{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:44:11Z","timestamp":1793227451408,"version":"4.5.0"},"reference-count":121,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Diagn Ther"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s40291-025-00799-1","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T17:38:10Z","timestamp":1752860290000},"page":"721-740","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Salivary Biomarkers in Periodontal Disease: Revolutionizing Early Detection and Precision Dentistry"],"prefix":"10.1007","volume":"29","author":[{"given":"Seyed Ebrahim","family":"Alavi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavanya A.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Ebrahimi Shahmabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"issue":"4","key":"799_CR1","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1515\/tjb-2022-0153","volume":"48","author":"F Shi","year":"2023","unstructured":"Shi F, Liu W, Yao Y, Zhang Q, Chen Z, Xian Y, et al. Predictive salivary biomarkers for early diagnosis of periodontal diseases: current and future developments. Turk Biyokim Derg. 2023;48(4):335\u201344. https:\/\/doi.org\/10.1515\/tjb-2022-0153.","journal-title":"Turk Biyokim Derg."},{"issue":"22","key":"799_CR2","doi-asserted-by":"publisher","first-page":"6962","DOI":"10.3390\/jcm12226962","volume":"12","author":"SE Alavi","year":"2023","unstructured":"Alavi SE, Gholami M, Shahmabadi HE, Reher P. Resorbable GBR scaffolds in oral and maxillofacial tissue engineering: design, fabrication, and applications. J Clin Med. 2023;12(22):6962. https:\/\/doi.org\/10.3390\/jcm12226962.","journal-title":"J Clin Med"},{"issue":"5","key":"799_CR3","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.oooo.2023.04.015","volume":"136","author":"SE Alavi","year":"2023","unstructured":"Alavi SE, Alavi SZ, Gholami M, Sharma A, Sharma LA, Shahmabadi HE. Biocomposite-based strategies for dental bone regeneration. Oral Surg Oral Med Oral Pathol Oral Radiol. 2023;136(5):554\u201368. https:\/\/doi.org\/10.1016\/j.oooo.2023.04.015.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"5","key":"799_CR4","doi-asserted-by":"publisher","first-page":"3166","DOI":"10.3390\/app13053166","volume":"13","author":"S Wijesundara","year":"2023","unstructured":"Wijesundara S, Sharma LA, Alavi SE, Sharma A. Peri-implantitis therapy using surgical methods: a systematic review. Appl Sci. 2023;13(5):3166. https:\/\/doi.org\/10.3390\/app13053166.","journal-title":"Appl Sci"},{"issue":"1","key":"799_CR5","doi-asserted-by":"publisher","first-page":"13175","DOI":"10.1038\/s41598-023-40391-3","volume":"13","author":"Y-H Lee","year":"2023","unstructured":"Lee Y-H, Shin S-I, Hong J-Y. Investigation of volatile sulfur compound level and halitosis in patients with gingivitis and periodontitis. Sci Rep. 2023;13(1):13175. https:\/\/doi.org\/10.1038\/s41598-023-40391-3.","journal-title":"Sci Rep"},{"issue":"11","key":"799_CR6","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.3390\/pharmaceutics14112293","volume":"14","author":"SE Alavi","year":"2022","unstructured":"Alavi SE, Raza A, Gholami M, Giles M, Al-Sammak R, Ibrahim A, et al. Advanced drug delivery platforms for the treatment of oral pathogens. Pharmaceutics. 2022;14(11):2293. https:\/\/doi.org\/10.3390\/pharmaceutics14112293.","journal-title":"Pharmaceutics"},{"issue":"3","key":"799_CR7","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s13205-025-04217-5","volume":"15","author":"SH Lee","year":"2025","unstructured":"Lee SH, Chan A, Griffith T, Sharma LA, Alavi SE, Robb N, et al. Factors associated with tooth loss in patients with stages 3 and 4 periodontitis: a short-term retrospective evaluation of patients. 3 Biotech. 2025;15(3):60. https:\/\/doi.org\/10.1007\/s13205-025-04217-5.","journal-title":"3 Biotech."},{"issue":"1","key":"799_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.job.2024.100591","volume":"67","author":"Y-H Lee","year":"2024","unstructured":"Lee Y-H, Park HJ, Jeong S-J, Auh Q-S, Jung J, Lee G-J, et al. Oral microbiome profiles of gingivitis and periodontitis by next-generation sequencing among a group of hospital patients in Korea: a cross-sectional study. J Oral Biosci. 2024;67(1): 100591. https:\/\/doi.org\/10.1016\/j.job.2024.100591.","journal-title":"J Oral Biosci"},{"issue":"4","key":"799_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0321220","volume":"20","author":"Q Song","year":"2025","unstructured":"Song Q, Zhang H, Su Y, Song J. The link between periodontitis and atherosclerotic cardiovascular disease in non-Hispanic white adults: NHANES 1999 to 2014. PLoS ONE. 2025;20(4): e0321220. https:\/\/doi.org\/10.1371\/journal.pone.0321220.","journal-title":"PLoS ONE"},{"key":"799_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.105436","volume":"93","author":"SE Alavi","year":"2024","unstructured":"Alavi SE, Malik L, Matti R, Al-Najafi F, Shahmabadi HE, Sharma LA. Bioresponsive nanotechnology in pediatric dental drug delivery. J Drug Deliv Sci Technol. 2024;93: 105436. https:\/\/doi.org\/10.1016\/j.jddst.2024.105436.","journal-title":"J Drug Deliv Sci Technol."},{"issue":"1","key":"799_CR11","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1186\/s12903-025-06007-0","volume":"25","author":"D\u0130 A\u015fk\u0131n","year":"2025","unstructured":"A\u015fk\u0131n D\u0130, Tayman MA, \u00c7elik B, Kamburo\u011flu K, \u00d6zen D. Comparison of gingival and periodontal phenotype classification methods and phenotype-related clinical parameters: cross-sectional observational study. BMC Oral Health. 2025;25(1):620. https:\/\/doi.org\/10.1186\/s12903-025-06007-0.","journal-title":"BMC Oral Health"},{"issue":"12","key":"799_CR12","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3390\/dj12120407","volume":"12","author":"D Fidyawati","year":"2024","unstructured":"Fidyawati D, Masulili SLC, Iskandar HB, Suhartanto H, Kiswanjaya B, Li X. Clinical and radiographic parameters for early periodontitis diagnosis: a comparative study. Dent J. 2024;12(12):407. https:\/\/doi.org\/10.3390\/dj12120407.","journal-title":"Dent J"},{"issue":"6","key":"799_CR13","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.identj.2023.05.003","volume":"73","author":"S Parveen","year":"2023","unstructured":"Parveen S, Al Qahtani AS, Halboub E, Hazzazi RAA, Madkhali IAH, Mughals AIH, et al. Periodontal-systemic disease: a study on medical practitioners\u2019 knowledge and practice. Int Dent J. 2023;73(6):854\u201361. https:\/\/doi.org\/10.1016\/j.identj.2023.05.003.","journal-title":"Int Dent J"},{"key":"799_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.625579","volume":"7","author":"F Zardawi","year":"2021","unstructured":"Zardawi F, Gul S, Abdulkareem A, Sha A, Yates J. Association between periodontal disease and atherosclerotic cardiovascular diseases: revisited. Front Cardiovasc Med. 2021;7: 625579. https:\/\/doi.org\/10.3389\/fcvm.2020.625579.","journal-title":"Front Cardiovasc Med."