{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:17:21Z","timestamp":1770833841489,"version":"3.50.1"},"reference-count":95,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["High Blood Press Cardiovasc Prev"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s40292-020-00400-2","type":"journal-article","created":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T16:02:41Z","timestamp":1596297761000},"page":"363-371","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["New Mechanisms of Vascular Dysfunction in Cardiometabolic Patients: Focus on Epigenetics"],"prefix":"10.1007","volume":"27","author":[{"given":"Samuele","family":"Ambrosini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shafeeq A.","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"L\u00fcscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Costantino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Paneni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,1]]},"reference":[{"issue":"5","key":"400_CR1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41574-019-0176-8","volume":"15","author":"M Bl\u00fcher","year":"2019","unstructured":"Bl\u00fcher M. Obesity: global epidemiology and pathogenesis. Nat Rev Endocrinol. 2019;15(5):288\u201398.","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"400_CR2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","volume":"377","author":"GBDO Collaborators","year":"2017","unstructured":"Collaborators GBDO, et al. Health effects of overweight and obesity in 195 Countries over 25 years. N Engl J Med. 2017;377(1):13\u201327.","journal-title":"N Engl J Med"},{"issue":"16","key":"400_CR3","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","volume":"120","author":"KG Alberti","year":"2009","unstructured":"Alberti KG, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120(16):1640\u20135.","journal-title":"Circulation"},{"issue":"19","key":"400_CR4","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1001\/jama.2015.4260","volume":"313","author":"M Aguilar","year":"2015","unstructured":"Aguilar M, et al. Prevalence of the metabolic syndrome in the United States, 2003\u20132012. JAMA. 2015;313(19):1973\u20134.","journal-title":"JAMA"},{"issue":"4","key":"400_CR5","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1161\/ATVBAHA.118.312135","volume":"39","author":"FM Davis","year":"2019","unstructured":"Davis FM, Gallagher KA. Epigenetic mechanisms in monocytes\/macrophages regulate inflammation in cardiometabolic and vascular disease. Arterioscler Thromb Vasc Biol. 2019;39(4):623\u201334.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"400_CR6","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ahj.2004.07.009","volume":"149","author":"GR Dagenais","year":"2005","unstructured":"Dagenais GR, et al. Prognostic impact of body weight and abdominal obesity in women and men with cardiovascular disease. Am Heart J. 2005;149(1):54\u201360.","journal-title":"Am Heart J"},{"issue":"12","key":"400_CR7","doi-asserted-by":"crossref","first-page":"e52036","DOI":"10.1371\/journal.pone.0052036","volume":"7","author":"KB Gast","year":"2012","unstructured":"Gast KB, et al. Insulin resistance and risk of incident cardiovascular events in adults without diabetes: meta-analysis. PLoS One. 2012;7(12):e52036.","journal-title":"PLoS One"},{"issue":"6067","key":"400_CR8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/321209a0","volume":"321","author":"AP Bird","year":"1986","unstructured":"Bird AP. CpG-rich islands and the function of DNA methylation. Nature. 1986;321(6067):209\u201313.","journal-title":"Nature"},{"issue":"1","key":"400_CR9","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1139\/bcb-2019-0045","volume":"98","author":"D Prasher","year":"2020","unstructured":"Prasher D, Greenway SC, Singh RB. The impact of epigenetics on cardiovascular disease. Biochem Cell Biol. 2020;98(1):12\u201322.","journal-title":"Biochem Cell Biol"},{"issue":"3","key":"400_CR10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0092-8674(00)81656-6","volume":"99","author":"M Okano","year":"1999","unstructured":"Okano M, et al. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell. 1999;99(3):247\u201357.","journal-title":"Cell"},{"issue":"2","key":"400_CR11","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/jcp.21224","volume":"213","author":"TB Miranda","year":"2007","unstructured":"Miranda TB, Jones PA. DNA methylation: the nuts and bolts of repression. J Cell Physiol. 2007;213(2):384\u201390.","journal-title":"J Cell Physiol"},{"issue":"6","key":"400_CR12","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2174\/138920101606150407113644","volume":"16","author":"S Costantino","year":"2015","unstructured":"Costantino S, Paneni F, Cosentino F. Targeting chromatin remodeling to prevent cardiovascular disease in diabetes. Curr Pharm Biotechnol. 2015;16(6):531\u201343.","journal-title":"Curr Pharm Biotechnol"},{"issue":"1","key":"400_CR13","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1074\/jbc.M411126200","volume":"280","author":"G Vilkaitis","year":"2005","unstructured":"Vilkaitis G, et al. Processive methylation of hemimethylated CpG sites by mouse Dnmt1 DNA methyltransferase. J Biol Chem. 2005;280(1):64\u201372.","journal-title":"J Biol Chem"},{"issue":"9","key":"400_CR14","first-page":"607","volume":"11","author":"SC Wu","year":"2010","unstructured":"Wu SC, Zhang Y. Active DNA demethylation: many roads lead to Rome. Nat Rev Mol Cell Biol. 2010;11(9):607\u201320.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7472","key":"400_CR15","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nature12750","volume":"502","author":"RM Kohli","year":"2013","unstructured":"Kohli RM, Zhang Y. TET enzymes, TDG and the dynamics of DNA demethylation. Nature. 2013;502(7472):472\u20139.","journal-title":"Nature"},{"issue":"4","key":"400_CR16","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","volume":"128","author":"T Kouzarides","year":"2007","unstructured":"Kouzarides T. Chromatin modifications and their function. Cell. 2007;128(4):693\u2013705.","journal-title":"Cell"},{"issue":"4","key":"400_CR17","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.cell.2007.01.033","volume":"128","author":"BE Bernstein","year":"2007","unstructured":"Bernstein BE, Meissner A, Lander ES. The mammalian epigenome. Cell. 2007;128(4):669\u201381.","journal-title":"Cell"},{"issue":"7","key":"400_CR18","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1161\/CIRCRESAHA.116.303630","volume":"116","author":"TG Gillette","year":"2015","unstructured":"Gillette TG, Hill JA. Readers, writers, and erasers: chromatin as the whiteboard of heart disease. Circ Res. 2015;116(7):1245\u201353.","journal-title":"Circ Res"},{"issue":"6","key":"400_CR19","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.sbi.2008.11.004","volume":"18","author":"CE Berndsen","year":"2008","unstructured":"Berndsen CE, Denu JM. Catalysis and substrate selection by histone\/protein lysine acetyltransferases. Curr Opin Struct Biol. 2008;18(6):682\u20139.","journal-title":"Curr Opin Struct Biol"},{"issue":"4","key":"400_CR20","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/MCO.0b013e328354bf5c","volume":"15","author":"A Baccarelli","year":"2012","unstructured":"Baccarelli A, Ghosh S. Environmental exposures, epigenetics and cardiovascular disease. Curr Opin Clin Nutr Metab Care. 2012;15(4):323\u20139.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"12","key":"400_CR21","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1161\/CIRCRESAHA.110.223552","volume":"107","author":"ME Cooper","year":"2010","unstructured":"Cooper ME, El-Osta A. Epigenetics: mechanisms and implications for diabetic complications. Circ Res. 2010;107(12):1403\u201313.","journal-title":"Circ Res"},{"issue":"19","key":"400_CR22","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1161\/CIRCULATIONAHA.110.956839","volume":"123","author":"DE Handy","year":"2011","unstructured":"Handy DE, Castro R, Loscalzo J. Epigenetic modifications: basic mechanisms and role in cardiovascular disease. Circulation. 2011;123(19):2145\u201356.","journal-title":"Circulation"},{"issue":"6683","key":"400_CR23","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/30764","volume":"393","author":"X Nan","year":"1998","unstructured":"Nan X, et al. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature. 