{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T15:39:54Z","timestamp":1770737994895,"version":"3.49.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Suez Canal University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Diagn Ther"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s40291-022-00598-y","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T20:02:51Z","timestamp":1656360171000},"page":"451-465","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The lncRNA PRINS-miRNA-mRNA Axis Gene Expression Profile as a Circulating Biomarker Panel in Psoriasis"],"prefix":"10.1007","volume":"26","author":[{"given":"Hoda Y.","family":"Abdallah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha Z.","family":"Tawfik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nourhan Hassan","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loaa A. Tag","family":"Eldeen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"issue":"12","key":"598_CR1","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1038\/nm.3016","volume":"18","author":"B Becher","year":"2012","unstructured":"Becher B, Pantelyushin S. Hiding under the skin: interleukin-17\u2013producing \u03b3\u03b4 T cells go under the skin? Nat Med. 2012;18(12):1748\u201350.","journal-title":"Nat Med"},{"issue":"2","key":"598_CR2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/jid.2012.339","volume":"133","author":"R Parisi","year":"2013","unstructured":"Parisi R, Symmons DP, Griffiths CE, Ashcroft DM. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Investig Dermatol. 2013;133(2):377\u201385.","journal-title":"J Investig Dermatol"},{"issue":"3","key":"598_CR3","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/bjd.15021","volume":"176","author":"DA Springate","year":"2017","unstructured":"Springate DA, Parisi R, Kontopantelis E, Reeves D, Griffiths CE, Ashcroft DM. Incidence, prevalence and mortality of patients with psoriasis: a UK population-based cohort study. Br J Dermatol. 2017;176(3):650\u20138.","journal-title":"Br J Dermatol"},{"issue":"11","key":"598_CR4","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1001\/jama.2015.10414","volume":"314","author":"AP Feinberg","year":"2015","unstructured":"Feinberg AP, Fallin MD. Epigenetics at the crossroads of genes and the environment. JAMA. 2015;314(11):1129\u201330.","journal-title":"JAMA"},{"issue":"7","key":"598_CR5","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1101\/gad.1787609","volume":"23","author":"SL Berger","year":"2009","unstructured":"Berger SL, Kouzarides T, Shiekhattar R, Shilatifard A. An operational definition of epigenetics. Genes Dev. 2009;23(7):781\u20133.","journal-title":"Genes Dev"},{"issue":"4","key":"598_CR6","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2007.02.006","volume":"128","author":"AD Goldberg","year":"2007","unstructured":"Goldberg AD, Allis CD, Bernstein E. Epigenetics: a landscape takes shape. Cell. 2007;128(4):635\u20138.","journal-title":"Cell"},{"issue":"7","key":"598_CR7","doi-asserted-by":"crossref","first-page":"R233","DOI":"10.1016\/j.cub.2007.02.030","volume":"17","author":"M Ptashne","year":"2007","unstructured":"Ptashne M. On the use of the word \u2018epigenetic.\u2019 Curr Biol. 2007;17(7):R233\u20136.","journal-title":"Curr Biol"},{"issue":"14","key":"598_CR8","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1101\/gad.1324305","volume":"19","author":"E Bernstein","year":"2005","unstructured":"Bernstein E, Allis CD. RNA meets chromatin. Gen Dev. 2005;19(14):1635\u201355.","journal-title":"Gen Dev"},{"issue":"1","key":"598_CR9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3892\/or.2016.5236","volume":"37","author":"JW Wei","year":"2017","unstructured":"Wei JW, Huang K, Yang C, Kang CS. Non-coding RNAs as regulators in epigenetics. Oncol Rep. 2017;37(1):3\u20139.","journal-title":"Oncol Rep"},{"issue":"1","key":"598_CR10","first-page":"151","volume":"1856","author":"A Bhan","year":"2015","unstructured":"Bhan A, Mandal SS. LncRNA HOTAIR: a master regulator of