{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:45:45Z","timestamp":1793274345097,"version":"4.5.0"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Universit\u00e0 degli Studi di Napoli Federico II","id":[{"id":"https:\/\/ror.org\/05290cv24","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["High Blood Press Cardiovasc Prev"],"DOI":"10.1007\/s40292-026-00821-5","type":"journal-article","created":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T09:57:22Z","timestamp":1788688642000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Interventional Treatment of Arterial Hypertension in The Modern Era: An Updated Review"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5151-5133","authenticated-orcid":false,"given":"Yusuf Ziya","family":"\u015eener","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6690-1408","authenticated-orcid":false,"given":"Costantino","family":"Mancusi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0043-9051","authenticated-orcid":false,"given":"Alexandr","family":"Ceasovschih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7848-6600","authenticated-orcid":false,"given":"Andrej","family":"Belan\u010di\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4258-9928","authenticated-orcid":false,"given":"Ariadni","family":"Menti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5164-7435","authenticated-orcid":false,"given":"Christina","family":"Antza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2062-3649","authenticated-orcid":false,"given":"Diana","family":"Ferrao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3322-4831","authenticated-orcid":false,"given":"Jelena","family":"Petrovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5455-8769","authenticated-orcid":false,"given":"Justine","family":"Huart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4738-8044","authenticated-orcid":false,"given":"Karel","family":"L\u00e1br","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8507-269X","authenticated-orcid":false,"given":"Ilaria","family":"Fucile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5306-4698","authenticated-orcid":false,"given":"Marijana","family":"Vu\u010dkovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Porcnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1268-0878","authenticated-orcid":false,"given":"Petra","family":"Sinigoj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0894-2644","authenticated-orcid":false,"given":"Niki","family":"Katsiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"key":"821_CR1","unstructured":"NCD Risk Factor Collaboration (NCD-RisC).Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet. 2021;398(10304):957-80."},{"issue":"15","key":"821_CR2","first-page":"1101","volume":"38","author":"MD Lobo","year":"2017","unstructured":"Lobo MD, Sobotka PA, Pathak A. Interventional procedures and future drug therapy for hypertension. Eur Heart J. 2017;38(15):1101\u201311.","journal-title":"Eur Heart J"},{"issue":"5","key":"821_CR3","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1097\/HJH.0b013e328352ce78","volume":"30","author":"RE Schmieder","year":"2012","unstructured":"Schmieder RE, Redon J, Grassi G, Kjeldsen SE, Mancia G, Narkiewicz K, et al. ESH position paper: renal denervation\u2014an interventional therapy of resistant hypertension. J Hypertens. 2012;30(5):837\u201341.","journal-title":"J Hypertens"},{"issue":"6","key":"821_CR4","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s40292-022-00539-0","volume":"29","author":"O Jami","year":"2022","unstructured":"Jami O, Tijani Y, Et-Tahir A. Device-based therapy for resistant hypertension: an up-to-date review. High Blood Press Cardiovasc Prev. 2022;29(6):537\u201346.","journal-title":"High Blood Press Cardiovasc Prev"},{"issue":"7","key":"821_CR5","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1161\/CIRCRESAHA.121.318091","volume":"128","author":"F Mahfoud","year":"2021","unstructured":"Mahfoud F, Schlaich MP, Lobo MD. Device therapy of hypertension. Circ Res. 2021;128(7):1080\u201399.","journal-title":"Circ Res"},{"issue":"12","key":"821_CR6","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1111\/jch.14945","volume":"26","author":"TD Wang","year":"2024","unstructured":"Wang TD. Renal denervation: new evidence supporting long-term efficacy, alternative access routes, and cost-effectiveness. J Clin Hypertens. 2024;26(12):1528\u201330.","journal-title":"J Clin Hypertens"},{"issue":"4","key":"821_CR7","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1161\/HYPERTENSIONAHA.123.21710","volume":"81","author":"VJ Dzau","year":"2024","unstructured":"Dzau VJ, Hodgkinson CP. Precision hypertension. Hypertension. 