1998;393(6683):386\u20139.","journal-title":"Nature"},{"issue":"2","key":"400_CR24","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1128\/MCB.01576-06","volume":"27","author":"R Eskeland","year":"2007","unstructured":"Eskeland R, Eberharter A, Imhof A. HP1 binding to chromatin methylated at H3K9 is enhanced by auxiliary factors. Mol Cell Biol. 2007;27(2):453\u201365.","journal-title":"Mol Cell Biol"},{"issue":"7","key":"400_CR25","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1093\/nar\/gkr1066","volume":"40","author":"AA Thambirajah","year":"2012","unstructured":"Thambirajah AA, et al. MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9\/H3K27 methylated nucleosomes in the brain. Nucleic Acids Res. 2012;40(7):2884\u2013977.","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"400_CR26","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1161\/CIRCRESAHA.113.302988","volume":"113","author":"P Gurha","year":"2013","unstructured":"Gurha P, Marian AJ. Noncoding RNAs in cardiovascular biology and disease. Circ Res. 2013;113(12):e115\u2013e12020.","journal-title":"Circ Res"},{"issue":"4","key":"400_CR27","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1161\/CIRCRESAHA.116.302521","volume":"116","author":"S Uchida","year":"2015","unstructured":"Uchida S, Dimmeler S. Long noncoding RNAs in cardiovascular diseases. Circ Res. 2015;116(4):737\u201350.","journal-title":"Circ Res"},{"issue":"24","key":"400_CR28","doi-asserted-by":"crossref","first-page":"6249","DOI":"10.3390\/ijms20246249","volume":"20","author":"M Correia de Sousa","year":"2019","unstructured":"Correia de Sousa M, et al. Deciphering miRNAs' Action through miRNA Editing. Int J Mol Sci. 2019;20(24):6249.","journal-title":"Int J Mol Sci"},{"issue":"10","key":"400_CR29","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.jacc.2015.12.051","volume":"67","author":"RA Boon","year":"2016","unstructured":"Boon RA, et al. Long noncoding RNAs: from clinical genetics to therapeutic targets? J Am Coll Cardiol. 2016;67(10):1214\u201326.","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"400_CR30","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1672-0229(08)60044-3","volume":"7","author":"Y Cai","year":"2009","unstructured":"Cai Y, et al. A brief review on the mechanisms of miRNA regulation. Genom Proteom Bioinform. 2009;7(4):147\u201354.","journal-title":"Genom Proteom Bioinform"},{"issue":"2","key":"400_CR31","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/10408363.2017.1422109","volume":"55","author":"P Agarwal","year":"2018","unstructured":"Agarwal P, et al. Maternal obesity, diabetes during pregnancy and epigenetic mechanisms that influence the developmental origins of cardiometabolic disease in the offspring. Crit Rev Clin Lab Sci. 2018;55(2):71\u2013101.","journal-title":"Crit Rev Clin Lab Sci"},{"issue":"2","key":"400_CR32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.maturitas.2011.06.017","volume":"70","author":"TJ Roseboom","year":"2011","unstructured":"Roseboom TJ, et al. Hungry in the womb: what are the consequences? Lessons from the Dutch famine. Maturitas. 2011;70(2):141\u20135.","journal-title":"Maturitas"},{"issue":"44","key":"400_CR33","doi-asserted-by":"crossref","first-page":"17046","DOI":"10.1073\/pnas.0806560105","volume":"105","author":"BT Heijmans","year":"2008","unstructured":"Heijmans BT, et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci USA. 2008;105(44):17046\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"400_CR34","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.earlhumdev.2006.07.001","volume":"82","author":"T Roseboom","year":"2006","unstructured":"Roseboom T, de Rooij S, Painter R. The Dutch famine and its long-term consequences for adult health. Early Hum Dev. 2006;82(8):485\u201391.","journal-title":"Early Hum Dev"},{"issue":"2","key":"400_CR35","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/sj.ejhg.5201538","volume":"14","author":"ME Pembrey","year":"2006","unstructured":"Pembrey ME, et al. Sex-specific, male-line transgenerational responses in humans. Eur J Hum Genet. 