},{"key":"799_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2021.103221","volume":"159","author":"SA Al-Maweri","year":"2021","unstructured":"Al-Maweri SA, Ibraheem WI, Al-Ak\u2019hali MS, Shamala A, Halboub E, Alhajj MN. Association of periodontitis and tooth loss with liver cancer: a systematic review. Crit Rev Oncol Hematol. 2021;159: 103221. https:\/\/doi.org\/10.1016\/j.critrevonc.2021.103221.","journal-title":"Crit Rev Oncol Hematol"},{"issue":"3","key":"799_CR16","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1093\/ndt\/gfv312","volume":"31","author":"V Grubbs","year":"2016","unstructured":"Grubbs V, Vittinghoff E, Taylor G, Kritz-Silverstein D, Powe N, Bibbins-Domingo K, et al. The association of periodontal disease with kidney function decline: a longitudinal retrospective analysis of the MrOS dental study. Nephrol Dial Transplant. 2016;31(3):466\u201372. https:\/\/doi.org\/10.1093\/ndt\/gfv312.","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"799_CR17","first-page":"256","volume":"9","author":"V Esfahanian","year":"2012","unstructured":"Esfahanian V, Shamami MS, Shamami MS. Relationship between osteoporosis and periodontal disease: review of the literature. J Dent (Tehran). 2012;9(4):256.","journal-title":"J Dent (Tehran)."},{"issue":"1","key":"799_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.14295\/bds.2021.v24i1.2148","volume":"24","author":"MS Alakhali","year":"2020","unstructured":"Alakhali MS, Ibraheem WIM, Al-Maweri SA, Al Neami SI, Alhuraysi FM. Oral health status of female hospitalized psychiatric patients in Jazan: a case-control study. Braz Dental Sci. 2020;24(1):1\u20136. https:\/\/doi.org\/10.14295\/bds.2021.v24i1.2148.","journal-title":"Braz Dental Sci."},{"key":"799_CR19","doi-asserted-by":"publisher","first-page":"S39","DOI":"10.1111\/jcpe.12685","volume":"44","author":"IL Chapple","year":"2017","unstructured":"Chapple IL, Bouchard P, Cagetti MG, Campus G, Carra MC, Cocco F, et al. Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint EFP\/ORCA workshop on the boundaries between caries and periodontal diseases. J Clin Periodontol. 2017;44:S39-51. https:\/\/doi.org\/10.1111\/jcpe.12685.","journal-title":"J Clin Periodontol"},{"issue":"03","key":"799_CR20","doi-asserted-by":"publisher","first-page":"20","DOI":"10.33279\/jkcd.v14i03.745","volume":"14","author":"M Iqbal","year":"2024","unstructured":"Iqbal M, Ashfaq HM, Jadoon MIK, Jamil M, Khan A, Hamid A. Knowledge & attitude of general dentist, regarding periodontal disease diagnosis, treatment protocol and periodontal specialist referral. J Khyber Coll Dentistry. 2024;14(03):20\u20137. https:\/\/doi.org\/10.33279\/jkcd.v14i03.745.","journal-title":"J Khyber Coll Dentistry."},{"issue":"4","key":"799_CR21","doi-asserted-by":"publisher","first-page":"C004714","DOI":"10.1002\/14651858.cd004714.pub4","volume":"4","author":"TC Simpson","year":"2022","unstructured":"Simpson TC, Clarkson JE, Worthington HV, MacDonald L, Weldon JC, Needleman I, et al. Treatment of periodontitis for glycaemic control in people with diabetes mellitus. Cochrane Database Syst Rev. 2022;4(4):C004714. https:\/\/doi.org\/10.1002\/14651858.cd004714.pub4.","journal-title":"Cochrane Database Syst Rev"},{"issue":"7","key":"799_CR22","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1177\/0022034517701901","volume":"96","author":"A Holmlund","year":"2017","unstructured":"Holmlund A, Lampa E, Lind L. Poor response to periodontal treatment may predict future cardiovascular disease. J Dent Res. 2017;96(7):768\u201373. https:\/\/doi.org\/10.1177\/0022034517701901.","journal-title":"J Dent Res"},{"key":"799_CR23","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1902\/jop.2007.060264","volume":"78","author":"RC Page","year":"2007","unstructured":"Page RC, Eke PI. Case definitions for use in population-based surveillance of periodontitis. J Periodontol. 2007;78:1387\u201399. https:\/\/doi.org\/10.1902\/jop.2007.060264.","journal-title":"J Periodontol"},{"issue":"3","key":"799_CR24","doi-asserted-by":"publisher","first-page":"e184","DOI":"10.1016\/j.ijid.2009.04.022","volume":"14","author":"DP Lima","year":"2010","unstructured":"Lima DP, Diniz DG, Moimaz SAS, Sumida DH, Okamoto AC. Saliva: reflection of the body. Int J Infect Dis. 2010;14(3):e184\u20138. https:\/\/doi.org\/10.1016\/j.ijid.2009.04.022.","journal-title":"Int J Infect Dis"},{"key":"799_CR25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.18502\/fid.v21i34.16472","volume":"21","author":"S Asgary","year":"2024","unstructured":"Asgary S. Letter to the Editor, \u201cAdvancements and Challenges in Precision Dentistry.\u201d Front Dent. 2024;21:34. https:\/\/doi.org\/10.18502\/fid.v21i34.16472.","journal-title":"Front Dent."},{"issue":"18","key":"799_CR26","doi-asserted-by":"publisher","first-page":"6969","DOI":"10.7150\/thno.100600","volume":"14","author":"Y Li","year":"2024","unstructured":"Li Y, Ou Y, Fan K, Liu G. Salivary diagnostics: opportunities and challenges. Theranostics. 2024;14(18):6969. https:\/\/doi.org\/10.7150\/thno.100600.","journal-title":"Theranostics."},{"issue":"10","key":"799_CR27","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1177\/0022034510380414","volume":"89","author":"J Loo","year":"2010","unstructured":"Loo J, Yan W, Ramachandran P, Wong D. Comparative human salivary and plasma proteomes. J Dent Res. 2010;89(10):1016\u201323. https:\/\/doi.org\/10.1177\/0022034510380414.","journal-title":"J Dent Res"},{"issue":"7","key":"799_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108402","volume":"33","author":"M Saitou","year":"2020","unstructured":"Saitou M, Gaylord EA, Xu E, May AJ, Neznanova L, Nathan S, et al. Functional specialization of human salivary glands and origins of proteins intrinsic to human saliva. Cell Rep. 2020;33(7): 108402. https:\/\/doi.org\/10.1016\/j.celrep.2020.108402.","journal-title":"Cell Rep"},{"key":"799_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2020.112723","volume":"171","author":"R Goldoni","year":"2021","unstructured":"Goldoni R, Farronato M, Connelly ST, Tartaglia GM, Yeo W-H. Recent advances in graphene-based nanobiosensors for salivary biomarker detection. Biosens Bioelectron. 2021;171: 112723. https:\/\/doi.org\/10.1016\/j.bios.2020.112723.","journal-title":"Biosens Bioelectron"},{"key":"799_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.medntd.2022.100115","volume":"13","author":"Y Cui","year":"2022","unstructured":"Cui Y, Yang M, Zhu J, Zhang H, Duan Z, Wang S, et al. Developments in diagnostic applications of saliva in human organ diseases. Med Nov Technol Devices. 2022;13: 100115. https:\/\/doi.org\/10.1016\/j.medntd.2022.100115.","journal-title":"Med Nov Technol Devices."