2024;81(4):702\u20138.","journal-title":"Hypertension"},{"issue":"2","key":"821_CR8","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/s41440-021-00827-7","volume":"45","author":"K Katsurada","year":"2022","unstructured":"Katsurada K, Shinohara K, Aoki J, Nanto S, Kario K. Renal denervation: basic and clinical evidence. Hypertens Res. 2022;45(2):198\u2013209.","journal-title":"Hypertens Res"},{"key":"821_CR9","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.carrev.2025.05.014","volume":"77","author":"A Iyer","year":"2025","unstructured":"Iyer A, Roh S, Muhammad H, Hammad A, Kumar V, Patel D, et al. Renal denervation for resistant hypertension: a review of current literature. Cardiovasc Revasc Med. 2025;77:122\u20137.","journal-title":"Cardiovasc Revasc Med"},{"issue":"15","key":"821_CR10","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1093\/eurheartj\/ehad054","volume":"44","author":"E Barbato","year":"2023","unstructured":"Barbato E, Azizi M, Schmieder RE, Lauder L, B\u00f6hm M, Brouwers S, et al. Renal denervation in the management of hypertension in adults. A clinical consensus statement of the ESC council on hypertension and the European association of percutaneous cardiovascular interventions (EAPCI). Eur Heart J. 2023;44(15):1313\u201330.","journal-title":"Eur Heart J"},{"issue":"4","key":"821_CR11","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jcin.2019.10.048","volume":"13","author":"F Mahfoud","year":"2020","unstructured":"Mahfoud F, Renkin J, Sievert H, Bertog S, Ewen S, B\u00f6hm M, et al. Alcohol-mediated renal denervation using the Peregrine system infusion catheter for treatment of hypertension. JACC Cardiovasc Interv. 2020;13(4):471\u201384.","journal-title":"JACC Cardiovasc Interv"},{"issue":"6","key":"821_CR12","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jcin.2015.11.041","volume":"9","author":"TA Fischell","year":"2016","unstructured":"Fischell TA, Ebner A, Gallo S, Ikeno F, Minarsch L, Vega F, et al. Transcatheter alcohol-mediated perivascular renal denervation with the peregrine system: first-in-human experience. JACC Cardiovasc Interv. 2016;9(6):589\u201398.","journal-title":"JACC Cardiovasc Interv"},{"issue":"24","key":"821_CR13","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1161\/CIRCULATIONAHA.124.069291","volume":"149","author":"DE Kandzari","year":"2024","unstructured":"Kandzari DE, Weber MA, Pathak A, Zidar JP, Saxena M, David SW, et al. Effect of alcohol-mediated renal denervation on blood pressure in the presence of antihypertensive medications: primary results from the TARGET BP I randomized clinical trial. Circulation. 2024;149(24):1875\u201384.","journal-title":"Circulation"},{"key":"821_CR14","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ahj.2021.05.015","volume":"239","author":"F Mahfoud","year":"2021","unstructured":"Mahfoud F, Weber M, Schmieder RE, Lobo MD, Blankestijn PJ, Persu A, et al. Catheter-based alcohol-mediated renal denervation for the treatment of uncontrolled hypertension: design of two sham-controlled, randomized, blinded trials in the absence (TARGET BP OFF-MED) and presence (TARGET BP I) of antihypertensive medications. Am Heart J. 2021;239:90\u20139.","journal-title":"Am Heart J"},{"issue":"1","key":"821_CR15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2174\/1573402115666191011111402","volume":"16","author":"G Lamirault","year":"2020","unstructured":"Lamirault G, Artifoni M, Daniel M, Barber-Chamoux N. Nantes University hospital working group on H. Resistant hypertension: novel insights. Curr Hypertens Rev. 2020;16(1):61\u201372.","journal-title":"Curr Hypertens Rev"},{"issue":"12","key":"821_CR16","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1097\/HJH.0000000000003480","volume":"41","author":"G Mancia","year":"2023","unstructured":"Mancia G, Kreutz R, Brunstrom M, Burnier M, Grassi G, Januszewicz A, et al. 2023 ESH guidelines for the management of arterial hypertension the task force for the management of arterial hypertension of the European Society of hypertension: endorsed by the international society of hypertension (ISH) and the European renal association (ERA). J Hypertens. 