{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:50:29Z","timestamp":1790970629534,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T00:00:00Z","timestamp":1466640000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Universit\u00e0 di Bologna (IT)","award":["RFO2015"],"award-info":[{"award-number":["RFO2015"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["High Blood Press Cardiovasc Prev"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1007\/s40292-016-0163-2","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T17:38:35Z","timestamp":1466703515000},"page":"13-18","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Effects of a Combined Nutraceutical on Lipid Pattern, Glucose Metabolism and Inflammatory Parameters in Moderately Hypercholesterolemic Subjects: A Double-blind, Cross-over, Randomized Clinical Trial"],"prefix":"10.1007","volume":"24","author":[{"given":"Arrigo Francesco Giuseppe","family":"Cicero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Colletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Fogacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilisa","family":"Bove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Rosticci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Borghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,23]]},"reference":[{"key":"163_CR1","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0140-6736(04)17018-9","volume":"364","author":"S Yusuf","year":"2004","unstructured":"Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, McQueen M, Budaj A, Pais P, Varigos J, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364:937\u201352.","journal-title":"Lancet"},{"issue":"2","key":"163_CR2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4330\/wjc.v8.i2.201","volume":"8","author":"AD Hendrani","year":"2016","unstructured":"Hendrani AD, Adesiyun T, Quispe R, Jones SR, Stone NJ, Blumenthal RS, Martin SS. Dyslipidemia\u00a0management in primary prevention of\u00a0cardiovascular\u00a0disease: Current guidelines and strategies. World J Cardiol. 2016;8(2):201\u201310.","journal-title":"World J Cardiol."},{"issue":"3","key":"163_CR3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3949\/ccjm.83gr.16001","volume":"83","author":"MS Sabatine","year":"2016","unstructured":"Sabatine MS. Advances in the treatment of\u00a0dyslipidemia. Cleve Clin J Med. 2016;83(3):181\u20136.","journal-title":"Cleve Clin J Med."},{"issue":"7","key":"163_CR4","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.ejim.2014.06.008","volume":"25","author":"MR Mannarino","year":"2014","unstructured":"Mannarino MR, Ministrini S, Pirro M. Nutraceuticals for the treatment of hypercholesterolemia. Eur J Intern Med. 2014;25(7):592\u20139.","journal-title":"Eur J Intern Med."},{"issue":"4","key":"163_CR5","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s11883-015-0495-8","volume":"17","author":"FM Burke","year":"2015","unstructured":"Burke FM. Red yeast rice\u00a0for the treatment of\u00a0dyslipidemia. Curr Atheroscler Rep. 2015;17(4):495.","journal-title":"Curr Atheroscler Rep."},{"key":"163_CR6","doi-asserted-by":"crossref","unstructured":"Wider B, Pittler MH, Thompson-Coon J, Ernst E. Artichoke leaf extract for treating hypercholesterolaemia. Cochrane Database Syst Rev. 2013;3:CD003335.","DOI":"10.1002\/14651858.CD003335.pub3"},{"issue":"7","key":"163_CR7","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.lfs.2004.07.018","volume":"76","author":"G Lupattelli","year":"2004","unstructured":"Lupattelli G, Marchesi S, Lombardini R, Roscini AR, Trinca F, Gemelli F, Vaudo G, Mannarino E. Artichoke juice improves endothelial function in hyperlipemia. Life Sci. 2004;76(7):775\u201382.","journal-title":"Life Sci"},{"issue":"4","key":"163_CR8","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s11130-015-0503-8","volume":"70","author":"M Ben Salem","year":"2015","unstructured":"Ben Salem M, Affes H, Ksouda K, Dhouibi R, Sahnoun Z, Hammami S, Zeghal KM. Pharmacological studies of Artichoke leaf extract and their health benefits. Plant Foods Hum Nutr. 2015;70(4):441\u201353.","journal-title":"Plant Foods Hum Nutr"},{"issue":"1","key":"163_CR9","first-page":"17","volume":"80","author":"M Rondanelli","year":"2013","unstructured":"Rondanelli M, Monteferrario F, Perna S, Faliva MA, Opizzi A. Health-promoting properties of\u00a0artichoke\u00a0in preventing cardiovascular disease by its lipidic and glycemic-reducing action. Monaldi Arch Chest Dis. 2013;80(1):17\u201326.","journal-title":"Monaldi Arch Chest Dis"},{"issue":"4","key":"163_CR10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/ecam\/nem013","volume":"4","author":"G Klein","year":"2007","unstructured":"Klein G, Kim J, Himmeldirk K, Cao Y, Chen X. Antidiabetes and Anti-obesity Activity of Lagerstroemia speciosa. Evid Based Complement Alternat Med. 2007;4(4):401\u20137.","journal-title":"Evid Based Complement Alternat Med."