},{"key":"799_CR31","doi-asserted-by":"publisher","unstructured":"L\u00f3pez A, Estebala P, Garc\u00eda-Ru\u00edz E, Serra F, Bonet ML, L\u00f3pez-Safont N. Biomarkers in saliva to assess the state of periodontal disease. In: Aitken-Saavedra J, Braz-Silva P, Rojas-Alcayaga G, editors. Salivary Analysis - Characteristics and Biomarkers in Human Health Research. London: IntechOpen Limited; 2025. pp. 1-25. https:\/\/doi.org\/10.5772\/intechopen.1010390.","DOI":"10.5772\/intechopen.1010390"},{"issue":"12","key":"799_CR32","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1111\/jcpe.14048","volume":"51","author":"FR Teles","year":"2024","unstructured":"Teles FR, Chandrasekaran G, Martin L, Patel M, Kallan MJ, Furquim C, et al. Salivary and serum inflammatory biomarkers during periodontitis progression and after treatment. J Clin Periodontol. 2024;51(12):1619\u201331. https:\/\/doi.org\/10.1111\/jcpe.14048.","journal-title":"J Clin Periodontol"},{"issue":"1","key":"799_CR33","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41368-023-00231-6","volume":"15","author":"P Dongiovanni","year":"2023","unstructured":"Dongiovanni P, Meroni M, Casati S, Goldoni R, Thomaz DV, Kehr NS, et al. Salivary biomarkers: novel noninvasive tools to diagnose chronic inflammation. Int J Oral Sci. 2023;15(1):27. https:\/\/doi.org\/10.1038\/s41368-023-00231-6.","journal-title":"Int J Oral Sci"},{"issue":"7","key":"799_CR34","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1039\/d3sd00317e","volume":"3","author":"A Griffith","year":"2024","unstructured":"Griffith A, Chande C, Kulkarni S, Morel J, Cheng Y-H, Shimizu E, et al. Point-of-care diagnostic devices for periodontitis: current trends and urgent need. Sens Diagn. 2024;3(7):1119\u201334. https:\/\/doi.org\/10.1039\/d3sd00317e.","journal-title":"Sens Diagn."},{"key":"799_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/EBC20150001","volume":"60","author":"B Nikhil","year":"2016","unstructured":"Nikhil B, Pawan J, Nello F, Pedro E. Introduction to biosensors. Essays Biochem. 2016;60:1\u20138.","journal-title":"Essays Biochem"},{"issue":"1","key":"799_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/ebc20150001","volume":"60","author":"MS Mannoor","year":"2016","unstructured":"Mannoor MS, Tao H, Clayton JD, Sengupta A, Kaplan DL, Naik RR, et al. Graphene-based wireless bacteria detection on tooth enamel. Essays Biochem. 2016;60(1):1\u20138. https:\/\/doi.org\/10.1042\/ebc20150001.","journal-title":"Essays Biochem"},{"key":"799_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2023.104553","volume":"134","author":"L Guida","year":"2023","unstructured":"Guida L, Bencivenga D, Annunziata M, Arcadio F, Borriello A, Della Ragione F, et al. An optical fiber-based point-of-care test for periodontal MMP-8 detection: a proof of concept. J Dent. 2023;134: 104553. https:\/\/doi.org\/10.1016\/j.jdent.2023.104553.","journal-title":"J Dent"},{"key":"799_CR38","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.talanta.2018.12.051","volume":"196","author":"F Pogacean","year":"2019","unstructured":"Pogacean F, Coros M, Magerusan L, Mirel V, Turza A, Katona G, et al. Exfoliation of graphite rods via pulses of current for graphene synthesis: sensitive detection of 8-hydroxy-2\u2032-deoxyguanosine. Talanta. 2019;196:182\u201390. https:\/\/doi.org\/10.1016\/j.talanta.2018.12.051.","journal-title":"Talanta"},{"issue":"2","key":"799_CR39","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1111\/jre.12963","volume":"57","author":"AR Kim","year":"2022","unstructured":"Kim AR, Bak EJ, Yoo YJ. Distribution of neutrophil and monocyte\/macrophage populations induced by the CXCR4 inhibitor AMD3100 in blood and periodontal tissue early after periodontitis induction. J Periodontal Res. 2022;57(2):332\u201340. https:\/\/doi.org\/10.1111\/jre.12963.","journal-title":"J Periodontal Res"},{"issue":"3","key":"799_CR40","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.3390\/ijms25031425","volume":"25","author":"A Goriuc","year":"2024","unstructured":"Goriuc A, Cojocaru K-A, Luchian I, Ursu R-G, Butnaru O, Foia L. Using 8-hydroxy-2\u2032-Deoxiguanosine (8-OHdG) as a reliable biomarker for assessing periodontal disease associated with diabetes. Int J Mol Sci. 2024;25(3):1425. https:\/\/doi.org\/10.3390\/ijms25031425.","journal-title":"Int J Mol Sci"},{"issue":"3","key":"799_CR41","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.7150\/thno.78872","volume":"13","author":"TW Pittman","year":"2023","unstructured":"Pittman TW, Decsi DB, Punyadeera C, Henry CS. Saliva-based microfluidic point-of-care diagnostic. Theranostics. 2023;13(3):1091. https:\/\/doi.org\/10.7150\/thno.78872.","journal-title":"Theranostics."},{"issue":"16","key":"799_CR42","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.1039\/c9lc00305c","volume":"19","author":"Z Li","year":"2019","unstructured":"Li Z, Ju R, Sekine S, Zhang D, Zhuang S, Yamaguchi Y. All-in-one microfluidic device for on-site diagnosis of pathogens based on an integrated continuous flow PCR and electrophoresis biochip. Lab Chip. 2019;19(16):2663\u20138. https:\/\/doi.org\/10.1039\/c9lc00305c.","journal-title":"Lab Chip"},{"issue":"1","key":"799_CR43","doi-asserted-by":"publisher","first-page":"8006278","DOI":"10.1155\/2024\/8006278","volume":"2024","author":"ZJ Raheem","year":"2024","unstructured":"Raheem ZJ, Abdulbaqi HR. Diagnostic potential of salivary interleukin-1\u03b2 and IL-10 for distinguishing periodontal health from periodontitis and stable from unstable periodontitis: a case-control study. Int J Dent. 2024;2024(1):8006278. https:\/\/doi.org\/10.1155\/2024\/8006278.","journal-title":"Int J Dent"},{"issue":"62B","key":"799_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.9734\/jpri\/2021\/v33i62B35163","volume":"33","author":"A Swetaa","year":"2021","unstructured":"Swetaa A, Jeevitha M, Jayaraman S. Measurement of salivary tumor necrosis factor-alpha (TNF-\u03b1) in periodontitis patients with or without diabetes mellitus. J Pharm Res Int. 2021;33(62B):1\u20137.","journal-title":"J Pharm Res Int."},{"issue":"8","key":"799_CR45","doi-asserted-by":"publisher","first-page":"e206","DOI":"10.1111\/j.1600-0625.2009.01050.x","volume":"19","author":"SH Jeong","year":"2010","unstructured":"Jeong SH, Park JH, Kim JN, Park YH, Shin SY, Lee YH, et al. Up-regulation of TNF-alpha secretion by cigarette smoke is mediated by Egr-1 in HaCaT human keratinocytes. Exp Dermatol. 2010;19(8):e206\u201312. https:\/\/doi.org\/10.1111\/j.1600-0625.2009.01050.x.","journal-title":"Exp Dermatol"},{"key":"799_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2020.104997","volume":"122","author":"G Isola","year":"2021","unstructured":"Isola G, Giudice AL, Polizzi A, Alibrandi A, Murabito P, Indelicato F. Identification of the different salivary Interleukin-6 profiles in patients with periodontitis: a cross-sectional study. Arch Oral Biol. 2021;122: 104997. https:\/\/doi.org\/10.1016\/j.archoralbio.2020.104997.","journal-title":"Arch Oral Biol"},{"key":"799_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2022.111652","volume":"181","author":"SE Alavi","year":"2022","unstructured":"Alavi SE, Panah N, Page F, Gholami M, Dastfal A, Sharma LA, et al. Hydrogel-based therapeutic coatings for dental implants. Eur Polym J. 2022;181: 111652. https:\/\/doi.org\/10.1016\/j.eurpolymj.2022.111652.","journal-title":"Eur Polym J"},{"issue":"11","key":"799_CR48","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1111\/jcpe.13521","volume":"48","author":"T Sorsa","year":"2021","unstructured":"Sorsa T, Grigoriadis A, Sakellari D, Gupta S, Sahni V, Tervahartiala T, et al. On the accuracy, sensitivity, and grading of mouthrinse active matrix metalloproteinase-8 (aMMP-8) point-of-care testing (POCT). J Clin Periodontol. 