2006;14(2):159\u201366.","journal-title":"Eur J Hum Genet"},{"key":"400_CR36","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/bs.pmbts.2018.03.003","volume":"158","author":"A Jawaid","year":"2018","unstructured":"Jawaid A, Roszkowski M, Mansuy IM. Transgenerational epigenetics of traumatic stress. Prog Mol Biol Transl Sci. 2018;158:273\u201398.","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"12","key":"400_CR37","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.2337\/diabetes.49.12.2208","volume":"49","author":"D Dabelea","year":"2000","unstructured":"Dabelea D, et al. Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes. 2000;49(12):2208\u201311.","journal-title":"Diabetes"},{"issue":"7","key":"400_CR38","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1210\/jc.2009-0305","volume":"94","author":"TD Clausen","year":"2009","unstructured":"Clausen TD, et al. Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes. J Clin Endocrinol Metab. 2009;94(7):2464\u201370.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"400_CR39","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/hmg\/ddr472","volume":"21","author":"G Toperoff","year":"2012","unstructured":"Toperoff G, et al. Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood. Hum Mol Genet. 2012;21(2):371\u201383.","journal-title":"Hum Mol Genet"},{"issue":"7","key":"400_CR40","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S2213-8587(15)00127-8","volume":"3","author":"JC Chambers","year":"2015","unstructured":"Chambers JC, et al. Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case\u2013control study. Lancet Diabetes Endocrinol. 2015;3(7):526\u201334.","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"400_CR41","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s00125-015-3773-7","volume":"59","author":"I Florath","year":"2016","unstructured":"Florath I, et al. Type 2 diabetes and leucocyte DNA methylation: an epigenome-wide association study in over 1500 older adults. Diabetologia. 2016;59(1):130\u20138.","journal-title":"Diabetologia"},{"issue":"18","key":"400_CR42","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.1093\/hmg\/ddv232","volume":"24","author":"H Kulkarni","year":"2015","unstructured":"Kulkarni H, et al. Novel epigenetic determinants of type 2 diabetes in Mexican\u2013American families. Hum Mol Genet. 2015;24(18):5330\u2013444.","journal-title":"Hum Mol Genet"},{"issue":"11","key":"400_CR43","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.jdiacomp.2018.08.012","volume":"32","author":"L Sommese","year":"2018","unstructured":"Sommese L, et al. Novel epigenetic-sensitive clinical challenges both in type 1 and type 2 diabetes. J Diabetes Complicat. 2018;32(11):1076\u201384.","journal-title":"J Diabetes Complicat"},{"issue":"7","key":"400_CR44","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1210\/me.2012-1004","volume":"26","author":"BT Yang","year":"2012","unstructured":"Yang BT, et al. Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes. Mol Endocrinol. 2012;26(7):1203\u201312.","journal-title":"Mol Endocrinol"},{"issue":"4","key":"400_CR45","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00125-007-0916-5","volume":"51","author":"C Ling","year":"2008","unstructured":"Ling C, et al. Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion. Diabetologia. 2008;51(4):615\u201322.","journal-title":"Diabetologia"},{"key":"400_CR46","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1471-2350-14-76","volume":"14","author":"E Hall","year":"2013","unstructured":"Hall E, et al. DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets. BMC Med Genet. 2013;14:76.","journal-title":"BMC Med Genet"},{"key":"400_CR47","doi-asserted-by":"crossref","first-page":"e30766","DOI":"10.7554\/eLife.30766","volume":"6","author":"D You","year":"2017","unstructured":"You D, et al. Dnmt3a is an epigenetic mediator of adipose insulin resistance. Elife. 2017;6:e30766.","journal-title":"Elife"},{"issue":"8","key":"400_CR48","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/ijo.2017.95","volume":"41","author":"M Muniandy","year":"2017","unstructured":"Muniandy M, et al. Gene expression profile of subcutaneous adipose tissue in BMI-discordant monozygotic twin pairs unravels molecular and clinical changes associated with sub-types of obesity. Int J Obes (Lond). 