2023;41(12):1874\u20132071.","journal-title":"J Hypertens"},{"issue":"15","key":"821_CR17","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1056\/NEJMoa1402670","volume":"370","author":"DL Bhatt","year":"2014","unstructured":"Bhatt DL, Kandzari DE, O\u2019Neill WW, D\u2019Agostino R, Flack JM, Katzen BT, et al. A controlled trial of renal denervation for resistant hypertension. N Engl J Med. 2014;370(15):1393\u2013401.","journal-title":"N Engl J Med"},{"issue":"10293","key":"821_CR18","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1016\/S0140-6736(21)00788-1","volume":"397","author":"M Azizi","year":"2021","unstructured":"Azizi M, Sanghvi K, Saxena M, Gosse P, Reilly JP, Levy T, et al. Ultrasound renal denervation for hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trial. Lancet. 2021;397(10293):2476\u201386.","journal-title":"Lancet"},{"key":"821_CR19","doi-asserted-by":"crossref","unstructured":"McEvoy JW, McCarthy CP, Bruno RM, Brouwers S, Canavan MD, Ceconi C, Christodorescu RM, Daskalopoulou SS, Ferro CJ, Gerdts E, Hanssen H, Harris J, Lauder L, McManus RJ, Molloy GJ, Rahimi K, Regitz-Zagrosek V, Rossi GP, Sandset EC, Scheenaerts B, Staessen JA, Uchmanowicz I, Volterrani M, Touyz RM; ESC Scientific Document Group. 2024 ESC Guidelines for the management of elevated blood pressure and hypertension. Eur Heart J. 2024;45(38):3912-4018.","DOI":"10.1093\/eurheartj\/ehae178"},{"issue":"2","key":"821_CR20","volume":"47","author":"L Xie","year":"2024","unstructured":"Xie L, Li Y, Luo S, Huang B. Impact of renal denervation on cardiac remodeling in resistant hypertension: a meta-analysis. Clin Cardiol. 2024;47(2):e24222.","journal-title":"Clin Cardiol"},{"issue":"8","key":"821_CR21","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1097\/HJH.0000000000001798","volume":"36","author":"A Kordalis","year":"2018","unstructured":"Kordalis A, Tsiachris D, Pietri P, Tsioufis C, Stefanadis C. Regression of organ damage following renal denervation in resistant hypertension: a meta-analysis. J Hypertens. 2018;36(8):1614\u201321.","journal-title":"J Hypertens"},{"issue":"3","key":"821_CR22","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1001\/jama.2019.21187","volume":"323","author":"JS Steinberg","year":"2020","unstructured":"Steinberg JS, Shabanov V, Ponomarev D, Losik D, Ivanickiy E, Kropotkin E, et al. Effect of renal denervation and catheter ablation vs catheter ablation alone on atrial fibrillation recurrence among patients with paroxysmal atrial fibrillation and hypertension: the ERADICATE-AF randomized clinical trial. JAMA. 2020;323(3):248\u201355.","journal-title":"JAMA"},{"issue":"5","key":"821_CR23","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.jacc.2022.11.038","volume":"81","author":"H Al Ghorani","year":"2023","unstructured":"Al Ghorani H, Kulenthiran S, Recktenwald MJM, Lauder L, Kunz M, G\u00f6tzinger F, et al. 10-year outcomes of catheter-based renal denervation in patients with resistant hypertension. J Am Coll Cardiol. 2023;81(5):517\u20139.","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"821_CR24","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1161\/01.HYP.0000111837.73693.9b","volume":"43","author":"TE Lohmeier","year":"2004","unstructured":"Lohmeier TE, Irwin ED, Rossing MA, Serdar DJ, Kieval RS. Prolonged activation of the baroreflex produces sustained hypotension. Hypertension. 2004;43(2):306\u201311.","journal-title":"Hypertension"},{"issue":"5","key":"821_CR25","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1161\/HYPERTENSIONAHA.107.099416","volume":"50","author":"MG Mohaupt","year":"2007","unstructured":"Mohaupt MG, Schmidli J, Luft FC. Management of uncontrollable hypertension with a carotid sinus stimulation device. Hypertension. 2007;50(5):825\u20138.","journal-title":"Hypertension"},{"issue":"8","key":"821_CR26","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nrcardio.2015.96","volume":"12","author":"RG Victor","year":"2015","unstructured":"Victor RG. Carotid baroreflex activation therapy for resistant hypertension. Nat Rev Cardiol. 2015;12(8):451\u201363.","journal-title":"Nat Rev Cardiol"},{"issue":"4","key":"821_CR27","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.ejvs.2006.11.025","volume":"33","author":"JH Tordoir","year":"2007","unstructured":"Tordoir JH, Scheffers I, Schmidli J, Savolainen H, Liebeskind U, Hansky B, et al. An implantable carotid sinus baroreflex activating system: surgical technique and short-term outcome from a multi-center feasibility trial for the treatment of resistant hypertension. Eur J Vasc Endovasc Surg. 2007;33(4):414\u201321.","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"Suppl R","key":"821_CR28","doi-asserted-by":"crossref","first-page":"R136","DOI":"10.4244\/EIJV9SRA23","volume":"9","author":"A Briasoulis","year":"2013","unstructured":"Briasoulis A, Bakris G. Efficacy of baroreflex activation therapy for the treatment of resistant hypertension. EuroIntervention. 