},{"issue":"3","key":"163_CR11","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ptr.3664","volume":"26","author":"SJ Stohs","year":"2012","unstructured":"Stohs SJ, Miller H, Kaats GR. A review of the efficacy and safety of\u00a0banaba\u00a0(Lagerstroemia speciosa L.) and corosolic acid. Phytother Res. 2012;26(3):317\u201324.","journal-title":"Phytother Res"},{"key":"163_CR12","doi-asserted-by":"publisher","unstructured":"Cicero AF, Colletti A. Role of phytochemicals in the management of metabolic syndrome. Phytomedicine. 2015 Dec 11. doi: 10.1016\/j.phymed.2015.11.009 .","DOI":"10.1016\/j.phymed.2015.11.009"},{"key":"163_CR13","doi-asserted-by":"crossref","first-page":"619","DOI":"10.2741\/4231","volume":"19","author":"J Garrido-Maraver","year":"2014","unstructured":"Garrido-Maraver J, Cordero MD, Oropesa-Avila M, Vega AF, de la Mata M, Pavon AD, Alcocer-Gomez E, Calero CP, Paz MV, Alanis M, de Lavera I, Cotan D, Sanchez-Alcazar JA. Clinical applications of coenzyme Q10. Front Biosci. 2014;19:619\u201333.","journal-title":"Front Biosci."},{"issue":"3","key":"163_CR14","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.pharmthera.2009.07.003","volume":"124","author":"A Kumar","year":"2009","unstructured":"Kumar A, Kaur H, Devi P, Mohan V. Role of\u00a0coenzyme Q10\u00a0(CoQ10) in cardiac disease, hypertension and Meniere-like syndrome. Pharmacol Ther. 2009;124(3):259\u201368.","journal-title":"Pharmacol Ther"},{"issue":"4","key":"163_CR15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00005082-200207000-00003","volume":"16","author":"B Sarter","year":"2002","unstructured":"Sarter B. Coenzyme Q10\u00a0and\u00a0cardiovascular\u00a0disease: a review. J Cardiovasc Nurs. 2002;16(4):9\u201320.","journal-title":"J Cardiovasc Nurs"},{"key":"163_CR16","doi-asserted-by":"publisher","unstructured":"Cicero AF, Colletti A. Combinations of phytomedicines with different lipid lowering activity for dyslipidemia management: The available clinical data. Phytomedicine. 2015 Nov 10. doi: 10.1016\/j.phymed.2015.10.011 .","DOI":"10.1016\/j.phymed.2015.10.011"},{"issue":"3","key":"163_CR17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s40292-015-0092-5","volume":"22","author":"R Volpe","year":"2015","unstructured":"Volpe R, Sotis G. Nutraceuticals: definition and epidemiological rationale for their use in clinical practice. High Blood Press Cardiovasc Prev. 2015;22(3):199\u2013201.","journal-title":"High Blood Press Cardiovasc Prev."},{"issue":"3","key":"163_CR18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000445359","volume":"68","author":"AF Cicero","year":"2016","unstructured":"Cicero AF, Morbini M, Rosticci M, D\u2019\u2019Addato S, Grandi E, Borghi C. Middle-term dietary supplementation with red yeast rice plus coenzyme Q10 improves lipid pattern, endothelial reactivity and arterial stiffness in moderately hypercholesterolemic subjects. Ann Nutr Metab. 2016;68(3):213\u20139.","journal-title":"Ann Nutr Metab"},{"issue":"2","key":"163_CR19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s40292-014-0077-9","volume":"22","author":"AF Cicero","year":"2015","unstructured":"Cicero AF, Rosticci M, Reggi A, Derosa G, Parini A, Grandi E, D\u2019Addato S, Borghi C. Relationship between serum uric acid and electrocardiographic alterations in a large sample of general population: data from the Brisighella Heart Study. High Blood Press Cardiovasc Prev. 2015;22(2):129\u201334.","journal-title":"High Blood Press Cardiovasc Prev."},{"key":"163_CR20","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412\u20139.","journal-title":"Diabetologia"},{"key":"163_CR21","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12902","author":"C Borghi","year":"2016","unstructured":"Borghi C, Cicero AF. Nutraceuticals with clinically detectable blood pressure lowering effect: a review of available randomized clinical trials and their meta-analyses. Br J Clin Pharmacol. 2016;. doi: 10.1111\/bcp.12902 .","journal-title":"Br J Clin Pharmacol"},{"key":"163_CR22","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1093\/eurheartj\/ehr080","volume":"32","author":"JR Banegas","year":"2011","unstructured":"Banegas JR, L\u00f3pez-Garc\u00eda E, Dallongeville J, Guallar E, Halcox JP, Borghi C, Mass\u00f3-Gonz\u00e1lez EL, Jim\u00e9nez FJ, Perk J, Steg PG, De Backer G, Rodr\u00edguez-Artalejo F. Achievement of treatment goals for primary prevention of cardiovascular disease in clinical practice across Europe: the EURIKA study. Eur Heart J. 2011;32:2143\u201352.","journal-title":"Eur Heart J"},{"key":"163_CR23","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.3390\/ijerph7083150","volume":"7","author":"S Saha","year":"2010","unstructured":"Saha S, Gerdtham UG, Johansson P. Economic evaluation of lifestyle interventions for preventing diabetes and cardiovascular diseases. Int J Environ Res Public Health. 