2021;48(11):1495\u20138. https:\/\/doi.org\/10.1111\/jcpe.13521.","journal-title":"J Clin Periodontol"},{"key":"799_CR49","unstructured":"Sorsa T, Gieselmann D-R, Korvuo A, Maier K, M\u00e4ntyl\u00e4 P, R\u00e5man I, et al. MMP-8 activation product, its determination and use. Google Patents. 2019."},{"issue":"3","key":"799_CR50","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3390\/dj13030127","volume":"13","author":"NRAS Aji","year":"2025","unstructured":"Aji NRAS, Sahni V, Penttala MT, Sakellari D, Grigoriadis A, P\u00e4til\u00e4 T, et al. Oral medicine and oral clinical chemistry game changers for future plaque control and maintenance: PerioSafe\u00ae aMMP-8 POCT, Lumoral\u00ae 2\u00d7 PDT-and Lingora\u00ae fermented lingonberry oral rinse-treatments. Dent J. 2025;13(3):127. https:\/\/doi.org\/10.3390\/dj13030127.","journal-title":"Dent J"},{"issue":"02","key":"799_CR51","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1055\/s-0043-1772779","volume":"18","author":"R Kainat","year":"2024","unstructured":"Kainat R, Ahmed I, Alolaywi AM, Waheed H, Sultan ZK, Moin SF. Assessment of salivary MMP-8 and IL-1\u03b2 for the diagnosis of periodontal diseases in Pakistani population. Eur J Dent. 2024;18(02):672\u20139. https:\/\/doi.org\/10.1055\/s-0043-1772779.","journal-title":"Eur J Dent"},{"issue":"3","key":"799_CR52","doi-asserted-by":"publisher","first-page":"75","DOI":"10.4103\/denthyp.denthyp_16_23","volume":"14","author":"AAJ Miran","year":"2023","unstructured":"Miran AAJ, Akram HM. Assessment of the salivary level of malondialdehyde in localized periodontitis versus generalized periodontitis: an analytical cross-sectional study. Dent Hypotheses. 2023;14(3):75\u20137. https:\/\/doi.org\/10.4103\/denthyp.denthyp_16_23.","journal-title":"Dent Hypotheses."},{"issue":"4","key":"799_CR53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174782","volume":"12","author":"S Kageyama","year":"2017","unstructured":"Kageyama S, Takeshita T, Asakawa M, Shibata Y, Takeuchi K, Yamanaka W, et al. Relative abundance of total subgingival plaque-specific bacteria in salivary microbiota reflects the overall periodontal condition in patients with periodontitis. PLoS ONE. 2017;12(4): e0174782. https:\/\/doi.org\/10.1371\/journal.pone.0174782.","journal-title":"PLoS ONE"},{"issue":"5","key":"799_CR54","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1002\/jper.17-0377","volume":"89","author":"D Belstr\u00f8m","year":"2018","unstructured":"Belstr\u00f8m D, Grande MA, Sembler-M\u00f8ller ML, Kirkby N, Cotton SL, Paster BJ, et al. Influence of periodontal treatment on subgingival and salivary microbiotas. J Periodontol. 2018;89(5):531\u20139. https:\/\/doi.org\/10.1002\/jper.17-0377.","journal-title":"J Periodontol"},{"issue":"5","key":"799_CR55","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.ajodo.2019.11.026","volume":"159","author":"R Guo","year":"2021","unstructured":"Guo R, Zheng Y, Zhang L, Shi J, Li W. Salivary microbiome and periodontal status of patients with periodontitis during the initial stage of orthodontic treatment. Am J Orthod Dentofacial Orthop. 2021;159(5):644\u201352. https:\/\/doi.org\/10.1016\/j.ajodo.2019.11.026.","journal-title":"Am J Orthod Dentofacial Orthop."},{"issue":"10","key":"799_CR56","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.3390\/pathogens11101173","volume":"11","author":"LH Aleksijevi\u0107","year":"2022","unstructured":"Aleksijevi\u0107 LH, Aleksijevi\u0107 M, \u0160krlec I, \u0160ram M, \u0160ram M, Talapko J. Porphyromonas gingivalis virulence factors and clinical significance in periodontal disease and coronary artery diseases. Pathogens. 2022;11(10):1173. https:\/\/doi.org\/10.3390\/pathogens11101173.","journal-title":"Pathogens"},{"key":"799_CR57","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.987683","volume":"12","author":"YC Chow","year":"2022","unstructured":"Chow YC, Yam HC, Gunasekaran B, Lai WY, Wo WY, Agarwal T, et al. Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases. Front Cell Infect Microbiol. 2022;12: 987683. https:\/\/doi.org\/10.3389\/fcimb.2022.987683.","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"799_CR58","doi-asserted-by":"publisher","first-page":"226","DOI":"10.3390\/antiox10020226","volume":"10","author":"M-A Martu","year":"2021","unstructured":"Martu M-A, Surlin P, Lazar L, Maftei GA, Luchian I, Gheorghe D-N, et al. Evaluation of oxidative stress before and after using laser and photoactivation therapy as adjuvant of non-surgical periodontal treatment in patients with rheumatoid arthritis. Antioxidants. 2021;10(2):226. https:\/\/doi.org\/10.3390\/antiox10020226.","journal-title":"Antioxidants"},{"key":"799_CR59","doi-asserted-by":"publisher","first-page":"910","DOI":"10.3389\/fphys.2017.00910","volume":"8","author":"Y Wang","year":"2017","unstructured":"Wang Y, Andrukhov O, Rausch-Fan X. Oxidative stress and antioxidant system in periodontitis. Front Physiol. 2017;8:910. https:\/\/doi.org\/10.3389\/fphys.2017.00910.","journal-title":"Front Physiol"},{"issue":"2","key":"799_CR60","doi-asserted-by":"publisher","first-page":"166","DOI":"10.3390\/jpm13020166","volume":"13","author":"G Viglianisi","year":"2023","unstructured":"Viglianisi G, Tartaglia GM, Santonocito S, Amato M, Polizzi A, Mascitti M, et al. The emerging role of salivary oxidative stress biomarkers as prognostic markers of periodontitis: new insights for a personalized approach in dentistry. J Pers Med. 2023;13(2):166. https:\/\/doi.org\/10.3390\/jpm13020166.","journal-title":"J Pers Med."},{"key":"799_CR61","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s12291-014-0446-0","volume":"30","author":"A Phaniendra","year":"2015","unstructured":"Phaniendra A, Jestadi DB, Periyasamy L. Free radicals: properties, sources, targets, and their implication in various diseases. Indian J Clin Biochem. 2015;30:11\u201326. https:\/\/doi.org\/10.1007\/s12291-014-0446-0.","journal-title":"Indian J Clin Biochem"},{"issue":"4","key":"799_CR62","doi-asserted-by":"publisher","first-page":"291","DOI":"10.3290\/j.cjdr.b5860259","volume":"27","author":"MY Yu","year":"2024","unstructured":"Yu MY, Liu XC, Yu ZL, Jun J. The application of salivary exosomes in the diagnosis of oral disease. Chin J Dent Res. 2024;27(4):291\u2013301. https:\/\/doi.org\/10.3290\/j.cjdr.b5860259.","journal-title":"Chin J Dent Res"},{"issue":"4","key":"799_CR63","doi-asserted-by":"publisher","first-page":"190","DOI":"10.18231\/j.ijpi.2023.037","volume":"8","author":"R Vijayalakshmi","year":"2023","unstructured":"Vijayalakshmi R, Senthil S, Dave PH, Mahendra J, Kumari BN, Lakshmi Priya KLP, et al. Metabolomics as a diagnostic tool for periodontal diseases: an overview. IP Int J Periodontol Implantol. 