2013;9(Suppl R):R136.","journal-title":"EuroIntervention"},{"issue":"6","key":"821_CR29","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.jvs.2006.08.024","volume":"44","author":"KA Illig","year":"2006","unstructured":"Illig KA, Levy M, Sanchez L, Trachiotis GD, Shanley C, Irwin E, et al. An implantable carotid sinus stimulator for drug-resistant hypertension: surgical technique and short-term outcome from the multicenter phase II Rheos feasibility trial. J Vasc Surg. 2006;44(6):1213\u20138.","journal-title":"J Vasc Surg"},{"issue":"15","key":"821_CR30","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.jacc.2010.03.089","volume":"56","author":"IJ Scheffers","year":"2010","unstructured":"Scheffers IJ, Kroon AA, Schmidli J, Jordan J, Tordoir JJ, Mohaupt MG, et al. Novel baroreflex activation therapy in resistant hypertension: results of a European multi-center feasibility study. J Am Coll Cardiol. 2010;56(15):1254\u20138.","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"821_CR31","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.jacc.2011.06.008","volume":"58","author":"JD Bisognano","year":"2011","unstructured":"Bisognano JD, Bakris G, Nadim MK, Sanchez L, Kroon AA, Schafer J, et al. Baroreflex activation therapy lowers blood pressure in patients with resistant hypertension: results from the double-blind, randomized, placebo-controlled rheos pivotal trial. J Am Coll Cardiol. 2011;58(7):765\u201373.","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"821_CR32","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jash.2012.04.004","volume":"6","author":"UC Hoppe","year":"2012","unstructured":"Hoppe UC, Brandt MC, Wachter R, Beige J, Rump LC, Kroon AA, et al. Minimally invasive system for baroreflex activation therapy chronically lowers blood pressure with pacemaker-like safety profile: results from the Barostim neo trial. J Am Soc Hypertens. 2012;6(4):270\u20136.","journal-title":"J Am Soc Hypertens"},{"issue":"3","key":"821_CR33","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s40292-015-0083-6","volume":"22","author":"G Seravalle","year":"2015","unstructured":"Seravalle G, Grassi G. Carotid baroreceptor stimulation in resistant hypertension and heart failure. High Blood Press Cardiovasc Prev. 2015;22(3):233\u20139.","journal-title":"High Blood Press Cardiovasc Prev"},{"issue":"5","key":"821_CR34","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s11906-018-0840-8","volume":"20","author":"M van Kleef","year":"2018","unstructured":"van Kleef M, Bates MC, Spiering W. Endovascular baroreflex amplification for resistant hypertension. Curr Hypertens Rep. 2018;20(5):46.","journal-title":"Curr Hypertens Rep"},{"issue":"2","key":"821_CR35","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-020-1019-7","volume":"22","author":"M Gierthmuehlen","year":"2020","unstructured":"Gierthmuehlen M, Plachta DTT, Zentner J. Implant-mediated therapy of arterial hypertension. Curr Hypertens Rep. 2020;22(2):16.","journal-title":"Curr Hypertens Rep"},{"issue":"10113","key":"821_CR36","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1016\/S0140-6736(17)32337-1","volume":"390","author":"W Spiering","year":"2017","unstructured":"Spiering W, Williams B, Van der Heyden J, van Kleef M, Lo R, Versmissen J, et al. Endovascular baroreflex amplification for resistant hypertension: a safety and proof-of-principle clinical study. Lancet. 2017;390(10113):2655\u201361.","journal-title":"Lancet"},{"issue":"7","key":"821_CR37","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1080\/17434440.2020.1779054","volume":"17","author":"MC Bates","year":"2020","unstructured":"Bates MC, Stone GW, Chen CY, Spiering W. Device profile of the MobiusHD EVBA system for the treatment of resistant hypertension: overview of its mechanism of action, safety and efficacy. Expert Rev Med Devices. 2020;17(7):649\u201358.","journal-title":"Expert Rev Med Devices"},{"issue":"3","key":"821_CR38","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2217\/fca-2020-0003","volume":"16","author":"J Halim","year":"2020","unstructured":"Halim J, Lycke M, Van der Heyden J. Endovascular baroreflex amplification for resistant hypertension: what you need to know. Future Cardiol. 2020;16(3):151\u20138.","journal-title":"Future Cardiol"},{"key":"821_CR39","doi-asserted-by":"crossref","unstructured":"van Kleef MEAM, Devireddy CM, van der Heyden J, Bates MC, Bakris GL, Stone GW, Williams B, Spiering W; CALM-FIM Investigators. Treatment of resistant hypertension with endovascular Baroreflex amplification: 3-year results from the CALM-FIM study. JACC Cardiovasc Interv. 