2010;7:3150\u201395.","journal-title":"Int J Environ Res Public Health"},{"key":"163_CR24","doi-asserted-by":"crossref","first-page":"871495","DOI":"10.1155\/2012\/871495","volume":"2012","author":"T Miura","year":"2012","unstructured":"Miura T, Takagi S, Ishida T. Management of diabetes and its complications with banaba (Lagerstroemia speciosa L.) and Corosolic Acid. Evid Based Complement Alternat Med. 2012;2012:871495.","journal-title":"Evid Based Complement Alternat Med."},{"issue":"8","key":"163_CR25","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.nutres.2013.05.015","volume":"33","author":"AF Cicero","year":"2013","unstructured":"Cicero AF, Derosa G, Parini A, Maffioli P, D\u2019Addato S, Reggi A, Giovannini M, Borghi C. Red yeast rice improves lipid pattern, high-sensitivity C-reactive protein, and vascular remodeling parameters in moderately hypercholesterolemic Italian subjects. Nutr Res. 2013;33(8):622\u20138.","journal-title":"Nutr Res."},{"issue":"1","key":"163_CR26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3109\/09637486.2012.700920","volume":"64","author":"M Rondanelli","year":"2013","unstructured":"Rondanelli M, Giacosa A, Opizzi A, Faliva MA, Sala P, Perna S, Riva A, Morazzoni P, Bombardelli E. Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial. Int J Food Sci Nutr. 2013;64(1):7\u201315.","journal-title":"Int J Food Sci Nutr"},{"issue":"1\u20134","key":"163_CR27","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/biof.5520320124","volume":"32","author":"T Hidaka","year":"2008","unstructured":"Hidaka T, Fujii K, Funahashi I, Fukutomi N, Hosoe K. Safety assessment of coenzyme Q10 (CoQ10). BioFactors. 2008;32(1\u20134):199\u2013208.","journal-title":"BioFactors"},{"issue":"8","key":"163_CR28","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1007\/s00394-012-0486-2","volume":"52","author":"E Barrat","year":"2013","unstructured":"Barrat E, Za\u00efr Y, Sirvent P, Chauveau P, Maudet C, Housez B, Derbord E, Lescuyer JF, Bard JM, Cazaubiel M, Peltier SL. Effect on LDL-cholesterol of a large dose of a dietary supplement with plant extracts in subjects with untreated moderate hypercholesterolaemia: a randomised, double-blind, placebo-controlled study. Eur J Nutr. 2013;52(8):1843\u201352.","journal-title":"Eur J Nutr"},{"issue":"4","key":"163_CR29","doi-asserted-by":"crossref","first-page":"565","DOI":"10.2174\/15701611113119990120","volume":"12","author":"AF Cicero","year":"2014","unstructured":"Cicero AF, Tartagni E, Ertek S. Nutraceuticals for metabolic syndrome management: from laboratory to benchside. Curr Vasc Pharmacol. 2014;12(4):565\u201371.","journal-title":"Curr Vasc Pharmacol"},{"issue":"5","key":"163_CR30","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1517\/14740338.2012.705827","volume":"11","author":"AF Cicero","year":"2012","unstructured":"Cicero AF, Ferroni A, Ertek S. Tolerability and safety of commonly used dietary supplements and nutraceuticals with lipid-lowering effects. Expert Opin Drug Saf. 2012;11(5):753\u201366.","journal-title":"Expert Opin Drug Saf."},{"key":"163_CR31","doi-asserted-by":"crossref","first-page":"g3743","DOI":"10.1136\/bmj.g3743","volume":"349","author":"CS Desai","year":"2014","unstructured":"Desai CS, Martin SS, Blumenthal RS. Non-cardiovascular effects associated with statins. BMJ. 2014;349:g3743.","journal-title":"BMJ"},{"key":"163_CR32","doi-asserted-by":"publisher","unstructured":"Francque SM, van der Graaff D, Kwanten WJ. Non-alcoholic fatty liver disease and cardiovascular risk: pathophysiological mechanisms and implications. J Hepatol. 2016 Apr 15. doi: 10.1016\/j.jhep.2016.04.005 .","DOI":"10.1016\/j.jhep.2016.04.005"}],"container-title":["High Blood Pressure &amp; Cardiovascular Prevention"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40292-016-0163-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40292-016-0163-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40292-016-0163-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40292-016-0163-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T20:14:39Z","timestamp":1600805679000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40292-016-0163-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,23]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["163"],"URL":"https:\/\/doi.org\/10.1007\/s40292-016-0163-2","relation":{},"ISSN":["1120-9879","1179-1985"],"issn-type":[{"value":"1120-9879","type":"print"},{"value":"1179-1985","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,23]]}}}