2017;41(8):1176\u201384.","journal-title":"Int J Obes (Lond)"},{"issue":"3","key":"400_CR49","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.cmet.2012.01.001","volume":"15","author":"R Barres","year":"2012","unstructured":"Barres R, et al. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab. 2012;15(3):405\u201311.","journal-title":"Cell Metab"},{"key":"400_CR50","first-page":"675021","volume":"2014","author":"CL do Amaral","year":"2014","unstructured":"do Amaral CL, et al. DNA methylation pattern in overweight women under an energy-restricted diet supplemented with fish oil. Biomed Res Int. 2014;2014:675021.","journal-title":"Biomed Res Int"},{"issue":"1","key":"400_CR51","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1038\/s41467-018-04127-6","volume":"9","author":"L Zhuang","year":"2018","unstructured":"Zhuang L, et al. Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function. Nat Commun. 2018;9(1):1796.","journal-title":"Nat Commun"},{"issue":"10","key":"400_CR52","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1084\/jem.20081188","volume":"205","author":"A El-Osta","year":"2008","unstructured":"El-Osta A, et al. Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med. 2008;205(10):2409\u201317.","journal-title":"J Exp Med"},{"issue":"1","key":"400_CR53","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1161\/CIRCGENETICS.114.000671","volume":"8","author":"F Paneni","year":"2015","unstructured":"Paneni F, et al. Adverse epigenetic signatures by histone methyltransferase Set7 contribute to vascular dysfunction in patients with type 2 diabetes mellitus. Circ Cardiovasc Genet. 2015;8(1):150\u20138.","journal-title":"Circ Cardiovasc Genet"},{"issue":"12","key":"400_CR54","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.2337\/db11-0616","volume":"60","author":"MP Gillum","year":"2011","unstructured":"Gillum MP, et al. SirT1 regulates adipose tissue inflammation. Diabetes. 2011;60(12):3235\u201345.","journal-title":"Diabetes"},{"issue":"9","key":"400_CR55","doi-asserted-by":"crossref","first-page":"970","DOI":"10.5551\/jat.4333","volume":"17","author":"CL Kao","year":"2010","unstructured":"Kao CL, et al. Resveratrol protects human endothelium from H(2)O(2)-induced oxidative stress and senescence via SirT1 activation. J Atheroscler Thromb. 2010;17(9):970\u20139.","journal-title":"J Atheroscler Thromb"},{"issue":"9","key":"400_CR56","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1161\/ATVBAHA.108.164368","volume":"28","author":"H Ota","year":"2008","unstructured":"Ota H, et al. Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells. Arterioscler Thromb Vasc Biol. 2008;28(9):1634\u20139.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"400_CR57","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1161\/CIRCRESAHA.112.266593","volume":"111","author":"F Paneni","year":"2012","unstructured":"Paneni F, et al. Gene silencing of the mitochondrial adaptor p66(Shc) suppresses vascular hyperglycemic memory in diabetes. Circ Res. 2012;111(3):278\u201389.","journal-title":"Circ Res"},{"issue":"6759","key":"400_CR58","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/46311","volume":"402","author":"E Migliaccio","year":"1999","unstructured":"Migliaccio E, et al. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature. 1999;402(6759):309\u201313.","journal-title":"Nature"},{"issue":"6","key":"400_CR59","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1161\/CIRCRESAHA.111.243592","volume":"109","author":"S Zhou","year":"2011","unstructured":"Zhou S, et al. Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction. Circ Res. 2011;109(6):639\u201348.","journal-title":"Circ Res"},{"issue":"6","key":"400_CR60","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.2337\/db12-1648","volume":"62","author":"F Paneni","year":"2013","unstructured":"Paneni F, et al. SIRT1, p66(Shc), and Set7\/9 in vascular hyperglycemic memory: bringing all the strands together. Diabetes. 2013;62(6):1800\u20137.","journal-title":"Diabetes"},{"key":"400_CR61","doi-asserted-by":"crossref","first-page":"d4169","DOI":"10.1136\/bmj.d4169","volume":"343","author":"R Boussageon","year":"2011","unstructured":"Boussageon R, et al. Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials. BMJ. 2011;343:d4169.","journal-title":"BMJ"},{"issue":"2","key":"400_CR62","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.atherosclerosis.2014.07.027","volume":"236","author":"F Paneni","year":"2014","unstructured":"Paneni F, Costantino S, Cosentino F. p66(Shc)-induced redox changes drive endothelial insulin resistance. Atherosclerosis. 2014;236(2):426\u20139.","journal-title":"Atherosclerosis"},{"issue":"1","key":"400_CR63","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2337\/db11-0416","volume":"61","author":"Z Zheng","year":"2012","unstructured":"Zheng Z, et al. Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1\/AMPK\/ROS pathway and therapeutic effects of metformin. Diabetes. 2012;61(1):217\u201328.","journal-title":"Diabetes"},{"issue":"4","key":"400_CR64","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/eurheartj\/ehx615","volume":"40","author":"S Costantino","year":"2019","unstructured":"Costantino S, et al. Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity. Eur Heart J. 2019;40(4):383\u201391.","journal-title":"Eur Heart J"},{"issue":"9","key":"400_CR65","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1161\/CIRCULATIONAHA.111.054346","volume":"125","author":"Y Hasegawa","year":"2012","unstructured":"Hasegawa Y, et al. Blockade of the nuclear factor-kappaB pathway in the endothelium prevents insulin resistance and prolongs life spans. Circulation. 2012;125(9):1122\u201333.","journal-title":"Circulation"},{"issue":"2","key":"400_CR66","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/hep.26207","volume":"58","author":"W Tian","year":"2013","unstructured":"Tian W, et al. Brahma-related gene 1 bridges epigenetic regulation of proinflammatory cytokine production to steatohepatitis in mice. Hepatology. 2013;58(2):576\u201388.","journal-title":"Hepatology"},{"issue":"21","key":"400_CR67","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1038\/emboj.2009.271","volume":"28","author":"F De Santa","year":"2009","unstructured":"De Santa F, et al. Jmjd3 contributes to the control of gene expression in LPS-activated macrophages. EMBO J. 2009;28(21):3341\u201352.","journal-title":"EMBO J"},{"issue":"23","key":"400_CR68","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1101\/gad.175950.111","volume":"25","author":"SE Mullican","year":"2011","unstructured":"Mullican SE, et al. Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation. Genes Dev. 2011;25(23):2480\u20138.","journal-title":"Genes Dev"},{"issue":"9","key":"400_CR69","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.15252\/emmm.201404170","volume":"6","author":"MA Hoeksema","year":"2014","unstructured":"Hoeksema MA, et al. Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions. EMBO Mol Med. 2014;6(9):1124\u201332.","journal-title":"EMBO Mol Med"},{"issue":"4","key":"400_CR70","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1210\/me.2013-1293","volume":"28","author":"X Yang","year":"2014","unstructured":"Yang X, et al. Epigenetic regulation of macrophage polarization by DNA methyltransferase 3b. Mol Endocrinol. 2014;28(4):565\u201374.","journal-title":"Mol Endocrinol"},{"issue":"19","key":"400_CR71","doi-asserted-by":"crossref","first-page":"e87748","DOI":"10.1172\/jci.insight.87748","volume":"1","author":"X Wang","year":"2016","unstructured":"Wang X, et al. Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity. JCI Insight. 2016;1(19):e87748.","journal-title":"JCI Insight"},{"issue":"3","key":"400_CR72","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/cvr\/cvr024","volume":"90","author":"MA Reddy","year":"2011","unstructured":"Reddy MA, Natarajan R. Epigenetic mechanisms in diabetic vascular complications. Cardiovasc Res. 2011;90(3):421\u20139.","journal-title":"Cardiovasc Res"},{"issue":"1","key":"400_CR73","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.cyto.2013.05.028","volume":"64","author":"HH Hermsdorff","year":"2013","unstructured":"Hermsdorff HH, et al. TNF-alpha promoter methylation in peripheral white blood cells: relationship with circulating TNFalpha, truncal fat and n-6 PUFA intake in young women. Cytokine. 