2023;8(4):190\u20134. https:\/\/doi.org\/10.18231\/j.ijpi.2023.037.","journal-title":"IP Int J Periodontol Implantol."},{"issue":"1","key":"799_CR64","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1186\/s12967-022-03676-1","volume":"20","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Wang M, Zheng Y, Dai Y, Chou J, Bian X, et al. MicroRNA-223 negatively regulates the osteogenic differentiation of periodontal ligament derived cells by directly targeting growth factor receptors. J Transl Med. 2022;20(1):465. https:\/\/doi.org\/10.1186\/s12967-022-03676-1.","journal-title":"J Transl Med"},{"issue":"5","key":"799_CR65","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.3390\/ijms22052423","volume":"22","author":"P Han","year":"2021","unstructured":"Han P, Bartold PM, Salomon C, Ivanovski S. Salivary outer membrane vesicles and DNA methylation of small extracellular vesicles as biomarkers for periodontal status: a pilot study. Int J Mol Sci. 2021;22(5):2423. https:\/\/doi.org\/10.3390\/ijms22052423.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"799_CR66","first-page":"106","volume":"22","author":"D Chukwuma","year":"2024","unstructured":"Chukwuma D, Arowojolu M, Ankita J. A review of salivary biomarkers of periodontal disease. Ann Ib Postgrad Med. 2024;22(2):106.","journal-title":"Ann Ib Postgrad Med."},{"issue":"7","key":"799_CR67","doi-asserted-by":"publisher","first-page":"ZE21","DOI":"10.7860\/jcdr\/2014\/8355.4646","volume":"8","author":"T Bansal","year":"2014","unstructured":"Bansal T, Pandey A, Deepa D, Asthana AK. C-reactive protein (CRP) and its association with periodontal disease: a brief review. J Clin Diagn Res. 2014;8(7):ZE21. https:\/\/doi.org\/10.7860\/jcdr\/2014\/8355.4646.","journal-title":"J Clin Diagn Res"},{"issue":"14","key":"799_CR68","doi-asserted-by":"publisher","first-page":"3326","DOI":"10.1039\/d4lc00295d","volume":"24","author":"J Korgaonkar","year":"2024","unstructured":"Korgaonkar J, Tarman AY, Koydemir HC, Chukkapalli SS. Periodontal disease and emerging point-of-care technologies for its diagnosis. Lab Chip. 2024;24(14):3326\u201346. https:\/\/doi.org\/10.1039\/d4lc00295d.","journal-title":"Lab Chip"},{"issue":"1","key":"799_CR69","doi-asserted-by":"publisher","first-page":"7891323","DOI":"10.1155\/2018\/7891323","volume":"2018","author":"A Al-Majid","year":"2018","unstructured":"Al-Majid A, Alassiri S, Rathnayake N, Tervahartiala T, Gieselmann D-R, Sorsa T. Matrix metalloproteinase-8 as an inflammatory and prevention biomarker in periodontal and peri-implant diseases. Int J Dent. 2018;2018(1):7891323. https:\/\/doi.org\/10.1155\/2018\/7891323.","journal-title":"Int J Dent"},{"issue":"1","key":"799_CR70","doi-asserted-by":"publisher","first-page":"17069","DOI":"10.1038\/nrdp.2017.69","volume":"3","author":"T Sorsa","year":"2017","unstructured":"Sorsa T, Gieselmann D, Arweiler NB, Hern\u00e1ndez M. A quantitative point-of-care test for periodontal and dental peri-implant diseases. Nat Rev Dis Primers. 2017;3(1):17069. https:\/\/doi.org\/10.1038\/nrdp.2017.69.","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"799_CR71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrdp.2017.38","volume":"3","author":"DF Kinane","year":"2017","unstructured":"Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases. Nat Rev Dis Primers. 2017;3(1):1\u201314. https:\/\/doi.org\/10.1038\/nrdp.2017.38.","journal-title":"Nat Rev Dis Primers"},{"key":"799_CR72","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1080\/14789450.2021.1976151","volume":"18","author":"T Sorsa","year":"2021","unstructured":"Sorsa T, Sahni V, Buduneli N, Gupta S, R\u00e4is\u00e4nen IT, Golub LM, et al. Active matrix metalloproteinase-8 (aMMP-8) point-of-care test (POCT) in the COVID-19 pandemic. Expert Rev Proteomics. 2021;18:707\u201317. https:\/\/doi.org\/10.1080\/14789450.2021.1976151.","journal-title":"Expert Rev Proteomics"},{"issue":"1","key":"799_CR73","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3390\/diagnostics1501007","volume":"15","author":"G S\u00e1enz-Ravello","year":"2024","unstructured":"S\u00e1enz-Ravello G, Hern\u00e1ndez M, Baeza M, Hern\u00e1ndez-R\u00edos P. The role of oral biomarkers in the assessment of noncommunicable diseases. Diagnostics. 2024;15(1):78. https:\/\/doi.org\/10.3390\/diagnostics1501007.","journal-title":"Diagnostics"},{"issue":"12","key":"799_CR74","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.50207","volume":"15","author":"SAA Alftaikhah","year":"2023","unstructured":"Alftaikhah SAA, Issrani R, Alnasser M, Almutairi HA, Khattak O, Iqbal A, et al. Salivary biomarkers in periodontitis: a scoping review. Cureus. 2023;15(12): e50207. https:\/\/doi.org\/10.7759\/cureus.50207.","journal-title":"Cureus."},{"issue":"10","key":"799_CR75","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1111\/jcpe.13349","volume":"47","author":"HD Kim","year":"2020","unstructured":"Kim HD, Kim S, Jeon S, Kim SJ, Cho HJ, Choi YN. Diagnostic and prognostic ability of salivary MMP-9 and S100A8 for periodontitis. J Clin Periodontol. 2020;47(10):1191\u2013200. https:\/\/doi.org\/10.1111\/jcpe.13349.","journal-title":"J Clin Periodontol"},{"issue":"1","key":"799_CR76","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s12951-024-02443-2","volume":"22","author":"L Cui","year":"2024","unstructured":"Cui L, Zheng J, Lu Y, Lin P, Lin Y, Zheng Y, et al. New frontiers in salivary extracellular vesicles: transforming diagnostics, monitoring, and therapeutics in oral and systemic diseases. J Nanobiotechnol. 2024;22(1):171. https:\/\/doi.org\/10.1186\/s12951-024-02443-2.","journal-title":"J Nanobiotechnol"},{"issue":"5","key":"799_CR77","doi-asserted-by":"publisher","first-page":"347","DOI":"10.5051\/jpis.2203700185","volume":"53","author":"A Yamaguchi","year":"2023","unstructured":"Yamaguchi A, Tsuruya Y, Igarashi K, Jin Z, Yamazaki-Takai M, Takai H, et al. Changes in the components of salivary exosomes due to initial periodontal therapy. J Periodontal Implant Sci. 2023;53(5):347. https:\/\/doi.org\/10.5051\/jpis.2203700185.","journal-title":"J Periodontal Implant Sci."},{"issue":"10","key":"799_CR78","doi-asserted-by":"publisher","first-page":"6339","DOI":"10.3390\/ijerph19106339","volume":"19","author":"HM Roberts","year":"2022","unstructured":"Roberts HM, Yonel Z, Kantarci A, Grant MM, Chapple ILC. Impact of gingivitis on circulating neutrophil reactivity and gingival crevicular fluid inflammatory proteins. Int J Environ Res Public Health. 2022;19(10):6339. https:\/\/doi.org\/10.3390\/ijerph19106339.","journal-title":"Int J Environ Res Public Health"},{"key":"799_CR79","volume-title":"Risk factors and active-matrix metalloproteinase-8 (aMMP-8) diagnostics for initial periodontitis in adolescents","author":"IT R\u00e4is\u00e4nen","year":"2023","unstructured":"R\u00e4is\u00e4nen IT. Risk factors and active-matrix metalloproteinase-8 (aMMP-8) diagnostics for initial periodontitis in adolescents. Helsinki: University of Helsinki Helsinki; 2023."