2022; 15(3):321\u201332.","DOI":"10.1016\/j.jcin.2021.12.015"},{"issue":"9","key":"821_CR40","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1038\/hr.2014.91","volume":"37","author":"M Sinski","year":"2014","unstructured":"Sinski M, Lewandowski J, Przybylski J, Zalewski P, Symonides B, Abramczyk P, et al. Deactivation of carotid body chemoreceptors by hyperoxia decreases blood pressure in hypertensive patients. Hypertens Res. 2014;37(9):858\u201362.","journal-title":"Hypertens Res"},{"key":"821_CR41","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1038\/ncomms3395","volume":"4","author":"FD McBryde","year":"2013","unstructured":"McBryde FD, Abdala AP, Hendy EB, Pijacka W, Marvar P, Moraes DJ, et al. The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension. Nat Commun. 2013;4:2395.","journal-title":"Nat Commun"},{"issue":"17","key":"821_CR42","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1113\/jphysiol.2012.237800","volume":"590","author":"AP Abdala","year":"2012","unstructured":"Abdala AP, McBryde FD, Marina N, Hendy EB, Engelman ZJ, Fudim M, et al. Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat. J Physiol. 2012;590(17):4269\u201377.","journal-title":"J Physiol"},{"issue":"5","key":"821_CR43","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jacbts.2016.06.004","volume":"1","author":"K Narkiewicz","year":"2016","unstructured":"Narkiewicz K, Ratcliffe LE, Hart EC, Briant LJ, Chrostowska M, Wolf J, et al. Unilateral carotid body resection in resistant hypertension: a safety and feasibility trial. JACC Basic Transl Sci. 2016;1(5):313\u201324.","journal-title":"JACC Basic Transl Sci."},{"issue":"3","key":"821_CR44","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/ejhf.641","volume":"19","author":"P Niewinski","year":"2017","unstructured":"Niewinski P, Janczak D, Rucinski A, Tubek S, Engelman ZJ, Piesiak P, et al. Carotid body resection for sympathetic modulation in systolic heart failure: results from first-in-man study. Eur J Heart Fail. 2017;19(3):391\u2013400.","journal-title":"Eur J Heart Fail"},{"key":"821_CR45","doi-asserted-by":"crossref","unstructured":"Neuzil P, Merkely B, Erglis A, Marinskis G, de Groot JR, Schmidinger H, Rodriguez Venegas M, Voskuil M, Sturmberger T, Petru J, Jongejan N, Aichinger J, Kamzola G, Aidietis A, Gell\u00e9r L, Mraz T, Osztheimer I, Mika Y, Evans S, Burkhoff D, Kuck KH; BackBeat Study Investigators. Pacemaker-mediated programmable hypertension control therapy. J Am Heart Assoc. 2017;6(12):e006974","DOI":"10.1161\/JAHA.117.006974"},{"issue":"4","key":"821_CR46","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/jmri.23881","volume":"37","author":"T Alhogbani","year":"2013","unstructured":"Alhogbani T, Strohm O, Friedrich MG. Evaluation of left atrial contraction contribution to left ventricular filling using cardiovascular magnetic resonance. J Magn Reson Imaging. 2013;37(4):860\u20134.","journal-title":"J Magn Reson Imaging"},{"issue":"1","key":"821_CR47","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2014-000177","volume":"1","author":"PJ Bradshaw","year":"2014","unstructured":"Bradshaw PJ, Stobie P, Knuiman MW, Briffa TG, Hobbs MS. Trends in the incidence and prevalence of cardiac pacemaker insertions in an ageing population. Open Heart. 2014;1(1):e000177.","journal-title":"Open Heart"},{"issue":"16","key":"821_CR48","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.020492","volume":"10","author":"Z Kalarus","year":"2021","unstructured":"Kalarus Z, Merkely B, Neu\u017eil P, Grabowski M, Mitkowski P, Marinskis G, et al. Pacemaker-based cardiac neuromodulation therapy in patients with hypertension: a pilot Study. J Am Heart Assoc. 2021;10(16):e020492.","journal-title":"J Am Heart Assoc"},{"key":"821_CR49","volume":"13","author":"R Ems","year":"2019","unstructured":"Ems R, Garg A, Ostergard TA, Miller JP. Potential deep brain stimulation targets for the management of refractory hypertension. Front Neurosci. 2019;13:93.","journal-title":"Front Neurosci"},{"issue":"3","key":"821_CR50","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1109\/TBME.2013.2244890","volume":"60","author":"MD Johnson","year":"2013","unstructured":"Johnson MD, Lim HH, Netoff TI, Connolly AT, Johnson N, Roy A, et al. Neuromodulation for brain disorders: challenges and opportunities. IEEE Trans Biomed Eng. 2013;60(3):610\u201324.","journal-title":"IEEE Trans Biomed Eng"},{"key":"821_CR51","doi-asserted-by":"crossref","unstructured":"Greenberg's Handbook of Neurosurgery. 