PLoS One. 2013;8:e75619.","journal-title":"PLoS One"},{"key":"268_CR7","doi-asserted-by":"crossref","first-page":"17875","DOI":"10.1038\/srep17875","volume":"5","author":"S Hwang","year":"2015","unstructured":"Hwang S, Kim E, Lee I, Marcotte EM. Systematic comparison of variant calling pipelines using gold standard personal exome variants. Sci Rep. 2015;5:17875.","journal-title":"Sci Rep."},{"key":"268_CR8","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s40291-014-0099-y","volume":"18","author":"G Millat","year":"2014","unstructured":"Millat G, Chanavat V, Rousson R. Evaluation of a new high-throughput next-generation sequencing method based on a custom AmpliSeq library and ion torrent PGM sequencing for the rapid detection of genetic variations in long QT syndrome. Mol Diagn Ther. 2014;18:533\u20139.","journal-title":"Mol Diagn Ther."},{"key":"268_CR9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s40291-015-0136-5","volume":"19","author":"D Dacheva","year":"2015","unstructured":"Dacheva D, Dodova R, Popov I, et al. Validation of an NGS approach for diagnostic BRCA1\/BRCA2 mutation testing. Mol Diagn Ther. 2015;19:119\u201330.","journal-title":"Mol Diagn Ther."},{"key":"268_CR10","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/humu.22332","volume":"34","author":"B Sikkema-Raddatz","year":"2013","unstructured":"Sikkema-Raddatz B, Johansson LF, de Boer EN, et al. Targeted next-generation sequencing can replace Sanger sequencing in clinical diagnostics. Hum Mutat. 2013;34:1035\u201342.","journal-title":"Hum Mutat"},{"key":"268_CR11","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jmoldx.2015.03.004","volume":"17","author":"LM Baudhuin","year":"2015","unstructured":"Baudhuin LM, Lagerstedt SA, Klee EW, Fadra N, Oglesbee D, Ferber MJ. Confirming variants in next-generation sequencing panel testing by Sanger sequencing. J Mol Diagn. 2015;17:456\u201361.","journal-title":"J Mol Diagn."},{"key":"268_CR12","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1373\/clinchem.2015.249623","volume":"62","author":"TF Beck","year":"2016","unstructured":"Beck TF, Mullikin JC, NISC Comparative Sequencing Program, Biesecker LG. Systematic evaluation of sanger validation of next-generation sequencing variants. Clin Chem. 2016;62:647\u201354.","journal-title":"Clin Chem"},{"key":"268_CR13","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.3390\/ijms13033245","volume":"13","author":"L Stuppia","year":"2012","unstructured":"Stuppia L, Antonucci I, Palka G, Gatta V. Use of the MLPA assay in the molecular diagnosis of gene copy number alterations in human genetic diseases. Int J Mol Sci. 2012;13:3245\u201376.","journal-title":"Int J Mol Sci"},{"key":"268_CR14","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/ejhg.2013.82","volume":"22","author":"X Wei","year":"2014","unstructured":"Wei X, Dai Y, Yu P, et al. Targeted next-generation sequencing as a comprehensive test for patients with and female carriers of DMD\/BMD: a multi-population diagnostic study. Eur J Hum Genet. 2014;22:110\u20138.","journal-title":"Eur J Hum Genet"},{"key":"268_CR15","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1093\/bioinformatics\/bts526","volume":"28","author":"V Plagnol","year":"2012","unstructured":"Plagnol V, Curtis J, Epstein M, et al. A robust model for read count data in exome sequencing experiments and implications for copy number variant calling. Bioinformatics. 2012;28:2747\u201354.","journal-title":"Bioinformatics"},{"key":"268_CR16","unstructured":"Povysil G, Tzika A, Vogt J, Haunschmid V, Messiaen L, Wimmer K, Klambauer G, Hochreiter S, panelcn.MOPS: CNV detection in targeted panel sequencing data for diagnostic use; (Abstract 1016T). In: Presented at the 66th annual meeting of the American society of human genetics, October 20, 2016, Vancouver."