},{"issue":"3","key":"799_CR80","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/jcpe.13923","volume":"51","author":"V Sahni","year":"2024","unstructured":"Sahni V, R\u00e4is\u00e4nen IT, Sorsa T. MMP-8 and active MMP-8 (aMMP-8) are not synonymous in periodontal disease diagnostics. J Clin Periodontol. 2024;51(3):365. https:\/\/doi.org\/10.1111\/jcpe.13923.","journal-title":"J Clin Periodontol"},{"issue":"2","key":"799_CR81","doi-asserted-by":"publisher","first-page":"48","DOI":"10.15761\/DOCR.1000111","volume":"1","author":"A Pavankumar","year":"2015","unstructured":"Pavankumar A, Jagdishreddy G, Raja BP. Biomarkers in periodontal disease. Dent Oral Craniofac Res. 2015;1(2):48\u201352. https:\/\/doi.org\/10.15761\/DOCR.1000111.","journal-title":"Dent Oral Craniofac Res."},{"issue":"1","key":"799_CR82","first-page":"3","volume":"7","author":"TE Van Dyke","year":"2005","unstructured":"Van Dyke TE, Dave S. Risk factors for periodontitis. J Int Acad Periodontol. 2005;7(1):3\u20137.","journal-title":"J Int Acad Periodontol"},{"key":"799_CR83","doi-asserted-by":"publisher","first-page":"751","DOI":"10.7326\/0003-4819-149-10-200811180-00009","volume":"149","author":"H Janes","year":"2008","unstructured":"Janes H, Pepe MS, Gu W. Assessing the value of risk predictions by using risk stratification tables. Ann Intern Med. 2008;149:751\u201360. https:\/\/doi.org\/10.7326\/0003-4819-149-10-200811180-00009.","journal-title":"Ann Intern Med"},{"issue":"5","key":"799_CR84","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.archoralbio.2009.02.007","volume":"54","author":"A Pradeep","year":"2009","unstructured":"Pradeep A, Daisy H, Hadge P. Gingival crevicular fluid levels of monocyte chemoattractant protein-1 in periodontal health and disease. Arch Oral Biol. 2009;54(5):503\u20139. https:\/\/doi.org\/10.1016\/j.archoralbio.2009.02.007.","journal-title":"Arch Oral Biol"},{"issue":"1","key":"799_CR85","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/odi.12300","volume":"22","author":"AH Kesarwala","year":"2016","unstructured":"Kesarwala AH, Krishna MC, Mitchell JB. Oxidative stress in oral diseases. Oral Dis. 2016;22(1):9\u201318. https:\/\/doi.org\/10.1111\/odi.12300.","journal-title":"Oral Dis"},{"issue":"5","key":"799_CR86","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.3390\/antiox12051120","volume":"12","author":"R Goldoni","year":"2023","unstructured":"Goldoni R, Thomaz DV, Strambini L, Tumedei M, Dongiovanni P, Isola G, et al. Quality-by-design R&D of a novel nanozyme-based sensor for saliva antioxidant capacity evaluation. Antioxidants. 2023;12(5):1120. https:\/\/doi.org\/10.3390\/antiox12051120.","journal-title":"Antioxidants"},{"key":"799_CR87","doi-asserted-by":"publisher","DOI":"10.5281\/ZENODO.10427760","author":"M El Bouhairi","year":"2024","unstructured":"El Bouhairi M, Lachhab O, Sidqui M. Advancements in Salivary Biomarkers: Transforming Diagnostic Landscape in Dentistry. Am J Innov Res Appl Sci. 2024;18(1):12-19. https:\/\/doi.org\/10.5281\/ZENODO.10427760."},{"issue":"1","key":"799_CR88","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/odi.14008","volume":"29","author":"S Gupta","year":"2023","unstructured":"Gupta S, Sahni V, R\u00e4is\u00e4nen IT, Grigoriadis A, Sakellari D, Gieselmann D-R, et al. Linking oral microbial proteolysis to aMMP-8 PoC diagnostics along with the stage and grade of periodontitis: a cross-sectional study. Oral Dis. 2023;29(1):285\u20139. https:\/\/doi.org\/10.1111\/odi.14008.","journal-title":"Oral Dis"},{"issue":"10","key":"799_CR89","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.3390\/diagnostics14101011","volume":"14","author":"NRAS Ji","year":"2024","unstructured":"Ji NRAS, Yucel-Lindberg T, R\u00e4is\u00e4nen IT, Kuula H, Nieminen MT, Mc Crudden MT, et al. In vivo regulation of active matrix metalloproteinase-8 (aMMP-8) in periodontitis: from transcriptomics to real-time online diagnostics and treatment monitoring. Diagnostics. 2024;14(10):1011. https:\/\/doi.org\/10.3390\/diagnostics14101011.","journal-title":"Diagnostics"},{"issue":"1","key":"799_CR90","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/odi.15014","volume":"31","author":"JT Thomas","year":"2025","unstructured":"Thomas JT, Joseph B, Varghese S, Thomas NG, Kamalasanan Vijayakumary B, Sorsa T, et al. Association between metabolic syndrome and salivary MMP-8, myeloperoxidase in periodontitis. Oral Dis. 2025;31(1):225\u201338. https:\/\/doi.org\/10.1111\/odi.15014.","journal-title":"Oral Dis"},{"issue":"17","key":"799_CR91","doi-asserted-by":"publisher","first-page":"9421","DOI":"10.3390\/ijms25179421","volume":"25","author":"NRAS Aji","year":"2024","unstructured":"Aji NRAS, R\u00e4is\u00e4nen IT, Rathnayake N, Lundy FT, Mc Crudden MT, Goyal L, et al. aMMP-8 POCT vs. other potential biomarkers in chair-side diagnostics and treatment monitoring of severe periodontitis. Int J Mol Sci. 2024;25(17):9421. https:\/\/doi.org\/10.3390\/ijms25179421.","journal-title":"Int J Mol Sci"},{"key":"799_CR92","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2020.104955","volume":"124","author":"V\u00d6 \u00d6zt\u00fcrk","year":"2021","unstructured":"\u00d6zt\u00fcrk V\u00d6, Emingil G, Umeizudike K, Tervahartiala T, Gieselmann D-R, Maier K, et al. Evaluation of active matrix metalloproteinase-8 (aMMP-8) chair-side test as a diagnostic biomarker in the staging of periodontal diseases. Arch Oral Biol. 2021;124: 104955. https:\/\/doi.org\/10.1016\/j.archoralbio.2020.104955.","journal-title":"Arch Oral Biol"},{"key":"799_CR93","doi-asserted-by":"publisher","unstructured":"Thomas JT, Joseph B, Waltimo T, Anil S. Matrix metalloproteinases (MMPs) in periodontium: is it a boon or a bane? In: Georgeta Sufaru I, Mihaela Solomon S, editors. Advances in Gingival Diseases and Conditions. London: IntechOpen Limited; 2024. pp. 1-31. https:\/\/doi.org\/10.5772\/intechopen.114353.","DOI":"10.5772\/intechopen.114353"},{"issue":"1","key":"799_CR94","doi-asserted-by":"publisher","first-page":"51","DOI":"10.54589\/aol.35\/1\/51","volume":"35","author":"CF Cornejo","year":"2022","unstructured":"Cornejo CF, Salgado PA, Molgatini SL, Gliosca LA, Squassi AF. Saliva sampling methods. Cariogenic streptococci count using two different methods of saliva collection in children. Acta Odontol Latinoam. 2022;35(1):51. https:\/\/doi.org\/10.54589\/aol.35\/1\/51.","journal-title":"Acta Odontol Latinoam"},{"issue":"11","key":"799_CR95","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.74381","volume":"16","author":"G Suragimath","year":"2024","unstructured":"Suragimath G, Patil S, Suragimath DG, Ashwinirani S. Salivaomics: a revolutionary non-invasive approach for oral cancer detection. Cureus. 