{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T09:03:00Z","timestamp":1792918980720,"version":"4.5.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Diagn Ther"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s40291-026-00863-4","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T08:25:23Z","timestamp":1784103923000},"page":"833-837","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Marnetegragene Autotemcel: First Approval"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0789-7765","authenticated-orcid":false,"given":"Simon","family":"Fung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"issue":"4","key":"863_CR1","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1016\/j.jaip.2017.12.008","volume":"6","author":"E Almarza Novoa","year":"2018","unstructured":"Almarza Novoa E, Kasbekar S, Thrasher AJ, et al. Leukocyte adhesion deficiency-I: a comprehensive review of all published cases. J Allergy Clin Immunol Pract. 2018;6(4):1418-20.e10.","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"4","key":"863_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-019-0227-1","volume":"51","author":"YM Hyun","year":"2019","unstructured":"Hyun YM, Choe YH, Park SA, et al. LFA-1 (CD11a\/CD18) and Mac-1 (CD11b\/CD18) distinctly regulate neutrophil extravasation through hotspots I and II. Exp Mol Med. 2019;51(4):1\u201313.","journal-title":"Exp Mol Med"},{"issue":"3","key":"863_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacig.2026.100682","volume":"5","author":"J Heimall","year":"2026","unstructured":"Heimall J, Gonzalez-Granado LI, Booth C, et al. International clinical consensus on leukocyte adhesion deficiency-I: modified Delphi analysis. J Allergy Clin Immunol Glob. 2026;5(3):100682.","journal-title":"J Allergy Clin Immunol Glob"},{"issue":"1","key":"863_CR4","first-page":"39","volume":"1","author":"A Fischer","year":"1988","unstructured":"Fischer A, Lisowska-Grospierre B, Anderson DC, et al. Leukocyte adhesion deficiency: molecular basis and functional consequences. Immunodefic Rev. 1988;1(1):39\u201354.","journal-title":"Immunodefic Rev"},{"issue":"3","key":"863_CR5","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1038\/s41409-022-01875-4","volume":"58","author":"C Lueck","year":"2023","unstructured":"Lueck C, Tzalavras A, Wohlfarth P, et al. Impact of chronic graft-versus-host-disease on intensive care outcome in allogeneic hematopoietic stem cell recipients. Bone Marrow Transplant. 2023;58(3):303\u201310.","journal-title":"Bone Marrow Transplant"},{"key":"863_CR6","unstructured":"Rocket Pharmaceuticals I. KRESLADI (marnetegragene autotemcel) suspension for intravenous infusion: US prescribing information. 2026. https:\/\/www.fda.gov\/vaccines-blood-biologics\/kresladi. Accessed 12 Jun 2026."},{"key":"863_CR7","unstructured":"Rocket Pharmaceuticals I. Rocket Pharmaceuticals announces FDA approval of KRESLADI\u2122 for pediatric patients with severe leukocyte adhesion deficiency-I (LAD-I). 2026. https:\/\/ir.rocketpharma.com\/news-releases\/news-release-details\/rocket-pharmaceuticals-announces-fda-approval-kresladitm. Accessed 12 Jun 2006."},{"key":"863_CR8","unstructured":"US Food & Drug Administration. FDA approves first gene therapy for severe leukocyte adhesion deficiency type I. 2026. https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-gene-therapy-severe-leukocyte-adhesion-deficiency-type-i. Accessed 12 Jun 2026."},{"key":"863_CR9","unstructured":"Lonza. Lonza supporting Rocket Pharma with clinical manufacturing of LAD-I for the treatment of leukocyte adhesion deficiency-I. 2020. http:\/\/www.lonza.com. Accessed 12 Jun 2026."},{"key":"863_CR10","unstructured":"Rocket Pharmaceuticals I. SEC Filing-Form 10-K. 2019. https:\/\/rocketpharmaceuticals.gcs-web.com\/sec-filings\/sec-filing\/10-k\/0001140361-19-004603. Accessed 12 Jun 2026."},{"issue":"9","key":"863_CR11","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1089\/hum.2016.016","volume":"27","author":"D Leon-Rico","year":"2016","unstructured":"Leon-Rico D, Aldea M, Sanchez-Baltasar R, et al. Lentiviral vector-mediated correction of a mouse model of leukocyte adhesion deficiency type I. Hum Gene Ther. 2016;27(9):668\u201378.","journal-title":"Hum Gene Ther"},{"issue":"17","key":"863_CR12","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1056\/NEJMoa2407376","volume":"392","author":"C Booth","year":"2025","unstructured":"Booth C, Sevilla J, Almarza E, et al. Lentiviral gene therapy for severe leukocyte adhesion deficiency type 1. N Engl J Med. 2025;392(17):1698\u2013709.","journal-title":"N Engl J Med"},{"key":"863_CR13","doi-asserted-by":"publisher","unstructured":"Booth C, Sevilla J, Almarza Novoa E, et al. Autologous ex vivo lentiviral gene therapy for pediatric patients with severe leukocyte adhesion deficiency-I provides sustained efficacy with a favorable safety profile. 2026. https:\/\/doi.org\/10.70962\/CIS2026abstract.4.","DOI":"10.70962\/CIS2026abstract.4"},{"key":"863_CR14","unstructured":"US Food and Drug Administration. BLA clinical & clinical pharmacology review memorandum. 2026. www.fda.gov. Accessed 12 Jun 2026."}],"container-title":["Molecular Diagnosis &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40291-026-00863-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40291-026-00863-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40291-026-00863-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:31:57Z","timestamp":1787380317000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40291-026-00863-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["863"],"URL":"https:\/\/doi.org\/10.1007\/s40291-026-00863-4","relation":{},"ISSN":["1177-1062","1179-2000"],"issn-type":[{"value":"1177-1062","type":"print"},{"value":"1179-2000","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]},"assertion":[{"value":"14 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"During the peer review process, the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. S. Fung is a salaried employee of Adis International Ltd\/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to this article and are responsible for its content.","order":1,"name":"Ethics","label":"Authorship and Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability","group":{"name":"EthicsHeading","label":"Declarations"}}]}}