2013;64(1):265\u201371.","journal-title":"Cytokine"},{"issue":"11","key":"400_CR74","doi-asserted-by":"crossref","first-page":"7450","DOI":"10.1093\/nar\/gku334","volume":"42","author":"GS Madugundu","year":"2014","unstructured":"Madugundu GS, Cadet J, Wagner JR. Hydroxyl-radical-induced oxidation of 5-methylcytosine in isolated and cellular DNA. Nucleic Acids Res. 2014;42(11):7450\u201360.","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"400_CR75","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1111\/bph.13792","volume":"174","author":"T Kietzmann","year":"2017","unstructured":"Kietzmann T, et al. The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system. Br J Pharmacol. 2017;174(12):1533\u201354.","journal-title":"Br J Pharmacol"},{"issue":"5\u20136","key":"400_CR76","first-page":"507","volume":"16","author":"DD Le","year":"2012","unstructured":"Le DD, Fujimori DG. Protein and nucleic acid methylating enzymes: mechanisms and regulation. Curr Opin Chem Biol. 2012;16(5\u20136):507\u201315.","journal-title":"Curr Opin Chem Biol"},{"issue":"49","key":"400_CR77","doi-asserted-by":"crossref","first-page":"25553","DOI":"10.1074\/jbc.M116.751453","volume":"291","author":"L Pan","year":"2016","unstructured":"Pan L, et al. Oxidized guanine base lesions function in 8-oxoguanine DNA glycosylase-1-mediated epigenetic regulation of nuclear factor kappaB-driven gene expression. J Biol Chem. 2016;291(49):25553\u2013666.","journal-title":"J Biol Chem"},{"issue":"5","key":"400_CR78","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.freeradbiomed.2012.07.020","volume":"53","author":"Y Chervona","year":"2012","unstructured":"Chervona Y, Costa M. The control of histone methylation and gene expression by oxidative stress, hypoxia, and metals. Free Radic Biol Med. 2012;53(5):1041\u20137.","journal-title":"Free Radic Biol Med"},{"key":"400_CR79","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.freeradbiomed.2015.01.028","volume":"82","author":"Y Niu","year":"2015","unstructured":"Niu Y, et al. Oxidative stress alters global histone modification and DNA methylation. Free Radic Biol Med. 2015;82:22\u20138.","journal-title":"Free Radic Biol Med"},{"issue":"12","key":"400_CR80","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1016\/j.bbapap.2015.09.006","volume":"1854","author":"T Liu","year":"2015","unstructured":"Liu T, et al. Master redox regulator Trx1 upregulates SMYD1 & modulates lysine methylation. Biochim Biophys Acta. 2015;1854(12):1816\u201322.","journal-title":"Biochim Biophys Acta"},{"issue":"6993","key":"400_CR81","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nature02583","volume":"429","author":"F Picard","year":"2004","unstructured":"Picard F, et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature. 2004;429(6993):771\u20136.","journal-title":"Nature"},{"issue":"6","key":"400_CR82","doi-asserted-by":"crossref","first-page":"e2264","DOI":"10.1371\/journal.pone.0002264","volume":"3","author":"JL Barger","year":"2008","unstructured":"Barger JL, et al. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS One. 2008;3(6):e2264.","journal-title":"PLoS One"},{"issue":"6","key":"400_CR83","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2006.11.013","volume":"127","author":"M Lagouge","year":"2006","unstructured":"Lagouge M, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006;127(6):1109\u201322.","journal-title":"Cell"},{"issue":"1","key":"400_CR84","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1124\/jpet.111.189910","volume":"341","author":"L Zhang","year":"2012","unstructured":"Zhang L, et al. Inhibition of histone deacetylases preserves myocardial performance and prevents cardiac remodeling through stimulation of endogenous angiomyogenesis. J Pharmacol Exp Ther. 2012;341(1):285\u201393.","journal-title":"J Pharmacol Exp Ther"},{"issue":"5","key":"400_CR85","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1016\/j.ajpath.2011.01.044","volume":"178","author":"A Advani","year":"2011","unstructured":"Advani A, et al. Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism. Am J Pathol. 