2024;16(11): e74381. https:\/\/doi.org\/10.7759\/cureus.74381.","journal-title":"Cureus."},{"issue":"1","key":"799_CR96","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/s12903-024-03902-w","volume":"24","author":"H Mortazavi","year":"2024","unstructured":"Mortazavi H, Yousefi-Koma A-A, Yousefi-Koma H. Extensive comparison of salivary collection, transportation, preparation, and storage methods: a systematic review. BMC Oral Health. 2024;24(1):168. https:\/\/doi.org\/10.1186\/s12903-024-03902-w.","journal-title":"BMC Oral Health"},{"issue":"8","key":"799_CR97","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.3390\/diagnostics11081304","volume":"11","author":"MM Costa","year":"2021","unstructured":"Costa MM, Benoit N, Saby F, Pradines B, Granjeaud S, Almeras L. Optimization and standardization of human saliva collection for MALDI-TOF MS. Diagnostics. 2021;11(8):1304. https:\/\/doi.org\/10.3390\/diagnostics11081304.","journal-title":"Diagnostics"},{"key":"799_CR98","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2019.115781","volume":"124","author":"FG Bellagambi","year":"2020","unstructured":"Bellagambi FG, Lomonaco T, Salvo P, Vivaldi F, Hangou\u00ebt M, Ghimenti S, et al. Saliva sampling: methods and devices: an overview. Trends Analyt Chem. 2020;124: 115781. https:\/\/doi.org\/10.1016\/j.trac.2019.115781.","journal-title":"Trends Analyt Chem."},{"key":"799_CR99","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2020.105069","volume":"124","author":"YZ Szabo","year":"2021","unstructured":"Szabo YZ, Slavish DC. Measuring salivary markers of inflammation in health research: a review of methodological considerations and best practices. Psychoneuroendocrinology. 2021;124: 105069. https:\/\/doi.org\/10.1016\/j.psyneuen.2020.105069.","journal-title":"Psychoneuroendocrinology"},{"issue":"8","key":"799_CR100","doi-asserted-by":"publisher","first-page":"823","DOI":"10.7150\/ijms.25146","volume":"15","author":"KR Bhattarai","year":"2018","unstructured":"Bhattarai KR, Kim H-R, Chae H-J. Compliance with saliva collection protocol in healthy volunteers: strategies for managing risk and errors. Int J Med Sci. 2018;15(8):823. https:\/\/doi.org\/10.7150\/ijms.25146.","journal-title":"Int J Med Sci"},{"issue":"4","key":"799_CR101","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1080\/14789450.2020.1763174","volume":"17","author":"A Van Gool","year":"2020","unstructured":"Van Gool A, Corrales F, \u010colovi\u0107 M, Krsti\u0107 D, Oliver-Martos B, Mart\u00ednez-C\u00e1ceres E, et al. Analytical techniques for multiplex analysis of protein biomarkers. Expert Rev Proteomics. 2020;17(4):257\u201373. https:\/\/doi.org\/10.1080\/14789450.2020.1763174.","journal-title":"Expert Rev Proteomics"},{"issue":"18\u201319","key":"799_CR102","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1002\/elps.201900126","volume":"40","author":"W Zhang","year":"2019","unstructured":"Zhang W, Segers K, Mangelings D, Van Eeckhaut A, Hankemeier T, Vander Heyden Y, et al. Assessing the suitability of capillary electrophoresis-mass spectrometry for biomarker discovery in plasma-based metabolomics. Electrophoresis. 2019;40(18\u201319):2309\u201320. https:\/\/doi.org\/10.1002\/elps.201900126.","journal-title":"Electrophoresis"},{"key":"799_CR103","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.aca.2012.05.049","volume":"750","author":"A Smolinska","year":"2012","unstructured":"Smolinska A, Blanchet L, Buydens LM, Wijmenga SS. NMR and pattern recognition methods in metabolomics: from data acquisition to biomarker discovery: a review. Anal Chim Acta. 2012;750:82\u201397. https:\/\/doi.org\/10.1016\/j.aca.2012.05.049.","journal-title":"Anal Chim Acta"},{"issue":"12","key":"799_CR104","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18203\/2394-6040.ijcmph20233523","volume":"10","author":"MA Munshi","year":"2023","unstructured":"Munshi MA, Almozher HA, Alqahtani FA, Youssef MM, Almtere AS, Alsadoon BK, et al. Types, accuracy, and efficacy of salivary biomarkers in periodontal diagnosis. Int J Community Med Public Health. 2023;10(12):1. https:\/\/doi.org\/10.18203\/2394-6040.ijcmph20233523.","journal-title":"Int J Community Med Public Health."},{"issue":"10","key":"799_CR105","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.3390\/diagnostics12102485","volume":"12","author":"HA Mohammed","year":"2022","unstructured":"Mohammed HA, Abdulkareem AA, Zardawi FM, Gul SS. Determination of the accuracy of salivary biomarkers for periodontal diagnosis. Diagnostics. 2022;12(10):2485. https:\/\/doi.org\/10.3390\/diagnostics12102485.","journal-title":"Diagnostics"},{"key":"799_CR106","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.3389\/fimmu.2020.01017","volume":"11","author":"K Hirai","year":"2020","unstructured":"Hirai K, Yamaguchi-Tomikawa T, Eguchi T, Maeda H, Takashiba S. Identification and modification of Porphyromonas gingivalis cysteine protease, gingipain, ideal for screening periodontitis. Front Immunol. 2020;11:1017. https:\/\/doi.org\/10.3389\/fimmu.2020.01017.","journal-title":"Front Immunol"},{"key":"799_CR107","volume-title":"Design and development of a point-of-care device for oral health assessment via salivary diagnostics","author":"R Goldoni","year":"2024","unstructured":"Goldoni R. Design and development of a point-of-care device for oral health assessment via salivary diagnostics. PhD thesis, POLITECNICO DI MILANO; 2024."},{"key":"799_CR108","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2021.116281","volume":"140","author":"X Zheng","year":"2021","unstructured":"Zheng X, Zhang F, Wang K, Zhang W, Li Y, Sun Y, et al. Smart biosensors and intelligent devices for salivary biomarker detection. Trends Analyt Chem. 2021;140: 116281. https:\/\/doi.org\/10.1016\/j.trac.2021.116281.","journal-title":"Trends Analyt Chem."},{"key":"799_CR109","doi-asserted-by":"publisher","DOI":"10.1149\/2754-2726\/ac5523","volume":"Plus 1","author":"AP Turner","year":"2022","unstructured":"Turner AP. Perspective-an age of sensors. ECS Sens Plus. 2022;Plus 1: 011601. https:\/\/doi.org\/10.1149\/2754-2726\/ac5523.","journal-title":"ECS Sens Plus."},{"issue":"2","key":"799_CR110","doi-asserted-by":"publisher","DOI":"10.1149\/2754-2726\/ac7533","volume":"1","author":"C Moonla","year":"2022","unstructured":"Moonla C, Lee DH, Rokaya D, Rasitanon N, Kathayat G, Lee W-Y, et al. Lab-in-a-mouth and advanced point-of-care sensing systems: detecting bioinformation from the oral cavity and saliva. ECS Sens Plus. 2022;1(2): 021603. https:\/\/doi.org\/10.1149\/2754-2726\/ac7533.","journal-title":"ECS Sens Plus."},{"issue":"11","key":"799_CR111","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.3390\/diagnostics15111411","volume":"15","author":"M Penttala","year":"2025","unstructured":"Penttala M, Sorsa T, Thomas JT, Grigoriadis A, Sakellari D, Sahni V, et al. Determination of the stage of periodontitis with 20 ng\/mL cut-off aMMP-8 mouth rinse test and polynomial functions in a mobile application. Diagnostics. 