chromatin dynamics and cancer. Biochim Biophys Acta. 2015;1856(1):151\u201364.","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"598_CR11","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s00424-016-1803-z","volume":"468","author":"M Sz\u00e9ll","year":"2016","unstructured":"Sz\u00e9ll M, Danis J, Bata-Cs\u00f6rg\u0151 Z, Kem\u00e9ny L. PRINS, a primate-specific long non-coding RNA, plays a role in the keratinocyte stress response and psoriasis pathogenesis. Pflugers Arch. 2016;468(6):935\u201343.","journal-title":"Pflugers Arch"},{"issue":"1","key":"598_CR12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3390\/ijms14010205","volume":"14","author":"K Szegedi","year":"2013","unstructured":"Szegedi K, G\u00f6bl\u00f6s A, Bacsa S, Antal M, N\u00e9meth IB, Bata-Cs\u00f6rg\u0151 Z, et al. Expression and functional studies on the noncoding RNA. PRINS Int J Mol Sci. 2013;14(1):205\u201325.","journal-title":"PRINS. Int J Mol Sci."},{"issue":"23","key":"598_CR13","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1038\/onc.2010.646","volume":"30","author":"E Colombo","year":"2011","unstructured":"Colombo E, Alcalay M, Pelicci PG. Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases. Oncogene. 2011;30(23):2595\u2013609.","journal-title":"Oncogene"},{"issue":"2","key":"598_CR14","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.molimm.2014.12.014","volume":"64","author":"A Chandra","year":"2015","unstructured":"Chandra A, Ray A, Senapati S, Chatterjee R. Genetic and epigenetic basis of psoriasis pathogenesis. Mol Immunol. 2015;64(2):313\u201323.","journal-title":"Mol Immunol"},{"issue":"3","key":"598_CR15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/exd.12604","volume":"24","author":"MB L\u00f8vendorf","year":"2015","unstructured":"L\u00f8vendorf MB, Mitsui H, Zibert JR, R\u00f8pke MA, Hafner M, Dyring-Andersen B, et al. Laser capture microdissection followed by next-generation sequencing identifies disease-related microRNA s in psoriatic skin that reflect systemic micro RNA changes in psoriasis. Exp Dermatol. 2015;24(3):187\u201393.","journal-title":"Exp Dermatol"},{"issue":"7","key":"598_CR16","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1111\/jdv.13132","volume":"29","author":"C Chow","year":"2015","unstructured":"Chow C, Simpson MJ, Luger TA, Chubb H, Ellis CN. Comparison of three methods for measuring psoriasis severity in clinical studies (part 1 of 2): change during therapy in psoriasis area and severity index, static Physician\u2019s Global Assessment and lattice system Physician\u2019s Global Assessment. J Eur Acad Dermatol Venereol. 2015;29(7):1406\u201314.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"D1","key":"598_CR17","doi-asserted-by":"crossref","first-page":"D1013","DOI":"10.1093\/nar\/gky1010","volume":"47","author":"Z Huang","year":"2019","unstructured":"Huang Z, Shi J, Gao Y, Cui C, Zhang S, Li J, et al. HMDD v.30: a database for experimentally supported human microRNA\u2013disease associations. Nucleic Acids Res. 2019;47(D1):D1013\u20137.","journal-title":"Nucleic Acids Res"},{"issue":"Suppl_1","key":"598_CR18","doi-asserted-by":"crossref","first-page":"D98","DOI":"10.1093\/nar\/gkn714","volume":"37","author":"Q Jiang","year":"2009","unstructured":"Jiang Q, Wang Y, Hao Y, Juan L, Teng M, Zhang X, et al. miR2Disease: a manually curated database for microRNA deregulation in human disease. Nucleic Acids Res. 2009;37(Suppl_1):D98-104.","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"598_CR19","doi-asserted-by":"crossref","first-page":"D1034","DOI":"10.1093\/nar\/gky905","volume":"47","author":"Z Bao","year":"2019","unstructured":"Bao Z, Yang Z, Huang Z, Zhou Y, Cui Q, Dong D. LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases. Nucleic Acids Res. 2019;47(D1):D1034\u20137.","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"598_CR20","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta C(T)) method. Methods. 