{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T23:07:55Z","timestamp":1773702475532,"version":"3.50.1"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["This study was partially supported by the Italian Ministry of Health"],"award-info":[{"award-number":["This study was partially supported by the Italian Ministry of Health"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Ricerca Corrente 2025"],"award-info":[{"award-number":["Ricerca Corrente 2025"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico"],"award-info":[{"award-number":["Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["High Blood Press Cardiovasc Prev"],"DOI":"10.1007\/s40292-025-00726-9","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T01:33:25Z","timestamp":1753320805000},"page":"495-509","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Obesity and Left Ventricular Mechanics in Children and Adolescents: A Systematic Review and Meta-Analysis"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3247-3203","authenticated-orcid":false,"given":"Andrea","family":"Faggiano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Gherbesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Sala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Carugo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Grassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijana","family":"Tadic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"Cuspidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"issue":"390","key":"726_CR1","first-page":"2627","volume":"2017","author":"NCD Risk Factor Collaboration (NCD-RisC)","year":"1975","unstructured":"NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 tto 2016: a pooled analysis of 2416 population-based measurement studies in 128\u00b79 million children, adolescents, and adults. Lancet. 1975;2017(390):2627\u201342.","journal-title":"Lancet"},{"key":"726_CR2","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1016\/S0140-6736(24)01548-4","volume":"404","author":"GBD 2021 US Obesity Forecasting Collaborators","year":"2024","unstructured":"GBD 2021 US Obesity Forecasting Collaborators. National-level and state-level prevalence of overweight and obesity among children, adolescents, and adults in the USA, 1990\u20132021, and forecasts up to 2050. Lancet. 2024;404:2278\u201398.","journal-title":"Lancet"},{"key":"726_CR3","first-page":"48","volume":"15","author":"T Tzotzas","year":"2011","unstructured":"Tzotzas T, Kapantais E, Tziomalos E, Ioannidis I, Mortoglou A, Bakatselos S, Kaklamanou M, Lanaras L, Kaklamanou D. Prevalence of overweight and abdominal obesity in Greek children 6\u201312 years old: Results from the national epidemiological survey. Hippokratia. 2011;15:48\u201353.","journal-title":"Hippokratia"},{"key":"726_CR4","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.clnesp.2024.12.013","volume":"65","author":"SL Muyulema","year":"2025","unstructured":"Muyulema SL, Carpio-Arias VT, Verdezoto N, Guanga Lara VE, Sol\u00eds Manzano A, Pulgar H, Vinueza Veloz MF. Worldwide trends in childhood overweight and obesity over the last 20 years. Clin Nutr ESPEN. 2025;65:453\u201360.","journal-title":"Clin Nutr ESPEN."},{"key":"726_CR5","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.2105\/AJPH.2016.303326","volume":"106","author":"A Hruby","year":"2016","unstructured":"Hruby A, Manson JE, Qi L, Malik VS, Rimm EB, Sun Q, et al. Determinants and consequences of obesity. Am J Public Health. 2016;106:1656\u201362.","journal-title":"Am J Public Health"},{"issue":"6","key":"726_CR6","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.18148","volume":"7","author":"N Kartiosuo","year":"2024","unstructured":"Kartiosuo N, Raitakari OT, Juonala M, Viikari JSA, Sinaiko AR, Venn AJ, et al. Cardiovascular risk factors in childhood and adulthood and cardiovascular disease in middle age. JAMA Netw Open. 2024;7(6): e2418148.","journal-title":"JAMA Netw Open"},{"key":"726_CR7","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1056\/NEJMoa072515","volume":"357","author":"JL Baker","year":"2007","unstructured":"Baker JL, Olsen LW, Sorensen TI. Childhood body-mass index and the risk of coronary heart disease in adulthood. N Engl J Med. 