},{"key":"268_CR17","doi-asserted-by":"crossref","unstructured":"Klambauer G, Schwarzbauer K, Mayr A, Mitterecker A, Clevert D, Bodenhofer U, Hochreiter S. cn.MOPS: mixture of poissons for discovering copy number variations in next generation sequencing data with a low false discovery rate. Nucleic Acids Res. 2012;40:e69.","DOI":"10.1093\/nar\/gks003"},{"key":"268_CR18","unstructured":"Oliveira C, Wolf T. CNVPanelizer: reliable CNV detection in targeted sequencing applications. R package version 1.4.0. 2016."},{"key":"268_CR19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ng.806","volume":"43","author":"MA DePristo","year":"2011","unstructured":"DePristo MA, Banks E, Poplin R, et al. A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat Genet. 2011;43:491\u20138.","journal-title":"Nat Genet"},{"key":"268_CR20","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","volume":"20","author":"A McKenna","year":"2010","unstructured":"McKenna A, Hanna M, Banks E, et al. The genome analysis toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res. 2010;20:1297\u2013303.","journal-title":"Genome Res"},{"key":"268_CR21","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/nar\/gkq603","volume":"38","author":"K Wang","year":"2010","unstructured":"Wang K, Li M, Hakonarson H. ANNOVAR: Functional annotation of genetic variants from next-generation sequencing data. Nucleic Acids Res. 2010;38:e164.","journal-title":"Nucleic Acids Res"},{"key":"268_CR22","unstructured":"R Core Team. R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. 2016. https:\/\/www.R-project.org\/ ."},{"key":"268_CR23","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1109\/TVCG.2014.2346248","volume":"20","author":"A Lex","year":"2014","unstructured":"Lex A, Gehlenborg N, Strobelt H, Vuillemot R, Pfister H. UpSet: visualization of intersecting sets. IEEE Trans Vis Comput Graph.\u00a02014;20:1983\u201392.","journal-title":"IEEE Trans Vis Comput Graph."},{"key":"268_CR24","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","volume":"29","author":"JT Robinson","year":"2011","unstructured":"Robinson JT, Thorvaldsd\u00f3ttir H, Winckler W, et al. Integrative genomics viewer. Nat Biotechnol. 2011;29:24\u20136.","journal-title":"Nat Biotechnol"},{"key":"268_CR25","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","volume":"26","author":"AR Quinlan","year":"2010","unstructured":"Quinlan AR, Hall IM. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics. 2010;26:841\u20132.","journal-title":"Bioinformatics"},{"key":"268_CR26","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","volume":"17","author":"S Richards","year":"2015","unstructured":"Richards S, Aziz N, Bale S, et al. ACMG Laboratory Quality Assurance Committee. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med. 2015;17:405\u201324.","journal-title":"Genet Med."},{"key":"268_CR27","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.atg.2014.06.001","volume":"3","author":"B Quint\u00e1ns","year":"2014","unstructured":"Quint\u00e1ns B, Ord\u00f3\u00f1ez-Ugalde A, Cacheiro P, Carracedo A, Sobrido MJ. Medical genomics: the intricate path from genetic variant identification to clinical interpretation. Appl Transl Genom. 2014;3:60\u20137.","journal-title":"Appl Transl Genom."},{"key":"268_CR28","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Handsaker B, Wysoker A, Fennell T, et al. 1000 Genome Project Data Processing Subgroup. The sequence alignment\/map format and SAMtools. Bioinformatics. 2009;25:2078\u20139.","journal-title":"Bioinformatics"},{"key":"268_CR29","doi-asserted-by":"crossref","unstructured":"The 1000 Genomes Project Consortium. A global reference for human genetic variation. Nature. 