{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:05:58Z","timestamp":1789049158397,"version":"build-2803163510"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Diagn Ther"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1007\/s40291-024-00714-0","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T03:38:20Z","timestamp":1716349100000},"page":"379-388","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["MicroRNA-146a Signature in Psoriasis: A Systematic Review and Meta-Analysis"],"prefix":"10.1007","volume":"28","author":[{"given":"Pei-Yun","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6382-3520","authenticated-orcid":false,"given":"Yu-Chen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"issue":"21","key":"714_CR1","doi-asserted-by":"publisher","first-page":"11574","DOI":"10.3390\/ijms222111574","volume":"22","author":"M Vi\u010di\u0107","year":"2021","unstructured":"Vi\u010di\u0107 M, Ka\u0161telan M, Brajac I, Soto\u0161ek V, Massari LP. Current concepts of psoriasis immunopathogenesis. Int J Mol Sci. 2021;22(21):11574. https:\/\/doi.org\/10.3390\/ijms222111574.","journal-title":"Int J Mol Sci"},{"key":"714_CR2","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3892\/br.2018.1146","volume":"9","author":"TL Timis","year":"2018","unstructured":"Timis TL, Orasan RI. Understanding psoriasis: role of miRNAs. Biomed Rep. 2018;9:367\u201374. https:\/\/doi.org\/10.3892\/br.2018.1146.","journal-title":"Biomed Rep."},{"key":"714_CR3","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3389\/fendo.2018.00402","volume":"9","author":"J O'Brien","year":"2018","unstructured":"O\u2019Brien J, Hayder H, Zayed Y, et al. Overview of MicroRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne). 2018;9:402. https:\/\/doi.org\/10.3389\/fendo.2018.00402.","journal-title":"Front Endocrinol (Lausanne)."},{"key":"714_CR4","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/s0960-9822(02)00809-6","volume":"12","author":"M Lagos-Quintana","year":"2002","unstructured":"Lagos-Quintana M, Rauhut R, Yalcin A, et al. Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002;12:735\u20139. https:\/\/doi.org\/10.1016\/s0960-9822(02)00809-6.","journal-title":"Curr Biol"},{"key":"714_CR5","doi-asserted-by":"publisher","first-page":"10513","DOI":"10.1073\/pnas.0804549105","volume":"105","author":"PS Mitchell","year":"2008","unstructured":"Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA. 2008;105:10513\u20138. https:\/\/doi.org\/10.1073\/pnas.0804549105.","journal-title":"Proc Natl Acad Sci USA"},{"key":"714_CR6","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/nrd.2016.246","volume":"16","author":"R Rupaimoole","year":"2017","unstructured":"Rupaimoole R, Slack FJ. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 2017;16:203\u201322. https:\/\/doi.org\/10.1038\/nrd.2016.246.","journal-title":"Nat Rev Drug Discov"},{"key":"714_CR7","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.gpb.2012.07.005","volume":"10","author":"Y Li","year":"2012","unstructured":"Li Y, Kowdley KV. MicroRNAs in common human diseases. Genom Proteom Bioinf. 2012;10:246\u201353. https:\/\/doi.org\/10.1016\/j.gpb.2012.07.005.","journal-title":"Genom Proteom Bioinf"},{"key":"714_CR8","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.jconrel.2017.11.013","volume":"269","author":"K Ross","year":"2018","unstructured":"Ross K. Towards topical microRNA-directed therapy for epidermal disorders. J Control Rel. 2018;269:136\u201347. https:\/\/doi.org\/10.1016\/j.jconrel.2017.11.013.","journal-title":"J Control Rel"},{"key":"714_CR9","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/j.1365-3083.2010.02383.x","volume":"71","author":"L Li","year":"2010","unstructured":"Li L, Chen XP, Li YJ. MicroRNA-146a and human disease. Scand J Immunol. 2010;71:227\u201331. https:\/\/doi.org\/10.1111\/j.1365-3083.2010.02383.x.","journal-title":"Scand J Immunol"},{"issue":"7","key":"714_CR10","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1038\/jid.2014.89","volume":"134","author":"F Meisgen","year":"2014","unstructured":"Meisgen F, Xu Land\u00e9n N, Wang A, et al. MiR-146a negatively regulates TLR2-induced inflammatory responses in keratinocytes. J Invest Dermatol. 