{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:48:00Z","timestamp":1790704080172,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["High Blood Press Cardiovasc Prev"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s40292-019-00336-2","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T11:03:11Z","timestamp":1566990191000},"page":"399-404","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Treatment with Free Triple Combination Therapy of Atorvastatin, Perindopril, Amlodipine in Hypertensive Patients: A Real-World Population Study in Italy"],"prefix":"10.1007","volume":"26","author":[{"given":"Valentina","family":"Perrone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Veronesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Gambera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Nati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Perone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Fausta","family":"Tagliabue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Degli Esposti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Volpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"336_CR1","unstructured":"World Health Organization. Cardiovascular diseases (CVDs). [Internet]. \n                    http:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/cardiovascular-diseases-(cvds)\n                    \n                  . Accessed 1 May 2019."},{"issue":"5","key":"336_CR2","first-page":"587","volume":"3","author":"L Erhardt","year":"2007","unstructured":"Erhardt L, Moller R, Puig JG. Comprehensive cardiovascular risk management\u2013what does it mean in practice? Vasc Health Risk Manag. 2007;3(5):587\u2013603.","journal-title":"Vasc Health Risk Manag."},{"issue":"5","key":"336_CR3","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1111\/j.1524-6175.2005.04533.x","volume":"7","author":"R Blank","year":"2005","unstructured":"Blank R, LaSalle J, Reeves R, Maroni J, Tarasenko L, Sun F. Single-pill therapy in the treatment of concomitant hypertension and dyslipidemia (the amlodipine\/atorvastatin Gemini Study). J Clin Hypertens. 2005;7(5):264\u201373.","journal-title":"J Clin Hypertens."},{"issue":"5","key":"336_CR4","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1177\/0300060518760158","volume":"46","author":"CA D\u00e9zsi","year":"2018","unstructured":"D\u00e9zsi CA. Treatment with triple combination of atorvastatin, perindopril, and amlodipine in patients with stable coronary artery disease: a subgroup analysis from the PAPA-CAD study. J Int Med Res. 2018;46(5):1902\u20139.","journal-title":"J Int Med Res."},{"issue":"5","key":"336_CR5","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1097\/00041552-200209000-00003","volume":"11","author":"C Borghi","year":"2002","unstructured":"Borghi C. Interactions between hypercholesterolemia and hypertension: implications for therapy. Curr Opin Nephrol Hypertens. 2002;11(5):489\u201396.","journal-title":"Curr Opin Nephrol Hypertens."},{"issue":"4","key":"336_CR6","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s40256-016-0175-2","volume":"16","author":"ME Bertrand","year":"2016","unstructured":"Bertrand ME, Vlachopoulos C, Mourad J-J. Triple combination therapy for global cardiovascular risk: atorvastatin, perindopril, and amlodipine. Am J Cardiovasc Drugs. 2016;16(4):241\u201353.","journal-title":"Am J Cardiovasc Drugs."},{"key":"336_CR7","unstructured":"Watson S, Gupta A, Poulter N. Prevention of coronary and stroke events with perindopril, amlodipine and atorvastatin in combination: sub-group analysis of the anglo-scandinavian cardiac outcomes trial (ASCOT). J Hypertens [Internet]. 2014;32(e-Supplement 1). http:\/\/file:\/\/\/C:\/Users\/AnnaGirardi\/Downloads\/odborna%20publikacia_Post%20hoc%20ASCOT_LLA.pdf ."},{"issue":"4","key":"336_CR8","doi-asserted-by":"publisher","first-page":"304","DOI":"10.4065\/mcp.2010.0575","volume":"86","author":"MT Brown","year":"2011","unstructured":"Brown MT, Bussell JK. Medication adherence: WHO cares? Mayo Clin Proc. 2011;86(4):304\u201314.","journal-title":"Mayo Clin Proc."},{"issue":"1","key":"336_CR9","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3109\/21556660.2013.801605","volume":"2","author":"N Katsiki","year":"2013","unstructured":"Katsiki N, Athyros VG, Karagiannis A. Single-pill combinations: a therapeutic option or necessity for vascular risk treatment? J Drug Assess. 2013;2(1):67\u201371.","journal-title":"J Drug Assess."},{"issue":"22","key":"336_CR10","doi-asserted-by":"publisher","first-page":"3384","DOI":"10.1161\/CIRCULATIONAHA.105.537472","volume":"112","author":"Asia Pacific Cohort Studies Collaboration","year":"2005","unstructured":"Asia Pacific Cohort Studies Collaboration. Joint effects of systolic blood pressure and serum cholesterol on cardiovascular disease in the Asia Pacific Region. Circulation. 2005;112(22):3384\u201390.","journal-title":"Circulation"},{"issue":"33","key":"336_CR11","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","volume":"39","author":"B Williams","year":"2018","unstructured":"Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. ESC\/ESH guidelines for the management of arterial hypertension. Eur Heart J. 2018;39(33):3021\u2013104.","journal-title":"Eur Heart J"},{"key":"336_CR12","unstructured":"Agenzia Italiana del Farmaco (AIFA). Guideline for the classification and conduction of the observational studies on medicines. [Internet]. 