{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:22:04Z","timestamp":1740144124823,"version":"3.37.3"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["954798"],"award-info":[{"award-number":["954798"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003500","name":"Universit\u00e0 degli Studi di Padova","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["High Blood Press Cardiovasc Prev"],"DOI":"10.1007\/s40292-024-00641-5","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T01:01:18Z","timestamp":1716166878000},"page":"299-308","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intracellular Calcium Dynamics in Primary Human Adrenocortical Cells Deciphered with a Novel Pipeline"],"prefix":"10.1007","volume":"31","author":[{"given":"Hala","family":"Ajjour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Pallafacchina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia","family":"Lenzini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brasilina","family":"Caroccia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4687-8033","authenticated-orcid":false,"given":"Gian Paolo","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"key":"641_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/35036035","volume":"1","author":"MJ Berridge","year":"2000","unstructured":"Berridge MJ, Lipp P, Bootman MD. 2000-review-calcium signalling. Nat Rev. 2000;1:11\u201321.","journal-title":"Nat Rev"},{"key":"641_CR2","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/nrm3412","volume":"13","author":"R Rizzuto","year":"2012","unstructured":"Rizzuto R, De Stefani D, Raffaello A, Mammucari C. Mitochondria as sensors and regulators of calcium signalling. Nat Rev Mol Cell Biol. 2012;13:566\u201378.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"641_CR3","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1073\/pnas.1614613114","volume":"114","author":"J Sneyd","year":"2017","unstructured":"Sneyd J, Han JM, Wang L, Chen J, Yang X, Tanimura A, et al. On the dynamical structure of calcium oscillations. Proc Natl Acad Sci U S A. 2017;114:1456\u201361.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"641_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1101\/cshperspect.a004226","volume":"3","author":"G Dupont","year":"2011","unstructured":"Dupont G, Combettes L, Bird GS, Putney JW. Calcium oscillations. Cold Spring Harb Perspect Biol. 2011;3:1\u201318.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"641_CR5","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1073\/pnas.0303472101","volume":"101","author":"J Sneyd","year":"2004","unstructured":"Sneyd J, Tsaneva-Atanasova K, Yule DI, Thompson JL, Shuttleworth TJ. Control of calcium oscillations by membrane fluxes. Proc Natl Acad Sci U S A. 2004;101:1392\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"641_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1101\/cshperspect.a038802","volume":"12","author":"MD Bootman","year":"2020","unstructured":"Bootman MD, Bultynck G. Fundamentals of cellular calcium signaling: a primer. Cold Spring Harb Perspect Biol. 2020;12:1\u201316.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"641_CR7","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1210\/endo-127-2-541","volume":"127","author":"SJ Quinn","year":"1990","unstructured":"Quinn SJ, Enyedi P, Tillotson DL, Williams GH. Cytosolic calcium and aldosterone response patterns of rat adrenal glomerulosa cells stimulated by vasopressin: comparison with angiotensin II. Endocrinology. 1990;127:541\u20138.","journal-title":"Endocrinology"},{"key":"641_CR8","doi-asserted-by":"publisher","first-page":"101671","DOI":"10.1016\/j.isci.2020.101671","volume":"23","author":"H Qi","year":"2020","unstructured":"Qi H, Li X, Jin Z, Simmen T, Shuai J. The oscillation amplitude, not the frequency of cytosolic calcium, regulates apoptosis induction. iScience [Internet]. 