2015;526:68\u201374. ftp:\/\/ftp.1000genomes.ebi.ac.uk\/vol1\/ftp\/release\/20130502\/ .","DOI":"10.1038\/nature15393"},{"key":"268_CR30","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/s13104-015-1385-4","volume":"8","author":"E Pranckevi\u010diene","year":"2015","unstructured":"Pranckevi\u010diene E, Ran\u010delis T, Pranculis A, Ku\u010dinskas V. Challenges in exome analysis by LifeScope and its alternative computational pipelines. BMC Res Notes. 2015;8:421.","journal-title":"BMC Res Notes."},{"key":"268_CR31","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/mgg3.223","volume":"4","author":"A Hamilton","year":"2016","unstructured":"Hamilton A, T\u00e9treault M, Dyment DA, Zou R, Kernohan K, Geraghty MT, FORGE Canada Consortium; Care4Rare Canada Consortium, Hartley T, Boycott KM. Concordance between whole-exome sequencing and clinical Sanger sequencing: implications for patient care. Mol Genet Genomic Med. 2016;4:504\u201312.","journal-title":"Mol Genet Genomic Med."},{"key":"268_CR32","doi-asserted-by":"crossref","first-page":"e0143199","DOI":"10.1371\/journal.pone.0143199","volume":"10","author":"MA Field","year":"2015","unstructured":"Field MA, Cho V, Andrews TD, Goodnow CC. Reliably detecting clinically important variants requires both combined variant calls and optimized filtering strategies. PLoS One. 2015;10:e0143199.","journal-title":"PLoS One"},{"key":"268_CR33","doi-asserted-by":"crossref","unstructured":"Chen R, Butte AJ. The reference human genome demonstrates high risk of type 1 diabetes and other disorders. Pac Symp Biocomput. 2011:231\u201342.","DOI":"10.1142\/9789814335058_0025"},{"key":"268_CR34","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/GIM.0b013e31820ed321","volume":"13","author":"B Moore","year":"2011","unstructured":"Moore B, Hu H, Singleton M, De La Vega FM, Reese MG, Yandell M. Global analysis of disease-related DNA sequence variation in 10 healthy individuals: implications for whole genome-based clinical diagnostics. Genet Med. 2011;13:210\u20137.","journal-title":"Genet Med."},{"key":"268_CR35","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1186\/s12864-015-1481-9","volume":"16","author":"A Magi","year":"2015","unstructured":"Magi A, D\u2019Aurizio R, Palombo F, et al. Characterization and identification of hidden rare variants in the human genome. BMC Genom. 2015;16:340.","journal-title":"BMC Genom"},{"key":"268_CR36","doi-asserted-by":"crossref","first-page":"e0132180","DOI":"10.1371\/journal.pone.0132180","volume":"10","author":"A Ferrarini","year":"2015","unstructured":"Ferrarini A, Xumerle L, Griggio F, et al. the use of non-variant sites to improve the clinical assessment of whole-genome sequence data. PLoS One. 2015;10:e0132180.","journal-title":"PLoS One"},{"key":"268_CR37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.1968411","volume":"25","author":"S Balasubramanian","year":"2011","unstructured":"Balasubramanian S, Habegger L, Frankish A, et al. Gene inactivation and its implications for annotation in the era of personal genomics. Genes Dev. 2011;25:1\u201310.","journal-title":"Genes Dev"},{"key":"268_CR38","doi-asserted-by":"crossref","first-page":"e1002280","DOI":"10.1371\/journal.pgen.1002280","volume":"7","author":"FE Dewey","year":"2011","unstructured":"Dewey FE, Chen R, Cordero SP, et al. Phased whole-genome genetic risk in a family quartet using a major allele reference sequence. PLoS Genet. 2011;7:e1002280.","journal-title":"PLoS Genet"},{"key":"268_CR39","doi-asserted-by":"crossref","first-page":"e94554","DOI":"10.1371\/journal.pone.0094554","volume":"9","author":"DL Bodian","year":"2014","unstructured":"Bodian DL, McCutcheon JN, Kothiyal P, et al. Germline variation in cancer-susceptibility genes in a healthy, ancestrally diverse cohort: I for individual genome sequencing. PLoS One. 2014;9:e94554.","journal-title":"PLoS One"},{"key":"268_CR40","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1186\/1756-0500-7-864","volume":"7","author":"DH Ghoneim","year":"2014","unstructured":"Ghoneim DH, Myers JR, Tuttle E, Paciorkowski AR. Comparison of insertion\/deletion calling algorithms on human next-generation sequencing data. BMC Res Notes. 