2007;357:2329\u201337. https:\/\/doi.org\/10.1056\/NEJMoa072515.","journal-title":"N Engl J Med"},{"key":"726_CR8","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1111\/joim.12741","volume":"283","author":"JM Kindblom","year":"2018","unstructured":"Kindblom JM, Bygdell M, Sonden A, Celind J, Rosengren A, Ohlsson C. BMI change during puberty and the risk of heart failure. J Intern Med. 2018;283:558\u201367. https:\/\/doi.org\/10.1111\/joim.12741.","journal-title":"J Intern Med"},{"key":"726_CR9","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1186\/s12889-017-4691-z","volume":"17","author":"A Umer","year":"2017","unstructured":"Umer A, Kelley GA, Cottrell LE, Giacobbi PJ, Innes KE, Lilly CL. Childhood obesity and adult cardiovascular disease risk factors: a systematic review with meta-analysis. BMC Public Health. 2017;17:683. https:\/\/doi.org\/10.1186\/s12889-017-4691-z.","journal-title":"BMC Public Health"},{"key":"726_CR10","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/obr.12334","volume":"17","author":"M Simmonds","year":"2016","unstructured":"Simmonds M, Llewellyn A, Owen CG, Woolacott N. Predicting adult obesity from childhood obesity: a systematic review and meta-analysis. Obes Rev. 2016;17:95\u2013107.","journal-title":"Obes Rev"},{"issue":"15","key":"726_CR11","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.035365","volume":"13","author":"Y Xiong","year":"2024","unstructured":"Xiong Y, Tang Y, Zhou J, Tian Y, Chen F, Li G, Huang H, Huang H. Zhou L Childhood adiposity and risk of major clinical heart diseases in adulthood: a mendelian randomization study. J Am Heart Assoc. 2024;13(15): e035365. https:\/\/doi.org\/10.1161\/JAHA.124.035365.","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"726_CR12","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s11906-025-01329-4","volume":"27","author":"AH Tran","year":"2025","unstructured":"Tran AH, Walsh A, Urbina EM. Hypertension, obesity, and target organ injury in children: an emerging health care crisis. Curr Hypertens Rep. 2025Feb 27;27(1):12. https:\/\/doi.org\/10.1007\/s11906-025-01329-4.","journal-title":"Curr Hypertens Rep"},{"key":"726_CR13","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1161\/ATVBAHA.114.305062","volume":"35","author":"AT Cote","year":"2015","unstructured":"Cote AT, Phillips AA, Harris KC, Sandor GGS, Panagiotopoulos C, Devlin AM. Obesity and arterial stiffness in children. Arterioscler Thromb Vasc Biol. 2015;35:1038\u201344.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"726_CR14","doi-asserted-by":"publisher","first-page":"3488","DOI":"10.1161\/01.CIR.0000149713.48317.27","volume":"110","author":"X Li","year":"2004","unstructured":"Li X, Li S, Ulusoy E, Chen W, Srinivasan SR, Berenson GS. Childhood adiposity as a predictor of cardiac mass in adulthood: the Bogalusa Heart Study. Circulation. 2004;110:3488\u201392.","journal-title":"Circulation"},{"key":"726_CR15","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1016\/j.amjcard.2008.01.045","volume":"101","author":"A Toprak","year":"2008","unstructured":"Toprak A, Wang H, Chen W, Paul T, Srinivasan S, Berenson G. Relation of childhood risk factors to left ventricular hypertrophy (eccentric or concentric) in relatively young adulthood (from the Bogalusa Heart Study). Am J Cardiol. 2008;101:1621\u20135.","journal-title":"Am J Cardiol"},{"issue":"13","key":"726_CR16","doi-asserted-by":"publisher","first-page":"1006588","DOI":"10.3389\/fendo.2022.1006588","volume":"29","author":"S Genovesi","year":"2022","unstructured":"Genovesi S, Tassistro E, Giussani M, Lieti G, Patti I, Orlando A, Montemerlo M, Antolini L, Parati G. Association of obesity phenotypes with left ventricular mass index and left ventricular hypertrophy in children and adolescents. Front Endocrinol (Lausanne). 2022;29(13):1006588. https:\/\/doi.org\/10.3389\/fendo.2022.1006588.","journal-title":"Front Endocrinol (Lausanne)."},{"key":"726_CR17","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s40292-024-00633-5","volume":"31","author":"A Annaloro","year":"2024","unstructured":"Annaloro A, Invernizzi C, Aguilar F, Alvarez J, Cuspidi C, Grassi G, Lurbe E. Association between elevated body mass index and cardiac organ damage in children and adolescents: evidence and mechanisms. High Blood Press Cardiovasc Prev. 2024;31:167\u201375.","journal-title":"High Blood Press Cardiovasc Prev."