2001;25(4):402\u20138. https:\/\/doi.org\/10.1006\/meth.2001.1262.","journal-title":"Methods"},{"issue":"3","key":"598_CR21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1089\/omi.2015.0168","volume":"20","author":"S Ben-Ari Fuchs","year":"2016","unstructured":"Ben-Ari Fuchs S, Lieder I, Stelzer G, Mazor Y, Buzhor E, Kaplan S, et al. GeneAnalytics: an integrative gene set analysis tool for next generation sequencing, RNAseq and microarray data. OMICS. 2016;20(3):139\u201351.","journal-title":"OMICS"},{"issue":"1","key":"598_CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-014-0577-x","volume":"16","author":"BJ Kelly","year":"2015","unstructured":"Kelly BJ, Fitch JR, Hu Y, Corsmeier DJ, Zhong H, Wetzel AN, et al. Churchill: an ultra-fast, deterministic, highly scalable and balanced parallelization strategy for the discovery of human genetic variation in clinical and population-scale genomics. Genome Biol. 2015;16(1):1\u20134.","journal-title":"Genome Biol"},{"issue":"7","key":"598_CR23","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1038\/jid.2014.28","volume":"134","author":"B Li","year":"2014","unstructured":"Li B, Tsoi LC, Swindell WR, Gudjonsson JE, Tejasvi T, Johnston A, et al. Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms. J Investig Dermatol. 2014;134(7):1828\u201338.","journal-title":"J Investig Dermatol"},{"issue":"25","key":"598_CR24","doi-asserted-by":"crossref","first-page":"24159","DOI":"10.1074\/jbc.M501704200","volume":"280","author":"E Sonkoly","year":"2005","unstructured":"Sonkoly E, Bata-Csorgo Z, Pivarcsi A, Polyanka H, Kenderessy-Szabo A, Molnar G, et al. Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene. PRINS J Biol Chem. 2005;280(25):24159\u201367.","journal-title":"PRINS. J Biol Chem."},{"issue":"4","key":"598_CR25","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.autrev.2014.11.012","volume":"14","author":"M Diani","year":"2015","unstructured":"Diani M, Altomare G, Reali E. T cell responses in psoriasis and psoriatic arthritis. Autoimmun Rev. 2015;14(4):286\u201392.","journal-title":"Autoimmun Rev"},{"issue":"1","key":"598_CR26","doi-asserted-by":"crossref","first-page":"13831","DOI":"10.1038\/s41598-017-14365-1","volume":"7","author":"NN Mehta","year":"2017","unstructured":"Mehta NN, Teague HL, Swindell WR, Baumer Y, Ward NL, Xing X, et al. IFN-\u03b3 and TNF-\u03b1 synergism may provide a link between psoriasis and inflammatory atherogenesis. Sci Rep. 2017;7(1):13831.","journal-title":"Sci Rep"},{"issue":"5","key":"598_CR27","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00109-009-0457-0","volume":"87","author":"K Wolk","year":"2009","unstructured":"Wolk K, Haugen HS, Xu W, Witte E, Waggie K, Anderson M, et al. IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-\u03b3 are not. J Mol Med. 2009;87(5):523\u201336.","journal-title":"J Mol Med"},{"issue":"8","key":"598_CR28","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1002\/jcp.24337.PMID:23359533;PMCID:PMC4072032","volume":"228","author":"I Chrobak","year":"2013","unstructured":"Chrobak I, Lenna S, Stawski L, Trojanowska M. Interferon-\u03b3 promotes vascular remodeling in human microvascular endothelial cells by upregulating endothelin (ET)-1 and transforming growth factor (TGF) \u03b22. J Cell Physiol. 2013;228(8):1774\u201383. https:\/\/doi.org\/10.1002\/jcp.24337.PMID:23359533;PMCID:PMC4072032.","journal-title":"J Cell Physiol"},{"key":"598_CR29","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1038\/s41375-018-0117-x","volume":"32","author":"B Wingelhofer","year":"2018","unstructured":"Wingelhofer B, Neubauer HA, Valent P, Han X, Constantinescu SN, Gunning PT, et al. Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer. Leukemia. 2018;32:1713\u201326.","journal-title":"Leukemia"},{"issue":"12","key":"598_CR30","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1038\/s41375-021-01296-0","volume":"35","author":"D Kim","year":"2021","unstructured":"Kim D, Park G, Huuhtanen J, Ghimire B, Rajala H, Moriggl R, et al. STAT3 activation in large granular lymphocyte leukemia is associated with cytokine signaling and DNA hypermethylation. Leukemia. 