2020;23:101671. https:\/\/doi.org\/10.1016\/j.isci.2020.101671.","journal-title":"iScience [Internet]"},{"key":"641_CR9","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1016\/j.jacc.2019.09.057","volume":"74","author":"GP Rossi","year":"2019","unstructured":"Rossi GP. Primary aldosteronism: JACC state-of-the-art review. J Am Coll Cardiol [Internet]. 2019;74:2799\u2013811. https:\/\/doi.org\/10.1016\/j.jacc.2019.09.057.","journal-title":"J Am Coll Cardiol [Internet]"},{"key":"641_CR10","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1161\/HYPERTENSIONAHA.121.16498","volume":"79","author":"UI Scholl","year":"2022","unstructured":"Scholl UI. Genetics of primary aldosteronism. Hypertension. 2022;79:887\u201397.","journal-title":"Hypertension"},{"key":"641_CR11","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1016\/j.surg.2012.08.042","volume":"152","author":"M Iacobone","year":"2012","unstructured":"Iacobone M, Citton M, Viel G, Boetto R, Bonadio I, Tropea S, et al. Unilateral adrenal hyperplasia: a novel cause of surgically correctable primary hyperaldosteronism. Surg (United States) [Internet]. 2012;152:1248\u201355. https:\/\/doi.org\/10.1016\/j.surg.2012.08.042.","journal-title":"Surg (United States) [Internet]"},{"key":"641_CR12","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s10741-005-2343-3","volume":"10","author":"GH Williams","year":"2005","unstructured":"Williams GH. Aldosterone biosynthesis, regulation, and classical mechanism of action. Heart Fail Rev. 2005;10:7\u201313.","journal-title":"Heart Fail Rev"},{"key":"641_CR13","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1530\/JOE-19-0259","volume":"244","author":"T Yang","year":"2020","unstructured":"Yang T, He M, Zhang H, Barrett PQ, Hu C. L- And T-type calcium channels control aldosterone production from human adrenals. J Endocrinol. 2020;244:237\u201347.","journal-title":"J Endocrinol"},{"key":"641_CR14","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.molmed.2020.05.005","volume":"26","author":"FL Fernandes-Rosa","year":"2020","unstructured":"Fernandes-Rosa FL, Boulkroun S, Zennaro MC. Genetic and genomic mechanisms of primary aldosteronism. Trends Mol Med [Internet]. 2020;26:819\u201332. https:\/\/doi.org\/10.1016\/j.molmed.2020.05.005.","journal-title":"Trends Mol Med [Internet]"},{"key":"641_CR15","doi-asserted-by":"publisher","first-page":"8863","DOI":"10.1016\/S0021-9258(17)47233-4","volume":"259","author":"AM Capponi","year":"1984","unstructured":"Capponi AM, Lew PD, Jornot L, Vallotton MB. Correlation between cytosolic free Ca2+ and aldosterone production in bovine adrenal glomerulosa cells. Evidence for a difference in the mode of action of angiotensin II and potassium. J Biol Chem. 1984;259:8863\u20139.","journal-title":"J Biol Chem"},{"key":"641_CR16","doi-asserted-by":"publisher","first-page":"2919","DOI":"10.1016\/S0021-9258(18)61595-9","volume":"262","author":"JA Connor","year":"1987","unstructured":"Connor JA, Carter Cornwall M, Williams GH. Spatially resolved cytosolic calcium response to angiotensin II and potassium in rat glomerulosa cells measured by digital imaging techniques. J Biol Chem. 1987;262:2919\u201327.","journal-title":"J Biol Chem"},{"key":"641_CR17","doi-asserted-by":"publisher","first-page":"5754","DOI":"10.1073\/pnas.85.15.5754","volume":"85","author":"SJ Quinn","year":"1988","unstructured":"Quinn SJ, Williams GH, Tillotson DL. Calcium oscillations in single adrenal glomerulosa cells stimulated by angiotensin II. Proc Natl Acad Sci U S A. 1988;85:5754\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"641_CR18","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1677\/joe.0.1220391","volume":"122","author":"EIM Johnson","year":"1989","unstructured":"Johnson EIM, Capponi AM, Vallotton MB. Cytosolic free calcium oscillates in single bovine adrenal glomerulosa cells in response to angiotensin II stimulation. J Endocrinol. 