2011;178(5):2205\u201314.","journal-title":"Am J Pathol"},{"issue":"1","key":"400_CR86","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3892\/etm.2014.1726","volume":"8","author":"X Hu","year":"2014","unstructured":"Hu X, et al. Anti-inflammatory effect of sodium butyrate preconditioning during myocardial ischemia\/reperfusion. Exp Ther Med. 2014;8(1):229\u201332.","journal-title":"Exp Ther Med"},{"issue":"10","key":"400_CR87","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1161\/CIRCULATIONAHA.113.002416","volume":"129","author":"M Xie","year":"2014","unstructured":"Xie M, et al. Histone deacetylase inhibition blunts ischemia\/reperfusion injury by inducing cardiomyocyte autophagy. Circulation. 2014;129(10):1139\u201351.","journal-title":"Circulation"},{"issue":"35","key":"400_CR88","doi-asserted-by":"crossref","first-page":"56071","DOI":"10.18632\/oncotarget.11267","volume":"7","author":"J Hong","year":"2016","unstructured":"Hong J, et al. Butyrate alleviates high fat diet-induced obesity through activation of adiponectin-mediated pathway and stimulation of mitochondrial function in the skeletal muscle of mice. Oncotarget. 2016;7(35):56071\u201382.","journal-title":"Oncotarget"},{"issue":"3","key":"400_CR89","first-page":"868","volume":"118","author":"T Morimoto","year":"2008","unstructured":"Morimoto T, et al. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. J Clin Investig. 2008;118(3):868\u201378.","journal-title":"J Clin Investig"},{"issue":"1","key":"400_CR90","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1074248408329608","volume":"14","author":"G Srivastava","year":"2009","unstructured":"Srivastava G, Mehta JL. Currying the heart: curcumin and cardioprotection. J Cardiovasc Pharmacol Ther. 2009;14(1):22\u20137.","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"4","key":"400_CR91","first-page":"273","volume":"36","author":"KB Soni","year":"1992","unstructured":"Soni KB, Kuttan R. Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers. Indian J Physiol Pharmacol. 1992;36(4):273\u20135.","journal-title":"Indian J Physiol Pharmacol"},{"issue":"3","key":"400_CR92","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1093\/cvr\/cvr250","volume":"92","author":"CS Kim","year":"2011","unstructured":"Kim CS, et al. Homocysteine promotes human endothelial cell dysfunction via site-specific epigenetic regulation of p66shc. Cardiovasc Res. 2011;92(3):466\u201375.","journal-title":"Cardiovasc Res"},{"issue":"1","key":"400_CR93","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.atherosclerosis.2014.06.008","volume":"236","author":"R Jahagirdar","year":"2014","unstructured":"Jahagirdar R, et al. A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice. Atherosclerosis. 2014;236(1):91\u2013100.","journal-title":"Atherosclerosis"},{"key":"400_CR94","doi-asserted-by":"crossref","first-page":"e12265","DOI":"10.1111\/1755-5922.12265","volume":"35","author":"GC Ghosh","year":"2017","unstructured":"Ghosh GC, et al. RVX 208: A novel BET protein inhibitor, role as an inducer of apo A-I\/HDL and beyond. Cardiovasc Ther. 2017;35:e12265.","journal-title":"Cardiovasc Ther"},{"issue":"16","key":"400_CR95","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1001\/jama.2020.3308","volume":"323","author":"KK Ray","year":"2020","unstructured":"Ray KK, et al. Effect of apabetalone added to standard therapy on major adverse cardiovascular events in patients with recent acute coronary syndrome and type 2 diabetes: a randomized clinical trial. JAMA. 2020;323(16):1565\u201373.","journal-title":"JAMA"}],"container-title":["High Blood Pressure &amp; Cardiovascular Prevention"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40292-020-00400-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40292-020-00400-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40292-020-00400-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T23:51:56Z","timestamp":1627775516000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40292-020-00400-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,1]]},"references-count":95,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["400"],"URL":"https:\/\/doi.org\/10.1007\/s40292-020-00400-2","relation":{},"ISSN":["1120-9879","1179-1985"],"issn-type":[{"value":"1120-9879","type":"print"},{"value":"1179-1985","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,1]]},"assertion":[{"value":"23 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}