2021;35(12):3430\u201343.","journal-title":"Leukemia"},{"issue":"1","key":"598_CR31","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nm1162","volume":"11","author":"S Sano","year":"2005","unstructured":"Sano S, Chan KS, Carbajal S, Clifford J, Peavey M, Kiguchi K, et al. Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med. 2005;11(1):43\u20139.","journal-title":"Nat Med"},{"issue":"9","key":"598_CR32","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3390\/life10090157","volume":"10","author":"YJ Hwang","year":"2020","unstructured":"Hwang YJ, Na JI, Byun SY, Kwon SH, Yang SH, Lee HS, et al. Histone deacetylase 1 and Sirtuin 1 expression in psoriatic skin: a comparison between guttate and plaque psoriasis. Life. 2020;10(9):157.","journal-title":"Life"},{"key":"598_CR33","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1684\/ejd.2011.1383","volume":"21","author":"P Zhang","year":"2011","unstructured":"Zhang P, Su Y, Zhao M, Huang W, Lu Q. Abnormal histone modifications in PBMCs from patients with psoriasis vulgaris. Eur J Dermatol. 2011;21:552\u20137.","journal-title":"Eur J Dermatol"},{"issue":"8","key":"598_CR34","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.3389\/fimmu.2017.01053","volume":"29","author":"J Danis","year":"2017","unstructured":"Danis J, G\u00f6bl\u00f6s A, Bata-Cs\u00f6rg\u0151 Z, Kem\u00e9ny L, Sz\u00e9ll M. PRINS non-coding RNA regulates nucleic acid-induced innate immune responses of human keratinocytes. Front Immunol. 2017;29(8):1053.","journal-title":"Front Immunol"},{"issue":"3","key":"598_CR35","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1600-0625.2010.01066.x","volume":"19","author":"K Szegedi","year":"2010","unstructured":"Szegedi K, Sonkoly E, Nagy N, N\u00e9meth IB, Bata-Cs\u00f6rg\u0151 Z, Kem\u00e9ny L, et al. The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS. Exp Dermatol. 2010;19(3):269\u201378.","journal-title":"Exp Dermatol"},{"issue":"1","key":"598_CR36","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1084\/jem.20050500","volume":"202","author":"FO Nestle","year":"2005","unstructured":"Nestle FO, Conrad C, Tun-Kyi A, Homey B, Gombert M, Boyman O, et al. Plasmacytoid predendritic cells initiate psoriasis through interferon-\u03b1 production. J Exp Med. 2005;202(1):135\u201343.","journal-title":"J Exp Med"},{"issue":"1","key":"598_CR37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ncrna.2016.11.002","volume":"1","author":"SA Bhat","year":"2016","unstructured":"Bhat SA, Ahmad SM, Mumtaz PT, Malik AA, Dar MA, Urwat U, et al. Long non-coding RNAs: mechanism of action and functional utility. Noncoding RNA Res. 2016;1(1):43\u201350.","journal-title":"Noncoding RNA Res"},{"issue":"257","key":"598_CR38","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.virusres.2018.08.018","volume":"15","author":"L Chen","year":"2018","unstructured":"Chen L, Zhou Y, Li H. LncRNA, miRNA and lncRNA-miRNA interaction in viral infection. Virus Res. 2018;15(257):25\u201332.","journal-title":"Virus Res"},{"key":"598_CR39","volume":"10","author":"FM Schmidt","year":"2015","unstructured":"Schmidt FM, Weschenfelder J, Sander C, Minkwitz J, Thormann J, Chittka T, et al. Inflammatory cytokines in general and central obesity and modulating effects of physical activity. PLoS\u00a0One. 2015;10: e0121971.","journal-title":"PLoS\u00a0One"},{"issue":"27","key":"598_CR40","doi-asserted-by":"crossref","first-page":"25179","DOI":"10.1074\/jbc.M302706200","volume":"278","author":"X Wang","year":"2003","unstructured":"Wang X, Phelan SA, Forsman-Semb K. Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress. J Biol Chem. 2003;278(27):25179\u201390.","journal-title":"J Biol Chem"},{"issue":"12","key":"598_CR41","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1002\/jcb.26135","volume":"118","author":"GY Liu","year":"2017","unstructured":"Liu GY, Shi JX, Shi SL, Liu F, Rui G, Li X, et al. Nucleophosmin regulates intracellular oxidative stress homeostasis via antioxidant PRDX6. J Cell Biochem. 