{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T19:47:01Z","timestamp":1748548021231,"version":"3.37.3"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100003500","name":"Universit\u00e0 degli Studi di Padova","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["High Blood Press Cardiovasc Prev"],"DOI":"10.1007\/s40292-023-00614-0","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T03:02:18Z","timestamp":1703127738000},"page":"15-21","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Water and Electrolyte Content in Salt-Dependent HYpertension in the SKIn (WHYSKI): Effect of Surgical Cure of Primary Aldosteronism"],"prefix":"10.1007","volume":"31","clinical-trial-number":[{"clinical-trial-number":"nct06090617","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Francesca","family":"Torresan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico Bernardo","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Zanin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Caputo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brasilina","family":"Caroccia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Iacobone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4687-8033","authenticated-orcid":false,"given":"Gian Paolo","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"614_CR1","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1681\/ASN.V86980","volume":"8","author":"BC Rossier","year":"1997","unstructured":"Rossier BC. The epithelial sodium channel and the control of blood pressure. J Am Soc Nephrol. 1997;8:980\u201392.","journal-title":"J Am Soc Nephrol"},{"key":"614_CR2","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/s41371-022-00690-0","volume":"37","author":"NRC Campbell","year":"2023","unstructured":"Campbell NRC, Whelton PK, Orias M, et al. 2022 World Hypertension League, resolve to save lives and International Society of Hypertension dietary sodium (salt) global call to action. J Hum Hypertens. 2023;37:428\u201337.","journal-title":"J Hum Hypertens"},{"key":"614_CR3","doi-asserted-by":"crossref","unstructured":"Ellison DH, Welling P. Insights into Salt Handling and Blood Pressure. N Engl J Med. 2021;385:1981-1993.","DOI":"10.1056\/NEJMra2030212"},{"key":"614_CR4","doi-asserted-by":"crossref","unstructured":"Laine GA, Allen SJ. Left ventricular myocardial edema lymph flow, interstitial fibrosis, and cardiac function. Circ Res [Internet]. 1991;68:1713\u20131721. Available from: http:\/\/ahajournals.org.","DOI":"10.1161\/01.RES.68.6.1713"},{"key":"614_CR5","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.advms.2023.08.001","volume":"68","author":"A Chachaj","year":"2023","unstructured":"Chachaj A, Stanimirova I, Chabowski M, et al. Sodium accumulation in the skin is associated with higher density of skin lymphatic vessels in patients with arterial hypertension. Adv Med Sci. 2023;68:276\u201389.","journal-title":"Adv Med Sci"},{"key":"614_CR6","doi-asserted-by":"crossref","unstructured":"Rossi GP, Bisogni V, Bacca AV, et al. The 2020 Italian Society of Arterial Hypertension (SIIA) practical guidelines for the management of primary aldosteronism. Int J Cardiol Hypertens. 2020;5:100029.","DOI":"10.1097\/01.hjh.0000745016.79540.85"},{"key":"614_CR7","first-page":"1029","volume":"39","author":"TM Seccia","year":"2018","unstructured":"Seccia TM, Caroccia B, Gomez-Sanchez EP, et al. The biology of normal zona glomerulosa and aldosterone-producing adenoma: pathological implications. Endocr Rev. 2018;39:1029\u201356.","journal-title":"Endocr Rev"},{"key":"614_CR8","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1210\/clinem\/dgz017","volume":"105","author":"G Rossitto","year":"2020","unstructured":"Rossitto G, Amar L, Azizi M, et al. Subtyping of primary aldosteronism in the AVIS-2 study: assessment of selectivity and lateralisation. J Clin Endocrinol Metab. 2020;105:2042\u201352.","journal-title":"J Clin Endocrinol Metab"},{"key":"614_CR9","doi-asserted-by":"crossref","unstructured":"Rossi GP, Bisogni V, Rossitto G, et al. Practice Recommendations for Diagnosis and Treatment of the Most Common Forms of Secondary Hypertension. High Blood Press Cardiovasc Prev. 2020;27:547-560.","DOI":"10.1007\/s40292-020-00415-9"},{"key":"614_CR10","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1177\/36.3.3343507","volume":"36","author":"IP Sussman","year":"1988","unstructured":"Sussman IP, MacGregor LC, Masters BR, et al. Quantitative histochemical determination of Na+ and K+ in microscopic samples using carbon furnace atomic absorption spectrometry. J Histochem Cytochem. 1988;36:237\u201344.","journal-title":"J Histochem Cytochem"},{"key":"614_CR11","doi-asserted-by":"publisher","first-page":"F1108","DOI":"10.1152\/ajprenal.00200.2003","volume":"285","author":"J Titze","year":"2003","unstructured":"Titze J, Lang R, Ilies C, et al. Osmotically inactive skin Na+ storage in rats. Am J Physiol Renal Physiol. 2003;285:F1108\u201317.","journal-title":"Am J Physiol Renal Physiol"},{"key":"614_CR12","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1161\/HYPERTENSIONAHA.111.00566","volume":"61","author":"C Kopp","year":"2013","unstructured":"Kopp C, Linz P, Dahlmann A, et al. 23Na magnetic resonance imaging-determined tissue sodium in healthy subjects and hypertensive patients. Hypertension. 2013;61:635\u201340.","journal-title":"Hypertension"},{"key":"614_CR13","doi-asserted-by":"crossref","unstructured":"Staffa SJ, Zurakowski D. Five steps to successfully implement and evaluate propensity score matching in clinical research studies. Anesth Analg [Internet]. 