},{"key":"726_CR18","doi-asserted-by":"publisher","first-page":"13022","DOI":"10.1038\/s41598-021-92463-x","volume":"11","author":"J Bartkowiak","year":"2021","unstructured":"Bartkowiak J, Spitzer E, Kurmann R, Z\u00fcrcher F, Kr\u00e4henmann P, Garcia-Ruiz V, et al. The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents. Sci Rep. 2021;11:13022.","journal-title":"Sci Rep"},{"key":"726_CR19","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.jcmg.2017.11.017","volume":"11","author":"E Potter","year":"2018","unstructured":"Potter E, Marwick TH. Assessment of left ventricular function by echocardiography: the case for routinely adding global longitudinal strain to ejection fraction. JACC Cardiovasc Imaging. 2018;11:260\u201374. https:\/\/doi.org\/10.1016\/j.jcmg.2017.11.017.","journal-title":"JACC Cardiovasc Imaging"},{"key":"726_CR20","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.jcmg.2024.07.011","volume":"18","author":"OA Smiseth","year":"2025","unstructured":"Smiseth OA, Rider O, Cvijic M, Valkovi\u010d L, Remme EW, Voigt JU. Myocardial strain imaging: theory, current practice, and the future. ACC Cardiovasc Imaging. 2025;18:340\u201381.","journal-title":"ACC Cardiovasc Imaging"},{"key":"726_CR21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009. https:\/\/doi.org\/10.1136\/bmj.b2535.","journal-title":"BMJ"},{"key":"726_CR22","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.echo.2011.12.018","volume":"25","author":"LP Koopman","year":"2012","unstructured":"Koopman LP, McCrindle BW, Slorach C, Chahal N, Hui W, Sarkola T, Manlhiot C, Jaeggi ET, Bradley TJ, Mertens L. Interaction between myocardial and vascular changes in obese children: a pilot study. J Am Soc Echocardiogr. 2012;25:401\u201310.","journal-title":"J Am Soc Echocardiogr"},{"key":"726_CR23","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1093\/ehjci\/jes238","volume":"14","author":"F Labombarda","year":"2013","unstructured":"Labombarda F, Zangl E, Dugue AE, Bougle D, Pellissier A, Ribault V, Maragnes P, Milliez P. Saloux E Alterations of left ventricular myocardial strain in obese children. Eur Heart J Cardiovasc Imaging. 2013;14:668\u201376.","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"726_CR24","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1093\/ehjci\/jes294","volume":"14","author":"JA Barbosa","year":"2013","unstructured":"Barbosa JA, Mota CC, Sim\u00f5es E Silva AC, Nunes Mdo C, Barbosa MM. Assessing pre-clinical ventricular dysfunction in obese children and adolescents: the value of speckle tracking imaging. Eur Heart J Cardiovasc Imaging. 2013;14:882\u20139.","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"726_CR25","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1002\/oby.20495","volume":"21","author":"P Obert","year":"2013","unstructured":"Obert P, Gueugnon C, Nottin S, Vinet A, Gayrard S, Rupp T, Dumoulin G, Tordi N, Mougin F. Impact of diet and exercise training-induced weight loss on myocardial mechanics in severely obese adolescents. Obesity (Silver Spring). 2013;21:2091\u20138.","journal-title":"Obesity (Silver Spring)"},{"key":"726_CR26","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1016\/j.jpeds.2012.11.024","volume":"162","author":"GK Singh","year":"2013","unstructured":"Singh GK, Vitola BE, Holland MR, Sekarski T, Patterson BW, Magkos F, Klein S. Alterations in ventricular structure and function in obese adolescents with nonalcoholic fatty liver disease. J Pediatr. 2013;162:1160\u20138.","journal-title":"J Pediatr"},{"key":"726_CR27","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1016\/j.jcmg.2014.08.006","volume":"7","author":"N Mangner","year":"2014","unstructured":"Mangner N, Scheuermann K, Winzer E, Wagner I, Hoellriegel R, Sandri M, Zimmer M, Mende M, Linke A, Kiess W, Schuler G, K\u00f6rner A, Erbs S. Childhood obesity: impact on cardiac geometry and function. JACC Cardiovasc Imaging. 