2017;118(12):4697\u2013707.","journal-title":"J Cell Biochem"},{"issue":"11","key":"598_CR42","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1002\/oby.21654","volume":"24","author":"F McMurray","year":"2016","unstructured":"McMurray F, Patten DA, Harper ME. Reactive oxygen species and oxidative stress in obesity: recent findings and empirical approaches. Obesity (Silver Spring). 2016;24(11):2301\u201310.","journal-title":"Obesity (Silver Spring)"},{"issue":"2","key":"598_CR43","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/oby.2010.166","volume":"19","author":"W Zhang","year":"2011","unstructured":"Zhang W, Ambati S, Della-Fera MA, Choi YH, Baile CA, Andacht TM. Leptin modulated changes in adipose tissue protein expression in OB\/OB mice. Obesity. 2011;19(2):255\u201361.","journal-title":"Obesity"},{"issue":"2","key":"598_CR44","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.imlet.2012.09.004","volume":"148","author":"P Xia","year":"2012","unstructured":"Xia P, Fang X, Zhang ZH, Huang Q, Yan KX, Kang KF, et al. Dysregulation of miRNA146a versus IRAK1 induces IL-17 persistence in the psoriatic skin lesions. Immunol Lett. 2012;148(2):151\u201362.","journal-title":"Immunol Lett"},{"issue":"15","key":"598_CR45","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1080\/15384101.2020.1783934","volume":"19","author":"Y Xiao","year":"2020","unstructured":"Xiao Y, Wang H, Wang C, Zeng B, Tang X, Zhang Y, et al. miR-203 promotes HaCaT cell overproliferation through targeting LXR-\u03b1 and PPAR-\u03b3. Cell Cycle. 2020;19(15):1928\u201340.","journal-title":"Cell Cycle"},{"issue":"122","key":"598_CR46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.molimm.2020.04.002","volume":"1","author":"Y Xiao","year":"2020","unstructured":"Xiao Y, Wang C, Zeng B, Tang X, Zhang Y, Xiang L, et al. miR124-3p\/FGFR2 axis inhibits human keratinocyte proliferation and migration and improve the inflammatory microenvironment in psoriasis. Mol Immunol. 2020;1(122):89\u201398.","journal-title":"Mol Immunol"},{"issue":"45","key":"598_CR47","doi-asserted-by":"crossref","first-page":"e2030","DOI":"10.1097\/MD.0000000000002030","volume":"94","author":"RY Huang","year":"2015","unstructured":"Huang RY, Li L, Wang MJ, Chen XM, Huang QC, Lu CJ. An exploration of the role of microRNAs in psoriasis: a systematic review of the literature. Medicine. 2015;94(45):e2030.","journal-title":"Medicine"},{"issue":"108","key":"598_CR48","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.biopha.2018.09.090","volume":"1","author":"G Singhvi","year":"2018","unstructured":"Singhvi G, Manchanda P, Rapalli VK, Dubey SK, Gupta G, Dua K. MicroRNAs as biological regulators in skin disorders. Biomed Pharmacother. 2018;1(108):996\u20131004.","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"598_CR49","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/bjd.13721","volume":"173","author":"L Raaby","year":"2015","unstructured":"Raaby L, Langkilde A, Kjellerup RB, Vinter H, Khatib SH, Hjuler KF, et al. Changes in mRNA expression precede changes in micro RNA expression in lesional psoriatic skin during treatment with adalimumab. Br J Dermatol. 2015;173(2):436\u201347.","journal-title":"Br J Dermatol"},{"issue":"5","key":"598_CR50","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1002\/art.24475","volume":"60","author":"Y Nakamachi","year":"2009","unstructured":"Nakamachi Y, Kawano S, Takenokuchi M, Nishimura K, Sakai Y, Chin T, et al. MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis Rheum. 2009;60(5):1294\u2013304.","journal-title":"Arthritis Rheum"},{"issue":"11","key":"598_CR51","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/cr.2013.116","volume":"23","author":"Y Sun","year":"2013","unstructured":"Sun Y, Li Q, Gui H, Xu DP, Yang YL, Su DF, et al. MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines. Cell Res. 2013;23(11):1270\u201383.","journal-title":"Cell Res"},{"issue":"1","key":"598_CR52","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.molimm.2014.06.014","volume":"62","author":"C Ma","year":"2014","unstructured":"Ma C, Li Y, Li M, Deng G, Wu X, Zeng J, et al. microRNA-124 negatively regulates TLR signaling in alveolar macrophages in response to mycobacterial infection. Mol Immunol. 