2014;7:864.","journal-title":"BMC Res Notes."},{"key":"268_CR41","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/humu.22387","volume":"34","author":"J Ligt de","year":"2013","unstructured":"de Ligt J, Boone PM, Pfundt R, et al. Detection of clinically relevant copy number variants with whole-exome sequencing. Hum Mutat. 2013;34:1439\u201348.","journal-title":"Hum Mutat"},{"key":"268_CR42","unstructured":"Plagnol V. ExomeDepth: R package version 1.1.10. https:\/\/cran.r-project.org\/web\/packages\/ExomeDepth\/vignettes\/ExomeDepth-vignette.pdf . Accessed 12 Dec 2016."},{"key":"268_CR43","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1136\/jmedgenet-2012-101189","volume":"49","author":"M Futema","year":"2012","unstructured":"Futema M, Plagnol V, Whittall RA, Neil HA, Simon Broome Register Group, Humphries SE, UK10K. Use of targeted exome sequencing as a diagnostic tool for familial hypercholesterolaemia. J Med Genet. 2012;49:644\u20139.","journal-title":"J Med Genet"},{"key":"268_CR44","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/gim.2013.55","volume":"15","author":"J Vandrovcova","year":"2013","unstructured":"Vandrovcova J, Thomas ER, Atanur SS, et al. The use of next-generation sequencing in clinical diagnosis of familial hypercholesterolemia. Genet Med. 2013;15:948\u201357.","journal-title":"Genet Med."},{"key":"268_CR45","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.ejmg.2015.10.001","volume":"58","author":"LR Lopes","year":"2015","unstructured":"Lopes LR, Murphy C, Syrris P, Dalageorgou C, McKenna WJ, Elliott PM, Plagnol V. Use of high-throughput targeted exome-sequencing to screen for copy number variation in hypertrophic cardiomyopathy. Eur J Med Genet. 2015;58:611\u20136.","journal-title":"Eur J Med Genet."},{"key":"268_CR46","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1093\/bib\/bbu027","volume":"16","author":"L Kadalayil","year":"2015","unstructured":"Kadalayil L, Rafiq S, Rose-Zerilli MJ, et al. Exome sequence read depth methods for identifying copy number changes. Brief Bioinform. 2015;16:380\u201392.","journal-title":"Brief Bioinform."},{"key":"268_CR47","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13073-014-0089-z","volume":"6","author":"H Fang","year":"2014","unstructured":"Fang H, Wu Y, Narzisi G, et al. Reducing INDEL calling errors in whole genome and exome sequencing data. Genome Med. 2014;6:89.","journal-title":"Genome Med."},{"key":"268_CR48","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1186\/s12864-015-2050-y","volume":"16","author":"A G\u00e9zsi","year":"2015","unstructured":"G\u00e9zsi A, Bolg\u00e1r B, Marx P, et al. VariantMetaCaller: automated fusion of variant calling pipelines for quantitative, precision-based filtering. BMC Genom. 2015;16:875.","journal-title":"BMC Genom"}],"container-title":["Molecular Diagnosis & Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40291-017-0268-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40291-017-0268-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40291-017-0268-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T13:27:27Z","timestamp":1568899647000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40291-017-0268-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,13]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["268"],"URL":"https:\/\/doi.org\/10.1007\/s40291-017-0268-x","relation":{},"ISSN":["1177-1062","1179-2000"],"issn-type":[{"value":"1177-1062","type":"print"},{"value":"1179-2000","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,13]]}}}