2014;7:1198\u2013205.","journal-title":"JACC Cardiovasc Imaging"},{"issue":"12","key":"726_CR28","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000071","volume":"93","author":"A Vitarelli","year":"2014","unstructured":"Vitarelli A, Martino F, Capotosto L, Martino E, Colantoni C, Ashurov R, Ricci S, Conde Y, Maramao F, Vitarelli M, De Chiara S, Zanoni C. Early myocardial deformation changes in hypercholesterolemic and obese children and adolescents: a 2D and 3D speckle tracking echocardiography study. Medicine (Baltimore). 2014;93(12): e71. https:\/\/doi.org\/10.1097\/MD.0000000000000071.","journal-title":"Medicine (Baltimore)"},{"key":"726_CR29","doi-asserted-by":"publisher","first-page":"56","DOI":"10.5152\/balkanmedj.2015.15136","volume":"32","author":"AE Kibar","year":"2015","unstructured":"Kibar AE, Pac FA, Ece \u0130, Oflaz MB, Ball\u0131 \u015e, Bas VN, Aycan Z. Effect of obesity on left ventricular longitudinal myocardial strain by speckle tracking echocardiography in children and adolescents. Balkan Med J. 2015;32:56\u201363.","journal-title":"Balkan Med J"},{"key":"726_CR30","doi-asserted-by":"publisher","first-page":"151","DOI":"10.5152\/akd.2014.5189","volume":"15","author":"FK Binneto\u011flu","year":"2015","unstructured":"Binneto\u011flu FK, Y\u0131ld\u0131r\u0131m \u015e, Topalo\u011flu N, Tekin M, Kaymaz N, Aylan\u00e7 H, Karakurt H. Early detection of myocardial deformation by 2D speckle tracking echocardiography in normotensive obese children and adolescents. Anatol J Cardiol. 2015;15:151\u20137.","journal-title":"Anatol J Cardiol"},{"key":"726_CR31","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.jpeds.2014.11.012","volume":"166","author":"AA Sanchez","year":"2015","unstructured":"Sanchez AA, Levy PT, Sekarski TJ, Arbelaez AM, Hildebolt CF, Holland MR, Singh GK. Markers of cardiovascular risk, insulin resistance, and ventricular dysfunction and remodeling in obese adolescents. J Pediatr. 2015;166:660\u20135.","journal-title":"J Pediatr"},{"issue":"10","key":"726_CR32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141149","volume":"10","author":"L Xie","year":"2015","unstructured":"Xie L, Man E, Cheung PT, Cheung YF. Myocardial integrated backscatter in obese adolescents: associations with measures of adiposity and left ventricular deformation. PLoS ONE. 2015;10(10): e0141149. https:\/\/doi.org\/10.1371\/journal.pone.0141149.","journal-title":"PLoS ONE"},{"issue":"3","key":"726_CR33","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002804","volume":"5","author":"P Bjornstad","year":"2016","unstructured":"Bjornstad P, Truong U, Dorosz JL, Cree-Green M, Baumgartner A, Coe G, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Cardiopulmonary dysfunction and adiponectin in adolescents with type 2 diabetes. J Am Heart Assoc. 2016;5(3): e002804. https:\/\/doi.org\/10.1161\/JAHA.115.002804.","journal-title":"J Am Heart Assoc"},{"key":"726_CR34","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1111\/ijpo.12278","volume":"13","author":"A Kulkarni","year":"2018","unstructured":"Kulkarni A, Gulesserian T, Lorenzo JMMD, Haroonian Y, Ngyuyen M, Lo Y, Wang D, Hsu D, Kaskel F, Mahgerefteh J. Left ventricular remodelling and vascular adaptive changes in adolescents with obesity. Pediatr Obes. 2018;13:541\u20139.","journal-title":"Pediatr Obes"},{"key":"726_CR35","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1111\/echo.13806","volume":"35","author":"P Zhang","year":"2018","unstructured":"Zhang P, Li D, Su Y, Wang X, Sun J, Xu Y, Sun J. Assessment of myocardial strain in children with risk factors for atherosclerosis with use of 3D speckle tracking echocardiography. Echocardiography. 2018;35:487\u201393.","journal-title":"Echocardiography"},{"issue":"10","key":"726_CR36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205177","volume":"13","author":"C Zhang","year":"2018","unstructured":"Zhang C, Deng Y, Liu Y, Xu Y, Liu Y, Zhang L, Chen X, Xie M, Ge S. Preclinical cardiovascular changes in children with obesity: a real-time 3-dimensional speckle tracking imaging study. PLoS ONE. 2018;13(10): e0205177. https:\/\/doi.org\/10.1371\/journal.pone.0205177.","journal-title":"PLoS ONE"},{"issue":"11","key":"726_CR37","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3389\/fendo.2020.00056","volume":"3","author":"D Corica","year":"2020","unstructured":"Corica D, Oreto L, Pepe G, Calabr\u00f2 MP, Longobardo L, Morabito L, Pajno GB, Alibrandi A, Aversa T, Wasniewska M. Precocious preclinical cardiovascular sonographic markers in metabolically healthy and unhealthy childhood obesity. Front Endocrinol (Lausanne). 