10th Edition ed: Thieme; 2023.","DOI":"10.1055\/b000000751"},{"issue":"16","key":"821_CR52","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1097\/01.wnr.0000183904.15773.47","volume":"16","author":"AL Green","year":"2005","unstructured":"Green AL, Wang S, Owen SL, Xie K, Liu X, Paterson DJ, et al. Deep brain stimulation can regulate arterial blood pressure in awake humans. NeuroReport. 2005;16(16):1741\u20135.","journal-title":"NeuroReport"},{"issue":"5","key":"821_CR53","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1161\/HYPERTENSIONAHA.113.02970","volume":"63","author":"YB Sverrisd\u00f3ttir","year":"2014","unstructured":"Sverrisd\u00f3ttir YB, Green AL, Aziz TZ, Bahuri NF, Hyam J, Basnayake SD, et al. Differentiated baroreflex modulation of sympathetic nerve activity during deep brain stimulation in humans. Hypertension. 2014;63(5):1000\u201310.","journal-title":"Hypertension"},{"issue":"Pt 1","key":"821_CR54","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1113\/jphysiol.1994.sp020174","volume":"477","author":"K Inui","year":"1994","unstructured":"Inui K, Murase S, Nosaka S. Facilitation of the arterial baroreflex by the ventrolateral part of the midbrain periaqueductal grey matter in rats. J Physiol. 1994;477(Pt 1):89\u2013101.","journal-title":"J Physiol"},{"issue":"7","key":"821_CR55","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/nrneurol.2012.100","volume":"8","author":"JA Hyam","year":"2012","unstructured":"Hyam JA, Kringelbach ML, Silburn PA, Aziz TZ, Green AL. The autonomic effects of deep brain stimulation\u2014a therapeutic opportunity. Nat Rev Neurol. 2012;8(7):391\u2013400.","journal-title":"Nat Rev Neurol"},{"issue":"2","key":"821_CR56","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1001\/jamaneurol.2017.3344","volume":"75","author":"N Lacuey","year":"2018","unstructured":"Lacuey N, Hampson JP, Theeranaew W, Zonjy B, Vithala A, Hupp NJ, et al. Cortical structures associated with human blood pressure control. JAMA Neurol. 2018;75(2):194\u2013202.","journal-title":"JAMA Neurol"},{"issue":"6","key":"821_CR57","volume":"59","author":"\u017d Chomanskis","year":"2023","unstructured":"Chomanskis \u017d, Jonkus V, Danielius T, Paulauskas T, Orvydait\u0117 M, Melaika K, et al. Hypotensive effect of electric stimulation of caudal ventrolateral medulla in freely moving rats. Medicina (Kaunas). 2023;59(6):1046.","journal-title":"Medicina (Kaunas)"},{"issue":"3","key":"821_CR58","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci13030504","volume":"13","author":"\u017d Chomanskis","year":"2023","unstructured":"Chomanskis \u017d, Jonkus V, Danielius T, Paulauskas T, Orvydait\u0117 M, Melaika K, et al. Remotely programmable deep brain stimulator combined with an invasive blood pressure monitoring system for a non-tethered rat model in hypertension research. Brain Sci. 2023;13(3):504.","journal-title":"Brain Sci"},{"issue":"4","key":"821_CR59","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.brs.2024.07.002","volume":"17","author":"J Mun","year":"2024","unstructured":"Mun J, Lee J, Park SM. Real-time closed-loop brainstem stimulation modality for enhancing temporal blood pressure reduction. Brain Stimul. 2024;17(4):826\u201335.","journal-title":"Brain Stimul"},{"issue":"6","key":"821_CR60","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.brs.2024.12.002","volume":"17","author":"H Lea-Banks","year":"2024","unstructured":"Lea-Banks H, Chauhan N, Hynynen K. Investigating the hypotensive effect of focused ultrasound neuromodulation and barbiturate-loaded nanodroplets in healthy and hypertensive rats. Brain Stimul. 2024;17(6):1317\u201327.","journal-title":"Brain Stimul"},{"issue":"6","key":"821_CR61","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.jocn.2006.04.015","volume":"14","author":"AL Green","year":"2007","unstructured":"Green AL, Wang S, Bittar RG, Owen SL, Paterson DJ, Stein JF, et al. Deep brain stimulation: a new treatment for hypertension? J Clin Neurosci. 2007;14(6):592\u20135.","journal-title":"J Clin Neurosci"},{"issue":"1","key":"821_CR62","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jocn.2009.02.041","volume":"17","author":"EA Pereira","year":"2010","unstructured":"Pereira EA, Wang S, Paterson DJ, Stein JF, Aziz TZ, Green AL. Sustained reduction of hypertension by deep brain stimulation. J Clin Neurosci. 2010;17(1):124\u20137.","journal-title":"J Clin Neurosci"},{"issue":"4","key":"821_CR63","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1212\/WNL.0b013e3182088108","volume":"76","author":"NK Patel","year":"2011","unstructured":"Patel NK, Javed S, Khan S, Papouchado M, Malizia AL, Pickering AE, et al. Deep brain stimulation relieves refractory hypertension. Neurology. 