2014;62(1):150\u20138.","journal-title":"Mol Immunol"},{"issue":"2","key":"598_CR53","first-page":"1","volume":"22","author":"L Zhu","year":"2021","unstructured":"Zhu L, Mei M. Interference of long non-coding RNA HAGLROS inhibits the proliferation and promotes the apoptosis of ovarian cancer cells by targeting miR-26b-5p. Exp Ther Med. 2021;22(2):1\u20138.","journal-title":"Exp Ther Med"},{"issue":"5","key":"598_CR54","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s12026-020-09149-1","volume":"68","author":"B Li","year":"2020","unstructured":"Li B, Huang L, Lv P, Li X, Liu G, Chen Y, et al. The role of Th17 cells in psoriasis. Immunol Res. 2020;68(5):296\u2013309.","journal-title":"Immunol Res"},{"issue":"1","key":"598_CR55","first-page":"1","volume":"5","author":"H Yao","year":"2014","unstructured":"Yao H, Ma R, Yang L, Hu G, Chen X, Duan M, et al. MiR-9 promotes microglial activation by targeting MCPIP1. Nat Commun. 2014;5(1):1\u20132.","journal-title":"Nat Commun"},{"issue":"5","key":"598_CR56","volume":"10","author":"TN Kj\u00e6r","year":"2015","unstructured":"Kj\u00e6r TN, Thorsen K, Jessen N, Stenderup K, Pedersen SB. Resveratrol ameliorates imiquimod-induced psoriasis-like skin inflammation in mice. PLoS\u00a0One. 2015;10(5): e0126599.","journal-title":"PLoS\u00a0One"},{"issue":"11","key":"598_CR57","volume":"6","author":"C Marban","year":"2011","unstructured":"Marban C, Su T, Ferrari R, Li B, Vatakis D, et al. Genome-wide binding map of the HIV-1 Tat protein to the human genome. PLoS\u00a0One. 2011;6(11): e26894.","journal-title":"PLoS\u00a0One"},{"issue":"9","key":"598_CR58","volume":"29","author":"E Alzyoud","year":"2021","unstructured":"Alzyoud E, Vedelek V, R\u00e9thi-Nagy Z, Lipinszki Z, Sinka R. Microtubule organizing centers contain testis-specific \u03b3-TuRC proteins in spermatids of Drosophila. Front Cell Dev Biol. 2021;29(9): 727264.","journal-title":"Front Cell Dev Biol"},{"issue":"5","key":"598_CR59","doi-asserted-by":"crossref","first-page":"e21534","DOI":"10.1096\/fj.201903253R","volume":"35","author":"X Chen","year":"2021","unstructured":"Chen X, He X, Guo Y, Liu L, Li H, Tan J, et al. Glucose-dependent insulinotropic polypeptide modifies adipose plasticity and promotes beige adipogenesis of human omental adipose-derived stem cells. FASEB J. 2021;35(5):e21534 (Erratum in: FASEB J. 2021 Jul;35(7):e21659).","journal-title":"FASEB J"},{"key":"598_CR60","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1038\/onc.2009.275","volume":"28","author":"Y Jian","year":"2009","unstructured":"Jian Y, Gao Z, Sun J, et al. RNA aptamers interfering with nucleophosmin oligomerization induce apoptosis of cancer cells. Oncogene. 2009;28:4201\u201311.","journal-title":"Oncogene"},{"issue":"6","key":"598_CR61","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00011-020-01346-w","volume":"69","author":"J Shao","year":"2020","unstructured":"Shao J, Ding Z, Peng J, Zhou R, Li L, Qian Q, et al. MiR-146a-5p promotes IL-1\u03b2-induced chondrocyte apoptosis through the TRAF6-mediated NF-kB pathway. Inflamm Res. 2020;69(6):619\u201330.","journal-title":"Inflamm Res"},{"issue":"4","key":"598_CR62","doi-asserted-by":"publisher","first-page":"e1533","DOI":"10.1002\/wrna.1533","volume":"10","author":"JR Iacona","year":"2019","unstructured":"Iacona JR, Lutz CS. miR-146a-5p: expression, regulation, and functions in cancer. Wiley Interdiscip Rev RNA. 2019;10(4):e1533. https:\/\/doi.org\/10.1002\/wrna.1533 (Epub 2019 Mar 20. PMID: 30895717).","journal-title":"Wiley Interdiscip Rev RNA"},{"issue":"1","key":"598_CR63","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1089\/jir.2010.0105","volume":"31","author":"V Cheriyath","year":"2011","unstructured":"Cheriyath V, Leaman DW, Borden EC. Emerging roles of FAM14 family members (G1P3\/ISG 