2020;3(11):56. https:\/\/doi.org\/10.3389\/fendo.2020.00056.","journal-title":"Front Endocrinol (Lausanne)."},{"key":"726_CR38","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1017\/S104795112000445X","volume":"31","author":"D El Amrousy","year":"2021","unstructured":"El Amrousy D, Elgendy E, Awad ME, El Razaky O. Three-dimensional speckle tracking echocardiography for early detection of left ventricular dysfunction in children with non-alcoholic fatty liver diseases. Cardiol Young. 2021;31:562\u20137.","journal-title":"Cardiol Young"},{"key":"726_CR39","doi-asserted-by":"publisher","first-page":"925","DOI":"10.2147\/DMSO.S245048","volume":"13","author":"T Imerbtham","year":"2020","unstructured":"Imerbtham T, Thitiwuthikiat P, Jongjitwimol J, Nuamchit T, Yingchoncharoen T, Siriwittayawan D. Leptin levels are associated with subclinical cardiac dysfunction in obese adolescents. Diabetes Metab Syndr Obes. 2020;13:925\u201333.","journal-title":"Diabetes Metab Syndr Obes."},{"issue":"20","key":"726_CR40","doi-asserted-by":"publisher","first-page":"4671","DOI":"10.3390\/jcm10204671","volume":"10","author":"J Paysal","year":"2021","unstructured":"Paysal J, Merlin E, Rochette E, Terral D, Nottin S. Global and regional myocardial work in female adolescents with weight disorders. J Clin Med. 2021;10(20):4671. https:\/\/doi.org\/10.3390\/jcm10204671.","journal-title":"J Clin Med"},{"issue":"6","key":"726_CR41","doi-asserted-by":"publisher","first-page":"562","DOI":"10.3390\/medicina57060562","volume":"57","author":"R \u0160ileikien\u0117","year":"2021","unstructured":"\u0160ileikien\u0117 R, Adamonyt\u0117 K, Ziutelien\u0117 A, Ramanauskien\u0117 E, Va\u0161kelyt\u0117 JJ. Atrial and ventricular structural and functional alterations in obese children. Medicina (Kaunas). 2021;57(6):562. https:\/\/doi.org\/10.3390\/medicina57060562.","journal-title":"Medicina (Kaunas)"},{"key":"726_CR42","doi-asserted-by":"crossref","unstructured":"Siurana JM, Ventura PS, Yeste D, Riaza-Martin L, Arciniegas L, Clemente M, Torres M, Amig\u00f3 N, Giralt G, Roses-Noguer F, Sabate-Rotes A. Myocardial geometry and dysfunction in morbidly obese adolescents (BMI 35\u201340 kg\/m2). Am J Cardiol. 2021;157:128\u201334.","DOI":"10.1016\/j.amjcard.2021.07.026"},{"key":"726_CR43","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1017\/S1047951121003991","volume":"32","author":"S Rakha","year":"2022","unstructured":"Rakha S, Salem N, Razek AAKA, Sobh DM, El-Moslemany F, Elmarsafawy H. The relevance of left ventricular functions to clinical and metabolic characteristics of prepubertal children with obesity. Cardiol Young. 2022;32:1246\u201353.","journal-title":"Cardiol Young"},{"key":"726_CR44","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.1161\/HYPERTENSIONAHA.122.19396","volume":"79","author":"Y Wu","year":"2022","unstructured":"Wu Y, Li Z, Du B, Ye Y, Wang H, Niu Y, Chen S, Wu Y, Jin H, Zhang X, Wang J, Sun K. Different associations of systolic blood pressure and body mass index with cardiac structure and function in young children. Hypertension. 2022;79:2583\u201392.","journal-title":"Hypertension"},{"issue":"10","key":"726_CR45","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.13069","volume":"18","author":"CH Aristiz\u00e1bal-Duque","year":"2023","unstructured":"Aristiz\u00e1bal-Duque CH, Fern\u00e1ndez Cabeza J, Blancas S\u00e1nchez IM, Delgado Ortega M, Aparicio-Martinez P, Romero Salda\u00f1a M, Fonseca Del Pozo FJ, \u00c1lvarez-Ossorio MP, Ru\u00edz Ortiz M, Mesa Rubio MD. The effects of obesity on longitudinal ventricular and atrial strain in a rural population of Spanish children and adolescents, evaluated by a new strain software. Pediatr Obes. 2023;18(10): e13069. https:\/\/doi.org\/10.1111\/ijpo.13069.","journal-title":"Pediatr Obes"},{"key":"726_CR46","doi-asserted-by":"publisher","first-page":"336","DOI":"10.26502\/fccm.92920345","volume":"7","author":"B Ria\u00f1o-M\u00e9ndez","year":"2023","unstructured":"Ria\u00f1o-M\u00e9ndez