2014;134(7):1931\u201340. https:\/\/doi.org\/10.1038\/jid.2014.89.","journal-title":"J Invest Dermatol"},{"issue":"2","key":"714_CR11","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.jaci.2016.07.025","volume":"139","author":"A Srivastava","year":"2017","unstructured":"Srivastava A, Nikamo P, Lohcharoenkal W, et al. MicroRNA-146a suppresses IL-17-mediated skin inflammation and is genetically associated with psoriasis. J Allergy Clin Immunol. 2017;139(2):550\u201361. https:\/\/doi.org\/10.1016\/j.jaci.2016.07.025.","journal-title":"J Allergy Clin Immunol"},{"key":"714_CR12","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.imlet.2012.09.004","volume":"148","author":"P Xia","year":"2012","unstructured":"Xia P, Fang X, Zhang ZH, et al. Dysregulation of miRNA146a versus IRAK1 induces IL-17 persistence in the psoriatic skin lesions. Immunol Lett. 2012;148:151\u201362. https:\/\/doi.org\/10.1016\/j.imlet.2012.09.004.","journal-title":"Immunol Lett"},{"key":"714_CR13","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.jdermsci.2014.01.005","volume":"74","author":"Y Koga","year":"2014","unstructured":"Koga Y, Jinnin M, Ichihara A, et al. Analysis of expression pattern of serum microRNA levels in patients with psoriasis. J Dermatol Sci. 2014;74:170\u20131. https:\/\/doi.org\/10.1016\/j.jdermsci.2014.01.005.","journal-title":"J Dermatol Sci"},{"key":"714_CR14","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/145769","volume":"2015","author":"AM Ele-Refaei","year":"2015","unstructured":"Ele-Refaei AM, El-Esawy FM. Effect of narrow-band ultraviolet B phototherapy and methotrexate on MicroRNA (146a) levels in blood of psoriatic patients. Dermatol Res Pract. 2015;2015: 145769. https:\/\/doi.org\/10.1155\/2015\/145769.","journal-title":"Dermatol Res Pract"},{"key":"714_CR15","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1111\/bjd.13721","volume":"173","author":"L Raaby","year":"2015","unstructured":"Raaby L, Langkilde A, Kjellerup RB, et al. Changes in mRNA expression precede changes in microRNA expression in lesional psoriatic skin during treatment with adalimumab. Br J Dermatol. 2015;173:436\u201347. https:\/\/doi.org\/10.1111\/bjd.13721.","journal-title":"Br J Dermatol"},{"key":"714_CR16","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.jep.2016.08.028","volume":"194","author":"Z Yang","year":"2016","unstructured":"Yang Z, Zeng B, Tang X, et al. MicroRNA-146a and miR-99a are potential biomarkers for disease activity and clinical efficacy assessment in psoriasis patients treated with traditional Chinese medicine. J Ethnopharmacol. 2016;194:727\u201332. https:\/\/doi.org\/10.1016\/j.jep.2016.08.028.","journal-title":"J Ethnopharmacol"},{"key":"714_CR17","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1016\/j.jid.2017.05.012","volume":"137","author":"H Hermann","year":"2017","unstructured":"Hermann H, Runnel T, Aab A, et al. miR-146b probably assists miRNA-146a in the suppression of keratinocyte proliferation and inflammatory responses in psoriasis. J Invest Dermatol. 2017;137:1945\u201354. https:\/\/doi.org\/10.1016\/j.jid.2017.05.012.","journal-title":"J Invest Dermatol"},{"key":"714_CR18","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1111\/bjd.16659","volume":"179","author":"E Mens\u00e0","year":"2018","unstructured":"Mens\u00e0 E, Recchioni R, Marcheselli F, et al. MiR-146a-5p correlates with clinical efficacy in patients with psoriasis treated with the tumour necrosis factor-alpha inhibitor adalimumab. Br J Dermatol. 2018;179:787\u20139. https:\/\/doi.org\/10.1111\/bjd.16659.","journal-title":"Br J Dermatol"},{"key":"714_CR19","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s40291-021-00531-9","volume":"25","author":"B Leal","year":"2021","unstructured":"Leal B, Carvalho C, Ferreira AM, et al. Serum levels of miR-146a in patients with psoriasis. Mol Diagn Ther. 2021;25:475\u201385. https:\/\/doi.org\/10.1007\/s40291-021-00531-9.","journal-title":"Mol Diagn Ther"},{"key":"714_CR20","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1080\/21655979.2021.1925205","volume":"12","author":"L Chen","year":"2021","unstructured":"Chen L, Li J, Yao Y, et al. Circulating microRNA profile unveils mechanisms of action of acitretin for psoriasis vulgaris. Bioengineered. 