2025;15(11):1411. https:\/\/doi.org\/10.3390\/diagnostics15111411.","journal-title":"Diagnostics"},{"issue":"3","key":"799_CR112","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3390\/diagnostics15030296","volume":"15","author":"M Penttala","year":"2025","unstructured":"Penttala M, Sorsa T, Thomas JT, Grigoriadis A, Sakellari D, Gupta S, et al. Periodontitis home screening with mouth rinse cut-off 20 ng\/mL aMMP-8 test and mobile application. Diagnostics. 2025;15(3):296. https:\/\/doi.org\/10.3390\/diagnostics15030296.","journal-title":"Diagnostics"},{"issue":"1","key":"799_CR113","doi-asserted-by":"publisher","first-page":"27226","DOI":"10.1038\/s41598-024-75735-0","volume":"14","author":"K Senevirathna","year":"2024","unstructured":"Senevirathna K, Mahakapuge TAN, Jayawardana NU, Rajapakse J, Gamage CU, Seneviratne B, et al. Diagnostic potential of salivary IL-1\u03b2, IL-8, SAT, S100P, and OAZ1 in oral squamous cell carcinoma, oral submucous fibrosis, and oral lichen planus based on findings from a Sri Lankan cohort. Sci Rep. 2024;14(1):27226. https:\/\/doi.org\/10.1038\/s41598-024-75735-0.","journal-title":"Sci Rep"},{"key":"799_CR114","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s10875-012-9771-3","volume":"33","author":"JL Ebersole","year":"2013","unstructured":"Ebersole JL, Schuster JL, Stevens J, Dawson D, Kryscio RJ, Lin Y, et al. Patterns of salivary analytes provide diagnostic capacity for distinguishing chronic adult periodontitis from health. J Clin Immunol. 2013;33:271\u20139. https:\/\/doi.org\/10.1007\/s10875-012-9771-3.","journal-title":"J Clin Immunol"},{"key":"799_CR115","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3389\/fcimb.2015.00062","volume":"5","author":"JL Ebersole","year":"2015","unstructured":"Ebersole JL, Nagarajan R, Akers D, Miller CS. Targeted salivary biomarkers for discrimination of periodontal health and disease (s). Front Cell Infect Microbiol. 2015;5:62. https:\/\/doi.org\/10.3389\/fcimb.2015.00062.","journal-title":"Front Cell Infect Microbiol"},{"issue":"8","key":"799_CR116","doi-asserted-by":"publisher","first-page":"889","DOI":"10.3390\/metabo13080889","volume":"13","author":"M Basilicata","year":"2023","unstructured":"Basilicata M, Pieri M, Marrone G, Nicolai E, Di Lauro M, Paolino V, et al. Saliva as biomarker for oral and chronic degenerative non-communicable diseases. Metabolites. 2023;13(8):889. https:\/\/doi.org\/10.3390\/metabo13080889.","journal-title":"Metabolites"},{"key":"799_CR117","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101587","volume":"76","author":"R Goldoni","year":"2022","unstructured":"Goldoni R, Dolci C, Boccalari E, Inchingolo F, Paghi A, Strambini L, et al. Salivary biomarkers of neurodegenerative and demyelinating diseases and biosensors for their detection. Ageing Res Rev. 2022;76: 101587. https:\/\/doi.org\/10.1016\/j.arr.2022.101587.","journal-title":"Ageing Res Rev"},{"issue":"10","key":"799_CR118","doi-asserted-by":"publisher","first-page":"396","DOI":"10.3390\/bios11100396","volume":"11","author":"R Goldoni","year":"2021","unstructured":"Goldoni R, Scolaro A, Boccalari E, Dolci C, Scarano A, Inchingolo F, et al. Malignancies and biosensors: a focus on oral cancer detection through salivary biomarkers. Biosensors. 2021;11(10):396. https:\/\/doi.org\/10.3390\/bios11100396.","journal-title":"Biosensors"},{"key":"799_CR119","doi-asserted-by":"publisher","DOI":"10.4103\/jmau.jmau_122_22","author":"AY Alzahrani","year":"2023","unstructured":"Alzahrani AY, Alblaihed DA, Jamal DY, Ibrahim ST, Ajabnoor GM, Elsamanoudy AZ. The potential use of salivary OMICs in understanding the pathogenesis and diagnosis of oral and medical diseases. J Microsc Ultrastruct. 2023;0(0):1-17. https:\/\/doi.org\/10.4103\/jmau.jmau_122_22.","journal-title":"J Microsc Ultrastruct."},{"issue":"1","key":"799_CR120","doi-asserted-by":"publisher","first-page":"64","DOI":"10.5281\/zenodo.10529724","volume":"18","author":"M El Bouhairi","year":"2024","unstructured":"El Bouhairi M, Lachheb O, Sidqui M. Exploring the efficacy and applications of salivary tests in modern dental practice. Am J Innov Res Appl Sci. 2024;18(1):64\u201381. https:\/\/doi.org\/10.5281\/zenodo.10529724.","journal-title":"Am J Innov Res Appl Sci."},{"issue":"4","key":"799_CR121","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1016\/j.jds.2020.12.002","volume":"16","author":"C Shi","year":"2021","unstructured":"Shi C, Cai L, Xun Z, Zheng S, Shao F, Wang B, et al. Metagenomic analysis of the salivary microbiota in patients with caries, periodontitis and comorbid diseases. J Dent Sci. 2021;16(4):1264\u201373. https:\/\/doi.org\/10.1016\/j.jds.2020.12.002.","journal-title":"J Dent Sci"}],"container-title":["Molecular Diagnosis &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40291-025-00799-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40291-025-00799-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40291-025-00799-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:52:58Z","timestamp":1761947578000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40291-025-00799-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,18]]},"references-count":121,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["799"],"URL":"https:\/\/doi.org\/10.1007\/s40291-025-00799-1","relation":{"references":[{"id-type":"doi","id":"10.5281\/ZENODO.10427760","asserted-by":"subject"}]},"ISSN":["1177-1062","1179-2000"],"issn-type":[{"value":"1177-1062","type":"print"},{"value":"1179-2000","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,18]]},"assertion":[{"value":"25 June 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No funding was used in the preparation of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Seyed Ebrahim Alavi, Lavanya Ajay Sharma, Ajay Sharma, and Hasan Ebrahimi Shahmabadi have no conflicts that are directly relevant to the content of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest\/Competing Interests"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Upon request, data are available.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of Data and Material"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code Availability"}},{"value":"SEA and HES participated in the conceptualization of the study, supervision of the study, and writing of the original draft of the manuscript. All authors provided feedback on earlier versions, and reviewed and approved the final manuscript.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 Contributions"}},{"value":"SEA: conceptualization, data curation, formal analysis, investigation, methodology, supervision, writing original draft, writing (review and editing). LAS: investigation, writing (review and editing). AS: investigation, writing (review and editing). HES: conceptualization, data curation, formal analysis, investigation, supervision, writing original draft.","order":10,"name":"Ethics","group":{"name":"EthicsHeading","label":"CRediT Authorship Contribution Statement"}}]}}