6\u201316 and ISG12\/IFI27) in innate immunity and cancer. J Interferon Cytokine Res. 2011;31(1):173\u201381.","journal-title":"J Interferon Cytokine Res"},{"issue":"5","key":"598_CR64","first-page":"3667","volume":"19","author":"P Shi","year":"2019","unstructured":"Shi P, Chen C, Li X, Wei Z, Liu Z, Liu Y. MicroRNA-124 suppresses cell proliferation and invasion of triple negative breast cancer cells by targeting STAT3. Mol Med Rep. 2019;19(5):3667\u201375.","journal-title":"Mol Med Rep"},{"issue":"9","key":"598_CR65","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.jid.2017.05.012","volume":"137","author":"H Hermann","year":"2017","unstructured":"Hermann H, Runnel T, Aab A, Baurecht H, Rodriguez E, Magilnick N, et al. miR-146b probably assists miRNA-146a in the suppression of keratinocyte proliferation and inflammatory responses in psoriasis. J Investig Dermatol. 2017;137(9):1945\u201354.","journal-title":"J Investig Dermatol"},{"issue":"4","key":"598_CR66","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s12276-022-00757-5","volume":"54","author":"YK Kim","year":"2022","unstructured":"Kim YK. RNA therapy: rich history, various applications, and unlimited prospects. Exp Mol Med. 2022;54(4):455\u201365.","journal-title":"Exp Mol Med"},{"key":"598_CR67","doi-asserted-by":"crossref","DOI":"10.1002\/wrna.1662","volume":"12","author":"LF Sempere","year":"2021","unstructured":"Sempere LF, Azmi AS, Moore A. microRNA-based diagnostic and therapeutic applications in cancer medicine. Wiley Interdiscip Rev RNA. 2021;12: e1662.","journal-title":"Wiley Interdiscip Rev RNA"},{"issue":"1","key":"598_CR68","doi-asserted-by":"crossref","first-page":"220","DOI":"10.7150\/ijbs.50730","volume":"17","author":"D Yuan","year":"2021","unstructured":"Yuan D, Chen Y, Li X, Li J, Zhao Y, Shen J, et al. Long non-coding RNAs: potential biomarkers and targets for hepatocellular carcinoma therapy and diagnosis. Int J Biol Sci. 2021;17(1):220\u201335.","journal-title":"Int J Biol Sci"}],"container-title":["Molecular Diagnosis & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40291-022-00598-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40291-022-00598-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40291-022-00598-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T09:33:18Z","timestamp":1657704798000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40291-022-00598-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,27]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["598"],"URL":"https:\/\/doi.org\/10.1007\/s40291-022-00598-y","relation":{},"ISSN":["1177-1062","1179-2000"],"issn-type":[{"value":"1177-1062","type":"print"},{"value":"1179-2000","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,27]]},"assertion":[{"value":"15 May 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB). Article processing charge (APC) was funded by the Egyptian Science, Technology & Innovation Funding Authority (STDF) via the Springer Nature - Egyptian open access agreement for supporting researchers inside Egypt.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors have no conflicts of interest that are directly relevant to the content of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Suez Canal University, Faculty of Medicine, Ethics Committee in Ismailia, Egypt (Approval No. 4503) and conducted according to the Declaration of Helsinki\u2019s guidelines.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The datasets used and\/or analyzed during the current study are available from the corresponding author on reasonable request.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"HYA and NZT designed the study, NZT collected the clinical data, NHS collected the patients\u2019 samples, HYA, NHS, and LATE carried out the experiments, and HYA and LATE analyzed and interpreted the patient data. All authors discussed the results, contributed to the final manuscript, and approved it for publication.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 contributions"}}]}}