2021;12:1838\u201350. https:\/\/doi.org\/10.1080\/21655979.2021.1925205.","journal-title":"Bioengineered"},{"key":"714_CR21","doi-asserted-by":"publisher","first-page":"207","DOI":"10.4236\/abb.2022.134011","volume":"13","author":"DC Gu","year":"2022","unstructured":"Gu DC, Cheng MJ, Feng JR. Expression of miR-155 and miR-146a in skin tissue, peripheral blood mononuclear cells and serum of patients with psoriasis and its clinical significance. Adv Biosci Biotechnol. 2022;13:207\u201315.","journal-title":"Adv Biosci Biotechnol"},{"key":"714_CR22","doi-asserted-by":"publisher","first-page":"22645","DOI":"10.1038\/s41598-022-27235-2","volume":"12","author":"G Carreras-Badosa","year":"2022","unstructured":"Carreras-Badosa G, Maslovskaja J, Vaher H, et al. miRNA expression profiles of the perilesional skin of atopic dermatitis and psoriasis patients are highly similar. Sci Rep. 2022;12:22645. https:\/\/doi.org\/10.1038\/s41598-022-27235-2.","journal-title":"Sci Rep"},{"key":"714_CR23","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24198","volume":"36","author":"H Shen","year":"2022","unstructured":"Shen H, Wang D, Zhan M, Ding H, et al. MicroRNA-146a and microRNA-146b deficiency correlates with exacerbated disease activity, and their longitude increment relates to etanercept response in psoriasis patients. J Clin Lab Anal. 2022;36: e24198. https:\/\/doi.org\/10.1002\/jcla.24198.","journal-title":"J Clin Lab Anal"},{"key":"714_CR24","doi-asserted-by":"publisher","first-page":"501","DOI":"10.25259\/IJDVL_111_2022","volume":"89","author":"L Uzun","year":"2023","unstructured":"Uzun L, Kutlu R, Ataseven A, et al. Total oxidant capacity, total antioxidant capacity, ischemic modified albumin, microRNA levels, and their relationship with psoriasis area and severity index. Indian J Dermatol Venereol Leprol. 2023;89:501\u20139. https:\/\/doi.org\/10.25259\/IJDVL_111_2022.","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"714_CR25","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1007\/s13555-023-00931-1","volume":"13","author":"F Diotallevi","year":"2023","unstructured":"Diotallevi F, Matacchione G, d\u2019Agostino GM, et al. InflammamiR-146a and -155 plasma levels are associated with clinical efficacy of risankizumab treatment in psoriatic patients: pilot study. Dermatol Ther (Heidelb). 2023;13:1377\u201387.","journal-title":"Dermatol Ther (Heidelb)."},{"key":"714_CR26","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/1471-2164-8-166","volume":"8","author":"Y Liang","year":"2007","unstructured":"Liang Y, Ridzon D, Wong L, et al. Characterization of microRNA expression profiles in normal human tissues. BMC Genom. 2007;8:166. https:\/\/doi.org\/10.1186\/1471-2164-8-166.","journal-title":"BMC Genom"},{"key":"714_CR27","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13223-019-0382","volume":"15","author":"D He","year":"2019","unstructured":"He D, Yang CX, Sahin B, et al. Whole blood vs PBMC: compartmental differences in gene expression profiling exemplified in asthma. Allergy Asthma Clin Immunol. 2019;15:67. https:\/\/doi.org\/10.1186\/s13223-019-0382.","journal-title":"Allergy Asthma Clin Immunol"},{"key":"714_CR28","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/437301","volume":"2011","author":"N Rusca","year":"2011","unstructured":"Rusca N, Monticelli S. MiR-146a in immunity and disease. Mol Biol Int. 2011;2011: 437301. https:\/\/doi.org\/10.4061\/2011\/437301.","journal-title":"Mol Biol Int"},{"key":"714_CR29","doi-asserted-by":"publisher","first-page":"2587104","DOI":"10.1155\/2023\/2587104","volume":"2023","author":"M Ghaffari","year":"2023","unstructured":"Ghaffari M, Razi S, Zalpoor H, et al. Association of MicroRNA-146a with type 1 and 2 diabetes and their related complications. J Diabetes Res. 2023;2023:2587104. https:\/\/doi.org\/10.1155\/2023\/2587104.","journal-title":"J Diabetes Res"},{"key":"714_CR30","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1161\/CIRCULATIONAHA.116.024171","volume":"136","author":"WA Heggermont","year":"2017","unstructured":"Heggermont WA, Papageorgiou AP, Quaegebeur A, et al. Inhibition of MicroRNA-146a and overexpression of its target dihydrolipoyl succinyltransferase protect against pressure overload-induced cardiac hypertrophy and dysfunction. Circulation. 2017;136:747\u201361. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.116.024171.","journal-title":"Circulation"},{"key":"714_CR31","doi-asserted-by":"publisher","first-page":"3702","DOI":"10.1172\/JCI94012","volume":"127","author":"B Li","year":"2017","unstructured":"Li B, Wang X, Choi IY, et al. miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity. J Clin Invest. 