2010. \n                    https:\/\/www.agenziafarmaco.gov.it\/ricclin\/sites\/default\/files\/files_wysiwyg\/files\/CIRCULARS\/Circular%2031st%20May%202010.pdf\n                    \n                  ."},{"key":"336_CR13","unstructured":"http:\/\/demo.istat.it\/pop2014\/index.html\n                    \n                  . Accessed 1 May 2019."},{"issue":"3","key":"336_CR14","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1161\/CIRCOUTCOMES.111.963439","volume":"5","author":"MT Crim","year":"2012","unstructured":"Crim MT, Yoon SSS, Ortiz E, Wall HK, Schober S, Gillespie C, et al. National surveillance definitions for hypertension prevalence and control among adults. Circ Cardiovasc Qual Outcomes. 2012;5(3):343\u201351.","journal-title":"Circ Cardiovasc Qual Outcomes."},{"issue":"7","key":"336_CR15","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1097\/HJH.0b013e3280fa83a6","volume":"25","author":"M Volpe","year":"2007","unstructured":"Volpe M, Tocci G, Trimarco B, Rosei EA, Borghi C, Ambrosioni E, et al. Blood pressure control in Italy: results of recent surveys on hypertension. J Hypertens. 2007;25(7):1491\u20138.","journal-title":"J Hypertens."},{"issue":"4","key":"336_CR16","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/jhh.2016.71","volume":"31","author":"G Tocci","year":"2017","unstructured":"Tocci G, Nati G, Cricelli C, Parretti D, Lapi F, Ferrucci A, Borghi C, Volpe M. Prevalence and control of hypertension in the general practice in Italy: updated analysis of a large database. J Hum Hypertens. 2017;31(4):258\u201362.","journal-title":"J Hum Hypertens."},{"key":"336_CR17","first-page":"1","volume":"22","author":"L Degli Esposti","year":"2018","unstructured":"Degli Esposti L, Perrone V, Veronesi C, Gambera M, Nati G, Perone F, et al. Modifications in drug adherence after switch to fixed-dose combination of perindopril\/amlodipine in clinical practice. Results of a large-scale Italian experience. The amlodipine\u2013perindopril in real settings (AMPERES) study. Curr Med Res Opin. 2018;22:1\u20137.","journal-title":"Curr Med Res Opin"},{"issue":"2","key":"336_CR18","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1177\/2042098617747836","volume":"9","author":"V Selak","year":"2018","unstructured":"Selak V, Webster R. Polypills for the secondary prevention of cardiovascular disease: effective in improving adherence but are they safe? Ther Adv Drug Saf. 2018;9(2):157\u201362.","journal-title":"Ther Adv Drug Saf."},{"issue":"3","key":"336_CR19","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s40292-018-0278-8","volume":"25","author":"M Volpe","year":"2018","unstructured":"Volpe M, Battistoni A, Gallo G, Rubattu S, Tocci G, Writing Committee; Scientific Societies. Executive summary of the 2018 joint consensus document on cardiovascular disease prevention in Italy. High Blood Press Cardiovasc Prev. 2018;25(3):327\u201341.","journal-title":"High Blood Press Cardiovasc Prev"},{"issue":"4","key":"336_CR20","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s40292-017-0239-7","volume":"24","author":"M Volpe","year":"2017","unstructured":"Volpe M, Tocci G, de la Sierra A, Kreutz R, Laurent S, Manolis AJ, Tsioufis K. Personalised single-pill combination therapy in hypertensive patients: an update of a practical treatment platform. High Blood Press Cardiovasc Prev. 2017;24(4):463\u201372.","journal-title":"High Blood Press Cardiovasc Prev."},{"issue":"5","key":"336_CR21","doi-asserted-by":"publisher","first-page":"e019719","DOI":"10.1136\/bmjopen-2017-019719","volume":"8","author":"Y Wang","year":"2018","unstructured":"Wang Y, Kuang ZM, Feng SJ, Jiang L, Chen QX, Ji XY, Cheng WL, Hu HJ. Combined antihypertensive and statin therapy for the prevention of cardiovascular events in patients with hypertension without complications: protocol for a systematic review and meta-analysis. BMJ Open. 2018;8(5):e019719.","journal-title":"BMJ Open."},{"key":"336_CR22","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1097\/HJH.0000000000001419","volume":"35","author":"G Tocci","year":"2017","unstructured":"Tocci G, Presta V, Citoni B, et al. Favorable impact of statin use on diastolic blood pressure levels: analysis of a large database of 24-hour ambulatory blood pressure monitoring. J Hypertens. 2017;35:2086\u201394.","journal-title":"J Hypertens."}],"container-title":["High Blood Pressure & Cardiovascular Prevention"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40292-019-00336-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40292-019-00336-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40292-019-00336-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T23:11:16Z","timestamp":1598483476000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40292-019-00336-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,28]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["336"],"URL":"https:\/\/doi.org\/10.1007\/s40292-019-00336-2","relation":{},"ISSN":["1120-9879","1179-1985"],"issn-type":[{"value":"1120-9879","type":"print"},{"value":"1179-1985","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,28]]},"assertion":[{"value":"31 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Manuscript development was supported by unconditional funding from Servier. MV\u00a0received honoraria for speaking bureau or scientific consulting Servier.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}