2011;76(4):405\u20137.","journal-title":"Neurology"},{"issue":"4","key":"821_CR64","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1161\/HYPERTENSIONAHA.116.08972","volume":"69","author":"EL O'Callaghan","year":"2017","unstructured":"O\u2019Callaghan EL, Hart EC, Sims-Williams H, Javed S, Burchell AE, Papouchado M, et al. Chronic deep brain stimulation decreases blood pressure and sympathetic nerve activity in a drug- and device-resistant hypertensive patient. Hypertension. 2017;69(4):522\u20138.","journal-title":"Hypertension"},{"issue":"3","key":"821_CR65","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1525-1403.2010.00274.x","volume":"13","author":"AL Green","year":"2010","unstructured":"Green AL, Hyam JA, Williams C, Wang S, Shlugman D, Stein JF, et al. Intra-operative deep brain stimulation of the periaqueductal grey matter modulates blood pressure and heart rate variability in humans. Neuromodulation. 2010;13(3):174\u201381.","journal-title":"Neuromodulation"},{"issue":"6","key":"821_CR66","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1161\/HYP.0000000000000066","volume":"71","author":"PK Whelton","year":"2018","unstructured":"Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: a report of the American college of cardiology\/American heart association task force on clinical practice guidelines. Hypertension. 2018;71(6):1269\u2013324.","journal-title":"Hypertension"},{"issue":"6","key":"821_CR67","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1097\/HJH.0000000000002453","volume":"38","author":"T Unger","year":"2020","unstructured":"Unger T, Borghi C, Charchar F, Khan NA, Poulter NR, Prabhakaran D, et al. 2020 International Society of Hypertension global hypertension practice guidelines. J Hypertens. 2020;38(6):982\u20131004.","journal-title":"J Hypertens"},{"issue":"5","key":"821_CR68","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2217\/fca.15.34","volume":"11","author":"TJ Brier","year":"2015","unstructured":"Brier TJ, Jain AK, Lobo MD. Central arteriovenous anastomosis for hypertension: it is not all about sympathomodulation. Future Cardiol. 2015;11(5):503\u20136.","journal-title":"Future Cardiol"},{"issue":"1","key":"821_CR69","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/MNH.0000000000000379","volume":"27","author":"V Kapil","year":"2018","unstructured":"Kapil V, Sobotka PA, Lobo MD, Schmieder RE. Central arteriovenous anastomosis to treat resistant hypertension. Curr Opin Nephrol Hypertens. 2018;27(1):8\u201315.","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"4","key":"821_CR70","doi-asserted-by":"crossref","first-page":"223","DOI":"10.14797\/mdcj-11-4-223","volume":"11","author":"N Paivanas","year":"2015","unstructured":"Paivanas N, Bisognano JD, Gassler JP. Carotid baroreceptor stimulation and arteriovenous shunts for resistant hypertension. Methodist Debakey Cardiovasc J. 2015;11(4):223\u20137.","journal-title":"Methodist Debakey Cardiovasc J"},{"issue":"8","key":"821_CR71","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.34067\/KID.0000000000000198","volume":"4","author":"G Masson","year":"2023","unstructured":"Masson G, Viva T, Huart J, Weekers L, Bonvoisin C, Bouquegneau A, et al. The effect of elective ligation of the arteriovenous fistula on cardiac and renal functions in kidney transplant recipients. Kidney360. 2023;4(8):1130\u20138.","journal-title":"Kidney360"},{"key":"821_CR72","doi-asserted-by":"crossref","unstructured":"Lobo MD, Sobotka PA, Stanton A, Cockcroft JR, Sulke N, Dolan E, van der Giet M, Hoyer J, Furniss SS, Foran JP, Witkowski A, Januszewicz A, Schoors D, Tsioufis K, Rensing BJ, Scott B, Ng GA, Ott C, Schmieder RE; ROX CONTROL HTN Investigators. Central arteriovenous anastomosis for the treatment of patients with uncontrolled hypertension (the ROX CONTROL HTN study): a randomised controlled trial. Lancet. 2015 Apr 25;385(9978):1634-41.","DOI":"10.1016\/S0140-6736(14)62053-5"},{"issue":"1","key":"821_CR73","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1161\/CIRCINTERVENTIONS.111.964494","volume":"5","author":"SC Bertog","year":"2012","unstructured":"Bertog SC, Kolmer C, Kleschnew S, Franke J, Wunderlich N, Kardos P, et al. Percutaneous femoral arteriovenous shunt creation for advanced chronic obstructive pulmonary disease: a single-center safety and efficacy study. Circ Cardiovasc Interv. 2012;5(1):118\u201326.","journal-title":"Circ Cardiovasc Interv"},{"issue":"6","key":"821_CR74","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1161\/HYPERTENSIONAHA.117.10142","volume":"70","author":"MD Lobo","year":"2017","unstructured":"Lobo MD, Ott C, Sobotka PA, Saxena M, Stanton A, Cockcroft JR, et al. Central iliac arteriovenous anastomosis for uncontrolled hypertension: one-year results from the ROX CONTROL HTN trial. Hypertension. 