B, CampoM RD, Garc\u00eda-Navas P, Ibiricu-Lecumberri A, Ruiz del Prado MY. Subclinical left ventricular disfunction in obese children: are we late? Cardiol Cardiovasc Med. 2023;7:336\u201342.","journal-title":"Cardiol Cardiovasc Med"},{"issue":"52","key":"726_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2024.101385","volume":"26","author":"VA Verpalen","year":"2024","unstructured":"Verpalen VA, Ververs FA, Slieker M, Nuboer R, Swart JF, van der Ent CK, Fejzic Z, Westenberg JJM, Leiner T, Grotenhuis HB, Schipper HS. Enhanced aortic stiffness in adolescents with chronic disease is associated with decreased left ventricular global longitudinal strain. Int J Cardiol Heart Vasc. 2024;26(52): 101385. https:\/\/doi.org\/10.1016\/j.ijcha.2024.101385.","journal-title":"Int J Cardiol Heart Vasc."},{"key":"726_CR48","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1177\/00099228231201203","volume":"63","author":"B Dehghan","year":"2024","unstructured":"Dehghan B, Sedighi M, Rostampour N, Hashemi E, Hovsepian S, Sabri MR, Ghaderian M, Mahdavi C, Ahmadi A, Esnaashari A. Childhood obesity is associated with subclinical left ventricular dysfunction detected by speckle tracking echocardiography. Clin Pediatr (Phila). 2024;63:936\u201341.","journal-title":"Clin Pediatr (Phila)"},{"key":"726_CR49","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1016\/j.jcmg.2022.03.007","volume":"15","author":"K Haji","year":"2022","unstructured":"Haji K, Huynh Q, Wong C, Stewart S, Carrington M, Marwick TH. Improving the characterization of stage A and B heart failure by adding global longitudinal strain. JACC Cardiovasc Imaging. 2022;15:1380\u20137.","journal-title":"JACC Cardiovasc Imaging"},{"key":"726_CR50","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1097\/HJH.0000000000003761","volume":"42","author":"E Gherbesi","year":"2024","unstructured":"Gherbesi E, Faggiano A, Sala C, Carugo S, Grassi G, Tadic M, Cuspidi C. Left ventricular systolic dysfunction in obesity: a meta-analysis of speckle tracking echocardiographic studies. J Hypertens. 2024;42:1449\u201359.","journal-title":"J Hypertens"},{"issue":"2","key":"726_CR51","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.317","volume":"5","author":"CZ Kalenga","year":"2022","unstructured":"Kalenga CZ, Ramesh S, Dumanski SM, MacRae JM, Nerenberg K, Metcalfe A, Sola DY, Ahmed SB. Sex influences the effect of adiposity on arterial stiffness and renin-angiotensin aldosterone system activity in young adults. Endocrinol Diabetes Metab. 2022;5(2): e00317. https:\/\/doi.org\/10.1002\/edm2.317.","journal-title":"Endocrinol Diabetes Metab"},{"key":"726_CR52","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-024-05008-x","author":"LS Peres D\u00edaz","year":"2024","unstructured":"Peres D\u00edaz LS, Aisicovich M, Schuman ML, et al. Novel leptin-cardiac TRH pathway is responsible for the cardiac alterations in the hyperleptinemic obesity. Mol Cell Biochem. 2024. https:\/\/doi.org\/10.1007\/s11010-024-05008-x.","journal-title":"Mol Cell Biochem"},{"key":"726_CR53","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s11906-022-01222-4","volume":"24","author":"JN Garcia","year":"2022","unstructured":"Garcia JN, Wanjalla CN, Mashayekhi M, Hasty AH. Immune cell activation in obesity and cardiovascular disease. Curr Hypertens Rep. 2022;24:627\u201337.","journal-title":"Curr Hypertens Rep"}],"container-title":["High Blood Pressure &amp; Cardiovascular Prevention"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40292-025-00726-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40292-025-00726-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40292-025-00726-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:34:01Z","timestamp":1758872041000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40292-025-00726-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,24]]},"references-count":53,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["726"],"URL":"https:\/\/doi.org\/10.1007\/s40292-025-00726-9","relation":{},"ISSN":["1179-1985"],"issn-type":[{"value":"1179-1985","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,24]]},"assertion":[{"value":"22 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}