2017;127:3702\u201316. https:\/\/doi.org\/10.1172\/JCI94012.","journal-title":"J Clin Invest"},{"key":"714_CR32","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.cell.2010.08.012","volume":"142","author":"LF Lu","year":"2010","unstructured":"Lu LF, Boldin MP, Chaudhry A, et al. Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell. 2010;142:914\u201329. https:\/\/doi.org\/10.1016\/j.cell.2010.08.012.","journal-title":"Cell"},{"key":"714_CR33","doi-asserted-by":"publisher","first-page":"4875","DOI":"10.1182\/blood-2012-08-452425","volume":"121","author":"Q Guo","year":"2013","unstructured":"Guo Q, Zhang J, Li J, et al. Forced miR-146a expression causes autoimmune lymphoproliferative syndrome in mice via downregulation of Fas in germinal center B cells. Blood. 2013;121:4875\u201383. https:\/\/doi.org\/10.1182\/blood-2012-08-452425.","journal-title":"Blood"},{"key":"714_CR34","doi-asserted-by":"publisher","first-page":"5763","DOI":"10.4049\/jimmunol.0900124","volume":"182","author":"U Maitra","year":"2009","unstructured":"Maitra U, Davis S, Reilly CM, et al. Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1. J Immunol. 2009;182:5763\u20139. https:\/\/doi.org\/10.4049\/jimmunol.0900124.","journal-title":"J Immunol"},{"issue":"4","key":"714_CR35","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.jaci.2014.05.022","volume":"134","author":"A Rebane","year":"2014","unstructured":"Rebane A, Runnel T, Aab A, et al. MicroRNA-146a alleviates chronic skin inflammation in atopic dermatitis through suppression of innate immune responses in keratinocytes. J Allergy Clin Immunol. 2014;134(4):836-847.e11. https:\/\/doi.org\/10.1016\/j.jaci.2014.05.022.","journal-title":"J Allergy Clin Immunol"},{"issue":"7","key":"714_CR36","doi-asserted-by":"publisher","first-page":"e610","DOI":"10.1371\/journal.pone.0000610","volume":"2","author":"E Sonkoly","year":"2007","unstructured":"Sonkoly E, Wei T, Janson PC, et al. MicroRNAs: novel regulators involved in the pathogenesis of psoriasis? PLoS ONE. 2007;2(7):e610. https:\/\/doi.org\/10.1371\/journal.pone.0000610.","journal-title":"PLoS ONE"},{"key":"714_CR37","doi-asserted-by":"publisher","first-page":"4025","DOI":"10.1093\/hmg\/ddr331","volume":"20","author":"CE Joyce","year":"2011","unstructured":"Joyce CE, Zhou X, Xia J, et al. Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome. Hum Mol Genet. 2011;20:4025\u201340. https:\/\/doi.org\/10.1093\/hmg\/ddr331.","journal-title":"Hum Mol Genet"}],"container-title":["Molecular Diagnosis & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40291-024-00714-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40291-024-00714-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40291-024-00714-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T10:03:54Z","timestamp":1719482634000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40291-024-00714-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,22]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["714"],"URL":"https:\/\/doi.org\/10.1007\/s40291-024-00714-0","relation":{},"ISSN":["1177-1062","1179-2000"],"issn-type":[{"value":"1177-1062","type":"print"},{"value":"1179-2000","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,22]]},"assertion":[{"value":"25 April 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No financial assistance was used to conduct the study described in the article or used to assist with the preparation of the manuscript. There was no sponsor for the open access fee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Pei-Yun Ho and Yu-Chen Huang declare that they have no conflicts of interest that might be relevant to the contents of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent"}},{"value":"PYH and YCH were responsible for study design. PYH was responsible for assembly of data, data interpretation\u201d, and manuscript draft preparation. YCH was responsible for the interpretation and final version of the manuscript.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}},{"value":"The data that support the findings of this study are available on request from the corresponding author.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability statement"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}]}}