1989;122:391\u2013402.","journal-title":"J Endocrinol"},{"key":"641_CR19","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1161\/HYPERTENSIONAHA.122.19557","volume":"79","author":"CA Gancayco","year":"2022","unstructured":"Gancayco CA, Gerding MR, Breault DT, Beenhakker MP, Barrett PQ, Guagliardo NA. Intrinsic adrenal TWIK-related acid-sensitive TASK Channel dysfunction produces spontaneous calcium oscillations sufficient to drive AngII (Angiotensin II)-unresponsive hyperaldosteronism. Hypertension. 2022;79:2552\u201364.","journal-title":"Hypertension"},{"key":"641_CR20","doi-asserted-by":"crossref","unstructured":"Seidel E, Schewe J, Zhang J, Dinh HA, Forslund SK, Mark\u00f3 L, et al. Enhanced Ca2+ signaling, mild primary aldosteronism, and hypertension in a familial hyperaldosteronism mouse model (Cacna1hM1560V\/+). Proc Natl Acad Sci U S A. 2021;118 (17)e2014876118.","DOI":"10.1073\/pnas.2014876118"},{"key":"641_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-020-15408-4","volume":"11","author":"NA Guagliardo","year":"2020","unstructured":"Guagliardo NA, Klein PM, Gancayco CA, Lu A, Leng S, Makarem RR, et al. Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes. Nat Commun [Internet]. 2020;11:1\u201315. https:\/\/doi.org\/10.1038\/s41467-020-15408-4.","journal-title":"Nat Commun [Internet]."},{"key":"641_CR22","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/s41588-023-01403-0","volume":"55","author":"X Wu","year":"2023","unstructured":"Wu X, Azizan EAB, Goodchild E, Garg S, Hagiyama M, Cabrera CP, et al. Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production. Nat Genet. 2023;55:1009\u201321.","journal-title":"Nat Genet"},{"key":"641_CR23","doi-asserted-by":"publisher","first-page":"294","DOI":"10.37349\/emed.2021.00047","volume":"2","author":"GP Rossi","year":"2021","unstructured":"Rossi GP, Lenzini L, Caroccia B, Rossitto G, Seccia TM. Angiotensin peptides in the regulation of adrenal cortical function. Explor Med. 2021;2:294\u2013304.","journal-title":"Explor Med."},{"key":"641_CR24","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1210\/en.2009-1243","volume":"151","author":"B Caroccia","year":"2010","unstructured":"Caroccia B, Fassina A, Seccia TM, Recarti C, Petrelli L, Belloni AS, et al. Isolation of human adrenocortical aldosterone-producing cells by a novel immunomagnetic beads method. Endocrinology. 2010;151:1375\u201380.","journal-title":"Endocrinology"},{"key":"641_CR25","doi-asserted-by":"publisher","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","volume":"260","author":"G Grynkiewicz","year":"1985","unstructured":"Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem. 1985;260:3440\u201350.","journal-title":"J Biol Chem"},{"key":"641_CR26","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/jpm14010009","volume":"14","author":"JJ Raposo-Neto","year":"2023","unstructured":"Raposo-Neto JJ, Kowalski-Neto E, Luiz WB, Fonseca EA, Cedro AKCL, Singh MN, et al. Near-infrared spectroscopy with supervised machine learning as a screening tool for neutropenia. J Pers Med. 2023;14:9.","journal-title":"J Pers Med."},{"key":"641_CR27","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1021\/ac60214a047","volume":"36","author":"A Savitzky","year":"1964","unstructured":"Savitzky A, Golay MJE. Smoothing and differentiation of data. Anal Chem [Internet]. 1964;36:1627\u201339. https:\/\/doi.org\/10.1021\/ac60214a047.","journal-title":"Anal Chem [Internet]"},{"key":"641_CR28","doi-asserted-by":"publisher","first-page":"123086","DOI":"10.1016\/j.saa.2023.123086","volume":"302","author":"C Gao","year":"2023","unstructured":"Gao C, Zhao P, Fan Q, Jing H, Dang R, Sun W, et al. Deep neural network: As the novel pipelines in multiple preprocessing for Raman spectroscopy. Spectrochim Acta Part A Mol Biomol Spectrosc [Internet]. 