2017;70(6):1099\u2013105.","journal-title":"Hypertension"},{"key":"821_CR75","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ijcard.2017.10.042","volume":"250","author":"H Triantafyllidi","year":"2018","unstructured":"Triantafyllidi H, Arvaniti C, Schoinas A, Benas D, Vlachos S, Palaiodimos L, et al. Bilateral sphenopalatine ganglion block reduces blood pressure in never treated patients with essential hypertension. A randomized controlled single-blinded study. Int J Cardiol. 2018;250:233\u20139.","journal-title":"Int J Cardiol"},{"issue":"1","key":"821_CR76","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0006-8993(95)01206-0","volume":"707","author":"PJ Goadsby","year":"1996","unstructured":"Goadsby PJ, Uddman R, Edvinsson L. Cerebral vasodilatation in the cat involves nitric oxide from parasympathetic nerves. Brain Res. 1996;707(1):110\u20138.","journal-title":"Brain Res"},{"key":"821_CR77","first-page":"2516953","volume":"2018","author":"M Binfalah","year":"2018","unstructured":"Binfalah M, Alghawi E, Shosha E, Alhilly A, Bakhiet M. Sphenopalatine ganglion block for the treatment of acute migraine headache. Pain Res Treat. 2018;2018:2516953.","journal-title":"Pain Res Treat"},{"key":"821_CR78","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/ehaa946.2786","author":"H Triantafyllidi","year":"2020","unstructured":"Triantafyllidi H, Arvaniti C, Benas D, Schoinas A, Voutsinos D, Ikonomidis I, et al. Bilateral sphenopalatine ganglion block reduces blood pressure and blood pressure variability in never treated patients with essential hypertension. Eur Heart J. 2020. https:\/\/doi.org\/10.1093\/ehjci\/ehaa946.2786.","journal-title":"Eur Heart J"},{"issue":"10","key":"821_CR79","first-page":"e212","volume":"82","author":"DW Jones","year":"2025","unstructured":"Jones DW, Ferdinand KC, Taler SJ, Johnson HM, Shimbo D, Abdalla M, et al. 2025 AHA\/ACC\/AANP\/AAPA\/ABC\/ACCP\/ACPM\/AGS\/AMA\/ASPC\/NMA\/PCNA\/SGIM guideline for the prevention, detection, evaluation and management of high blood pressure in adults: a report of the American college of cardiology\/American heart association joint committee on clinical practice guidelines. Hypertension. 2025;82(10):e212\u2013316.","journal-title":"Hypertension"},{"issue":"2","key":"821_CR80","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s40292-020-00367-0","volume":"27","author":"RM Bruno","year":"2020","unstructured":"Bruno RM, Taddei S, Borghi C, Colivicchi F, Desideri G, Grassi G, et al. Italian society of arterial hypertension (SIIA) position paper on the role of renal denervation in the management of the difficult-to-treat hypertensive patient. High Blood Press Cardiovasc Prev. 2020;27(2):109\u201317.","journal-title":"High Blood Press Cardiovasc Prev"},{"issue":"4","key":"821_CR81","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/BF03297636","volume":"19","author":"M Volpe","year":"2012","unstructured":"Volpe M, Rosei EA, Ambrosioni E, Cottone S, Cuspidi C, Borghi C, et al. Renal artery denervation for treating resistant hypertension: definition of the disease, patient selection and description of the procedure. High Blood Press Cardiovasc Prev. 2012;19(4):237\u201344.","journal-title":"High Blood Press Cardiovasc Prev"}],"updated-by":[{"DOI":"10.1007\/s40292-026-00831-3","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:00:00Z","timestamp":1793145600000}}],"container-title":["High Blood Pressure & Cardiovascular Prevention"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40292-026-00821-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40292-026-00821-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40292-026-00821-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T10:54:45Z","timestamp":1793271285000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40292-026-00821-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,6]]},"references-count":81,"alternative-id":["821"],"URL":"https:\/\/doi.org\/10.1007\/s40292-026-00821-5","relation":{},"ISSN":["1179-1985"],"issn-type":[{"value":"1179-1985","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,6]]},"assertion":[{"value":"4 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: \"the article title has been updated","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.\n                      Ethical approval\n                      Not applicable","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}]}}