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VF: substantial contributions to the acquisition, analysis and interpretation of data and to substantively revising the work. ES: contribution to substantively revising the work. CM: contribution to substantively revising the work. AB: contribution to substantively revising the work. AM: contribution to substantively revising the work. VA: contribution to substantively revising the work. GV: contribution to substantively revising the work. EP: contribution to substantively revising the work. AL: contribution to substantively revising the work. ID: contribution to substantively revising the work. FE: contribution to the conception and design of the work, to the analysis and interpretation of data and to substantively revising the work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}},{"value":"All patients or their legal representatives provided signed, informed consent to allow the collection of personal clinical and genetic data and their use for research purposes. The data were collected in compliance with the national French data protection regulations (Commission Nationale de l\u2019Informatique et des Libert\u00e9s [CNIL]). Due to the design of the study being based on routine clinical practice, approval of the study protocol by an institutional review board was not necessary. Conversely, according to French legislation, the study protocol was approved by the appropriate hospital committee and complied with the Declaration of Helsinki 1975 and with its further amendments.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics declaration"}},{"value":"The authors (APP, VF, ES, CM, AB, AM, VA, GV, EP, AL, ID, FE) have no conflicts of interest to declare.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent (participation and publication)"}},{"value":"MutScore is available from\u00a0\u00a0or from\u00a0, and it can be used under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. For commercial uses of MutScore, please contact Carlo Rivolta (carlo.rivolta@iob.ch).","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}]}}