2023;302:123086. https:\/\/doi.org\/10.1016\/j.saa.2023.123086.","journal-title":"Spectrochim Acta Part A Mol Biomol Spectrosc [Internet]"},{"key":"641_CR29","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1038\/icb.2015.34","volume":"93","author":"SN Christo","year":"2015","unstructured":"Christo SN, Diener KR, Hayball JD. The functional contribution of calcium ion flux heterogeneity in T cells. Immunol Cell Biol [Internet]. 2015;93:694\u2013704. https:\/\/doi.org\/10.1038\/icb.2015.34.","journal-title":"Immunol Cell Biol [Internet]"},{"key":"641_CR30","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1002\/bmb.21230","volume":"47","author":"D Mariano","year":"2019","unstructured":"Mariano D, Martins P, Helene Santos L, de Melo- Minardi RC. Introducing Programming Skills for Life Science Students. Biochem Mol Biol Educ. 2019;47:288\u201395.","journal-title":"Biochem Mol Biol Educ"},{"key":"641_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S2633903X21000039","volume":"1","author":"N Jamali","year":"2022","unstructured":"Jamali N, Dobson ETA, Eliceiri KW, Carpenter AE, Cimini BA. 2020 BioImage Analysis Survey: community experiences and needs for the future. Biol Imaging. 2022;1:1\u201313.","journal-title":"Biol Imaging."},{"key":"641_CR32","doi-asserted-by":"crossref","unstructured":"Mackay L, Mikolajewicz N, Komarova S V., Khadra A. Systematic characterization of dynamic parameters of intracellular calcium signals. Front Physiol. 2016;7:525.","DOI":"10.3389\/fphys.2016.00525"},{"key":"641_CR33","doi-asserted-by":"publisher","first-page":"111287","DOI":"10.1016\/j.mce.2021.111287","volume":"530","author":"S Leng","year":"2021","unstructured":"Leng S, Carlone DL, Guagliardo NA, Barrett PQ, Breault DT. Rosette morphology in zona glomerulosa formation and function. Mol Cell Endocrinol Internet. 2021;530:111287. https:\/\/doi.org\/10.1016\/j.mce.2021.111287.","journal-title":"Mol Cell Endocrinol Internet."},{"key":"641_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-020-15332-7","volume":"11","author":"S Leng","year":"2020","unstructured":"Leng S, Pignatti E, Khetani RS, Shah MS, Xu S, Miao J, et al. \u03b2-Catenin and FGFR2 regulate postnatal rosette-based adrenocortical morphogenesis. Nat Commun [Internet]. 2020;11:1\u201314. https:\/\/doi.org\/10.1038\/s41467-020-15332-7.","journal-title":"Nat Commun [Internet]"}],"container-title":["High Blood Pressure & Cardiovascular Prevention"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40292-024-00641-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40292-024-00641-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40292-024-00641-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T09:02:06Z","timestamp":1732698126000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40292-024-00641-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,20]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["641"],"URL":"https:\/\/doi.org\/10.1007\/s40292-024-00641-5","relation":{},"ISSN":["1179-1985"],"issn-type":[{"type":"electronic","value":"1179-1985"}],"subject":[],"published":{"date-parts":[[2024,5,20]]},"assertion":[{"value":"27 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have nothing to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Research involved Human Participants who provided signed consents. The collection of samples was approved by the local ethics committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Open access funding provided by Universit\u2026 degli Studi di Padova within the CRUI-CARE Agreement. This work was supported by research grants from the European Commission Marie Sk\u0142odowska-Curie Actions PhD program: MINDSHIFT (grant number 954798, website: ).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}}]}}