2018;127:1066\u20131073. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29324498.","DOI":"10.1213\/ANE.0000000000002787"},{"key":"614_CR14","doi-asserted-by":"publisher","unstructured":"Rossi GP. Primary aldosteronism: JACC state-of-the-art review [Internet]. J Am Coll Cardiol. 2019:2799\u20132811. Available from: https:\/\/doi.org\/10.1016\/j.jacc.2019.09.057.","DOI":"10.1016\/j.jacc.2019.09.057"},{"key":"614_CR15","doi-asserted-by":"crossref","unstructured":"Rossi GP, Ceolotto G, Rossitto G, et al. Effects of Mineralocorticoid and AT1 Receptor Antagonism on The Aldosterone-Renin Ratio In Primary Aldosteronism-the EMIRA Study. J Clin Endocrinol Metab. 2020;105:dgaa080.","DOI":"10.1210\/clinem\/dgaa080"},{"key":"614_CR16","doi-asserted-by":"crossref","unstructured":"Rossi G, Fouad-Tarazi FM. Sodium depletion increases calcium-activated left ventricular pressure in the rat. hypertension [Internet]. 1990;15:894\u2013899. Available from: http:\/\/ahajournals.org.","DOI":"10.1161\/01.HYP.15.6.894"},{"key":"614_CR17","doi-asserted-by":"publisher","first-page":"K33","DOI":"10.1530\/EJE-22-0074","volume":"168","author":"M Christa","year":"2022","unstructured":"Christa M, Hahner S, Kostler H, et al. Primary hyperaldosteronism induces congruent alterations of sodium homeostasis in different skeletal muscles: a 23Na-MRI study. Eur J Endocrinol. 2022;168:K33\u20138.","journal-title":"Eur J Endocrinol"},{"key":"614_CR18","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/ehjci\/jey134","volume":"20","author":"M Christa","year":"2019","unstructured":"Christa M, Weng AM, Geier B, et al. Increasedmyocardial sodiumsignal intensity in Conn\u2019s syndrome detected by 23Na magnetic resonance imaging. Eur Heart J Cardiovasc Imaging. 2019;20:263\u201370.","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"614_CR19","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1161\/HYPERTENSIONAHA.111.183517","volume":"59","author":"C Kopp","year":"2012","unstructured":"Kopp C, Linz P, Wachsmuth L, et al. 23Na magnetic resonance imaging of tissue sodium. Hypertension. 2012;59:167\u201372.","journal-title":"Hypertension"},{"key":"614_CR20","doi-asserted-by":"crossref","unstructured":"Alsouqi A, Deger SM, Sahinoz M, et al. Tissue Sodium in Patients With Early Stage Hypertension: A Randomized Controlled Trial. J Am Heart Assoc. 2022;11:e022723.","DOI":"10.1161\/JAHA.121.022723"},{"key":"614_CR21","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1002\/mrm.1311","volume":"46","author":"CD Constantinides","year":"2001","unstructured":"Constantinides CD, Kraitchman DL, O\u2019Brien KO, et al. Noninvasive quantification of total sodium concentrations in acute reperfused myocardial infarction using 23Na MRI. Magn Reson Med. 2001;46:1144\u201351.","journal-title":"Magn Reson Med"},{"key":"614_CR22","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1097\/RLI.0000000000000931","volume":"58","author":"LV Gast","year":"2023","unstructured":"Gast LV, Baier LM, Meixner CR, et al. MRI of potassium and sodium enables comprehensive analysis of ion perturbations in skeletal muscle tissue after eccentric exercise. Invest Radiol. 2023;58:265\u201372.","journal-title":"Invest Radiol"},{"key":"614_CR23","doi-asserted-by":"crossref","unstructured":"Rossi GP, Cesari M, Cuspidi C, et al. Long-term control of arterial hypertension and regression of left ventricular hypertrophy with treatment of primary aldosteronism. Hypertension. 2013;62:62-69.","DOI":"10.1161\/HYPERTENSIONAHA.113.01316"},{"key":"614_CR24","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.jid.2021.06.013","volume":"142","author":"A Maifeld","year":"2022","unstructured":"Maifeld A, Wild J, Karlsen TV, et al. Skin sodium accumulates in psoriasis and reflects disease severity. J Investig Dermatol. 2022;142:166-178.e8.","journal-title":"J Investig Dermatol"},{"key":"614_CR25","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1056\/NEJMra2115011","volume":"386","author":"E Braunwald","year":"2022","unstructured":"Braunwald E. Gliflozins in the management of cardiovascular disease. N Engl J Med. 2022;386:2024\u201334.","journal-title":"N Engl J Med"}],"container-title":["High Blood Pressure & Cardiovascular Prevention"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40292-023-00614-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40292-023-00614-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40292-023-00614-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T18:49:05Z","timestamp":1710355745000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40292-023-00614-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,21]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["614"],"URL":"https:\/\/doi.org\/10.1007\/s40292-023-00614-0","relation":{},"ISSN":["1179-1985"],"issn-type":[{"type":"electronic","value":"1179-1985"}],"subject":[],"published":{"date-parts":[[2023,12,21]]},"assertion":[{"value":"16 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest. All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"GPR was supported by grants from the FOundation for advanced Research In hypertension and Cardiovascular disease (FORICA).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The local Institution review Board and the Ethics committee approved the protocol of this prospective case-control observational study (number of approval: CESC n. 5090\/AO\/21; URC: AOP1615). All procedures that will be performed in the WHYSKI study are in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}